Freedom in Nature

The paper starts with the proposal that the cause of the apparent insolubility of the free-will problem are several popular but strongly metaphysical notions and hypotheses. To reduce the metaphysics, some ideas are borrowed from physics. A concept of event causality is discussed. The importance of Hume's Principle of Causality is stressed and his Principle of Causation is weakened. The key concept of the paper, the so-called relative freedom, is also suggested by physics. It is a kind of freedom that can be observed everywhere in nature. Turning to biology, incomplete knowledge is defined for all organisms. They cope with the problem by Popper's trial and error processes. One source of their success is the relative freedom of choice from the basic option ranges: mutations, motions and neural connections. Finally, the conjecture is adopted that communicability can be used as a criterion of consciousness and free will is defined as a conscious version of relative freedom. The resulting notion is logically self-consistent and it describes an observable phenomenon that agrees with our experience.Comment: Changes: Improved formulation, three references added; 22 pages, no figure. Comments are welcom

Implementing, monitoring and measuring a programme of relationship marketing

This single, embedded case study examined the marketing activities of Flensted Catering A/S, a Danish food company. The case is the first one in a series of case studies constituting a larger research project with the overall objective of understanding how to implement relationship marketing, how to monitor the outputs and how to measure the returns. In 1996, the company embarked on a three-phase programme directed at building relations with customers. As a prelude to the implementation, Flensted Catering A/S conducted focus groups and issued questionnaires to determine customer perceptions of how the company could meliorate its performance. Subsequently, the Danish firm established project teams, instituted customer-focused staff training and sought to improve communications with customers. Following the implementation, the monitoring revealed that Flensted Catering A/S was rated as a better supplier by 43 per cent of its customers and that customer retention had risen to 94 per cen

Cytotoxicity and DNA damage in the neutrophils of patients with sickle cell anaemia treated with hydroxyurea

Hydroxyurea (HU) is the most important advance in the treatment of sickle cell anaemia (SCA) for preventing complications and improving quality of life for patients. However, some aspects of treatment with HU remain unclear, including their effect on and potential toxicity to other blood cells such as neutrophils. This study used the measurement of Lactate Dehydrogenase (LDH) and Methyl ThiazolTetrazolium (MTT) and the comet assay to investigate the cytotoxicity and damage index (DI) of the DNA in the neutrophils of patients with SCA using HU.In the LDH and MTT assays, a cytoprotective effect was observed in the group of patients treated, as well as an absence of toxicity. When compared to patients without the treatment, the SS group (n=20, 13 women and 07 men, aged 18-69 years), and the group of healthy individuals (AA) used as a control group (n=52, 28 women and 24 men, aged 19-60 years), The SSHU group (n=21, 11 women and 10 men, aged 19-63 years) showed a significant reduction (p20 months), demonstrating that despite the cytoprotective effects in terms of cell viability, the use of HU can induce DNA damage in neutrophils

Prosperity along Australia's eastern seaboard: Sydney and the geopolitics of urban and economic change

Throughout the last decade, the Australian economy has experienced its second longest period of uninterrupted prosperity in recorded history. The paper argues that this prosperity is sourced from an extraordinary surge in finance-based economic activity along Australia’s eastern seaboard, especially in the Sydney region. Population growth in the Sydney basin has further fueled the region’s economic growth. The spatialised nature of this prosperity has produced a major shift in distributional outcomes across Australian regions and among households. Sydney-based households, especially those in inner ‘global Sydney’ neighbourhoods, have had access to high rates of job creation and sustained increases in income and house values. On the other hand, non-metropolitan households away from Sydney—those in regional and rural Australia—have experienced largely negative consequences as historical inter-sectoral and spatial redistribution mechanisms have been dismantled. The paper shows how divergent experiences of the new prosperity have produced an unstable political landscape in regional and rural Australia. It concludes by urging further research into the spatialised nature of economic changes in Australia, especially research that is conscious of distributional flows and outcomes