Understanding heritage: multiple meanings and values.

This research aims to explore the ways in which people understand and value heritage through a focus on the lay rather than the expert view. This focus was considered important in order to move beyond the emphasis on expert knowledge within heritage discourses and in turn, privilege lay understandings of heritage. This study adds to current knowledge by offering an in-depth understanding of the non-expert view of heritage and the multiple meanings and values that heritage represents within this context. The rationale for this research is based on the increasingly important role heritage plays within the wider visitor economy and the recognised interrelationships between heritage and tourism. In order to develop long-term, meaningful relationships with current and potential heritage audiences, there is a need to appreciate the ways in which people engage with heritage in a much broader sense and to understand the meanings and relevance that heritage may represent within this context. In order to meet the aim of this research, an inductive qualitative methodology was designed which prioritises the emic or insider perspective of heritage. To further enhance the inductive nature of this study, the primary research took place away from a pre-defined „heritage’ context in order to allow the participants themselves to define and shape heritage as they understand and value it. Eight focus groups were carried out with forty-seven members of the public and the data was analysed through a thematic framework. Nine themes and related sub-themes were constructed to represent the lay understandings, meanings and values of heritage. The social nature of the focus group method, along with the interaction it fosters between participants, led to a range of insights about the relevance of heritage. The majority of heritage research to date has taken place within a pre-defined heritage context, which inevitably limits the scope for accessing and understanding the views of those who do not typically engage with heritage in this way. Therefore, this study further contributes by incorporating the views of those who do not typically fall within heritage user or visitor categories. By exploring the views of the so called non-user or non-visitor of heritage the barriers that prevent engagement with „heritage‟ and „heritage tourism‟ as it is defined and presented by the industry are identified. The implications of this study relate to the need for more engaging and personally relevant heritage narratives that build from an understanding of the meanings and values that shape engagement with heritage beyond a personal level. Heritage practitioners and academics need to embrace lay understandings of heritage within their activities and seek to empower current and potential audiences to critically engage with and actively interpret meanings from the heritage they present

A cohort study of duplex Doppler examinations of the carotid artery in primary open angle glaucoma

Objectives To explore the possibility of pathological change in the common carotid artery at the bifurcation and in the internal carotid artery beyond the bifurcation which could contribute to a reduced diastolic pressure as observed in primary open angle glaucoma. Design Duplex ultrasonic examinations of carotid bifurcations were conducted on 80 patients. Carotid artery defects were allocated into three types: no demonstrable flow defects, internal carotid artery abnormalities and disease in the carotid bulb. Setting Bristol Royal Infirmary Vascular Laboratory. Participants Eighty patients (mean age 69.6 years) providing a total of 160 sides to the analysis. Main outcome measures An estimated central retinal artery pressure, intraocular pressure and field loss were recorded for each side measured. Results Doppler investigations revealed significant levels of pathological change in the internal carotid distinct from changes at the carotid bulb. The disease revealed in the internal carotid artery was significantly associated with intraocular pressure (p = 0.032), with an effect small to medium in magnitude. The Q2 measure, derived from mean arterial pressure and intraocular pressure, was also substantively associated with disease in the internal carotid artery. Both intraocular pressure and the Q2 measure effectively discriminated between groups, with field loss providing rather less discriminating capability. There was a strong trend towards a higher intraocular pressures and a greater visual field loss with internal carotid artery disease. Conclusions Pathological changes in the extra cranial carotid artery in primary open angle glaucoma exceed those in the arteries classified as normal. The presence of disease specifically in the internal carotid artery emphasised the need for a mechanism for the evaluation of the internal carotid apart from the carotid bulb. A basis for clarifying the presence of an ischaemic zone is proposed

NILS: a Neutrality-based Iterated Local Search and its application to Flowshop Scheduling

This paper presents a new methodology that exploits specific characteristics from the fitness landscape. In particular, we are interested in the property of neutrality, that deals with the fact that the same fitness value is assigned to numerous solutions from the search space. Many combinatorial optimization problems share this property, that is generally very inhibiting for local search algorithms. A neutrality-based iterated local search, that allows neutral walks to move on the plateaus, is proposed and experimented on a permutation flowshop scheduling problem with the aim of minimizing the makespan. Our experiments show that the proposed approach is able to find improving solutions compared with a classical iterated local search. Moreover, the tradeoff between the exploitation of neutrality and the exploration of new parts of the search space is deeply analyzed

Cosmology and galactic angular momenta

The plan of this paper is to present some observations and then in subsequent chapters to examine the two basic cosmological ideas in the light of these observations. The first of the observations involves an estimate of the angular momentum in a given volume of space and the ratio of this momentum to the mass or number of nucleons in the given volume. We therefore wish to obtain a rough estimate of the angular momentum in that part of the universe which man may call his immediate surroundings, i.e., the solar system and galaxy

A new distance measure based on the exchange operator for the HFF-AVRP

The Heterogeneous Fixed Fleet Asymmetric Vehicle Routing Prob- lem (HFF-AVRP) is a N P-hard optimization problem. Instances analysis and in particular, fitness landscape analysis, may help problem solving. Such anal- ysis require the definition of a distance between feasible solutions. Such a dis- tance does not exist for the HFF-AVRP and this report aims at proposing a new distance measure defined from the exchange operator. In order to compute the exchange-distance between two solutions, four algorithms are suggested and then experimented. One of them is proved to be robust and to give the exact distance whereas others only compute an upper bound

A novel anti-cancer bifunctional platinum drug candidate with dual DNA binding and histone deacetylase inhibitory activity.

The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA binding, histone deacetylase inhibitory activity and enhanced selectivity for cancer cells are described

Monohydroxamic acids and bridging dihydroxamic acids as chelators to ruthenium(III) and as nitric oxide donors: syntheses, speciation studies and nitric oxide releasing investigations.

The synthesis and spectroscopic characterisation of novel mononuclear Ru(III)(edta)(hydroxamato) complexes of general formula [Ru(H2edta)(monoha)] (where monoha = 3- or 4-NH2, 2-, 3- or 4-C1 and 3-Me-phenylhydroxamato), as well as the first example of a Ru(III)-N-aryl aromatic hydroxamate, [Ru(H2edta)(N-Me-bha)].H2O (N-Me-bha = N-methylbenzohydroxamato) are reported. Three dinuclear Ru(III) complexes with bridging dihydroxamato ligands of general formula [{Ru(H2edta)}2(mu-diha)] where diha = 2,6-pyridinedihydroxamato and 1,3- or 1,4-benzodihydroxamato, the first of their kind with Ru(III), are also described. The speciation of all of these systems (with the exception of the Ru-1,4-benzodihydroxamic acid and Ru-N-methylbenzohydroxamic systems) in aqueous solution was investigated. We previously proposed that nitrosyl abstraction from hydroxamic acids by Ru(III) involves initial formation of Ru(III)-hydroxamates. Yet, until now, no data on the rate of nitric oxide (NO) release from hydroxamic acids has been published. We now describe a UV-VIS spectroscopic study, where we monitored the decrease in the ligand-to-metal charge-transfer band of a series of Ru(III)-monohydroxamates with time, with a view to gaining an insight into the NO-releasing properties of hydroxamic acids

Faculty Attitudes Towards Integrating Technology and Innovation

Technological innovation is an important aspect of teaching and learning in the 21st century. This article examines faculty attitudes toward technology use in the classroom at one regional public university in the United States. Building on a faculty-led initiative to develop a Community of Practice for improving education, this study used a mixed-method approach of a faculty-developed, electronic survey to assess this topic. Findings from 72 faculty members revealed an overall positive stance toward technology in the classroom and the average faculty member utilized about six technology tools in their courses. The opportunities, barriers and future uses for technologies in the higher education classroom emerged from the open-ended questions on the survey. One finding of particular concern is that faculty are fearful that technology causes a loss of the humanistic perspective in education. The university is redesigning ten of its most popular courses to increase flexibility, accessibility and student success