1,006 research outputs found
Graded contractions and bicrossproduct structure of deformed inhomogeneous algebras
A family of deformed Hopf algebras corresponding to the classical maximal
isometry algebras of zero-curvature N-dimensional spaces (the inhomogeneous
algebras iso(p,q), p+q=N, as well as some of their contractions) are shown to
have a bicrossproduct structure. This is done for both the algebra and, in a
low-dimensional example, for the (dual) group aspects of the deformation.Comment: LaTeX file, 20 pages. Trivial changes. To appear in J. Phys.
Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension.
Background:
Resolution of inflammation is orchestrated by specialized proresolving lipid mediators (SPMs), and this would be impaired in some cardiovascular diseases. Among SPMs, resolvins (Rv) have beneficial effects in cardiovascular pathologies, but little is known about their effect on cardiovascular damage in hypertension.
Methods:
Aorta, small mesenteric arteries, heart, and peritoneal macrophages were taken from C57BL/6J mice, infused or not with angiotensin II (AngII; 1.44 mg/kg/day, 14 days) in presence or absence of resolvin D2 (RvD2) (100 ng/mice, every second day) starting 1 day before or 7 days after AngII infusion.
Results:
Enzymes and receptors involved in SPMs biosynthesis and signaling were increased in aorta or heart from AngII-infused mice. We also observed a differential regulation of SPMs in heart from these mice. Preventive treatment with RvD2 partially avoided AngII-induced hypertension and protected the heart and large and small vessels against functional and structural alterations induced by AngII. RvD2 increased the availability of vasoprotective factors, modified SPMs profile, decreased cardiovascular fibrosis, and increased the infiltration of pro-resolving macrophages. When administered in hypertensive animals with established cardiovascular damage, RvD2 partially improved cardiovascular function and structure, decreased fibrosis, reduced the infiltration of neutrophils, and shifted macrophage phenotype toward a pro-resolving phenotype.
Conclusions:
There is a disbalance between proinflammatory and resolution mediators in hypertension. RvD2 protects cardiovascular function and structure when administered before and after the development of hypertension by modulating vascular factors, fibrosis and inflammation. Activating resolution mechanisms by treatment with RvD2 may represent a novel therapeutic strategy for the treatment of hypertensive cardiovascular disease.pre-print362 K
First results on light readout from the 1-ton ArDM liquid argon detector for dark matter searches
ArDM-1t is the prototype for a next generation WIMP detector measuring both
the scintillation light and the ionization charge from nuclear recoils in a
1-ton liquid argon target. The goal is to reach a minimum recoil energy of
30\,keVr to detect recoiling nuclei. In this paper we describe the experimental
concept and present results on the light detection system, tested for the first
time in ArDM on the surface at CERN. With a preliminary and incomplete set of
PMTs, the light yield at zero electric field is found to be between 0.3-0.5
phe/keVee depending on the position within the detector volume, confirming our
expectations based on smaller detector setups.Comment: 14 pages, 10 figures, v2 accepted for publication in JINS
Accidental Inflation in String Theory
We show that inflation in type IIB string theory driven by the volume modulus
can be realized in the context of the racetrack-based Kallosh-Linde model (KL)
of moduli stabilization. Inflation here arises through the volume modulus
slow-rolling down from a flat hill-top or inflection point of the scalar
potential. This situation can be quite generic in the landscape, where by
uplifting one of the two adjacent minima one can turn the barrier either to a
flat saddle point or to an inflection point supporting eternal inflation. The
resulting spectral index is tunable in the range of 0.93 < n_s < 1, and there
is only negligible production of primordial gravitational waves r < 10^{-6}.
The flatness of the potential in this scenario requires fine-tuning, which may
be justified taking into account the exponential reward by volume factors
preferring the regions of the universe with the maximal amount of slow-roll
inflation. This consideration leads to a tentative prediction of the spectral
index or depending on whether the
potential has a symmetry phi -> - phi or not.Comment: 15 pages, 6 figures, LaTeX, uses RevTex
Search for the exotic resonance in the NOMAD experiment
A search for exotic Theta baryon via Theta -> proton +Ks decay mode in the
NOMAD muon neutrino DIS data is reported. The special background generation
procedure was developed. The proton identification criteria are tuned to
maximize the sensitivity to the Theta signal as a function of xF which allows
to study the Theta production mechanism. We do not observe any evidence for the
Theta state in the NOMAD data. We provide an upper limit on Theta production
rate at 90% CL as 2.13 per 1000 of neutrino interactions.Comment: Accepted to European Physics Journal
A light-reflecting balloon catheter for atraumatic tissue defect repair
A catheter-based technology reflects light to activate a photocurable adhesive for minimally invasive, atraumatic tissue defect closure
LEMUR: Large European Module for solar Ultraviolet Research. European contribution to JAXA's Solar-C mission
Understanding the solar outer atmosphere requires concerted, simultaneous
solar observations from the visible to the vacuum ultraviolet (VUV) and soft
X-rays, at high spatial resolution (between 0.1" and 0.3"), at high temporal
resolution (on the order of 10 s, i.e., the time scale of chromospheric
dynamics), with a wide temperature coverage (0.01 MK to 20 MK, from the
chromosphere to the flaring corona), and the capability of measuring magnetic
fields through spectropolarimetry at visible and near-infrared wavelengths.
Simultaneous spectroscopic measurements sampling the entire temperature range
are particularly important.
These requirements are fulfilled by the Japanese Solar-C mission (Plan B),
composed of a spacecraft in a geosynchronous orbit with a payload providing a
significant improvement of imaging and spectropolarimetric capabilities in the
UV, visible, and near-infrared with respect to what is available today and
foreseen in the near future.
The Large European Module for solar Ultraviolet Research (LEMUR), described
in this paper, is a large VUV telescope feeding a scientific payload of
high-resolution imaging spectrographs and cameras. LEMUR consists of two major
components: a VUV solar telescope with a 30 cm diameter mirror and a focal
length of 3.6 m, and a focal-plane package composed of VUV spectrometers
covering six carefully chosen wavelength ranges between 17 and 127 nm. The
LEMUR slit covers 280" on the Sun with 0.14" per pixel sampling. In addition,
LEMUR is capable of measuring mass flows velocities (line shifts) down to 2
km/s or better.
LEMUR has been proposed to ESA as the European contribution to the Solar C
mission.Comment: 35 pages, 14 figures. To appear on Experimental Astronom
Magnetic Imaging of the Outer Solar Atmosphere (MImOSA): Unlocking the driver of the dynamics in the upper solar atmosphere
The magnetic activity of the Sun directly impacts the Earth and human life.
Likewise, other stars will have an impact on the habitability of planets
orbiting these host stars. The lack of information on the magnetic field in the
higher atmospheric layers hampers our progress in understanding solar magnetic
activity. Overcoming this limitation would allow us to address four paramount
long-standing questions: (1) How does the magnetic field couple the different
layers of the atmosphere, and how does it transport energy? (2) How does the
magnetic field structure, drive and interact with the plasma in the
chromosphere and upper atmosphere? (3) How does the magnetic field destabilise
the outer solar atmosphere and thus affect the interplanetary environment? (4)
How do magnetic processes accelerate particles to high energies? New
ground-breaking observations are needed to address these science questions. We
suggest a suite of three instruments that far exceed current capabilities in
terms of spatial resolution, light-gathering power, and polarimetric
performance: (a) A large-aperture UV-to-IR telescope of the 1-3 m class aimed
mainly to measure the magnetic field in the chromosphere by combining high
spatial resolution and high sensitivity. (b) An extreme-UV-to-IR coronagraph
that is designed to measure the large-scale magnetic field in the corona with
an aperture of about 40 cm. (c) An extreme-UV imaging polarimeter based on a 30
cm telescope that combines high throughput in the extreme UV with polarimetry
to connect the magnetic measurements of the other two instruments. This mission
to measure the magnetic field will unlock the driver of the dynamics in the
outer solar atmosphere and thereby greatly advance our understanding of the Sun
and the heliosphere.Comment: Submitted to Experimental Astronomy (on 28. Jul. 2020). Based on a
proposal submitted in response to a call for white papers in the Voyage 2050
long-term plan in the ESA science programme. 36 pages, 10 figure
Production properties of K*(892) vector mesons and their spin alignment as measured in the NOMAD experiment
First measurements of K*(892) mesons production properties and their spin
alignment in nu_mu charged current (CC) and neutral current (NC) interactions
are presented. The analysis of the full data sample of the NOMAD experiment is
performed in different kinematic regions. For K*+ and K*- mesons produced in
nu_mu CC interactions and decaying into K0 pi+/- we have found the following
yields per event: (2.6 +/- 0.2 (stat.) +/- 0.2 (syst.))% and (1.6 +/- 0.1
(stat.) +/- 0.1 (syst.))% respectively, while for the K*+ and K*- mesons
produced in nu NC interactions the corresponding yields per event are: (2.5 +/-
0.3 (stat.) +/- 0.3 (syst.))% and (1.0 +/- 0.3 (stat.) +/- 0.2 (syst.))%. The
results obtained for the rho00 parameter, 0.40 +/- 0.06 (stat) +/- 0.03 (syst)
and 0.28 +/- 0.07 (stat) +/- 0.03 (syst) for K*+ and K*- produced in nu_mu CC
interactions, are compared to theoretical predictions tuned on LEP measurements
in e+e- annihilation at the Z0 pole. For K*+ mesons produced in nu NC
interactions the measured rho00 parameter is 0.66 +/- 0.10 (stat) +/- 0.05
(syst).Comment: 20 p
Prediction of Neutrino Fluxes in the NOMAD Experiment
The method developed for the calculation of the flux and composition of the
West Area Neutrino Beam used by NOMAD in its search for neutrino oscillations
is described. The calculation is based on particle production rates computed
using a recent version of FLUKA and modified to take into account the cross
sections measured by the SPY and NA20 experiments. These particles are
propagated through the beam line taking into account the material and magnetic
fields they traverse. The neutrinos produced through their decays are tracked
to the NOMAD detector. The fluxes of the four neutrino flavours at NOMAD are
predicted with an uncertainty of about 8% for nu(mu) and nu(e), 10% for
antinu(mu), and 12% for antinu(e). The energy-dependent uncertainty achieved on
the R(e, mu) prediction needed for a nu(mu)->nu(e) oscillation search ranges
from 4% to 7%, whereas the overall normalization uncertainty on this ratio is
4.2%.Comment: 43 pages, 20 figures. Submitted to Nucl. Phys.
- …