Socially relevant ethnic groups, ethnic structure, and AMAR

Protracted conflicts over the status and demands of ethnic and religious groups have caused more instability and loss of human life than any other type of local, regional, and international conflict since the end of World War II. Yet we still have accumulated little in the way of accepted knowledge about the ethnic landscape of the world. In part this is due to empirical reliance on the limited data in the Minorities at Risk (MAR) project, whose selection biases are well known. In this article we tackle the construction of a list of ‘socially relevant’ ethnic groups meeting newly justified criteria in a dataset we call AMAR (A for All). We find that one of the principal difficulties in constructing the list is determining the appropriate level of aggregation for groups. To address this issue, we enumerate subgroups of the commonly recognized groups meeting our criteria so that scholars can use the subgroup list as one reference in the construction of the list of ethnic groups most appropriate for their study. Our conclusion outlines future work on the data using this expanded dataset on ethnic groups

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans