8,848 research outputs found
Understanding the determinants of stability and folding of small globular proteins from their energetics
The results of minimal model calculations suggest that the stability and the
kinetic accessibility of the native state of small globular proteins are
controlled by few "hot" sites. By mean of molecular dynamics simulations around
the native conformation, which simulate the protein and the surrounding solvent
at full--atom level, we generate an energetic map of the equilibrium state of
the protein and simplify it with an Eigenvalue decomposition. The components of
the Eigenvector associated with the lowest Eigenvalue indicate which are the
"hot" sites responsible for the stability and for the fast folding of the
protein. Comparison of these predictions with the results of mutatgenesis
experiments, performed for five small proteins, provide an excellent agreement
Correlated Binomial Models and Correlation Structures
We discuss a general method to construct correlated binomial distributions by
imposing several consistent relations on the joint probability function. We
obtain self-consistency relations for the conditional correlations and
conditional probabilities. The beta-binomial distribution is derived by a
strong symmetric assumption on the conditional correlations. Our derivation
clarifies the 'correlation' structure of the beta-binomial distribution. It is
also possible to study the correlation structures of other probability
distributions of exchangeable (homogeneous) correlated Bernoulli random
variables. We study some distribution functions and discuss their behaviors in
terms of their correlation structures.Comment: 12 pages, 7 figure
Influence of conformational fluctuations on enzymatic activity: modelling the functional motion of beta-secretase
Considerable insight into the functional activity of proteins and enzymes can
be obtained by studying the low-energy conformational distortions that the
biopolymer can sustain. We carry out the characterization of these large scale
structural changes for a protein of considerable pharmaceutical interest, the
human -secretase. Starting from the crystallographic structure of the
protein, we use the recently introduced beta-Gaussian model to identify, with
negligible computational expenditure, the most significant distortion occurring
in thermal equilibrium and the associated time scales. The application of this
strategy allows to gain considerable insight into the putative functional
movements and, furthermore, helps to identify a handful of key regions in the
protein which have an important mechanical influence on the enzymatic activity
despite being spatially distant from the active site. The results obtained
within the Gaussian model are validated through an extensive comparison against
an all-atom Molecular Dynamics simulation.Comment: To be published in a special issue of J. Phys.: Cond. Mat. (Bedlewo
Workshop
Poisson-Bracket Approach to the Dynamics of Nematic Liquid Crystals. The Role of Spin Angular Momentum
Nematic liquid crystals are well modeled as a fluid of rigid rods. Starting
from this model, we use a Poisson-bracket formalism to derive the equations
governing the dynamics of nematic liquid crystals. We treat the spin angular
momentum density arising from the rotation of constituent molecules about their
centers of mass as an independent field and derive equations for it, the mass
density, the momentum density, and the nematic director. Our equations reduce
to the original Leslie-Ericksen equations, including the inertial director term
that is neglected in the hydrodynamic limit, only when the moment of inertia
for angular momentum parallel to the director vanishes and when a dissipative
coefficient favoring locking of the angular frequencies of director rotation
and spin angular momentum diverges. Our equations reduce to the equations of
nematohydrodynamics in the hydrodynamic limit but with dissipative coefficients
that depend on the coefficient that must diverge to produce the Leslie-Ericksen
equations.Comment: 10 pages, to be published in Phys. Rev. E 72(5
Fifteen years of XMM-Newton and Chandra monitoring of Sgr A*: Evidence for a recent increase in the bright flaring rate
We present a study of the X-ray flaring activity of Sgr A* during all the 150
XMM-Newton and Chandra observations pointed at the Milky Way center over the
last 15 years. This includes the latest XMM-Newton and Chandra campaigns
devoted to monitoring the closest approach of the very red Br-Gamma emitting
object called G2. The entire dataset analysed extends from September 1999
through November 2014. We employed a Bayesian block analysis to investigate any
possible variations in the characteristics (frequency, energetics, peak
intensity, duration) of the flaring events that Sgr A* has exhibited since
their discovery in 2001. We observe that the total bright-or-very bright flare
luminosity of Sgr A* increased between 2013-2014 by a factor of 2-3 (~3.5 sigma
significance). We also observe an increase (~99.9% significance) from
0.27+-0.04 to 2.5+-1.0 day^-1 of the bright-or-very bright flaring rate of Sgr
A*, starting in late summer 2014, which happens to be about six months after
G2's peri-center passage. This might indicate that clustering is a general
property of bright flares and that it is associated with a stationary noise
process producing flares not uniformly distributed in time (similar to what is
observed in other quiescent black holes). If so, the variation in flaring
properties would be revealed only now because of the increased monitoring
frequency. Alternatively, this may be the first sign of an excess accretion
activity induced by the close passage of G2. More observations are necessary to
distinguish between these two hypotheses.Comment: Accepted for publication in MNRA
A model to explain angular distributions of and decays into and
BESIII data show a particular angular distribution for the decay of the
and mesons into the hyperons
and . More in details the angular distribution of
the decay exhibits an opposite trend
with respect to that of the other three channels: , and
. We define a model to explain the
origin of this phenomenon.Comment: 6 pages, 7 figures, to be published in Chinese Physics
Caracterização e avaliação econômica de sistemas de cultivo de trigo nos Biomas Pampa, Mata Atlântica e Cerrado.
Este capítulo tem por objetivos descrever a evolução da produção de trigo nos biomas Pampa, Mata Atlântica e Cerrado, bem como analisar os sistemas de cultivo do cereal e seus indicadores técnicos em cada um desses biomas e, especificamente, caracterizar tais sistemas sob a perspectiva da viabilidade socioeconômica.bitstream/item/208335/1/CaracterizacaoAvaliacaoEconomica.pd
Temperature dependence of the resistivity in the double-exchange model
The resistivity around the ferromagnetic transition temperature in the double
exchange model is studied by the Schwinger boson approach. The spatial spin
correlation responsible for scattering of conduction electrons are taken into
account by adopting the memory function formalism. Although the correlation
shows a peak lower than the transition temperature, the resistivity in the
ferromagnetic state monotonically increases with increasing temperature due to
a variation of the electronic state of the conduction electron. In the
paramagnetic state, the resistivity is dominated by the short range correlation
of scattering and is almost independent of the temperature. It is attributed to
a cancellation between the nearest-neighbor spin correlation, the fermion
bandwidth, and the fermion kinetic energy. This result implies the importance
of the temperature dependence of the electronic states of the conduction
electron as well as the localized spin states in both ferromagnetic and
paramagnetic phases.Comment: RevTex, 4 pages, 4 PostScript figures, To appear in Phys. Rev.
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