178 research outputs found
An 'expert approach' to enhance GIS training: the case study of land-use suitability mapping
To enhance the learning and teaching of geographic information systems in higher-education Earth sciences, we present results from a research which identified the strategies and concepts that underlie the suitability-mapping process. The analysis of common practices in mapping and GIS environmental projects led our attention to a particular kind of mapping: GIS-bases land-use suitability mapping, with multi criteria spatial analysis method. This method has a professionalizing nature since it supports the debate on territorial choices that involve decision making. Indeed, from a pedagogical point of view, this method, allows a progressive and comprehensive approach to the use of GIS. Based on the expert-novice continuum approach, this study focuses on two dimensions: a cognitive dimension, which explores and compares the way of thinking of experienced and novice users when solving site location problems with GIS; and on an instructional dimension, which identifies and integrate the expert methods in the resolution strategies of learners
Computationally efficient methods for modelling laser wakefield acceleration in the blowout regime
Electron self-injection and acceleration until dephasing in the blowout
regime is studied for a set of initial conditions typical of recent experiments
with 100 terawatt-class lasers. Two different approaches to computationally
efficient, fully explicit, three-dimensional particle-in-cell modelling are
examined. First, the Cartesian code VORPAL using a perfect-dispersion
electromagnetic solver precisely describes the laser pulse and bubble dynamics,
taking advantage of coarser resolution in the propagation direction, with a
proportionally larger time step. Using third-order splines for macroparticles
helps suppress the sampling noise while keeping the usage of computational
resources modest. The second way to reduce the simulation load is using
reduced-geometry codes. In our case, the quasi-cylindrical code CALDER-CIRC
uses decomposition of fields and currents into a set of poloidal modes, while
the macroparticles move in the Cartesian 3D space. Cylindrical symmetry of the
interaction allows using just two modes, reducing the computational load to
roughly that of a planar Cartesian simulation while preserving the 3D nature of
the interaction. This significant economy of resources allows using fine
resolution in the direction of propagation and a small time step, making
numerical dispersion vanishingly small, together with a large number of
particles per cell, enabling good particle statistics. Quantitative agreement
of the two simulations indicates that they are free of numerical artefacts.
Both approaches thus retrieve physically correct evolution of the plasma
bubble, recovering the intrinsic connection of electron self-injection to the
nonlinear optical evolution of the driver
A clinimetric study of lateroplusion measure by Verticam for patients recovering from a stroke
High-Flux Femtosecond X-Ray Emission from Controlled Generation of Annular Electron Beams in a Laser Wakefield Accelerator
Annular quasimonoenergetic electron beams with a mean energy in the range 200-400 MeV and charge on the order of several picocoulombs were generated in a laser wakefield accelerator and subsequently accelerated using a plasma afterburner in a two-stage gas cell. Generation of these beams is associated with injection occurring on the density down ramp between the stages. This well-localized injection produces a bunch of electrons performing coherent betatron oscillations in the wakefield, resulting in a significant increase in the x-ray yield. Annular electron distributions are detected in 40% of shots under optimal conditions. Simultaneous control of the pulse duration and frequency chirp enables optimization of both the energy and the energy spread of the annular beam and boosts the radiant energy per unit charge by almost an order of magnitude. These well-defined annular distributions of electrons are a promising source of high-brightness laser plasma-based x rays
Phenotype of autosomal dominant spastic paraplegia linked to chromosome 2
Summary We report the clinical features of 12 families with autosomal dominant spastic paraplegia (ADSP) linked to the SPG4 locus on chromosome 2p, the major locus for this disorder that accounts for ∼40% of the families. Among 93 gene carriers, 32 (34%) were unaware of symptoms but were clinically affected. Haplotype reconstruction showed that 90% of the asymptomatic gene carriers presented increased reflexes and/or extensor plantar responses independent of age at examination. The mean age at onset was 29 years, ranging from 1 to 63 years. Intra- as well as inter-familial variability of age at onset was important, but did not result from anticipation. Phenotype—genotype correlations and comparison with SPG3 and SPG5 families indicated that despite the variability of age at onset, SPG4 is a single genetic entity but no clinical features distinguish individual SPG4 patients from those with SPG3 or SPG5 mutation
Loss of paraplegin drives spasticity rather than ataxia in a cohort of 241 patients with SPG7
Objective : We took advantage of a large multinational recruitment to delineate genotype-phenotype correlations in a large, trans-European multicenter cohort of patients with spastic paraplegia gene 7 (SPG7).
Methods : We analyzed clinical and genetic data from 241 patients with SPG7, integrating neurologic follow-up data. One case was examined neuropathologically.
Results : Patients with SPG7 had a mean age of 35.5 +/- 14.3 years (n = 233) at onset and presented with spasticity (n = 89), ataxia (n = 74), or both (n = 45). At the first visit, patients with a longer disease duration (> 20 years, n = 62) showed more cerebellar dysarthria (p < 0.05), deep sensory loss (p < 0.01), muscle wasting (p < 0.01), ophthalmoplegia (p < 0.05), and sphincter dysfunction (p < 0.05) than those with a shorter duration (< 10 years, n = 93). Progression, measured by Scale for the Assessment and Rating of Ataxia evaluations, showed a mean annual increase of 1.0 +/- 1.4 points in a subgroup of 30 patients. Patients homozygous for loss of function (LOF) variants (n = 65) presented significantly more often with pyramidal signs (p < 0.05), diminished visual acuity due to optic atrophy (p < 0.0001), and deep sensory loss (p < 0.0001) than those with at least 1 missense variant (n = 176). Patients with at least 1 Ala510Val variant (58%) were older (age 37.6 +/- 13.7 vs 32.8 +/- 14.6 years, p < 0.05) and showed ataxia at onset (p < 0.05). Neuropathologic examination revealed reduction of the pyramidal tract in the medulla oblongata and moderate loss of Purkinje cells and substantia nigra neurons.
Conclusions : This is the largest SPG7 cohort study to date and shows a spasticity-predominant phenotype of LOF variants and more frequent cerebellar ataxia and later onset in patients carrying at least 1 Ala510Val variant
The LUNEX5 project
http://accelconf.web.cern.ch/AccelConf/FEL2012/papers/froa03.pdfInternational audienceLUNEX5 (free electron Laser Using a New accelerator for the Exploitation of X-ray radiation of 5th generation) aims at investigating the production of short, intense, and coherent pulses in the soft X-ray region. The project consists of a Free Electron Laser (FEL) line enabling the most advanced seeding configurations: High order Harmonic in Gas (HHG) seeding and Echo Enable Harmonic Generation (EEHG) with in-vacuum (potentially cryogenic) undulators of 15 and 30 mm period. Two accelerator types feed this FEL line : a 400 MeV Conventional Linear Accelerator (CLA) using superconducting cavities compatible with a future upgrade towards high repetition rate, for the investigations of the advanced FEL schemes; and a 0.4 - 1 GeV Laser Wake Field Accelerator (LWFA), to be qualified in view of FEL application, in the single spike or seeded regime. Two pilot user experiments for timeresolved studies of isolated species and solid state matter dynamics will take benefit of LUNEX5 FEL radiation and provide feedback of the performance of the different schemes under real user conditions
Spatiotemporal dynamics of ultrarelativistic beam-plasma instabilities
An electron or electron-positron beam streaming through a plasma is
notoriously prone to micro-instabilities. For a dilute ultrarelativistic
infinite beam, the dominant instability is a mixed mode between longitudinal
two-stream and transverse filamentation modes, with a phase velocity oblique to
the beam velocity. A spatiotemporal theory describing the linear growth of this
oblique mixed instability is proposed, which predicts that spatiotemporal
effects generally prevail for finite-length beams, leading to a significantly
slower instability evolution than in the usually assumed purely temporal
regime. These results are accurately supported by particle-in-cell (PIC)
simulations. Furthermore, we show that the self-focusing dynamics caused by the
plasma wakefields driven by finite-width beams can compete with the oblique
instability. Analyzed through PIC simulations, the interplay of these two
processes in realistic systems bears important implications for upcoming
accelerator experiments on ultrarelativistic beam-plasma interactions
Efficacy of exome-targeted capture sequencing to detect mutations in known cerebellar ataxia genes
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