11 research outputs found
Bridging the Gap: A Program to Enhance Medical Students\u27 Learning Experience in the Foundation Year
Objective: To evaluate students’ perceptions of the intervention program based on small group teaching, regular continuous assessment, science-based tailored study skills program and recorded attendance on students’ enhanced learning experience in the first year of study in an outcome-based medical course.
Design: Descriptive study.
Setting: RCSI Bahrain.
Method: A Twenty-seven-item questionnaire was administered to foundation year students at the Royal College of Surgeons in Ireland – Medical University of Bahrain (RCSI Bahrain) after the completion of the first semester to explore whether these interventions enriched the students’ learning experience or not. Comparisons of pass rates in all modules over the four years were also included. Students’ perceptions of the academic study skills course were collected through a questionnaire activity (version 2007120102) via the Virtual Learning Environment (VLE).
Result: The results suggest that local adaptations of undergraduate programs may lead to pedagogical expertise that contribute to enhanced learning experience of students and better integration of pre-university and third-level courses. The majority of questionnaire items were rated positively and the comparison of pass rates showed the highest results in the year the intervention was implemented.
Conclusion: Making local adaptations to medical programs without changing the core curriculum can mark good academic practice. Considering specific socio-cultural frameworks of students may lead to improvements in the delivery of programs in universities
fac-Tris(4-aminoÂbenzohydroxamato)iron(III) ethanol solvate
In the structure of the title compound, [Fe(C7H7N2O2)3]·CH3CH2OH, the FeIII atom is in a distorted octaÂhedral O6 environment with the three hydroxamate O atoms (and the three carbonyl O atoms) arranged in a fac configuration and one of the hydroxamate ligands being puckered. The methyl C atom of the ethanol solvent molÂecule is disordered over two positions with occupancies of 0.626 (13) and 0.374 (13), respectively. The cocrystallized ethanol molÂecule is hydrogen bonded to one of the hydroxamate O atoms. O—H⋯O and N—H⋯O interÂactions generate infinite three-dimensional networks along [100], [010] and [001]
BA in Photographic Media Graduate Show 2016
The work seen in this book relates to the students’ major final photographic project of 20 Credits, consisting of:
Book/Folio, Written Visual Diary to support the project + Exhibition.
Contributors:
Alexksandra Isats,
Charlotte Herron,
Claudia Verdecchia,
David Fogarty,
Declan Kelly,
Deirdre Fallon,
Giselle Sanguino Romero,
Hannah Tiernan,
Joseph Chatham,
John Carroll,
Jozsef Kukola,
Justina Brazauskalte,
Lauren Gaynor,
Pablo Jean,
Paul Quigley,
Simon Walsh,
Sunniva Lervik,
Tetyana Voloshyn
Exploring changes in levels and patterns of physical activity in undergraduate medical and nursing students during the COVID-19 pandemic
This study reports the physical activity (PA) levels among medical and nursing students at a university in Bahrain during the COVID-19 pandemic. Through self-selection sampling of an online survey, participants' data on general demographics, PA levels before and during the COVID-19 pandemic and reasons for PA changes were collected. From the 110 valid responses, 70 participants (63%) experienced a decrease in PA during the COVID-19 lockdown. Fear of contracting COVID-19 and lack of motivation were two significant reasons for reduced PA levels (p < 0.001) compared to those who did not experience a decrease in PA. Other factors significantly associated with reduced PA levels include living alone (p < 0.018) or with roommates (p < 0.006) compared to living with family. Having more time available was associated with positive changes to PA levels (p < 0.001). Significant differences in MET-min/week were seen between students who experienced increased PA (median of 1605 MET-min/week) compared to those who experienced a decrease (424 MET-min/week) or no change (1070 MET-min/week) in PA levels (p < 0.001). In conclusion, low PA levels are prevalent within medical and nursing students in Bahrain (51% reported < 600 MET-min/week), with ~2 in 3 students reporting a decrease in PA levels during the COVID-19 pandemic. Support programs and strategies to increase engagement in PA within this population are warranted
Progressive Decoration of a Pentanuclear Cu(II) 12-Metallocrown-4 Towards Targeted 1- and 2-D Extended Networks
Journal article (pre-print)The synthesis, structures and magnetic characterisation of a family of discrete planar pentanuclear Cu(II) 12-MC-4 metallacrowns of formulae [Cu5(L1)4(MeOH)4](ClO4)2 (1), [Cu5(L1)4(py)2](ClO4)2·py (2), [Cu5(L1)4(py)6](ClO4)2 (3) and [Cu5(L2)4(MeOH)4](ClO4)2·H2O (7) (where L1H2 = 2-(dimethylamino)phenylhydroxamic acid and L2H2 = 2-(amino)phenylhydroxamic acid) are reported. UV-vis and Electrospray MS studies indicate solution stability with respect to their {Cu5(L)4}2+ cores. Magnetic susceptibility measurements confirm strong antiferromagnetic exchange between the Cu(II) ions resulting in isolated S = 1/2 ground spin states. The introduction of ditopic co-ligands such as 4,4¿-bipyridine (4,4¿-bipy), pyrazine (pz) and 4,4¿-azopyridine (4,4¿-azp) results in their coordination at a number of axial Cu(II) sites within the {Cu5} metallacrown nodes to afford the extended networks {[Cu5(L1)4(4,4¿-bipy)3](ClO4)2·(H2O)}n (4), {[Cu5(L1)4(4,4¿-azp)2(MeOH)2](ClO4)2}n (5) and {[Cu5(L2)4(pz)2(MeOH)3](ClO4)2·MeOH}n (6).IRCSE
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Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain
Neuropsychiatric genome-wide association studies (GWASs), including those for autism spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the developing brain. However, prioritizing risk genes and mechanisms is challenging without a unified regulatory atlas. Across 672 diverse developing human brains, we identified 15,752 genes harboring gene, isoform, and/or splicing quantitative trait loci, mapping 3739 to cellular contexts. Gene expression heritability drops during development, likely reflecting both increasing cellular heterogeneity and the intrinsic properties of neuronal maturation. Isoform-level regulation, particularly in the second trimester, mediated the largest proportion of GWAS heritability. Through colocalization, we prioritized mechanisms for about 60% of GWAS loci across five disorders, exceeding adult brain findings. Finally, we contextualized results within gene and isoform coexpression networks, revealing the comprehensive landscape of transcriptome regulation in development and disease
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Massively parallel characterization of regulatory elements in the developing human cortex
Nucleotide changes in gene regulatory elements are important determinants of neuronal development and diseases. Using massively parallel reporter assays in primary human cells from mid-gestation cortex and cerebral organoids, we interrogated the cis-regulatory activity of 102,767 open chromatin regions, including thousands of sequences with cell type-specific accessibility and variants associated with brain gene regulation. In primary cells, we identified 46,802 active enhancer sequences and 164 variants that alter enhancer activity. Activity was comparable in organoids and primary cells, suggesting that organoids provide an adequate model for the developing cortex. Using deep learning we decoded the sequence basis and upstream regulators of enhancer activity. This work establishes a comprehensive catalog of functional gene regulatory elements and variants in human neuronal development