BRSMG Realce: Common bean cultivar with striped grains for the state of Minas Gerais

The common bean cultivar “BRSMG Realce”, recommended for the state of Minas Gerais, has high yield potential and resistance to powdery mildew, bacterial wilt and to anthracnose pathotypes 65, 73, 77, 81, 91, 475 and 479. The plants and pods are high, resulting in lower loss during mechanical harves

Relatório de estágio em farmácia comunitária

Relatório de estágio realizado no âmbito do Mestrado Integrado em Ciências Farmacêuticas, apresentado à Faculdade de Farmácia da Universidade de Coimbr

Time of perineal analgesia by cryotherapy after vaginal delivery: uncontrolled clinical trial

Introdução: A dor perineal é uma morbidade frequente no pós-parto vaginal. A crioterapia, aplicação de frio para fins terapêuticos, é eficaz para seu alívio, além de ser uma prática de baixo custo, fácil preparo e compatível com a amamentação. No entanto, ainda não se conhece a duração do efeito analgésico da crioterapia quando aplicada à região perineal. Objetivo: Avaliar a duração da analgesia perineal em multíparas, após a aplicação de bolsa de gelo por 20 minutos no pós-parto normal. Método: Trata-se de ensaio clínico não controlado, realizado no Alojamento Conjunto de uma maternidade de São Paulo. Foram incluídas 50 mulheres com idade igual ou maior que 18 anos com, pelo menos, um parto vaginal prévio ao atual, sem intercorrências clínicas ou obstétricas, sem ter recebido anestesia peridural, anti-inflamatório ou analgésico nas últimas 3 horas antes da inclusão no estudo e com dor perineal igual ou maior que 3 pontos, entre 6 e 24h do pós-parto. A intervenção foi realizada por meio de uma única aplicação da bolsa de gelo na região perineal por 20 minutos, sendo controladas as temperaturas perineais, da bolsa de gelo, do ambiente e da axila. As participantes foram avaliadas em três momentos: 1) antes da crioterapia (T0); 2) imediatamente, após a crioterapia (T20); 3) 120 minutos após o término da crioterapia (T120). Para avaliação da dor, foi utilizada a escala numérica de zero a dez, sendo zero ausência de dor e dez dor insuportável. Resultados: A idade média foi 27,1 anos (dp=5,4); 52% tinham ensino médio; 40% eram pardas; 90% possuíam companheiro com coabitação; 52% tinham trabalho remunerado e 62% tiveram o companheiro como acompanhante no parto. O trauma perineal ocorreu em 58,0% das participantes, destes, 44,0% foram laceração espontânea de primeiro grau e 14,0% laceração de segundo grau ou episiotomia. Quanto às variáveis numéricas, as médias observadas foram: a queixa de dor perineal ocorreu com 11,6h (dp=0,2) de pós-parto, temperatura axilar de 36,3ºC (dp=0,6), temperatura ambiental de 25,8°C (dp=1,6), temperatura inicial do períneo de 33,2°C (dp=0,8) e peso do RN de 3.305g (dp=454). As médias de intensidade da dor apresentaram diferenças significativas ao longo do tempo (teste de Friedman p<0,0005). Entre T0 e T20, houve uma redução estatisticamente significante da dor perineal (5,4 e dp=1,8 versus 1,0 e dp=1,7). Comparando a intensidade da dor perineal entre T20 e T120 constatou-se que não houve diferença significante (1,0 e dp=1,7 versus 1,6 e dp=2,4), o que corresponde à manutenção do efeito analgésico. O tempo médio foi avaliado para o retorno da dor perineal, após a crioterapia, sendo de 94,6 minutos (IC 95%: 84,8; 104,5 minutos), estimado pela curva de sobrevida. Conclusão: A aplicação de bolsa de gelo por 20 minutos no períneo de multíparas no pós-parto normal promove o alívio da dor, com redução significativa de sua intensidade e manutenção de efeito analgésico por até 120 minutos, sendo necessária reavaliação, após este período. A crioterapia foi considerada pelas puérperas como um procedimento confortável, gerador de satisfação por diminuir a dor e promover o bem-estar.Introduction: Perineal pain is a common morbidity after vaginal delivery. The cryotherapy, application of cold for therapeutic purposes, is effective for its relief, besides being a low cost practice, easy preparation and compatibility with breastfeeding. However, one still does not know the duration of the analgesic effect of cryotherapy when applied to the perineal region. Objective: To evaluate the duration of perineal analgesia in multiparous, after applying ice pack for 20 minutes in normal postpartum. Method: This is an uncontrolled clinical trial conducted in the rooming at a maternity hospital in São Paulo. The study included 50 women aged 18 years or above, who had experienced at least one prior vaginal delivery free of clinical or obstetric complications, who did not receive epidural anti-inflammatory nor analgesic over the past 3 hours prior to study entry and who experienced perineal pain equal to or greater than 3 points, between 6 and 24 hours of postpartum. The intervention, in which the temperature of the perineum, ice pack, environment and armpit were controlled, was performed by a single application of ice packs on the perineal region for 20 minutes. Participants were assessed at three moments: 1) before cryotherapy (T0); 2) immediately after cryotherapy (T20); 3) 120 minutes after the cryotherapy (T120). For the assessment of pain, the numerical scale from zero to ten was used, zero and ten representing no pain and excruciating pain respectively. Results: The mean age was 27.1 years (sd=5.4); 52% had completed high school; 40% were brown; 90% lived with a partner; 52% had paid job and 62% had as companion during childbirth. The perineal trauma occurred in 58.0% of participants, of whom 44.0% suffered first degree spontaneous laceration and 14.0% second degree laceration or episiotomy. As for numerical variables, the averages observed were: the complain of perineal pain occurred with 11.6 hours (sd=0.2) of postpartum, axillary temperature of 36.3ºC (sd=0.6), environmental temperature of 25.8°C (sd=1.6), perineum initial temperature of 33.2°C (sd=0.8) and birth weight of 3.305g (sd=454). The means of pain intensity showed significant differences over time (Friedman test p < 0.0005). Between T0 and T20, there was a statistically significant reduction in perineal pain (5.4 and sd=1.8 versus 1.0 and sd=1.7). Comparing the intensity of perineal pain between T20 and T120, one could find that there was no statistically significant difference (1.0 and sd=1.7 versus 1.6 and sd=2.4), corresponding to the maintenance of the analgesic effect. The average time for the return of perineal pain was evaluated, after cryotherapy, as 94.6 minutes (95% CI: 84.8, 104.5 minutes), estimated by the survival curve. Conclusion: The application of ice packs for 20 minutes in the perineum of normal multiparous in the postpartum promotes pain relief with significant reduction of its intensity and maintenance of analgesic effect for up to 120 minutes, requiring reassessment after this period. Cryotherapy was considered by the women as a comfortable procedure, generating satisfaction by reduction of pain and promotion of well-being

Introducing a very low carbohydrate diet for a child with type 1 diabetes

Type 1 diabetes mellitus is a serious autoimmune disease for which no cure is available. The treatment includes insulin therapy, carbohydrate counting, eating healthy foods, exercising regularly, and maintaining a healthy weight. The goal is to keep blood glucose levels close to normal most of the time to delay or prevent complications. Despite the increase in the use of insulin pumps and continuous glucose monitors in recent years, the management of type 1 diabetes remains suboptimal in terms of glycaemic control and normal glycated haemoglobin (HbA1c) level. This article discusses the case of a child with type 1 diabetes who was successfully treated with a very low-carbohydrate diet, resulting in normal levels of HbA1c and normal blood glucose 95% of the time in a range of 70-4180 mg/dL (4.0 mmol/L-10 mmol/L). Therefore, further studies are needed to verify how a very low carbohydrate diet impacts child development28151015101

Neonatal admission and its relationship to maternal pain: Pain scores and analgesia

The aim of this study was to determine whether postnatal women whose babies required neonatal intensive care unit (NICU) admission self-reported lower pain scores and required less analgesia than women whose babies remained with them. A prospective matched audit comparing pain scores and analgesia requirements where every woman with a baby admitted to the NICU was matched to 2 women whose babies remained on the ward was undertaken. Matches were based on age, number of previous births, type of birth, episiotomy, and epidural or spinal analgesia use. Data were collected on pain scores and analgesia administered in the first 72 hours postbirth. A total of 150 women were recruited and matched from November 2015 to May 2017. No statistically significant differences were found between the 2 groups for opiate analgesia use (P =.91) or pain scores (P =.89). Regardless of NICU admission, significantly higher pain scores were reported in participants who had episiotomies (P =.03). Birth via cesarean birth resulted in significantly higher pain scores (P <.01) and greater opiate administration (P <.01). This study found no statistically significant difference between pain scores or analgesia use of mothers whose babies required NICU admission and mothers whose babies remained with them

CULTIVAR RELEASE - BRSMG União: common bean cultivar with jalo grain for the state of Minas Gerais

The bean cultivar BRSMG União as a new option of a bean cultivar with jalo grains for the state of Minas Gerais. The cultivar BRSMG União had an average grain yield of 9.8% above the mean of the controls (Jalo EEP 558 and BRS Radiante) and was resistant to powdery-mildew

BRSMG Realce: Common bean cultivar with striped grains for the state of Minas Gerais

The common bean cultivar “BRSMG Realce”, recommended for the state of Minas Gerais, has high yield potential and resistance to powdery mildew, bacterial wilt and to anthracnose pathotypes 65, 73, 77, 81, 91, 475 and 479. The plants and pods are high, resulting in lower loss during mechanical harves

Fibromyalgia and the relevance of the whole-body vibration exercises in vibratory platforms: a short review

Among nonpharmacological strategy to manage fibromyalgia, exercise (aerobic) has shown efficacy. Whole-body vibration (WBV) exercise has been proposed as a potential clinical intervention. WBV would induce increase in growth hormone (GH). An impairment of the hypothalamic-pituitary-GH-Insulin Growth Factor-1(IGF-1) axis has been implicated in the pathophysiology of fibromyalgia. This article aims to review the studies on exploring the relationship between WBV and fibromyalgia. Literature searches were performed in the PubMed database on 04/03/2010 using terms related to "pain", "whole body vibration" and "fibromyalgia". An important number of publications were identified with the term "pain" and in comparison, only a small number of articles were found related to "fibromyalgia". Three publications found with "whole body vibration" and fibromyalgia were analyzed.There are reports describing increase in serum IGF-1 following exposure to WBV in elderly patients. However, one randomized fibromyalgia trial revealed no changes in serum IGF-1 levels in women undergoing WBV. Due to the paucity of available, effective therapies for fibromyalgia, further studies that explore the relationship between the neuroendocrine system, fibromyalgia and WBV are merited

A Transcript Finishing Initiative for Closing Gaps in the Human Transcriptome

We report the results of a transcript finishing initiative, undertaken for the purpose of identifying and characterizing novel human transcripts, in which RT-PCR was used to bridge gaps between paired EST clusters, mapped against the genomic sequence. Each pair of EST clusters selected for experimental validation was designated a transcript finishing unit (TFU). A total of 489 TFUs were selected for validation, and an overall efficiency of 43.1% was achieved. We generated a total of 59,975 bp of transcribed sequences organized into 432 exons, contributing to the definition of the structure of 211 human transcripts. The structure of several transcripts reported here was confirmed during the course of this project, through the generation of their corresponding full-length cDNA sequences. Nevertheless, for 21% of the validated TFUs, a full-length cDNA sequence is not yet available in public databases, and the structure of 69.2% of these TFUs was not correctly predicted by computer programs. The TF strategy provides a significant contribution to the definition of the complete catalog of human genes and transcripts, because it appears to be particularly useful for identification of low abundance transcripts expressed in a restricted set of tissues as well as for the delineation of gene boundaries and alternatively spliced isoforms