Observing the build-up of the colour-magnitude relation at redshift ~0.8

We analyse the rest-frame (U-V) colour-magnitude relation for 2 clusters at redshift 0.7 and 0.8, drawn from the ESO Distant Cluster Survey. By comparing with the population of red galaxies in the Coma cluster, we show that the high redshift clusters exhibit a deficit of passive faint red galaxies. Our results show that the red-sequence population cannot be explained in terms of a monolithic and synchronous formation scenario. A large fraction of faint passive galaxies in clusters today has moved onto the red sequence relatively recently as a consequence of the fact that their star formation activity has come to an end at z<0.8.Comment: 5 pages, 2 figures, to appear in Proc. of IAU Colloq. 195: "Outskirts of Galaxy Clusters: Intense Life in the Suburbs" -- minor typos correcte

Neuro-hormonal effects of physical activity in the elderly.

Thanks to diagnostic and therapeutic advances, the elderly population is continuously increasing in the western countries. Accordingly, the prevalence of most chronic age-related diseases will increase considerably in the next decades, thus it will be necessary to implement effective preventive measures to face this epidemiological challenge. Among those, physical activity exerts a crucial role, since it has been proven to reduce the risk of cardiovascular diseases, diabetes, obesity, cognitive impairment and cancer. The favorable effects of exercise on cardiovascular homeostasis can be at least in part ascribed to the modulation of the neuro-hormonal systems implicated in cardiovascular pathophysiology. In the elderly, exercise has been shown to affect catecholamine secretion and biosynthesis, to positively modulate the renin-angiotensin-aldosterone system and to reduce the levels of plasma brain natriuretic peptides. Moreover, drugs modulating the neuro-hormonal systems may favorably affect physical capacity in the elderly. Thus, efforts should be made to actually make physical activity become part of the therapeutic tools in the elderly. © 2013 Femminella, de Lucia, Iacotucci, Formisano, Petraglia, Allocca, Ratto, DAmico, Rengo, Pagano, Bonaduce, Rengo and Ferrara

Mining Version Histories for Detecting Code Smells

Code smells are symptoms of poor design and implementation choices that may hinder code comprehension, and possibly increase change- and fault-proneness. While most of the detection techniques just rely on structural information, many code smells are intrinsically characterized by how code elements change over time. In this paper, we propose HIST (Historical Information for Smell deTection), an approach exploiting change history information to detect instances of five different code smells, namely Divergent Change, Shotgun Surgery, Parallel Inheritance, Blob, and Feature Envy.We evaluate HIST in two empirical studies. The first, conducted on twenty open source projects, aimed at assessing the accuracy of HIST in detecting instances of the code smells mentioned above. The results indicate that the precision of HIST ranges between 72% and 86%, and its recall ranges between 58% and 100%. Also, results of the first study indicate that HIST is able to identify code smells that cannot be identified by competitive approaches solely based on code analysis of a single system’s snapshot. Then, we conducted a second study aimed at investigating to what extent the code smells detected by HIST (and by competitive code analysis techniques) reflect developers’ perception of poor design and implementation choices. We involved twelve developers of four open source projects that recognized more than 75% of the code smell instances identified by HIST as actual design/implementation problems

The cluster galaxy luminosity function at z=0.3z=0.3: a recent origin for the faint-end upturn ?

We derive deep luminosity functions (to $M_z=-15$) for galaxies in Abell 1835 ($z=0.25$) and AC 114 ($z=0.31$) and compare these with the local $z'$ luminosity function for 69 clusters. The data show that the faint-end upturn, the excess of galaxies above a single Schechter function at $M_z < -17$, does not exist in the higher redshift clusters. This suggests that the faint-end upturn galaxies have been created recently, by infall into clusters of star-forming field populations or via tidal disruption of brighter objects.^MComment: 6 pages, MNRAS main journal, accepted for publicatio

Stress–Strain Investigation of the Rock Mass Based on Overcoring with CSIRO HI Cell Test and Numerical Modeling: A Case Study from an Italian Underground Marble Quarry

The present research illustrates the application of a methodological approach to studying the stress–strain distribution in a marble quarry of the Apuan Alps mining area (Italy). This study has been carried out in the framework of a project involving the University of Siena and the UOC Ingegneria Mineraria—USL Toscana Nord-Ovest, Tuscany Region. This stress–strain analysis aims foremost to monitor the slope stability conditions to guarantee a safe workplace for the personnel involved in mining activities, and to enable more sustainable long-term planning for excavation and production. The involved survey activities are as follows: (i) terrestrial laser scanning; (ii) engineering–geological data mapping; and (iii) in situ marble stress measuring through four CSIRO-type cell tests executed in different locations and at various depths within the underground excavation walls. The gathered data converged into numerical models of the quarry, both in 2D (DEM) and 3D (FEM), calibrated by in situ stress results through a rigorous back analysis assessment using least squares procedures. The created models represent a valuable tool for the identification and securing of risk areas and for future excavation planning in respect of the site efficiency and safety

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

<p>Abstract</p> <p>Background</p> <p>Overproduction of proinflammatory cytokines from activated microglia has been implicated as an important contributor to pathophysiology progression in both acute and chronic neurodegenerative diseases. Therefore, it is critical to elucidate intracellular signaling pathways that are significant contributors to cytokine overproduction in microglia exposed to specific stressors, especially pathways amenable to drug interventions. The serine/threonine protein kinase p38α MAPK is a key enzyme in the parallel and convergent intracellular signaling pathways involved in stressor-induced production of IL-1β and TNFα in peripheral tissues, and is a drug development target for peripheral inflammatory diseases. However, much less is known about the quantitative importance of microglial p38α MAPK in stressor-induced cytokine overproduction, or the potential of microglial p38α MAPK to be a druggable target for CNS disorders. Therefore, we examined the contribution of microglial p38αMAPK to cytokine up-regulation, with a focus on the potential to suppress the cytokine increase by inhibition of the kinase with pharmacological or genetic approaches.</p> <p>Methods</p> <p>The microglial cytokine response to TLR ligands 2/3/4/7/8/9 or to Aβ_1-42was tested in the presence of a CNS-penetrant p38α MAPK inhibitor, MW01-2-069A-SRM. Primary microglia from mice genetically deficient in p38α MAPK were used to further establish a linkage between microglia p38α MAPK and cytokine overproduction. The <it>in vivo </it>significance was determined by p38α MAPK inhibitor treatment in a LPS-induced model of acute neuroinflammation.</p> <p>Results</p> <p>Increased IL-1β and TNFα production by the BV-2 microglial cell line and by primary microglia cultures was inhibited in a concentration-dependent manner by the p38α MAPK-targeted inhibitor. Cellular target engagement was demonstrated by the accompanying decrease in the phosphorylation state of two p38α MAPK protein substrates, MK2 and MSK1. Consistent with the pharmacological findings, microglia from p38α-deficient mice showed a diminished cytokine response to LPS. Further, oral administration of the inhibitor blocked the increase of IL-1β in the cerebral cortex of mice stressed by intraperitoneal injection of LPS.</p> <p>Conclusion</p> <p>The p38α MAPK pathway is an important contributor to the increased microglial production of proinflammatory cytokines induced by diverse stressors. The results also indicate the feasibility of targeting p38α MAPK to modulate CNS proinflammatory cytokine overproduction.</p

The evolution of the galaxy Red Sequence in simulated clusters and groups

N-body + hydrodynamical simulations of the formation and evolution of galaxy groups and clusters in a LambdaCDM cosmology are used in order to follow the building-up of the colour-magnitude relation in two clusters and in 12 groups. We have found that galaxies, starting from the more massive, move to the Red Sequence (RS) as they get aged over times and eventually set upon a ``dead sequence'' (DS) once they have stopped their bulk star formation activity. Fainter galaxies keep having significant star formation out to very recent epochs and lie broader around the RS. Environment plays a role as galaxies in groups and cluster outskirts hold star formation activity longer than the central cluster regions. However galaxies experiencing infall from the outskirts to the central parts keep star formation on until they settle on to the DS of the core galaxies. Merging contributes to mass assembly until z~1, after which major events only involve the brightest cluster galaxies. The emerging scenario is that the evolution of the colour-magnitude properties of galaxies within the hierarchical framework is mainly driven by star formation activity during dark matter halos assembly. Galaxies progressively quenching their star formation settle to a very sharp ``red and dead'' sequence, which turns out to be universal, its slope and scatter being almost independent of the redshift (since at least z~1.5) and environment. Differently from the DS, the operatively defined RS evolves more evidently with z, the epoch when it changes its slope being closely corresponding to that at which the passive galaxies population takes over the star forming one: this goes from z~1 in clusters down to 0.4 in normal groups.Comment: MNRAS in pres

H^+_2$ in a strong magnetic field described via a solvable model

We consider the hydrogen molecular ion $H^+_2$ in the presence of a strong homogeneous magnetic field. In this regime, the effective Hamiltonian is almost one dimensional with a potential energy which looks like a sum of two Dirac delta functions. This model is solvable, but not close enough to our exact Hamiltonian for relevant strenght of the magnnetic field. However we show that the correct values of the equilibrium distance as well as the binding energy of the ground state of the ion, can be obtained when incorporating perturbative corrections up to second order. Finally, we show that $He_2^{3+}$ exists for sufficiently large magnetic fields