Nuevos táxones para la Flora de la Montaña Palentina (España)

En este trabajo se aportan citas de plantas que, en la mayoría de los casos, constituyen novedades provinciales para Palencia o bien su presencia es muy escasa en el territorio que nos ocupa. Todos los táxones han sido herborizados en la zona norte de la provincia, concretamente en el Parque Natural de Fuentes Carrionas y Fuente Cobre - Montaña Palentina (fig.1).Los pliegos correspondientes se encuentran depositados en el Herbario LEBJaime Andrés Rodríguez de la Universidad de León. A continuación se relacionan por orden alfabético y se detallan los siguientes datos: localidad, coordenadas UTM, altitud, ecología, fecha de recolección, colectores y número de registro en el herbari

Nuevos táxones para la flora de la montaña palentina (España)

P. 309-313En este trabajo se aportan citas de plantas que, en la mayoría de los casos, constituyen novedades provinciales para Palencia o bien su presencia es muy escasa en el territorio que nos ocupa. Todos los táxones han sido herborizados en la zona norte de la provincia, concretamente en el Parque Natural de Fuentes Carrionas y Fuente Cobre - Montaña Palentina (fig.1). Los pliegos correspondientes se encuentran depositados en el Herbario LEBJaime Andrés Rodríguez de la Universidad de León. A continuación se relacionan por orden alfabético y se detallan los siguientes datos: localidad, coordenadas UTM, altitud, ecología, fecha de recolección, colectores y número de registro en el herbario.S

Genomic mutation profile in progressive chronic lymphocytic leukemia patients prior to first-line chemoimmunotherapy with FCR and rituximab maintenance (REM)

Chronic Lymphocytic Leukemia (CLL) is the most prevalent leukemia in Western countries and is notable for its variable clinical course. This variability is partly reflected by the mutational status of IGHV genes. Many CLL samples have been studied in recent years by next-generation sequencing. These studies have identified recurrent somatic mutations in NOTCH1, SF3B1, ATM, TP53, BIRC3 and others genes that play roles in cell cycle, DNA repair, RNA metabolism and splicing. In this study, we have taken a deep-targeted massive sequencing approach to analyze the impact of mutations in the most frequently mutated genes in patients with CLL enrolled in the REM (rituximab en mantenimiento) clinical trial. The mutational status of our patients with CLL, except for the TP53 gene, does not seem to affect the good results obtained with maintenance therapy with rituximab after front-line FCR treatment

CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3

ObjectivesCARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain.MethodsIn total, 71 hospitals, representing all 50 Spanish provinces, collected the first 10 isolates per hospital (February to May 2019); CPE isolates were first identified according to EUCAST (meropenem MIC > 0.12 mg/L with immunochromatography, colorimetric tests, carbapenem inactivation, or carbapenem hydrolysis with MALDI-TOF). Prevalence and incidence were calculated according to population denominators. Antibiotic susceptibility testing was performed using the microdilution method (EUCAST). All 403 isolates collected were sequenced for high-resolution single-nucleotide polymorphism (SNP) typing, core genome multilocus sequence typing (cgMLST), and resistome analysis.ResultsIn total, 377 (93.5%) CP-Kpn and 26 (6.5%) CP-Eco isolates were collected from 62 (87.3%) hospitals in 46 (92%) provinces. CP-Kpn was more prevalent in the blood (5.8%, 50/853) than in the urine (1.4%, 201/14,464). The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. The main carbapenemase genes identified in CP-Kpn were blaOXA–48 (263/377), blaKPC–3 (62/377), blaVIM–1 (28/377), and blaNDM–1 (12/377). All isolates were susceptible to at least two antibiotics. Interregional dissemination of eight high-risk CP-Kpn clones was detected, mainly ST307/OXA-48 (16.4%), ST11/OXA-48 (16.4%), and ST512-ST258/KPC (13.8%). ST512/KPC and ST15/OXA-48 were the most frequent bacteremia-causative clones. The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5).ConclusionThis study serves as a first step toward WGS integration in the surveillance of carbapenemase-producing Enterobacterales in Spain. We detected important epidemiological changes, including increased CP-Kpn and CP-Eco prevalence and incidence compared to previous studies, wide interregional dissemination, and increased dissemination of high-risk clones, such as ST307/OXA-48 and ST512/KPC-3

Estudio del sistema HLA en la púrpura trombocitopénica idopática

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid. Facultad de Medicina. Departamento de Cirugía. Fecha de lectura: 24 de Mayo de 200