A hybrid-integrated diode laser in the visible spectral range

Generating visible light with wide tunability and high coherence based on photonic integrated circuits is of high interest for applications in biophotonics, precision metrology and quantum technology. Here we present the first demonstration of a hybrid-integrated diode laser in the visible spectral range. Using an AlGaInP optical amplifier coupled to a low-loss Si3N4 feedback circuit based on microring resonators, we obtain a spectral coverage of 10.8 nm around 684.4 nm wavelength with up to 4.8 mW output power. The measured intrinsic linewidth is 2.3$\pm$0.2 kHz.Comment: 8 pages, 6 figure

Vincristine, doxorubicin and dexamethasone (VAD) administered as rapid intravenous infusion for first-line treatment in untreated multiple myeloma

We examined the feasibility of achieving a rapid response in patients with previously untreated multiple myeloma by administering vincristine 0.4 mR and doxorubicin 9 mg/m2 as a rapid intravenous infusion for 4 d together with intermittent high-dose dexamethasone 40 mg (VAD) for remission induction treatment in patients who were scheduled to receive high-dose therapy. 139 patients (86 male, 53 female; median age 53 years, range 32-65 years; Durie and Salmon stage IIA: 42, IIB: one, IIIA: 89, IIIB: seven) were included in a prospective multicentre study in which VAD was administered as remission induction treatment and was followed by intensified treatment. The response was evaluated according to the criteria of the Eastern Cooperative Oncology Group (ECOG). The results of treatment were evaluable in 134 patients. Five patients died before evaluation. 86 patients (62%) achieved a partial response (PR) and seven patients (5%) achieved a complete response (CR), which equates to a response rate of 67%. The main side-effect was mild neurotoxicity, which was observed in 18% of the patients. Fever or infections were reported in 27% of the patients. VAD administered as an outpatient regimen, based on rapid intravenous infusion, is an effective induction regimen for untreated myeloma with a 67% response rate and acceptable toxicity

Taxonomy based on science is necessary for global conservation

Peer reviewe

Dermaseptins, Multifunctional Antimicrobial Peptides: A Review of Their Pharmacology, Effectivity, Mechanism of Action, and Possible Future Directions

International audienceDermaseptins are a group of α-helical shaped polycationic peptides isolated from the Hylid frogs, with antimicrobial effects against bacteria, parasites, protozoa, viruses in vitro. Besides, anti-tumor effects have been demonstrated. However, few animal experiments and no clinical trials have been conducted thus far. This review summarizes the current knowledge on the pharmacology, ethno pharmacology, effectivity against infectious pathogens and tumors cells and the mechanism of action of the Dermaseptins. Future research should focus on further clarification of the mechanisms of action, the effectivity of Dermaseptins against several cancer cell lines and their applicability in humans

Reverse logistics: A review of case studies

This paper gives an overview of scientific literature that describes and discusses cases of reverse logistics activities in practice. Over sixty case studies are considered. Based on these studies we are able to indicate critical factors for the practice of reverse logistics. In addition we compare practice with theoretical models and point out research opportunities in the field

A characterisation of logistics networks for product recovery

Recovery of used products is receiving much attention recently due to growing environmental concern. Efficient implementation requires appropriate logistics structures to be set up for the arising goods flow from users to producers. We investigate the design of such logistics networks. As a basis for our analysis we review recent case studies on logistics network design for product recovery in different industries. We identify general characteristics of product recovery networks and compare them with traditional logistics structures. Moreover, we derive a classification scheme for different types of recovery networks

Microresonators as promising building blocks for VLSI photonics

In the last years much effort has been taken to arrive at optical integrated circuits with high complexity and advanced functionality. For this aim high index contrast structures are employed that allow for a large number of functional elements within a given chip area: VLSI photonics. It is shown that optical microresonators can be considered as promising basic building blocks for filtering, amplification, modulation, switching and sensing. Active functions can be obtained by monolithic integration or a hybrid approach using materials with thermo-, electro- and opto-optic properties and materials with optical gain. Examples are mainly taken from work at MESA'