11 research outputs found
The utility of Next Generation Sequencing for molecular diagnostics in Rett syndrome
- Author
- Aguirre F.J.
- Aleu M.
- Alonso X.
- Alsius M.
- Antiñolo G.
- Antonio V.S.
- Aquino L.
- Arellano C.
- Armstrong J.
- Arriola G.
- Arteaga R.
- Baena N.
- Barcos M.
- Belzunces N.
- Blasco L.
- Boronat S.
- Brandi N.
- Camacho T.
- Campistol J.
- Campo A.
- Cancho R.
- Candau R.
- Canós I.
- Carrascosa M.D.C.
- Carratalá-Marco F.
- Casano J.
- Castro P.
- Cobo A.
- Colomer J.
- Conejo D.
- Corrales M.J.
- Cortés R.
- Cruz G.
- Csányi G.
- De Santos M.T.
- De Toledo M.
- Del Campo M.
- Del Mar O''Callaghan M.
- Derdak S.
- Domingo R.
- Duat A.
- Duque R.
- Esparza A.M.
- Fernández R.
- Fons M.C.
- Fontalba A.
- Gallano P.
- Galán E.
- Gamundi M.J.
- Garcia-Catalan M.J.
- Garcia-Cazorla À.
- Garcia-Peñas J.J.
- García M.D.M.
- García P.L.
- García-Barcina M.
- García-Miñaur S.
- García-Silva M.T.
- Gassio R.
- Gerotina E.
- Geán E.
- Gil B.
- Gonzalez J.
- Gonzalez L.
- Gonzalez V.
- González G.
- Guillén E.
- Guitart M.
- Guitet M.
- Gutierrez J.M.
- Gutiérrez E.
- Gökben S.
- Herranz J.L.
- Iglesias G.
- Inmaculada Amorós M.
- Jimenez A.M.
- Karacic I.
- Lahoz C.H.
- Lao J.I.
- Lapunzina P.
- Lautre-Ecenarro M.J.
- Lluch M.D.
- López L.
- López-Ariztegui A.
- Macaya A.
- Marquez C.M.L.
- Martin-Tamayo P.
- Martinez F.
- Martín E.
- Martínez B.
- Martínez-Salcedo E.
- Marín R.
- Mas M.J.
- Mateo G.
- Mendez P.
- Moreno S.
- Mulas F.
- Narbona J.
- Nascimento A.
- Nieto M.
- Nunes T.F.
- Núñez N.
- Obón M.
- Onsurbe I.
- Ortez C.I.
- Orts E.
- Pacheco P.
- Parrilla R.
- Pascual S.I.
- Patiño A.
- Pineda M.
- Puche E.
- Pérez-Dueñas B.
- Pérez-Poyato M.
- Póo P.
- Ramos F.
- Raspall M.
- Roche A.
- Roldan S.
- Rosell J.
- Ruiz C.
- Ruiz-Falcó M.L.
- Russi M.E.
- Samarra J.
- Sanchez I.
- Sanmartin X.
- Sans A.
- Santacana A.
- Scholl-Bürgi S.
- Serrano M.
- Serrano N.
- Tendero A.
- Toro M.D.
- Torrents J.
- Tortosa D.
- Triviño E.
- Troncoso L.
- Trotta J.-R.
- Turrón E.
- Velázquez R.
- Ventura C.
- Verdú A.
- Vernet A.
- Vidal S.
- Vila M.T.
- Villar C.
- Vázquez C.
- Vázquez P.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Rett syndrome (RTT) is an early-onset neurodevelopmental disorder that almost exclusively affects girls and is totally disabling. Three genes have been identified that cause RTT: MECP2, CDKL5 and FOXG1. However, the etiology of some of RTT patients still remains unknown. Recently, next generation sequencing (NGS) has promoted genetic diagnoses because of the quickness and affordability of the method. To evaluate the usefulness of NGS in genetic diagnosis, we present the genetic study of RTT-like patients using different techniques based on this technology. We studied 1577 patients with RTT-like clinical diagnoses and reviewed patients who were previously studied and thought to have RTT genes by Sanger sequencing. Genetically, 477 of 1577 patients with a RTT-like suspicion have been diagnosed. Positive results were found in 30% by Sanger sequencing, 23% with a custom panel, 24% with a commercial panel and 32% with whole exome sequencing. A genetic study using NGS allows the study of a larger number of genes associated with RTT-like symptoms simultaneously, providing genetic study of a wider group of patients as well as significantly reducing the response time and cost of the study
Negative emissions—Part 1: Research landscape and synthesis
- Author
- Baes C F
- Barker T ed Metz B
- Betz G
- Blanford G J
- Caldecott B
- Ciais P ed Stocker T F
- Clarke L E ed Edenhofer O
- Clingerman F
- Dominic Lenzi
- Edenhofer O ed Edenhofer O
- Felix Creutzig
- Flegal J A
- Fleming J R
- Friends of the Earth
- Fuss S
- Fuss S
- Gardiner S M
- Gardiner S M ed Gardiner S
- Gregory F Nemet
- Gunnar Luderer
- Hale B ed Preston C J
- Hamilton C
- Hourcade J-C ed Bruce J P
- Humpenöder F
- IPCC ed Bruce J P
- IPCC ed Core Writing Team
- IPCC ed Edenhofer O
- IPCC ed Edenhofer O
- IPCC ed Edenhofer O
- IPCC ed Field C B
- IPCC ed Houghton J T
- IPCC ed McCarthy J J
- IPCC ed Meira-Filho L G
- IPCC ed Metz B
- IPCC ed Metz B
- IPCC ed Parry M
- IPCC ed Solomon S
- IPCC ed Stocker T F
- IPCC ed Watson R T
- Jan C Minx
- Jennifer Wilcox
- Jens Hartmann
- Jepma C J
- Joeri Rogelj
- Johannessen S C
- Jose Luis Vicente Vicente
- Jérôme Hilaire
- Kauppi P
- Kolstad C
- Kriegler E
- Kupfer D
- Lenzi D
- Luderer G
- Luderer G
- Lukacs M
- Maria del Mar Zamora Dominguez
- Max W Callaghan
- McLaren D ed Preston C J
- Minx J
- Minx J C
- Morrow D R
- Nabuurs G J ed Metz B
- National Academy of Sciences
- National Research Council
- National Research Council
- Nemet G F
- Pete Smith
- Petticrew M
- Preston C J
- Rao S
- Rickels W
- Ringquist E
- Royal Society
- Sabine Fuss
- Shepherd J
- Shindell D ed Stocker T F
- Shrader-Frechette K S ed Maltais A
- Smith P ed Metz B
- Strefler J
- Tarun Khanna
- Thorben Amann
- Tim Beringer
- UNFCCC
- Wagner de Oliveira Garcia
- William F Lamb
- Publication venue
- 'IOP Publishing'
- Publication date
- Field of study
All-sky search for continuous gravitational waves from isolated neutron stars using Advanced LIGO and Advanced Virgo O3 data
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- Y. Himemoto
- Y. Hsu
- Y. Inoue
- Y. Itoh
- Y. Kao
- Y. Kobayashi
- Y. Kuromiya
- Y. Levin
- Y. Michimura
- Y. Minenkov
- Y. Mori
- Y. Moriwaki
- Y. Nakayama
- Y. Obayashi
- Y. Okutani
- Y. Saito
- Y. Sekiguchi
- Y. Setyawati
- Y. Shikano
- Y. Verma
- Y. Yang
- Y. Zhang
- Y. Zhao
- Yang Yang
- Yiting Huang
- Yiwen Huang
- Yue Zhao
- Z. -H. Zhu
- Z. ???J. Holmes
- Z. Cao
- Z. Chen
- Z. Doctor
- Z. Etienne
- Z. Frei
- Z. M??rka
- Z. Mark
- Z. Tornasi
- Z. Zhou
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2022
- Field of study
We present results of an all-sky search for continuous gravitational waves which can be produced by spinning neutron stars with an asymmetry around their rotation axis, using data from the third observing run of the Advanced LIGO and Advanced Virgo detectors. Four different analysis methods are used to search in a gravitational-wave frequency band from 10 to 2048 Hz and a first frequency derivative from −10^−8 to 10^−9 Hz/s. No statistically significant periodic gravitational-wave signal is observed by any of the four searches. As a result, upper limits on the gravitational-wave strain amplitude h0 are calculated. The best upper limits are obtained in the frequency range of 100 to 200 Hz and they are ∼1.1×10^−25 at 95% confidence level. The minimum upper limit of 1.10×10^−25 is achieved at a frequency 111.5 Hz. We also place constraints on the rates and abundances of nearby planetary- and asteroid-mass primordial black holes that could give rise to continuous gravitational-wave signals
All-sky search for gravitational wave emission from scalar boson clouds around spinning black holes in LIGO O3 data
- Author
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- A. ???B. Yelikar
- A. ???B. Zimmerman
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- A. ???G. Hernandez
- A. ???G. Sullivan
- A. ???J. Tanasijczuk
- A. ???J. Weinstein
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- A. ???K. Divakarla
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- Y. Bai
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- Y. Fujikawa
- Y. Fujimoto
- Y. Guo
- Y. Himemoto
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- Y. Itoh
- Y. Kao
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- Y. Levin
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- Y. Obayashi
- Y. Okutani
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- Y. Setyawati
- Y. Shikano
- Y. Verma
- Y. Yang
- Y. Zhang
- Y. Zhao
- Yang Yang
- Yiting Huang
- Yiwen Huang
- Yue Zhao
- Z. -H. Zhu
- Z. ???J. Holmes
- Z. Cao
- Z. Chen
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- Z. Etienne
- Z. Frei
- Z. M??rka
- Z. Mark
- Z. Tornasi
- Z. Zhou
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2022
- Field of study
This paper describes the first all-sky search for long-duration, quasimonochromatic gravitational-wave signals emitted by ultralight scalar boson clouds around spinning black holes using data from the third observing run of Advanced LIGO. We analyze the frequency range from 20 to 610 Hz, over a small frequency derivative range around zero, and use multiple frequency resolutions to be robust towards possible signal frequency wanderings. Outliers from this search are followed up using two different methods, one more suitable for nearly monochromatic signals, and the other more robust towards frequency fluctuations. We do not find any evidence for such signals and set upper limits on the signal strain amplitude, the most stringent being ???10???25 at around 130 Hz. We interpret these upper limits as both an ???exclusion region??? in the boson mass/black hole mass plane and the maximum detectable distance for a given boson mass, based on an assumption of the age of the black hole/boson cloud system
Search for continuous gravitational wave emission from the Milky??Way center in O3 LIGO-Virgo data
- Author
- A. ???A. Ciobanu
- A. ???B. Yelikar
- A. ???C. Green
- A. ???C. Jenkins
- A. ???D. Huddart
- A. ???D. Viets
- A. ???E. Gleckl
- A. ???E. Pace
- A. ???E. Tolley
- A. ???F. Brooks
- A. ???F. Helmling-Cornell
- A. ???F. Vargas
- A. ???G. Hernandez
- A. ???G. Sullivan
- A. ???J. Tanasijczuk
- A. ???J. Weinstein
- A. ???K. ???H. Kong
- A. ???K. ???Y. Li
- A. ???K. Divakarla
- A. ???K. Mehta
- A. ???K. Prajapati
- A. ???K. Srivastava
- A. ???L. Hewitt
- A. ???L. James
- A. ???L. Miller
- A. ???L. Stuver
- A. ???L. Urban
- A. ???M. Baer
- A. ???M. Farah
- A. ???M. Gretarsson
- A. ???M. Gunny
- A. ???M. Knee
- A. ???M. Sintes
- A. ???M. Toivonen
- A. ???P. Lundgren
- A. ???P. Spencer
- A. ???R. Guimaraes
- A. ???R. Williamson
- A. ???S. Gruson
- A. ???S. Hines
- A. ???S. Markosyan
- A. ???S. Patron
- A. ???S. Sengupta
- A. ???S. Ubhi
- A. ???V. Bhandari
- A. ???W. Criswell
- A. ???W. Jones
- A. ???Z. Jan
- A. Ain
- A. Allocca
- A. Amato
- A. Ananyeva
- A. Araya
- A. Balsamo
- A. Basti
- A. Bertolini
- A. Bianchi
- A. Bisht
- A. Bozzi
- A. Bramley
- A. Branch
- A. Brillet
- A. Buonanno
- A. Chincarini
- A. Chiummo
- A. Colombo
- A. Corsi
- A. Cumming
- A. Dana
- A. Dasgupta
- A. Depasse
- A. Di Lieto
- A. Di Michele
- A. Dmitriev
- A. Effler
- A. Ejlli
- A. Fernandez-Galiana
- A. Fiori
- A. Franke
- A. Freise
- A. Ganguly
- A. Gennai
- A. Grado
- A. Grant
- A. Grimaldi
- A. Heidmann
- A. Heidt
- A. Hreibi
- A. Iess
- A. Jue
- A. Kim
- A. Kontos
- A. Kr??lak
- A. Kumar
- A. Lamberts
- A. Lartaux-Vollard
- A. Lazzarini
- A. Lema??tre
- A. Longo
- A. Macquet
- A. Malik
- A. Markowitz
- A. Marquina
- A. Masserot
- A. Matas
- A. Melatos
- A. Menendez-Vazquez
- A. Mhaske
- A. Miani
- A. Miller
- A. Mishkin
- A. More
- A. Mullavey
- A. Nagar
- A. Nelson
- A. Neunzert
- A. Nishizawa
- A. Pai
- A. Paoli
- A. Paolone
- A. Parisi
- A. Pasqualetti
- A. Pele
- A. Perego
- A. Pereira
- A. Perreca
- A. Placidi
- A. Poverman
- A. Puecher
- A. Ramos-Buades
- A. Ray
- A. Renzini
- A. Reza
- A. Rocchi
- A. Romero
- A. Samajdar
- A. Sanuy
- A. Sch??nbeck
- A. Sergeev
- A. Sharma
- A. Sheela
- A. Shoda
- A. Singha
- A. Strunk
- A. Sur
- A. Taruya
- A. Torres-Forn??
- A. Trapananti
- A. Tripathee
- A. Trovato
- A. Ueda
- A. Utina
- A. Vajpeyi
- A. Vecchio
- A. Vicer??
- A. Vijaykumar
- A. Virtuoso
- A. Zadro??ny
- Abhirup Ghosh
- Anchal Gupta
- Anuradha Gupta
- Archisman Ghosh
- Arunava Mukherjee
- B-H. Hsieh
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- B. ???B. Lane
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- B. ???C. Pant
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- B. ???U. Gadre
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- B. Banerjee
- B. Barr
- B. Biswas
- B. Cousins
- B. D???Angelo
- B. Ding
- B. Edelman
- B. Farr
- B. Fornal
- B. Garaventa
- B. Gateley
- B. Giacomazzo
- B. Goncharov
- B. Grace
- B. Haskell
- B. Hughey
- B. Idzkowski
- B. Kamai
- B. Lantz
- B. Li
- B. Miller
- B. Mours
- B. Nayak
- B. O???Reilly
- B. Patricelli
- B. Revenu
- B. Sassolas
- B. Shams
- B. Weaver
- B. Willke
- C-Y. Chiang
- C-Y. Lin
- C. -H. Chan
- C. -J. Haster
- C. ???A. Costa
- C. ???A. Rose
- C. ???C. Perkins
- C. ???C. Wipf
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- C. ???G. Collette
- C. ???G. Hoy
- C. ???I. Torrie
- C. ???J. Moore
- C. ???J. Perez
- C. ???J. Talbot
- C. ???K. Cheong
- C. ???L. Chan
- C. ???L. Romel
- C. ???M. Compton
- C. ???M. Mow-Lowry
- C. ???M. Weller
- C. ???O. Lousto
- C. ???R. Weaving
- C. ???S. Menoni
- C. ???S. Unnikrishnan
- C. ???V. Kalaghatgi
- C. Affeldt
- C. Anand
- C. Austin
- C. Badger
- C. Barbieri
- C. Bradaschia
- C. Buy
- C. Cahillane
- C. Casentini
- C. Chan
- C. Chapman-Bird
- C. Chatterjee
- C. Chen
- C. Darsow-Fromm
- C. De Rossi
- C. Di Fronzo
- C. Di Giorgio
- C. Eassa
- C. Garc??a N????ez
- C. Garc??a-Quir??s
- C. Gier
- C. Gray
- C. Hanna
- C. Henshaw
- C. Hirose
- C. Hsiung
- C. Jeon
- C. Karathanasis
- C. Kim
- C. Kimball
- C. Kozakai
- C. Lazzaro
- C. Levesque
- C. Magazz??
- C. Markakis
- C. McIsaac
- C. Messenger
- C. Messick
- C. Michel
- C. Mishra
- C. Moreno
- C. Nguyen
- C. North
- C. Olivetto
- C. Osthelder
- C. P??rigois
- C. Palomba
- C. Pankow
- C. Pineda-Bosque
- C. Pluchar
- C. Rajan
- C. Stachie
- C. Talbot
- C. Taranto
- C. Van Den Broeck
- C. Vorvick
- C. Whittle
- C. Wu
- C. Zhao
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- D. ???A. Steer
- D. ???B. Kozak
- D. ???B. Tanner
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- D. ???C. Coyne
- D. ???C. Vander-Hyde
- D. ???D. Brown
- D. ???D. White
- D. ???E. Cohen
- D. ???E. Holz
- D. ???E. McClelland
- D. ???G. Blair
- D. ???G. Holcomb
- D. ???H. Reitze
- D. ???H. Shoemaker
- D. ???I. Jones
- D. ???J. Ottaway
- D. ???J. Stops
- D. ???J. Wilson
- D. ???L. Ferguson
- D. ???M. Coward
- D. ???M. Macleod
- D. ???M. Shoemaker
- D. ???M. Wysocki
- D. ???P. Kapasi
- D. ???P. Mihaylov
- D. ???R. Gibson
- D. ???S. Wu
- D. ???V. Martynov
- D. ???W. Gould
- D. ???W. Yeeles
- D. ???Y. ???T. Pong
- D. Agarwal
- D. Bankar
- D. Barker
- D. Barta
- D. Beniwal
- D. Bersanetti
- D. Beveridge
- D. Bhattacharjee
- D. Buskulic
- D. Chen
- D. Corre
- D. D???Urso
- D. Davis
- D. DeBra
- D. Dell???Aquila
- D. Estevez
- D. Ganapathy
- D. Gao
- D. Griffith
- D. Guerra
- D. Hartwig
- D. Hofman
- D. Hoyland
- D. Jariwala
- D. Keitel
- D. Laghi
- D. Lopez
- D. Lumaca
- D. Mar??n Pina
- D. Meacher
- D. Moraru
- D. Mukherjee
- D. Pascucci
- D. Passuello
- D. Pesios
- D. Petterson
- D. Richards
- D. Rosi??ska
- D. Rozza
- D. Schaetzl
- D. Sellers
- D. Sentenac
- D. Sigg
- D. Singh
- D. T??yr??
- D. Tao
- D. Tsai
- D. Tsuna
- D. Tuyenbayev
- D. Verkindt
- D. Veske
- D. Wilken
- D. Williams
- D. Wong
- Debarati Chatterjee
- Deep Chatterjee
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- E. ???A. Khazanov
- E. ???A. Mu??iz
- E. ???D. Hall
- E. ???E. Thompson
- E. ???G. Seo
- E. ???J. Daw
- E. ???J. Fauchon-Jones
- E. ???J. Howell
- E. ???J. Marx
- E. ???J. Sanchez
- E. ???K. Porter
- E. ???L. Merilh
- E. ???M. Gretarsson
- E. ???N. Tapia San Mart??n
- E. ???R. ???G. von Reis
- E. ???T. Lin
- E. ???Z. Appavuravther
- E. ???Z. Hamilton
- E. Bonilla
- E. Calloni
- E. Capocasa
- E. Capote
- E. Cesarini
- E. Champion
- E. Chassande-Mottin
- E. Coccia
- E. Codazzo
- E. Cuoco
- E. Engelby
- E. Fenyvesi
- E. Floden
- E. Goetz
- E. Grimes
- E. Hennes
- E. Katsavounidis
- E. Knyazev
- E. Lalande
- E. Lee
- E. Leonova
- E. Majorana
- E. Maros
- E. Massera
- E. Milotti
- E. Moguel
- E. Nitoglia
- E. O???Shea
- E. Oelker
- E. Payne
- E. Placidi
- E. Polini
- E. Schwartz
- E. Sowell
- E. Thrane
- F-K. Lin
- F-L. Lin
- F. ???E. Pe??a Arellano
- F. ???H. Panther
- F. ???J. Hayes
- F. ???J. Raab
- F. ???W. Yang
- F. ???Y. Khalili
- F. Acernese
- F. Aubin
- F. Badaracco
- F. Barone
- F. Beirnaert
- F. Bergamin
- F. Bobba
- F. Bondu
- F. Bucci
- F. Carbognani
- F. Cavalier
- F. Chiadini
- F. Cipriano
- F. Clara
- F. Cleva
- F. De Lillo
- F. De Matteis
- F. Di Giovanni
- F. Di Renzo
- F. Donovan
- F. Fabrizi
- F. Faedi
- F. Fidecaro
- F. Frasconi
- F. Garufi
- F. Gissi
- F. Guzman
- F. Hellman
- F. Hernandez Vivanco
- F. K??f??lian
- F. Kuei
- F. Linde
- F. Llamas
- F. Marchesoni
- F. Marion
- F. Martelli
- F. Matichard
- F. Meylahn
- F. Morawski
- F. Muciaccia
- F. Nocera
- F. Ohme
- F. Pannarale
- F. Paoletti
- F. Piergiovanni
- F. Pilo
- F. Puosi
- F. Ricci
- F. Robinet
- F. Salces-Carcoba
- F. Salemi
- F. Sorrentino
- F. Stachurski
- F. Travasso
- F. Vetrano
- F. Wellmann
- G. -G. Ge
- G. ???A. Prodi
- G. ???C. Liu
- G. ???G. Fronz??
- G. ???I. McGhee
- G. ???L. Mansell
- G. ???M. Guidi
- G. ???M. Harry
- G. ???N. Bolingbroke
- G. ???R. Johns
- G. ???S. Cabourn Davies
- G. ???S. Wallace
- G. Ashton
- G. Ballardin
- G. Baltus
- G. Billingsley
- G. Bogaert
- G. Bruno
- G. Cabras
- G. Cagnoli
- G. Carapella
- G. Carrillo
- G. Carullo
- G. Castaldi
- G. Cella
- G. Chiarini
- G. Ciani
- G. D??lya
- G. Eddolls
- G. Favaro
- G. Gemme
- G. Gonz??lez
- G. Greco
- G. Grignani
- G. Guix??
- G. Hammond
- G. Hemming
- G. Kang
- G. Koekoek
- G. Kuehn
- G. Lacaille
- G. Losurdo
- G. Lovelace
- G. Mendell
- G. Mitselmakher
- G. Moreno
- G. Nurbek
- G. Oganesyan
- G. Pagano
- G. Pagliaroli
- G. Pappas
- G. Pillant
- G. Pratten
- G. Raaijmakers
- G. Riemenschneider
- G. Stratta
- G. Traylor
- G. Ueshima
- G. Vajente
- G. Valdes
- G. Vedovato
- G. Venugopalan
- G. Woan
- G. Zhao
- Geoffrey Mo
- H-F. Hsieh
- H-Y. Huang
- H. -B. Jin
- H. -K. Guo
- H. ???A. Gabbard
- H. ???G. Suh
- H. ???J. Bulten
- H. ???K. Fong
- H. ???K. Gulati
- H. ???L. Griggs
- H. ???L. Lin
- H. ???L. Sawant
- H. ???M. Lee
- H. ???P. Pfeiffer
- H. ???W. Lee
- H. ???Y. Chen
- H. ???Y. Cheung
- H. ???Y. Chia
- H. Abe
- H. Asada
- H. Cao
- H. Cheng
- H. Estell??s
- H. Fair
- H. Grote
- H. Hansen
- H. Hayakawa
- H. Heitmann
- H. L??ck
- H. Masalehdan
- H. Miao
- H. Middleton
- H. Nakano
- H. Narola
- H. Ohta
- H. Overmier
- H. Pan
- H. Park
- H. Pham
- H. Phurailatpam
- H. Qi
- H. Radkins
- H. Satari
- H. Shimizu
- H. Shinkai
- H. Tagoshi
- H. Takahashi
- H. Takeda
- H. van Haevermaet
- H. Vocca
- H. Wu
- H. Yamamoto
- H. Yuzurihara
- H. Zhang
- Hang Yu
- Haocun Yu
- I. ???A. ???O. MacMillan
- I. ???A. Bilenko
- I. ???C. ???F. Wong
- I. ???J. Hollows
- I. ???M. Gupta
- I. ???M. Pinto
- I. ???M. Romero-Shaw
- I. ???N. Legred
- I. ???P. ???W. Hadiputrawan
- I. ???P. Chang
- I. ???S. Heng
- I. ???W. Harry
- I. ???W. Martin
- I. Bartos
- I. Belahcene
- I. Cordero-Carri??n
- I. Dave
- I. Di Palma
- I. Ferrante
- I. Fiori
- I. La Rosa
- I. Maga??a Hernandez
- I. Maksimovic
- I. Michaloliakos
- I. Molina
- I. Nardecchia
- I. Song
- I. Tosta e Melo
- J-S. Tsao
- J. -G. Ducoin
- J. -P. Coulon
- J. -P. Zendri
- J. -Y. Vinet
- J. ???A. Clark
- J. ???A. Font
- J. ???A. Giaime
- J. ???B. Camp
- J. ???B. Carlin
- J. ???B. Kanner
- J. ???B. Machtinger
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- J. ???C. Bayley
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- J. ???D. Bentley
- J. ???D. Callaghan
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- J. ???D. Tasson
- J. ???E. ???S. Terhune
- J. ???E. Brau
- J. ???E. Lynam
- J. ???E. Thompson
- J. ???F. ???J. van den Brand
- J. ???F. Lucaccioni
- J. ???G. Rollins
- J. ???H. Briggs
- J. ???H. Romie
- J. ???H. Sanchez
- J. ???J. McCann
- J. ???J. Oh
- J. ???K. Blackburn
- J. ???K. Wofford
- J. ???L. Willis
- J. ???M. Antelis
- J. ???N. Hohmann
- J. ???N. Leviton
- J. ???N. Linley
- J. ???P. Freed
- J. ???R. Cudell
- J. ???R. Gair
- J. ???R. Palamos
- J. ???R. Sanders
- J. ???R. Smith
- J. ???S. ???A. von Wrangel
- J. ???S. Areeda
- J. ???S. Hathaway
- J. ???S. Key
- J. ???S. Kissel
- J. ???T. Whelan
- J. ???V. van Heijningen
- J. ???W. Richardson
- J. ???Z. Wang
- J. Baird
- J. Bartlett
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- J. Gais
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- J. Smetana
- J. Soldateschi
- J. Steinlechner
- J. Suresh
- J. Veitch
- J. Venneberg
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- J. Watchi
- J. Woehler
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- J. Yoo
- J. Zhang
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- K. -C. Pan
- K. ???A. Pham
- K. ???A. Strain
- K. ???A. Thorne
- K. ???C. Cannon
- K. ???D. Giardina
- K. ???E. Ramirez
- K. ???G. Arun
- K. ???J. Wagner
- K. ???L. Dooley
- K. ???L. Li
- K. ???R. Corley
- K. ???S. Phukon
- K. ???W. Chung
- K. ???W. Tsang
- K. ???Y. Ng
- K. ???Z. Yang
- K. Ackley
- K. Agatsuma
- K. Arai
- K. AultONeal
- K. Burtnyk
- K. Chan
- K. Chandra
- K. Chen
- K. Danzmann
- K. Haris
- K. Hasegawa
- K. Hattori
- K. Haughian
- K. Hayama
- K. Holt
- K. Inayoshi
- K. Isleif
- K. Ito
- K. Jani
- K. Janssens
- K. Jenner
- K. Jung
- K. Kaihotsu
- K. Kawabe
- K. Kawaguchi
- K. Kim
- K. Kohri
- K. Kokeyama
- K. Komori
- K. Kuns
- K. Kwak
- K. Lee
- K. Leyde
- K. Liu
- K. Martinovic
- K. Mason
- K. Merfeld
- K. Miyo
- K. Mogushi
- K. Nagano
- K. Nakamura
- K. Oh
- K. Oohara
- K. Piotrzkowski
- K. Prasai
- K. Riles
- K. Rink
- K. Ruiz-Rocha
- K. Ryan
- K. Sakai
- K. Shimode
- K. Somiya
- K. Soni
- K. Staats
- K. Tanaka
- K. Turbang
- K. Ueno
- K. Wette
- K. Yamamoto
- K. Yamashita
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- L. ???A. Rees
- L. ???C. -C. Lin
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- L. ???D. Bonavena
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- L. ???E. Sanchez
- L. ???E. Wade
- L. ???K. Nuttall
- L. ???M. DeMarchi
- L. ???M. Modafferi
- L. ???P. Singer
- L. ???T. London
- L. Aiello
- L. Barsotti
- L. Cadonati
- L. Conti
- L. Cunningham
- L. D???Onofrio
- L. Di Fiore
- L. Donahue
- L. Errico
- L. Gergely
- L. Giacoppo
- L. Haegel
- L. Ju
- L. McCuller
- L. Mereni
- L. Milano
- L. Naticchioni
- L. Nguyen Quynh
- L. Pierini
- L. Pinard
- L. Prokhorov
- L. Prudenzi
- L. Rei
- L. Richardson
- L. Rolland
- L. Rosa
- L. Salconi
- L. Shao
- L. Silenzi
- L. Smith
- L. Sun
- L. Tao
- L. Terkowski
- L. Troiano
- L. Trozzo
- L. Tsukada
- L. Wallace
- L. Wen
- L. Xiao
- L. Yang
- L. Zhang
- Ll. ???M. Mir
- M. -A. Bizouard
- M. ???A. Barton
- M. ???A. Okada
- M. ???A. Page
- M. ???A. Shaikh
- M. ???C. Araya
- M. ???C. D??az
- M. ???C. Davis
- M. ???C. Heintze
- M. ???C. Tringali
- M. ???D. Hannam
- M. ???D. Pitkin
- M. ???D. Strong
- M. ???E. Zucker
- M. ???F. Carney
- M. ???G. Benjamin
- M. ???G. Schiworski
- M. ???H. ???P. ???M. van Putten
- M. ???H. Hennig
- M. ???J. Cowart
- M. ???J. Szczepa??czyk
- M. ???J. Williams
- M. ???J. Yap
- M. ???K. ???M. Bader
- M. ???K. Singh
- M. ???L. Chiofalo
- M. ???L. Planas
- M. ???M. Fejer
- M. ???P. Ross
- M. ???P. Thirugnanasambandam
- M. ???S. Shahriar
- M. ???T. H??bner
- M. ???W. Coughlin
- M. Agathos
- M. Ando
- M. Andr??s-Carcasona
- M. Ar??ne
- M. Arogeti
- M. Assiduo
- M. Ball
- M. Barsuglia
- M. Bawaj
- M. Bazzan
- M. Bejger
- M. BenYaala
- M. Berbel
- M. Bischi
- M. Bitossi
- M. Bo??r
- M. Boldrini
- M. Branchesi
- M. Breschi
- M. Brinkmann
- M. Caesar
- M. Canepa
- M. Cannavacciuolo
- M. Carlassara
- M. Carpinelli
- M. Cavagli??
- M. Chan
- M. Chaturvedi
- M. Cie??lar
- M. Cifaldi
- M. Colleoni
- M. Colpi
- M. Constancio
- M. Croquette
- M. Cury??o
- M. Davier
- M. De Laurentis
- M. Deenadayalan
- M. Di Giovanni
- M. Drago
- M. Ebersold
- M. Eisenmann
- M. Evans
- M. Favata
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- M. Fishbach
- M. Fyffe
- M. Giesler
- M. Gosselin
- M. Granata
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- M. Magnozzi
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- M. Merzougui
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- M. Pegoraro
- M. Pichot
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- M. Pinto
- M. Pirello
- M. Pracchia
- M. Principe
- M. Punturo
- M. Razzano
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- M. Trevor
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- Yiwen Huang
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
We present a directed search for continuous gravitational wave (CW) signals emitted by spinning neutron stars located in the inner parsecs of the Galactic Center (GC). Compelling evidence for the presence of a numerous population of neutron stars has been reported in the literature, turning this region into a very interesting place to look for CWs. In this search, data from the full O3 LIGO-Virgo run in the detector frequency band [10, 2000] Hz have been used. No significant detection was found and 95% confidence level upper limits on the signal strain amplitude were computed, over the full search band, with the deepest limit of about 7.6 x 10(-26) at similar or equal to 142 Hz. These results are significantly more constraining than those reported in previous searches. We use these limits to put constraints on the fiducial neutron star ellipticity and r-mode amplitude. These limits can be also translated into constraints in the black hole mass-boson mass plane for a hypothetical population of boson clouds around spinning black holes located in the GC
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- Publication venue
- Springer Nature
- Publication date
- 17/05/2023
- Field of study
Data availability: Downloadable summary data are available through the GenOMICC data site (https://genomicc.org/data). Summary statistics are available, but without the 23andMe summary statistics, except for the 10,000 most significant hits, for which full summary statistics are available. The full GWAS summary statistics for the 23andMe discovery dataset will be made available through 23andMe to qualified researchers under an agreement with 23andMe that protects the privacy of the 23andMe participants. For further information and to apply for access to the data, see the 23andMe website (https://research.23andMe.com/dataset-access/). All individual-level genotype and whole-genome sequencing data (for both academic and commercial uses) can be accessed through the UKRI/HDR UK Outbreak Data Analysis Platform (https://odap.ac.uk). A restricted dataset for a subset of GenOMICC participants is also available through the Genomics England data service. Monocyte RNA-seq data are available under the title ‘Monocyte gene expression data’ within the Oxford University Research Archives (https://doi.org/10.5287/ora-ko7q2nq66). Sequencing data will be made freely available to organizations and researchers to conduct research in accordance with the UK Policy Framework for Health and Social Care Research through a data access agreement. Sequencing data have been deposited at the European Genome–Phenome Archive (EGA), which is hosted by the EBI and the CRG, under accession number EGAS00001007111.Extended data figures and tables are available online at https://www.nature.com/articles/s41586-023-06034-3#Sec21 .Supplementary information is available online at https://www.nature.com/articles/s41586-023-06034-3#Sec22 .Code availability:
Code to calculate the imputation of P values on the basis of SNPs in linkage disequilibrium is available at GitHub (https://github.com/baillielab/GenOMICC_GWAS).Acknowledgements: We thank the members of the Banco Nacional de ADN and the GRA@CE cohort group; and the research participants and employees of 23andMe for making this work possible. A full list of contributors who have provided data that were collated in the HGI project, including previous iterations, is available online (https://www.covid19hg.org/acknowledgements).Change history: 11 July 2023: A Correction to this paper has been published at: https://doi.org/10.1038/s41586-023-06383-z. -- In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.Copyright © The Author(s) 2023, Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).GenOMICC was funded by Sepsis Research (the Fiona Elizabeth Agnew Trust), the Intensive Care Society, a Wellcome Trust Senior Research Fellowship (to J.K.B., 223164/Z/21/Z), the Department of Health and Social Care (DHSC), Illumina, LifeArc, the Medical Research Council, UKRI, a BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070 and BBS/E/D/30002275) and UKRI grants MC_PC_20004, MC_PC_19025, MC_PC_1905 and MRNO2995X/1. A.D.B. acknowledges funding from the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z), the Edinburgh Clinical Academic Track (ECAT) programme. This research is supported in part by the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation (grant MC_PC_20029). Laboratory work was funded by a Wellcome Intermediate Clinical Fellowship to B.F. (201488/Z/16/Z). We acknowledge the staff at NHS Digital, Public Health England and the Intensive Care National Audit and Research Centre who provided clinical data on the participants; and the National Institute for Healthcare Research Clinical Research Network (NIHR CRN) and the Chief Scientist’s Office (Scotland), who facilitate recruitment into research studies in NHS hospitals, and to the global ISARIC and InFACT consortia. GenOMICC genotype controls were obtained using UK Biobank Resource under project 788 funded by Roslin Institute Strategic Programme Grants from the BBSRC (BBS/E/D/10002070 and BBS/E/D/30002275) and Health Data Research UK (HDR-9004 and HDR-9003). UK Biobank data were used in the GSMR analyses presented here under project 66982. The UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government, British Heart Foundation and Diabetes UK. The work of L.K. was supported by an RCUK Innovation Fellowship from the National Productivity Investment Fund (MR/R026408/1). J.Y. is supported by the Westlake Education Foundation. SCOURGE is funded by the Instituto de Salud Carlos III (COV20_00622 to A.C., PI20/00876 to C.F.), European Union (ERDF) ‘A way of making Europe’, Fundación Amancio Ortega, Banco de Santander (to A.C.), Cabildo Insular de Tenerife (CGIEU0000219140 ‘Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19’ to C.F.) and Fundación Canaria Instituto de Investigación Sanitaria de Canarias (PIFIISC20/57 to C.F.). We also acknowledge the contribution of the Centro National de Genotipado (CEGEN) and Centro de Supercomputación de Galicia (CESGA) for funding this project by providing supercomputing infrastructures. A.D.L. is a recipient of fellowships from the National Council for Scientific and Technological Development (CNPq)-Brazil (309173/2019-1 and 201527/2020-0)
Children living with HIV in Europe: do migrants have worse treatment outcomes?
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- Antoinette Frick Maria
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- de Groot‐de Jonge H
- de Martino Maurizio
- de Ory Santiago Jimenez
- de Villeneuve Arnaud
- del Prado Yolanda Ruiz
- Delforge Marc
- Di Biagio Antonio
- Di Costanzo Pasquale
- Dialla Olivia
- Djoechro E.
- Dobson Donna
- Dodi Icilio
- Doerholt Katja
- Doherty Conor
- Dollenmaier G
- Dollfus Catherine
- Donà Daniele
- Doroba Małgorzata
- Dowie M
- Dueñas Joaquín
- Duff Charlotte
- Duncan K
- Duppenthaler A
- Egger M
- EI Berkaoui A.
- Eisenhut M
- Elzi L
- Epalza Cristina
- Escosa Luis
- Esposito Susanna
- Evans J
- Fairbrother Keith
- Falcón Lola
- Fehr J
- Fellay J
- Fernandes Alexandre
- Fialaire Pascale
- Fidler K
- Firtion Ghislaine
- Floch‐Tudal Corinne
- Flood T
- Flynn J
- Fortuny Clàudia
- Foster Caroline
- Fourcade Corinne
- Fraaij P.L.A.
- Francini K
- Francis Kate
- Freeman A
- Freeman H
- Furrer H
- Fux CA
- Gabiano Clara
- Galli Luisa
- Garazzino Silvia
- García Hortelano Milagros
- García Lourdes
- Garrote Elisa
- Garzón Mónica
- Gavilán César
- Geelen S.P.M.
- Genovese Orazio
- Giacomet Vania
- Giaquinto Carlo
- Gibb Diana
- Gloria Andrés Ana
- Goetghebuer Tessa
- Gomezpena Daniel
- González‐Tomé María Isabel
- Goodall Ruth
- Gordon A
- Grande Ana
- Granier Michèle
- Greenberg M
- Grignolo Sara
- Groters M.
- Guillén Sara
- Gómez Sirvent Jorge
- Günthard HF
- Haerry D
- Hague R
- Hagås Vendela
- Hainaut Marc
- Hancock J
- Harrison Ian
- Hasse B
- Hau Isabelle
- Hawkins S
- Heller‐Roussin Brigitte
- Henriet S.S.V.
- Herranz Mercedes
- Hillebregt M.M.J.
- Hirsch HH
- Hoffmann M
- Hofstra L.M.
- Huber M
- Hösli I
- Ibberson L
- Isabel Menasalvas Ana
- Isabel Piqueras Ana
- Jackson Charlotte
- Jiménez Beatriz
- Jones L
- José Mellado María
- José Romero Francisco
- Judd Ali
- Jurriaans S.
- Kahlert Christian
- Kaiser L
- Kebaili Kamila
- Keiser O
- Kenny Julia
- Kinderziekenhuis Emma
- Kirkhope N
- Klein Nigel
- Klimkait T
- Knoester M
- Kohns Vasconcelos Malte
- Koopmans M.P.G.
- Kottanattu L
- Kouyos Rd
- Kovari H
- Kruijne E.
- Labrune Philippe
- Lachassine Eric
- Lalande Muriel
- Larovere Domenico
- Laurent Corine
- Le Chenadec Jerome
- Ledergerber B
- Lees Y
- Lelivelt K.J
- Lelivelt K.J.
- Lendínez Francisco
- Letting Gillian
- Levine Martine
- Leymarie Isabelle
- Libeschutz S
- Lillo Miguel
- Lo Vecchio Andrea
- Lodewijk C.
- Loeffen Y.G.T.
- Losada Begoña
- Lucas E.
- Luis Santos Juan
- Lundin Rebecca
- Lyall EGH
- Lyall Hermione
- López Núria
- Mangiarini Laura
- Manyika F
- Marchisio Paola
- Marczynska Magdalena
- Marques Laura
- Martinetti G
- Martinez de Tejada B
- Martínez Jorge
- Marugán Víctor
- Marzolini C
- Mayol Lluís
- Mazingue Françoise
- MAZZA Antonio
- McMaster Paddy
- Metzner KJ
- Mignone Federica
- Milanzi Edith
- Miniaci Angela
- Monpoux Fabrice
- Montagnani Carlotta
- Montesinos Elena
- Moreno David
- Munjishvili L.
- Mur Antonio
- Murau Fungai
- Murphy C
- Muñoz‐Fernández Mª Angeles
- Méndez María
- Müller N
- Nardone Alessandra
- Nauta N.
- Navarro Marissa Luisa
- Navarro María Luisa
- Naver Lars
- NavérNavér Lars
- Neth Olaf
- Nicca D
- Niesters H.G.M.
- Noguera-Julian Antoni
- Noguera‐Julian Antoni
- Nsangi Edith
- Ochoa Carlos
- Oltra Manuel
- Oñate Eider
- Ołdakowska Agnieszka
- Paioni P
- Pajkrt D
- Paling F.
- Pantaleo G
- Pantò Grazia
- Partisani Maria Luisa
- Patel S
- Peeck B.
- Penín María
- Percival E
- Peromingo Estrella
- Perreau M
- Pession Andrea
- Peters Helen
- Pickering A
- Pineda Valentí
- Pocheville Itziar
- Pokorska‐Śpiewak Maria
- Polli Ch
- Pope S
- Popielska Jolanta
- Portelli Vincenzo
- Prata Filipa
- Prevost Marthe Le
- Price V
- Prieto‐Tato Luis
- Prime Katia
- Pérez Carlos
- Pérez‐Hoyos Santiago
- Raghunanan S
- Rahamat‐Langendoen J
- Ramos Elisa
- Ramos Jose
- Rampon Osvalda
- Rauch A
- Ree C.
- Regtop R.
- Reiss P
- Reliquet Véronique
- Riordan Andrew
- Rius Neus
- Rodrigues Laura
- Rojo Pablo
- Romano Amelia
- Román Vicente
- Rosie Hague D
- Rovira Núria
- Rudin C
- Ruijs Y.
- Ruiz Beatriz
- Runel‐Belliard Camille
- Rutkens T
- Saavedra Jesús
- Sainz Talía
- Santiago Begoña
- Santos Mar
- Scheijgrond A
- Scherpbier H.J.
- Scherpbier Henriette
- Scherrer AU
- Schinkel C.J.
- Schmid P
- Schnörr P.
- Schoorl M.
- Schuurman R
- Schölvinck E.H.
- Seery P
- Segal S
- Shackley Fiona
- Sharland M
- Sharpe G
- Shingadia Delane
- Silvestro Erika
- Smit Colette
- Soeria‐Atmadja Sandra
- Soler‐Palacín Pere
- Southall S
- Speck R
- Spolou Vana
- Stelma F.F.
- Storey Sharon
- Strik‐Albers R
- Stöckle M
- Subramaniam B
- Sultan‐Beyer L
- Tagliabue Claudia
- Tarr P
- Teixeira Carla
- Terol Pedro
- Thanh Lecompte M
- Thompson F
- Thorne Claire
- Thrasyvoulou L
- Tomás Ramos José
- Tricoire Joëlle
- Trkola A
- Tudor‐Williams Gareth
- Tuijn E.
- Turkova Anna
- Uberos José
- Vallmanya Teresa
- Van Aerde M.
- van de Sande L.
- Van Den Akker M.
- Van der Kelen Evelyne
- van der Knaap L.C.
- van der Kuip M.
- van der Vliet S.
- van Kampen J.J.A.
- van Leer‐Buter C.C.
- Van Looy Nadine
- van Rossum A.M.C.
- van Sighem A.I.
- Veenenberg L.
- Venturini Elisabetta
- Vermont C.L.
- Vernazza P
- Vila Leticia
- Visser E
- Visser K.M.
- Wack Thierry
- Wagner N
- Wandeler G
- Warszawski Josiane
- Weber R
- Weijsenfeld A.M.
- Welch Steve
- Wensing A.M.J.
- Williams A
- Williams B
- Wit F.W.M.N.
- Witte E.C.
- Wolfs T.F.W.
- Wolthers K.C.
- Woudstra T.J.
- Wren L
- Yannoulias A
- Yeadon S
- Yerly S
- Zaaijer H.L.
- Zaheri S
- Zanaboni Domenico
- Zawadka Konrad
- Zuccaro Valentina
- Álvarez Cristina
- Ángel Roa Miguel
- Publication venue
- 'Wiley'
- Publication date
- 01/10/2021
- Field of study
International audienceTo assess the effect of migrant status on treatment outcomes among children living with HIV in Europe
Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study
- Author
- \u160a\u161inkov\ue1 Pavla
- \u160enk\ue1rov\ue1 Zuzana
- \uc5man Jaana
- Aaserud Olaf
- Abbruzzese Giovanni
- Agarwal Veena
- Akhtar Shahbana
- Alarc\uf3n Moreau Mar\ueda Dolores
- Albanese Alberto
- Allain Philippe
- Almagro Carmen Ant\ufanez
- Almeida Manuel
- Alonso-Frech Fernando
- Alusi Sundus
- Anderson Mary
- Andersson Christian
- Andrade Carlos
- Andrew Alyson
- Andrews Thomasin
- Andrich J\ufcrgen
- Angeles Maria
- Aniola Jacek
- Anjum Uruj
- Annic Agn\ue8s
- Antczak Jakub
- Arbelo Jos\ue9 Mat\uedas
- Arkuszewski Michal
- Armstrong Richard
- Arntsen Vibeke
- Arques Penelope Navas
- Arran Natalie
- Artiga Mar\ueda Jos\ue9 Sainz
- Azulay Jean-Philippe
- B\ue1rcenas Antonio Herranz
- B\uf6ringer Regina
- Baake Verena
- Babiloni Blandine
- Bachmeier Michael
- Bachoud-L\ue9vi Anne-Catherine
- Badei Farideh
- Bailey Wendy
- Banaszkiewicz Krzysztof
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A.
- Barral Ver\uf3nica Ma\uf1anes
- Barrero Francisco
- Barth Katrin
- Barth\ue9l\ue9my Recka
- Bas Jordi
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Benaich Sandra
- Benoit Alexandra
- Bentivoglio Anna Rita
- Berglund Maria
- Berglund Peter
- Bergmann Ulrike
- Berrisoul Hassan
- Bertini Elisabetta
- Bethwaite Pamela
- Betz Sabrina
- Beuth Markus
- Bioux Sandrine
- Biunno Ida
- Bj\uf6rnsson Elisabeth
- Bj\uf8rgo Kathrine
- Bj\uf8rnevoll Inga
- Blaszczyk Magdalena
- Bliaux Evangeline
- Blin St\ue9phanie
- Blinkenberg Ellen 8kland
- Blondeau Leily
- Bo\u107wi\u144ska Dorota
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Boiss\ue9 Marie-Fran\ue7oise
- Bojakowska-Jaremek Kamila
- Bojarsky Jaime Kulisevsky
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Borge\uf8d Nancy
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boudali Lotfi
- Bove Francesco
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brice Alexis
- Brockie Peter
- Bronzova Juliana
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bryl Anna
- Buchanan Lindsay
- Buck Andrea
- Buongiorno Mar\ueda Teresa
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burn John
- Burrows Liz
- Busquets N\ufaria
- Busse Monica
- Butcher Cynthia
- Cabaret Maryline
- Calado Ana
- Calandra-Buonaura Giovanna
- Caldentey Juan Garc\ueda
- Callaghan Jenny
- Calopa Matilde
- Calvas Fabienne
- Calzado Noemi
- Campolongo Antonia
- Cannella Milena
- Capellari Sabina
- Capetian Philipp
- Capodarca Selene
- Cardoso Helena
- Carette Anne-Sophie
- Carri\ue8re Nicolas
- Carrillo F\ue1tima
- Carruesco Gemma Tome
- Casado Roc\uedo Villagr\ue1n
- Cass Ginette
- Castagliuolo Simona
- Castaldo Anna
- Catalli Claudio
- Catena Judit L\uf3pez
- Chabot Christelle
- Charles Perrine
- Charpentier S\ue9bastien
- Cheriet Samia
- Chu Carol
- Chu Elvina
- Ciach-Wysocka Ewelina
- Ciesielska Anna
- Classen Serge Jaum\ue1
- Clayton Carole
- Clenaghan Catherine
- Coarelli Giulia
- Codella Valentina
- Coebergh Jan
- Coelho Miguel
- Coleman Caroline
- Come Adrien
- Connemann Julia
- Constant Eric
- Constantinescu Radu
- Cormio Claudia
- Corrales Koldo Berganzo
- Cortegana Eva Mar\ueda Pacheco
- Cortelli Pietro
- Costa Andreia
- Costa Cristina
- Coulthard Elizabeth
- Courtin Fran\ue7oise
- Couttier Julien
- Craufurd David
- Craven Janet
- Crooks Jenny
- Cubillo Patricia Trigo
- Cubo Esther
- Curtis Adrienne
- D\ucdaz-Zorita Juan Pablo Tartari
- Da Silva Wildson Vieira
- Das Purkayastha Debasish
- Davidson Lynn
- Davies Rhys
- Davison Jill
- De Bobadilla Ramon Fernandez
- De Bruycker Christelle
- De Gregorio Francesca
- De La Cerda Santa Mar\ueda Andr\ue9s
- De Langavant Laurent Cleret
- De Michele Giuseppe
- De Molina Roc\uedo Malo
- De Nicola Annunziata
- De Souza Keylock Jenny
- De Tommaso Marina
- De Weert A. Marit
- De Y\ue9benes Justo Garc\ueda
- Debilly B\ue9reng\ue8re
- Debruxelles Sabrina
- Dec Malgorzata
- Decorte Eric
- Dedich\ue1 Nadia Rodr\uedguez
- Defebvre Luc
- Deith Catherine
- Dekker Meike
- Del Mar Fenollar Mar\ueda
- Del Valle Loarte Mar\ueda
- Delabaere Hel\ue8ne
- Delaigue Christine
- Delfini Marie
- Delliaux Marie
- Delval Arnaud
- Demonet Jean-Fran\ue7ois
- Depelchin Aliz\ue9
- Destee Alain
- Dewulf-Pasz Nelly
- DI Bella Daniela
- DI Donato Stefano
- DI Giacopo Raffaella
- DI Maio Luigi
- DI Maria Emilio
- DI Pietro Anna Gerrtiz
- DI Poggio Monica Bandettini
- DI Renzo Martina
- DI\ue9guez Esther
- DIas Margarida
- DIercks Gabriele
- DIfruscolo Olimpia
- DIpple Heather
- Doherty Karen
- Dondaine Thibaut
- Donovan John O
- Dose Matthias
- Dougherty Andrew
- Downie Lorna
- Dramstad Elisabeth
- Dressler DIrk
- Duch\ue9 Charlotte
- Dugauquier Florence
- Duits Annelien
- Dujardin Kathy
- Dumas Eve M.
- Dunnett Stephen
- Dupuis Michel
- Durif Franck
- Durr Alexandra
- Duru C\ue9cile
- Dziadkiewicz Artur
- Ecker Daniel
- Eddy Charlotte
- Edwards Maureen
- Edwards Rachel
- Eklund Pia
- Ekwall Camilla
- Elifani Francesca
- Ellrichmann Gisa
- Esposito Federica
- Esteban Juan Carlos Gomez
- Eusebio Alexandre
- Evans Carole
- Ewenczyk Claire
- Fairtlough Helen
- Fannemel Madeleine
- Farewell Daniel
- Fasano Alfonso
- Fasquel V\ue9ronique
- Fernandez Cristina Melgar
- Ferraldeschi Michela
- Ferrandes Giovanna
- Ferreira Joaquim J
- Ferrer Pilar Quil\ue9z
- Figuerola Bego\uf1a Jeweinat
- Fillingham Kay
- Finisterra Ana Maria
- Fisher Kate
- Flament M\ue9lanie
- Fletcher Amy
- Fluchere Fr\ue9d\ue9rique
- Fortuna Lorenza
- Foster Jillian
- Foustanos Isabella
- Foy Kevin
- Frades Bel\ue9n
- Francis Flverly
- Francisque H\ue9l\ue8ne
- Franco Giovanni
- Frech Fernando Alonso
- Fredlund Gunnel
- Freire-Patino Dawn
- Frich Jan C.
- Frontali Marina
- Frost Julie
- Fullam Ruth
- Fuller Kathleen
- G\uf6ller Marie-Lousie
- G\uf6pfert Nicole
- G\uf8rvell Per F.
- Gago Miguel
- Gallassi Roberto
- Gallentree Deena
- Ganos Christos
- Garc\ueda Ana
- Garc\ueda Roc\uedo Garc\ueda-Ramos
- Garcia-Amigot Fermin
- Garde M\uf3nica Bascu\uf1ana
- Garrett Carolina
- Gaston Itziar
- Gayde-Stephan Sabine
- Geitner Carolin
- Gelderblom Harald
- Gellera Cinzia
- Genitrini Silvia
- Genoves Camille
- Gerrans Emily
- Ghelli Elena
- Gil Acera
- Gill Paul
- Gillardin Anne-Fran\ue7oise
- Gilling Mette
- Ginestroni Andrea
- Girard Carole
- Giuliano Joe
- Godefroy Olivier
- Goerendt Ines
- Gogol Anna
- Gohier B\ue9n\ue9dicte
- Goizet Cyril
- Golding Charlotte
- Gonz\ue1lez Amaia
- Gonz\ue1lez Laura Vargas
- Gonz\ue1lez Sonia
- Good Jean-Marc
- Goodman Anna
- Gorzkowska Agnieszka
- Gorzolla Heike
- Goudie David
- Gowers Lesley
- Grabska Natalia
- Grosjean H\ue9l\ue8ne
- Gu\ue9rid Marie-Anne
- Guedes Leonor Correia
- Guia Dolors Badenes
- Guidubaldi Arianna
- Guimar\ue3es Joana
- Guisasola Luis Men\ue9ndez
- Gunner Kerry
- Guyant-Mar\ue9chal Lucie
- Guzman Natalie Valle
- H\uf6lzner Eva
- H\uf8sterey-Ugander Ulrika
- Haider Salman
- Haig-Brown DIane
- Hallam Caroline
- Hamer Stephanie
- Hametner Eva-Maria
- Handley Olivia J.
- Hannequin DIdier
- Hannier V\ue9ronique
- Harding Alison
- Hare Marianne
- Harris Kayla
- Harrison David
- Harrower Timothy
- Hart't Ellen P.
- Hartikainen Paivi
- Haug Marte Gj\uf8l
- Hauge Erik
- Hayward Beverley
- Hayward Elaine
- Hecht Karen
- Heiberg Arvid
- Heinicke Walburgis
- Held Christine
- Hensman Davina
- Hepperger Caroline
- Hermoso F\ue1tima Damas
- Hernanz Laura Casas
- Herranhof Brigitte
- Herrera Carmen Dur\ue1n
- Herrmann Lennard
- Heywood Melanie
- Hidding Ute
- Hiivola Heli
- Hill Susan
- Hjermind Lena
- Ho Carrie
- Hobson Emma
- Hoffmann Rainer
- Hofstetter Nina
- Holas Christiane
- Holl Anna
- Holmans Peter
- Hopes Lucie
- Hotter Anna
- Howard Liz
- Hughes Alis
- Hughes Max
- Hunger Ulrike
- Hunt Sarah
- Huson Susan
- Hussl Anna
- Hvalstedt Carina
- Hypp\uf6nen Hannele
- Ialongo Tamara
- Idiago Jes\ufas Miguel Ruiz
- Ignatius Jaakko
- Illarioshkin Sergey
- Illmann Torsten
- Ireland Jane
- Irvine Sarah
- J\ue4\ue4skalainen Outi
- J\ufalio Filipa
- Jachinska Katarzyna
- Jack Roisin
- Jacobsen Oda
- Jacopini Gioia
- Jameau Laetitia
- Jamieson Stuart
- Jamrozik Zygmunt
- Janik Piotr
- Janu\ue1rio Cristina
- Jasi\u144ska-Myga Barbara
- Jauffret C\ue9line
- Johns Nicola
- Johnson Liz
- Jones Lesley
- Jones Mary
- Jones Una
- Jourdain S\ue9verine
- Jung Hans H.
- Justo Damian
- K\ue4rpp\ue4 Mikko
- Kaczmarczyk Aleksandra
- Kaelin Alain
- Kaiserova Michaela
- Kajula Outi
- Kaminska Anna
- Kaminski Barbara
- Kammel Gerit
- Kampstra Anne
- Kapfhammer Hans-Peter
- Kassar Abdulrahman
- Kavalier Fred
- Kazoka Mbombe
- Kesse Andrea
- Keys Liane
- Khalil Hanan
- Kipps Christopher
- Klebe Stephan
- Klemp\ued\u159 Ji\u159\ued
- Klimberg Aneta
- Klodowska-Duda Gabriela
- Klooster Jesper
- Knight Caroline
- Kohl Zacharias
- Koivisto Susana Pro
- Komati Suresh
- Koppers Kerstin
- Koppitz Michael
- Kosinski Christoph Michael
- Kozay Christina
- Kramer Bianca
- Kraus Alison
- Kraus Peter
- Krawczyk Malgorzata
- Kremer Berry
- Krishnamoorthy Ashok
- Krysa Wioletta
- Krystkowiak Pierre
- Kubowicz Ewelina
- Kwiecinski Hubert
- L\ue9onard Marie-Claude
- L\uf3pez Rosa Guerrero
- L\uf6hle Matthias
- L\ufcsebrink Antje
- Ladurner Gunther
- Lafoucri\ue8re Danielle
- Lagha-Boukbiza Ouhaid
- Lahiri Nayana
- Laing Hana
- Lamanna Claudia
- Lambeck Johann
- Landwehrmeyer Bernhard
- Lange Herwig
- Larcher Barbara
- Large Sandra
- Larsen Ida Unmack
- Lashwood Alison
- Laur\ue1 Matilde
- Laver Fiona
- Leenders Nico
- Legendre Perrine
- Lemaire Marie-H\ue9l\ue8ne
- Lemoine Laurie
- Lemos Mar\ueda Dolores Romero
- Lesne Fabien
- Levey Jamie
- Lewerenz Jan
- Lewis Monica
- Leypold Christine
- Lezius Franziska
- Ligon-Auer Maria
- Lilek Sabine
- Lilek Stefan
- Lindquist Suzanne
- Linnsand Petra
- Loiseau Sylvie
- Lolk Annette
- Longato Nadine
- Longinus Bernhard
- Longthorpe Mandy
- Lopera Monica Rodriguez
- Loria Giovanna
- Loutfi Ghada
- Lovo Francesca
- Lozano Pablo S\ue1nchez
- Lucena Carolina Mendez
- Lundsgaard Marianne
- M\ue4chtel Miriam
- M\uf8ller Anette Torvin
- M\ufchlau Mark
- M\ufchlb\ue4ck Alzbeta
- M\ufcller Christoph
- M\ufcller Nicole
- M\ufcnchau Alexander
- M\ufcnkel Kristina
- M\ufctze Lisanne
- Maass Antonia
- MacKinnon Lesley
- Madsen Louise Hasselstr\uf8m
- Magnet Markus
- Mahlknecht Philipp
- Maiwald Robert
- Majeed Tahir
- Majerov\ue1 Veronika
- Malec-Litwinowicz Michalina
- Malt\ueate David
- Mandich Paola
- Mandich Paola
- Manouvrier Sylvie
- Mantaux B\ue9atrice
- Manzanares Salvadora
- Marcel Christophe
- Marchese Roberta
- Marcinkowski Jerzy
- Mariotti Caterina
- Mariscal Natividad
- Markova Ivana
- Marquard Ralf
- Mart\uedn Idaira
- Mart\uednez Noelia Rodr\uedguez
- Mart\uednez-Descals Asunci\uf3n
- Martikainen Kirsti
- Martin Veronica Puertas
- Martinez-Horta Saul
- Martinez-Jaurrieta Maria Dolores
- Martino Tiziana
- Mason Sarah
- Massano Jo\ue3o
- Massarelli Marco
- Mata Maite Paredes
- Matheson Kirsty
- Mazzante Irene
- McDonnell Sharon
- McEntagart Meriel
- McFadyen Paula
- McGill Marie
- McKenzie Sue
- McLean Tim
- McNulty Paul
- Mechi Claudia
- Meier Simone
- Meireles Joana
- Mendes Tiago
- Merino Beatriz Tijero
- Mestre Tiago
- Middleton Julia
- Miedzybrodzka Zosia
- Mihaylova Violeta
- Milani Paolo
- Milkereit Eva
- Minet C\ue9cile
- Minschke Rebecca
- Minster Sara
- Mir Pablo
- Modoni Anna
- Mohammed Zeid
- Moilanen Jukka
- Monin Marie-Lorraine
- Monteiro Ana
- Monza Daniela
- Morales Blas
- Moreno Jos\ue9 Luis L\uf3pez-Send\uf3n
- Moreno Jose Manuel Garc\ueda
- Moreno Patrocinio Garcia
- Morgado Graca
- Morgado Joana
- Morgan Karen
- Mu\uf1oz Esteban
- Mu\uf1oz Juan Mar\uedn
- Mundler Laura
- Murphy Helen
- Musacchio Thomas
- Musgrave Hannah
- Mustonen Aki
- Mutez Eug\ue9nie
- N\uf6th Kerstin
- Nanetti Lorenzo
- Necuiniate Renata
- Neleborn-Lingefj\ue4rd Liselotte
- Nemeth Andrea H
- Nepper Solveig
- Nevitt Louise
- Nielsen J\uf8rgen
- Niess Anke
- Noad Rupert
- Novak Marianne
- Nowak Malgorzata
- Nowak Marielle
- Nyberg Clara
- O'Donovan Kirsty
- O'Keefe Deidre
- O'Neill Mari
- Oehmen Martin
- Olivier Audrey
- Ollokainen Mari
- Olofsson Carina
- Oosterloo Mayke
- Opala Grzegorz
- Orth Michael
- Ossig Christiana
- Otti Daniela
- Oughton Emma
- Owen Michael
- P\ue4iv\ue4rinta Markku
- P\ue5lhagen Sven
- Padieu Helene
- Paganini Marco
- Pagonabarraga Javier
- Painold Annamaria
- Palanca Paloma Millan
- Palmer Amy
- Panzeri Marta
- Pardo Sonia Arribas
- Paridi Dominga
- Pariente J\ue9r\ue9mie
- Parkinson Andrew
- Partington-Jones Lucy
- Pastor Barbara Vives
- Pate Louise
- Patel Aakta
- Paterski Laurent
- Patton Michael
- Paucar Martin
- Paus Karin
- Pe\uf1a Jos\ue9 Chac\uf3n
- Peacy Caroline
- Pearson Pauline
- Peinemann Alexander
- Peippo Maarit
- Peluso Silvio
- Peppa Nadia
- Perea Fuensanta Noguera
- Perez Jesus Perez
- Peria\uf1ez Juan Manuel
- Peter Mireille
- Petersen Jens A.
- Peterson Maria
- Petracca Martina
- Petrollini Martina
- Phillipps Cl\ue9lie
- Phillips Michelle
- Piacentini Silvia
- Piano Carla
- Piccininni Chiara
- Pierre Mich\ue8le
- Pilcher Richard
- Pinter Bernadette
- Playe Alicia
- Plomhause Lucie
- Poda Roberto
- Poewe Werner
- Polo Cecilia Gil
- Porteous Mary
- Pouliquen Doroth\ue9e
- Powell Kingsley
- Pr\ufc f Harald
- Pradella Silvia
- Price Kathleen
- Prieto Marta Para
- Priller Josef
- Probst Daniela
- Prouzet Julie
- Prundean Adriana
- Pueyo Angel Mart\uednez
- Quaranta Davide
- Quarrell Oliver
- R\uf8ren Niini
- R\uf8sby Oddveig
- Rae Daniela
- Rakowicz Maryla
- Raman Ashok
- Ramesh Raviram
- Ramirez In\ue9s Legarda
- Ramos-Arroyo Maria Antonia
- Raseta Rolland
- Redondo Luis
- Redondo Mar\ueda Teresa C\ue1ceres
- Reetz Kathrin
- Regeur Lisbeth
- Reilmann Ralf
- Reisinger Karin
- Reiter Eva-Magdalena
- Retterst\uf8l Lars
- Riba\uef Pascale
- Ribacoba Ren\ue9
- Ribas Guillermo Garc\ueda
- Ribbat Michael
- Ribosa Roser
- Richter Przemyslaw
- Rickards Hugh
- Rijntjes Michel
- Rinaldi Carlo
- Rindal Beate
- Ristori Giovanni
- Ritchie Stuart
- Robert Misericordia Floriach
- Robertson Dene
- Robertson Nicola
- Robowski Piotr
- Roca Alessandro
- Roca Elvira
- Rogers Dawn
- Rohm Stefanie
- Rola Rafal
- Rolland Sandrine
- Romano Silvia
- Romero Irene
- Romero Sandra Gutierrez
- Romoli Anna Maria
- Roos Raymund A. C.
- Rose Sarah
- Rosser Anne
- Rosser Elisabeth
- Roth Jan
- Rothery Jean
- Roussel Martine
- Rowett Liz
- Roze Emmanuel
- Ru\uedz Pedro Jos\ue9 Garc\ueda
- Ruddy Deborah
- Rudolf Gabrielle
- Rudzi\u144ska Monika
- Rumpf Silke
- Russo Cinzia Valeria
- Ryglewicz Danuta
- S\ue1nchez Vicenta
- S\ue1nchez Violeta S\ue1nchez
- S\ufcssmuth Sigurd
- Sablonni\ue8re Bernard
- Saft Carsten
- Salvador Carlos
- Salvatore Elena
- Samara Husam
- Sando Sigrid Botne
- Santacruz Pilar
- Santala Maire
- Santhouse Alastair
- Sass Christian
- Savage Lois
- Scaglione Cesa
- Sch\uf6ggl Helmut
- Sch\ufcler B\ue9atrice
- Sch\ufcpbach Michael
- Scheibl Monika
- Schepers Sigrun
- Scherer-Gagou Clarisse
- Schiefer Johannes
- Schlangen Christiane
- Schmalfeld Jenny
- Schmidt Simone
- Schneider Ariane
- Schoonderbeek Anne
- Schrader Christoph
- Schwenk Daniela
- Sciruicchio Vittorio
- Sebasti\ue1n Ana Rojo
- Seliverstov Yury
- Semedo Cristina
- Sempolowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sevilla Maria Ascension Zea
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Sikiric Alma
- Silva Mark
- Simonelli Maria
- Simonin Cl\ue9mence
- Simpson Sheila A
- Simpson Steve
- Sinadinosa Daniela
- Singh Baldev
- Sipponen Marjett
- Sitek Emilia
- Siuda Gill
- Slawek Jaroslaw
- Smalley Sarah
- Snowden Julie
- Sol\ueds Pilar
- Soleti Francesco
- Solito Marcella
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- Sorbi Sandro
- Sorrentino Pierpaolo
- Spadaro Maria
- Spagnolo Francesca
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike
- Squitieri Ferdinando
- St 9pniak Iwona
- St\ue4dtler Michael
- St\uf8rseth Hanna Haugan
- Staffen Wolfgang
- Stamm Christiane
- Stattin Eva-Lena
- Stebler Yanik
- Steinmetz Gis\ue9le
- Stenwak Agata
- Stockholm Jette
- Stokke Bodil
- Stompel Daniel
- Stopford Cheryl
- Storch Alexander
- Stubbe Lars
- Sulek Anna
- Summers Fiona
- Sundblom Jimmy
- Svenningsson Per
- Swain Rachel
- Szczudlik Andrzej
- Szczygiel Elzbieta
- Szinwelski Michal
- Tabrizi Sarah
- Tacik Pawel
- Tard C\ue9line
- Taroni Franco
- Tataru Alina
- Taylor Anne-Marie
- Taylor Cat
- Taylor Rachel
- Tchikviladz\ue9 Maya
- Thibault-Tanchou St\ue9phanie
- Thiel Silvia
- Thomas Gareth
- Thompson Jennifer
- Thomson Aileen
- Tidswell Katherine
- Timewell Erika
- Timings Leanne
- Tir M\ue9lissa
- Tomasello Chiara
- Tonner Alison
- Torlizzi Flavia
- Torres Mar\ueda Martirio Antequera
- Toscano Jean
- Townhill Jenny
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tucci Tecla
- Tuuha Katri
- Tyvoll Hilde
- Udaeta Beatriz
- Uhrova Tereza
- Ulla Miguel
- Ullah Jasmin
- Ure Alexandra
- Valadas Anabela
- Valentine Ruth
- Van De Wyngaerde Fran\ue7oise
- Van Den Bogaard Simon J. A.
- Van Hout Monique S. E.
- Van Oostrom Joost
- Van Paemel Dominique
- Van Reijen Dimphna
- Van Vugt Jeroen P. P.
- Van Walsem Marleen
- Vandenberghe Wim
- Vangsted-Hansen Christina
- Vaughan Vivien
- Ventura Marta Fat\ue1s
- Verellen-Dumoulin Christine
- Verhoeven Marloes
- Vernon Nathan
- Verny Christophe
- Verstappen Carla
- Verstraelen Nicola
- Vezza Maurizio
- Vidal Tiphaine
- Viladrich C\ue8lia Mareca
- Vilaplana Carmen Peir\uf3
- Villa Riballo Antonio
- Villa Carolina
- Villanueva Clara
- Villanueva Marina \uc1vila
- Vingerhoets Francois
- Vinther-Jensen Tua
- Vivancos Laura
- Vogel Melanie
- Vuillaume Isabelle
- W\uf3jcik Magdalena
- Waber Mirella
- Wagner Caroline
- Wahlstr\uf6m Jan
- Wallden Tina
- Walleczek Anna Maria
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Nathalia
- Weekes Rebecca
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wermuth Lene
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Wi\u15bniewski Bartlomiej
- Wider Christian
- Wikstr\uf6m Birgitta
- Wild Edward
- Wild Sue
- Williams Josh
- Winkelmann Juliane
- Winkler J\ufcrgen
- Witjes-An\ue9 Marie-Noelle
- Witkowski Grzegorz
- Wolz Annett
- Wolz Martin
- Wood Josh
- Wright Abigail
- Wright Jan
- Yardumian Pam
- Yates Shona
- Youssov Katia
- Yudina Elizaveta
- Zaremba Jacek
- Zaugg Sabine Weber
- Zdzienicka Elzbieta
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zucker Birgit
- Publication venue
- 'IOS Press'
- Publication date
- 01/01/2018
- Field of study
Background: People with Huntington's disease (HD) have been observed to have lower rates of cancers. Objective: To investigate the relationship between age of onset of HD, CAG repeat length, and cancer diagnosis. Methods: Data were obtained from the European Huntington's disease network REGISTRY study for 6540 subjects. Population cancer incidence was ascertained from the GLOBOCAN database to obtain standardised incidence ratios of cancers in the REGISTRY subjects. Results: 173/6528 HD REGISTRY subjects had had a cancer diagnosis. The age-standardised incidence rate of all cancers in the REGISTRY HD population was 0.26 (CI 0.22-0.30). Individual cancers showed a lower age-standardised incidence rate compared with the control population with prostate and colorectal cancers showing the lowest rates. There was no effect of CAG length on the likelihood of cancer, but a cancer diagnosis within the last year was associated with a greatly increased rate of HD onset (Hazard Ratio 18.94, p < 0.001). Conclusions: Cancer is less common than expected in the HD population, confirming previous reports. However, this does not appear to be related to CAG length in HTT. A recent diagnosis of cancer increases the risk of HD onset at any age, likely due to increased investigation following a cancer diagnosis
Clinical manifestations of intermediate allele carriers in Huntington disease
- Author
- A Marit de Weert
- Aakta Patel
- Abigail Wright
- Abigail Wright
- Adriana Prundean
- Adrien Come
- Adrienne Curtis
- Agata Stenwak
- Agnieszka Gorzkowska
- Agnieszka Konkel
- Aicha Ghenam
- Alain Kaelin
- Aleksandra Kaczmarczyk
- Alessandro Roca
- Alexander Münchau
- Alexandra Ure
- Alexandre Eusebio
- Alice Seris
- Alison Kraus
- Alma Sikiric
- Alyson Andrew
- Alyson Bradbury
- Alzbeta Mühlbäck
- Amaia González
- Amy Palmer
- Ana Calado
- Ana García
- Ana Maria Finisterra
- Ana Maria Finisterra
- Ana Rojo Sebastián
- Ana Rojo Sebastián
- Ana Salgueiro
- Anabela Valadas
- Andrea Buck
- Andrea Ginestroni
- Andrea H Nemeth
- Andrea Horta-Barba
- Andrea Kesse
- Andrea Sollom
- Andrew Parkinson
- Andrzej Szczudlik
- Aneta Klimberg
- Angel Martínez Pueyo
- Anke Niess
- Anna Ciesielska
- Anna Gogol
- Anna Kaminska
- Anna Maria Romoli
- Anna Rita Bentivoglio
- Anna Rita Dellomonaco
- Anna Sułek
- Anna Wasielewska
- Anne Kampstra
- Anne Rosser
- Anne Schoonderbeek
- Anne-Catherine Bachoud-Lévi
- Annunziata De Nicola
- Antonella Muroni
- Antonia Campolongo
- Antonio Herranz Bárcenas
- Antonio Villa Riballo
- Ariane Schneider
- Artur Dziadkiewicz
- Arvid Heiberg
- Arvid Heiberg
- Aránzazu Gorospe
- Ashok Krishnamoorthy
- Ashok Raman
- Asunción Martínez Descals
- Asunción Martínez-Descals
- Audrey Olivier
- Baldev Singh
- Barbara D'Alessio
- Barbara Jasińska-Myga
- Barbara Kaminski
- Barbara Vives Pastor
- Bartłomiej Wiśniewski
- Beate Rindal
- Beatriz Tijero Merino
- Beatriz Udaeta
- Belén Frades
- Bernhard Landwehrmeyer
- Beverley Hayward
- Beverley Soltysiak
- Bianca Kramer
- Blandine Babiloni
- Bénédicte Gohier
- Calvo S.
- Camille Genoves
- Carina Hvalstedt
- Carlo Rinaldi
- Carlos Salvador
- Carmen Antúnez Almagro
- Carmen Durán Herrera
- Carole Clayton
- Carolin Geitner
- Carolina Mendez Lucena
- Carolina Villa
- Caroline Hallam
- Caroline Peacy
- Carsten Saft
- Cat Taylor
- Caterina Bartoli
- Catherine Bourdet
- Catherine Clenaghan
- Catherine Taylor
- Cecilie Haggag Johannessen
- Charlotte Duché
- Charlotte Eddy
- Charlotte Golding
- Cheryl Stopford
- Chiara Esposito
- Christelle Chabot
- Christian Sass
- Christian Sass
- Christiane Schlangen
- Christina Vangsted-Hansen
- Christine Garreau
- Christine Held
- Christine Held
- Christine Leypold
- Christine Verellen-Dumoulin
- Christine Verellen-Dumoulin
- Christoph Michael Kosinski
- Christoph Schrader
- Christophe Verny
- Christos Ganos
- Cici Feliz Feliz
- Cinzia Valeria Russo
- Claire Thiriez
- Clara Villanueva
- Clarisse Scherer-Gagou
- Claudia Cormio
- Claudia Lamanna
- Claudia Mechi
- Claudia Serpino
- Cornelius J Werner
- Cristina Januário
- Cristina Melgar Fernandez
- Cristina Semedo
- Cubo E.
- Cynthia Butcher
- Cyril Goizet
- Cèlia Mareca Viladrich
- Cécile Focseneanu
- Cécile Minet
- Daniel Ecker
- Daniel Ecker
- Daniel Stompel
- Daniel Zielonka
- Daniel Zielonka
- Daniela Monza
- Daniela Probst
- Daniela Rae
- Daniela Schwenk
- Danielle Lafoucrière
- Danuta Ryglewicz
- David Craufurd
- David Harrison
- Davina Hensman
- Dawn Freire- Patino
- Dawn Rogers
- Dawn Rogers
- Deena Gallantree
- Dirk Dressler
- Dolors Badenes Guia
- Dominique Bonneau Marie Bost
- Dominique Van Paemel
- Dorota Boćwińska
- Edward Wild
- Elena Bellosta Diago
- Elena Ghelli
- Elena López
- Elena Salvatore
- Elisabeth Dramstad
- Elisabeth Rosser
- Elisabetta Bertini
- Elizabeth Coulthard
- Elizaveta Yudina
- Ellen P 't Hart
- Elvina Chu
- Elvira Roca
- Elzbieta Zdzienicka
- Elżbieta Szczygieł
- Emilia Sitek
- Emma Hobson
- Emma Oughton
- Erika Timewell
- Esther Cubo
- Eugeniusz Zielonka
- Eva Hölzner
- Eva Milkereit
- Eva Pacheco Cortegana
- Eve M Dumas
- Ewa Narożańska
- Ewelina Ciach-Wysocka
- Ewelina Kubowicz
- Fabienne Calvas
- Farideh Badei
- Ferdinando Squitieri
- Fernanda Fortunato
- Fernando Alonso Frech
- Fernando Alonso-Frech
- Filipa Júlio
- Fiona Summers
- Flverly Francis
- Francesca De Gregorio
- Francesca Elifani
- Francesca Lovo
- Francesco Marrosu
- Francisco Castera Brugada Carmen Peiró Vilaplana
- Franziska Lezius
- Frédérique Fluchere
- Fuensanta Noguera Perea
- Fátima Damas Hermoso
- G Bernhard Landwehrmeyer
- Gabriela Kłodowska-Duda
- Gabriele Diercks
- Gareth Thomas
- Gemma Tome Carruesco
- Gil-Polo CAnne-Catherine Bachoud-Lévi
- Gill Siuda
- Ginette Cass
- Gioia Jacopini
- Giovanni Franco
- Giovanni Ristori
- Gisa Ellrichmann
- Giulia Coarelli
- Giuseppe De Michele
- Graça Morgado
- Grzegorz Opala
- Grzegorz Witkowski
- Grzegorz Witkowski
- Guillermo García Ribas
- Gunnel Fredlund
- Halina Sienkiewicz-Jarosz
- Hanan Khalil
- Hannah Musgrave
- Hannele Hypponen
- Heather Dipple
- Heike Beckmann
- Heike Gorzolla
- Helen Fairtlough
- Helen Gundersen
- Helen Murphy
- Helene Padieu
- Heli Hiivola
- Herwig Lange
- Hubert Kwiecinski
- Hugh Rickards
- Husam Samara
- Hélène Grosjean
- Ida Biunno
- Ida Unmack Larsen
- Idaira Martín
- Ines Goerendt
- Inés Legarda Ramirez
- Irene Mazzante
- Irene Romero
- Iris Trender-Gerhard
- Isabella Foustanos
- Itziar Gaston
- Ivana Markova
- Iwona Stępniak
- Jacek Anioła Anna Bryl
- Jacek Zaremba
- Jacek Zaremba
- Jaime Kulisevsky Bojarsky
- Jakub Antczak
- Jamie Levey
- Jan Coebergh
- Jan Frich
- Jan Lewerenz
- Jan Lewerenz
- Jan Wahlström
- Jan Wahlström
- Jan Wright
- Jaroslaw Slawek
- Javier Del Val Fernandez
- Javier López Del Val
- Javier Pagonabarraga
- Jean Rothery
- Jean Toscano
- Jean-Marc Burgunder
- Jean-Marc Burgunder
- Jean-Philippe Azulay
- Jennifer Thompson
- Jenny Callaghan
- Jenny Callaghan
- Jenny Callaghan
- Jenny Crooks
- Jenny de Souza
- Jenny Schmalfeld
- Jenny Townhill
- Jenny Townhill
- Jeremy Cosgrove
- Jeroen P P van Vugt
- Jerzy Marcinkowski
- Jesus Perez Perez
- Jesús Miguel Ruiz Idiago
- Jette Stockholm
- Jill Davison
- Jillian Foster
- Joana Morgado
- Joaquim J Ferreira
- Joaquim J Ferreira
- Johannes Schiefer
- John O Donovan
- John Piedad
- Jordi Bas
- Josh Williams
- Josh Wood
- José Chacón Peña
- José Luis López-Sendón Moreno
- José Manuel García Moreno
- José Matías Arbelo
- Joy Read
- Juan Andres Burguera
- Juan Carlos Gomez Esteban
- Juan García Caldentey
- Juan García Caldentey
- Juan García Caldentey
- Juan Manuel Periañez
- Juan Marín Muñoz
- Juan Pablo Tartari Díaz-Zorita
- Judit López Catena
- Judith Bek
- Julia Connemann
- Julia Middleton
- Julie Frost
- Julie Prouzet
- Julie Snowden
- Justo García de Yébenes
- Justyna Sempołowicz
- Jutta Rummel
- Jérémie Pariente
- Jørgen E Nielsen
- Jørgen Nielsen
- Kai Boelmans
- Kamila Bojakowska-Jaremek
- Karen Doherty
- Karen Morgan
- Karolina Ziora-Jakutowicz
- Kasia Sieradzan
- Katarzyna Jachinska
- Katherine Tidswell
- Kathleen Fuller
- Kathleen Price
- Kathrin Reetz
- Kathrine Bjørgo
- Kathrine Haggag
- Kathryn Dixon
- Katia Youssov
- Katri Tuuha
- Katrin Barth
- Katrin Barth
- Katrina Holmes
- Kay Fillingham
- Kerstin Koppers
- Kerstin Nöth
- Kingsley Powell
- Kirsti Martikainen
- Kirsty Matheson
- Kirsty O'Donovan
- Kirsty O'Donovan
- Koldo Berganzo Corrales
- Krzysztof Banaszkiewicz
- Laetitia Jameau
- Laetitia Vervoitte
- Lars Retterstøl
- Lars Stubbe
- Laura Casas Hernanz
- Laura Martinez Martinez
- Laura Mundler
- Laura Vivancos Moreau
- Laurent Cléret
- Laurent Marquine
- Laurent Paterski
- Laurie Lemoine
- Leann Westmoreland
- Leanne Timings
- Lena Hjermind
- Lennard Herrmann
- Leonor Correia Guedes
- Leonor Correia Guedes
- Lesley Gowers
- Lesley Jones
- Lisanne Mütze
- Lisbeth Regeur
- Liselotte Neleborn-Lingefjärd
- Liv Barnett
- Liz Howard
- Liz Johnson
- Liz Rowett
- Lois Savage
- Lorna Downie
- Lotfi Boudali
- Louise Gethin
- Louise Nevitt
- Lucy Partington-Jones
- Luigi Di Maio
- Luis Menéndez Guisasola
- Luis Redondo
- Lynn Davidson
- Madeleine Fannemel
- Magdalena Boczarska-Jedynak
- Magdalena Błaszczyk
- Magdalena Wójcik
- Maite Paredes Mata
- Malgorzata Krawczyk
- Malgorzata Nowak
- Mandy Longthorpe
- Manuel Almeida
- Marco Massarelli
- Marco Paganini
- Margarida Dias
- Maria Angeles Acera Gil
- Maria Antonia Ramos-Arroyo
- Maria Ascension Zea Sevilla
- Maria Bosca
- Maria Dolores Martinez-Jaurrieta
- Maria Dolores Romero Lemos
- Maria Peterson
- Maria Ramos-Arroyo
- Maria Simonelli
- Marianne Hare
- Marianne Novak
- Marie Delfini
- Marie-Anne Guérid
- Marie-Noelle Witjes-Ané
- Marielle Nowak
- Marina de Tommaso
- Marina Frontali
- Marina Ávila Villanueva
- Markku Päivärinta
- Marleen R van Walsem
- Marleen van Walsem
- Marloes Verhoeven
- Marta Fatás Ventura
- Marta Para Prieto
- Martin Oehmen
- Martina Di Renzo
- Martina Petrollini
- Martinez-Descalls A.
- Martinez-Horta S.
- Mary Jones
- Maryla Rakowicz
- Maryline Couette
- María Del Mar Fenollar
- María José Sainz Artiga
- María Martirio Antequera Torres
- Matilde Calopa
- Matilde Laurà
- Matthias Dose
- Maurizio Vezza
- Max Hughes
- Maïté Bertrand
- Małgorzata Dec
- Mbombe Kazoka
- Mehdi Sebaiti
- Melisa Vacca
- Meriel McEntagart
- Mette Gilling
- Michael Bachmeier
- Michael Orth
- Michael Orth
- Michael Owen
- Michael Patton
- Michael Schüpbach
- Michal Szinwelski
- Michalina Malec-Litwinowicz
- Michał Arkuszewski
- Michela Ferraldeschi
- Michela Figorilli
- Michelle Phillips
- Michèle Pierre
- Miguel Coelho
- Milena Cannella
- Milou Jacobs
- Miquel Aguilar Barbera
- Misericordia Floriach Robert
- Monica Bascuñana Garde
- Monica Busse
- Monica Lewis
- Monica Rodriguez Lopera
- Monika Rudzińska
- Monika Rudzińska
- Monique S E van Hout
- Mário Miguel Rosa
- Mónica Bascuñana
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- Nadia Peppa
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- Nayana Lahiri
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- Susana Pro Koivisto
- Suzanne Lindquist
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- Tecla Tucci
- Tereza Uhrova
- Thomas Musacchio
- Thomas Warner
- Thomasin Andrews
- Tiago Mendes
- Tiago Mestre
- Tiago Mestre
- Tiziana Martino
- Torsten Illmann
- Tua Vinther-Jensen
- Ulrika Høsterey-Ugander
- Umberto Spampinato
- Una Jones
- Uruj Anjum
- Ute Hidding
- Valentina Codella
- Valeria Piras
- Valérie Vaquie
- Verena Baake
- Verena Baake
- Veronica Puertas Martin
- Verónica Mañanes Barral
- Vicenta Sánchez
- Vittorio Sciruicchio
- Vivien Vaughn
- Walburgis Heinicke
- Wildson Vieira da Silva
- Wim Vandenberghe
- Wioletta Krysa
- Witold Soltan
- Yanik Stebler
- Yuri Seliverstov
- Zeid Mohammed
- Zosia Miedzybrodzka
- Zygmunt Jamrozik
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2016
- Field of study
Objective: There is controversy about the clinical consequences of intermediate alleles (IAs) in Huntington disease (HD). The main objective of this study was to establish the clinical manifestations of IA carriers for a prospective, international, European HD registry. Methods: We assessed a cohort of participants at risk with <36 CAG repeats of the huntingtin (HTT) gene. Outcome measures were the Unified Huntington's Disease Rating Scale (UHDRS) motor, cognitive, and behavior domains, Total Functional Capacity (TFC), and quality of life (Short Form-36 [SF-36]). This cohort was subdivided into IA carriers (27-35 CAG) and controls (<27 CAG) and younger vs older participants. IA carriers and controls were compared for sociodemographic, environmental, and outcome measures. We used regression analysis to estimate the association of age and CAG repeats on the UHDRS scores. Results: Of 12,190 participants, 657 (5.38%) with <36 CAG repeats were identified: 76 IA carriers (11.56%) and 581 controls (88.44%). After correcting for multiple comparisons, at baseline, we found no significant differences between IA carriers and controls for total UHDRS motor, SF-36, behavioral, cognitive, or TFC scores. However, older participants with IAs had higher chorea scores compared to controls (p 0.001). Linear regression analysis showed that aging was the most contributing factor to increased UHDRS motor scores (p 0.002). On the other hand, 1-year follow-up data analysis showed IA carriers had greater cognitive decline compared to controls (p 0.002). Conclusions: Although aging worsened the UHDRS scores independently of the genetic status, IAs might confer a late-onset abnormal motor and cognitive phenotype. These results might have important implications for genetic counseling. ClinicalTrials.gov identifier: NCT01590589
Clinical and genetic characteristics of late-onset Huntington's disease
- Author
- Aanonsen Nils Olaf
- Aaserud Olaf
- Abbruzzese Giovanni
- Acera Gil Maria Angeles
- Ackermann Oda
- Adarmes Astrid
- Agarwal Veena
- Agosti Chiara
- Akhtar Shahbana
- Alaerts Nick
- Alarcón María Dolores
- Albanese Alberto (ORCID:0000-0002-5864-0006)
- Allain Philippe
- Almagro Carmen Antúnez
- Almeida Manuel
- Alonso-Frech Fernando
- Alusi Sundus
- Anderson Mary
- Andersson Christian
- Andrade Carlos
- Andrew Alyson
- Andrews Thomasin
- Andrews Thomasin
- Andrich Jürgen
- Anheim Mathieu
- Anjum Uruj
- Anna Bryl Jacek Anioła
- Annic Agnès
- Antczak Jakub
- Antequera Torres María Martirio
- Antonova Victoria
- Arbelo José Matías
- Arkuszewski Michał
- Armstrong Richard
- Armstrong Richard
- Arntsen Vibeke
- Arques Penelope Navas
- Arran Natalie
- Azulay Jean-Philippe
- Baake Verena
- Babiloni Blandine
- Bachmeier Michael
- Bachoud-Lévi Anne-Catherine
- Bachoud-Lévi Anne-Catherine
- Badei Farideh
- Bailey Wendy
- Banaszkiewicz Krzysztof
- Bandettini di Poggio Monica
- Bandmann Oliver
- Barbera Miquel Aguilar
- Barker Roger A.
- Barlati Sergio
- Barral Verónica Mañanes
- Barrero Francisco
- Barrett Wendy
- Barth Katrin
- Barth Katrin
- Barthélémy Recka
- Bartoli Caterina
- Barun Nadia
- Bas Jordi
- Bascuñana Mónica
- Becanovic Kristina
- Bechtel Natalie
- Beckmann Heike
- Bek Judith
- Bellonet Marcellin
- Benaich Sandra
- Benaminov Stanislav
- Benito Dolors Moragues
- Bentivoglio Anna Rita (ORCID:0000-0002-9663-095X)
- Bentivoglio Anna-Rita
- Berglund Maria
- Berglund Måns
- Berglund Peter
- Bergmann Ulrike
- Bernal-Escudero Maravilla
- Bernard Tomáš
- Bertini Elisabetta
- Bethwaite Pamela
- Betz Sabrina
- Beuth Markus
- Bezdíček Ondřej
- Bijlsma Emilia K.
- Bioux Sandrine
- Biunno Ida
- Björnsson Elisabeth
- Bjørgo Kathrine
- Bjørnevoll Inga
- Bled Déborah
- Bliaux Evangeline
- Blin Stéphanie
- Blinkenberg Ellen Økland
- Blondeau Leily
- Boczarska-Jedynak Magdalena
- Boelmans Kai
- Bohlen Stefan
- Boissé Marie-Françoise
- Bojakowska-Jaremek Kamila
- Bojarsky Jaime Kulisevsky
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonelli Raphael M.
- Bonneau Dominique
- Boogaerts Andrea
- Boogaerts Andrea
- Borgerød Nancy
- Bos Reineke
- Bos Reineke
- Bosca Maria
- Bosredon Cecile
- Bost Marie
- Boster Sarah
- Boudali Lotfi
- Bove Francesco
- Boćwińska Dorota
- Bradbury Alyson
- Braunwarth Eva-Maria
- Brice Alexis
- Brockie Peter
- Bronzova Juliana
- Brown Pauline
- Brugada Francisco Castera
- Brugger Florian
- Bruno Stefania
- Bruun Anu
- Buchanan Lindsay
- Buck Andrea
- Buongiorno María Teresa
- Buratti Lisa
- Burguera Juan Andres
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burgunder Jean-Marc
- Burn John
- Burrows Liz
- Busquets Núria
- Busse Monica
- Butcher Cynthia
- Bárcenas Antonio Herranz
- Böringer Regina
- Bürk Katrin
- Błaszczyk Magdalena
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- Caldentey Juan García
- Caldentey Juan García
- Caldentey Juan García
- Callaghan Jenny
- Callaghan Jenny
- Callaghan Jenny
- Calmeyn Godelinde
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- Campolongo Antonia
- Cannella Milena
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- Cass Ginette
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- Chu Elvina
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- Clayton Carole
- Clenaghan Catherine
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- Craven Janet
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- Cubo Esther
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- D'Alessio Barbara
- Damásio Joana
- Davidson Lynn
- Davies Rhys
- Davison Jill
- De Bruycker Christelle
- de Die-Smulders Christine EM.
- De Gregorio Francesca
- De Michele Giuseppe
- De Nicola Annunziata
- de Raedt Sylvie
- de Souza (Keylock) Jenny
- de Tommaso Marina
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- Decorte Eric
- Dedichá Nadia Rodríguez
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- Derost Philippe
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- Destee Alain
- Dewulf-Pasz Nelly
- Di Bella Daniela
- Di Donato Stefano
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- Dixon Kathryn
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- Doherty Karen
- Dondaine Thibaut
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- Dose Matthias
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- Fernandez Cristina Melgar
- Ferraldeschi Michela
- Ferrandes Giovanna
- Ferreira Joaquim J.
- Ferreira Joaquim J.
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- Figorilli Michela
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- Finisterra Ana Maria
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- Schmalfeld Jenny
- Schmidt Simone
- Schneider Ariane
- Schoonderbeek Anne
- Schrader Christoph
- Schwenk Daniela
- Schöggl Helmut
- Schüler Béatrice
- Schüpbach Michael
- Sciruicchio Vittorio
- Scott Adrienne
- Sebastián Ana Rojo
- Sebastián Ana Rojo
- Seliverstov Yury
- Seliverstov Yury
- Semedo Cristina
- Sempołowicz Justyna
- Seppi Klaus
- Serpino Claudia
- Sidorova Olga
- Sienkiewicz-Jarosz Halina
- Sieradzan Kasia
- Sikiric Alma
- Silva Mark
- Simonelli Maria
- Simonin Clémence
- Simpson Sheila A.
- Simpson Steve
- Simpson Steve
- Sinadinosa Daniela
- Singh Baldev
- Sipponen Marjatta
- Sitek Emilia
- Siuda Gill
- Slama Hichem
- Slawek Jaroslaw
- Smalley Sarah
- Smirnov Oleg
- Snowden Julie
- Soleti Francesco
- Solis Pilar
- Solito Marcella
- Soliveri Paola
- Sollom Andrea
- Soltan Witold
- Soltysiak Beverley
- Solís Pilar
- Somers Nele
- Sorbi Sandro
- Sorrentino Pierpaolo
- Souyris Corinne
- Spadaro Maria
- Spagnolo Francesca
- Spampinato Umberto
- Sprenger Fabienne
- Spruth Eike
- Squitieri Ferdinando
- Staffen Wolfgang
- Stamm Christiane
- Stattin Eva-Lena
- Stebler Yanik
- Steinmetz Gisèle
- Stenwak Agata
- Stockholm Jette
- Stokke Bodil
- Stompel Daniel
- Stopford Cheryl
- Storch Alexander
- Stoy Nicholas
- Stubbe Lars
- Stubbe Lars
- Stárková Irena
- Städtler Michael
- Størseth Hanna Haugan
- Stępniak Iwona
- Summers Fiona
- Sundblom Jimmy
- Sundblom Jimmy
- Supiot Frédéric
- Sułek Anna
- Svenningsson Per
- Swain Rachel
- Szczudlik Andrzej
- Szczygieł Elżbieta
- Szinwelski Michal
- Sánchez Jesús
- Sánchez Vicenta
- Sánchez Violeta Sánchez
- Süssmuth Sigurd
- t Hart Ellen P.
- Tabrizi Sarah
- Tabrizi Sarah J.
- Tacik Pawel
- Tadic Vera
- Tamburini Tiziano
- Tan Louis
- Tard Céline
- Taroni Franco
- Tartari Díaz-Zorita Juan Pablo
- Tataru Alina
- Taylor Anne-Marie
- Taylor Cat
- Taylor Catherine
- Taylor Rachel
- Tchikviladzé Maya
- Tedroff Joakim
- Thibault-Tanchou Stéphanie
- Thiel Silvia
- Thomas Gareth
- Thompson Jennifer
- Thomson Aileen
- Thomson David
- Tidswell Katherine
- Timewell Erika
- Timings Leanne
- Tir Mélissa
- Tomasello Chiara
- Tonner Alison
- Torlizzi Flavia
- Toscano Jean
- Townhill Jenny
- Townhill Jenny
- Tranchant Christine
- Trautmann Sonja
- Trender-Gerhard Iris
- Tucci Tecla
- Tuuha Katri
- Tyvoll Hilde
- Tähkäpää Sirkku
- Tübing Jennifer
- Udaeta Beatriz
- Uhrova Tereza
- Ulla Miguel
- Ullah Jasmin
- Ullah Jasmin
- Ure Alexandra
- Vacca Melisa
- Valadas Anabela
- Valentine Ruth
- van de Wyngaerde Françoise
- van den Bogaard Simon J. A.
- van Hout Monique S. E.
- van Kuijk Sander MJ.
- van Oostrom Joost
- Van Paemel Dominique
- van Reijen Dimphna
- van Vugt Jeroen P. P.
- van Walsem Marleen
- van Walsem Marleen R.
- Vandenberghe Wim
- Vandenberghe Wim
- Vangsted-Hansen Christina
- Vargas-González Laura
- Vaughan Vivien
- Vaughn Jenny
- Ventura Marta Fatás
- Verellen-Dumoulin Christine
- Verellen-Dumoulin Christine
- Verellen-Dumoulin Christine
- Verena Baake
- Verhoeven Marloes
- Vernon Nathan
- Verny Christophe
- Verstappen Carla
- Verstraelen (formerly Ritchie) Nichola
- Verstraelen (Ritchie) Nicola
- Vezza Maurizio
- Vidal Tiphaine
- Vieira da Silva Wildson
- Viladrich Cèlia Mareca
- Vilaplana Carmen Peiró
- Villa Carolina
- Villanueva Clara
- Villanueva Marina Ávila
- Vingerhoets Francois
- Vinther-Jensen Tua
- Vivancos Laura
- Vogel Melanie
- Vuillaume Isabelle
- Waber Mirella
- Wagner Caroline
- Wahlström+ Jan
- Wahlström+ Jan
- Wallden Tina
- Walleczek Anna Maria
- Wannepain Sandrine
- Warner Thomas
- Wasielewska Anna
- Weber Nathalia
- Weckx Petra
- Weekes Rebecca
- Weekes Rebecca
- Wehus Ragnhild
- Weindl Adolf
- Wenning Gregor
- Wermuth Lene
- Werner Cornelius J.
- Westman Laila
- Westmoreland Leann
- Weydt Patrick
- Whaite Anna
- Wider+ Christian
- Widner Håkan
- Wiklund Leif
- Wikström Birgitta
- Wild Edward
- Wild Sue
- Williams Josh
- Winkelmann Juliane
- Winkler Jürgen
- Winnberg Elisabeth
- Witjes-Ané Marie-Noelle
- Witjes-Ané Marie-Noëlle
- Witkowski Grzegorz
- Witkowski Grzegorz
- Wiśniewski Bartłomiej
- Wolz Annett
- Wolz Martin
- Wood Josh
- Wood Sue
- Wright Abigail
- Wright Abigail
- Wright Jan
- Wójcik Magdalena
- Yardumian Pam
- Yates Shona
- Youssov Katia
- Yudina Elizaveta
- Yudina Elizaveta
- Zalyalova Zuleykha
- Zaremba
- Zaremba Jacek
- Zaugg Sabine Weber
- Zdzienicka Elzbieta
- Zea Sevilla Maria Ascension
- Ziegler Cornelia
- Zielonka Daniel
- Zielonka Daniel
- Zielonka Eugeniusz
- Zimmermann Marie-Agathe
- Zinzi Paola
- Zinzi Paola
- Zinzi Paola
- Ziora-Jakutowicz Karolina
- Zittel Simone
- Zouitina Yassine
- Zucker Birgit
- Åman Jaana
- Østern Rune
- Šašinková Pavla
- Šenkárová Zuzana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P <.001). Overall motor and cognitive performance (P <.001) were worse, however only disease motor progression was slower (coefficient, −0.58; SE 0.16; P <.001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P <.001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P <.001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosing HD in elderly patients