Pole Arrangements that Introduce Prismatic Joints into the Design Space of Four- and Five-Position Rigid-Body Synthesis

Although a general five-position, rigid-body guidance problem admits a discrete number of revolute–revolute (RR) dyads, this paper identifies arrangements of five task positions that result in a center-point curve. For these special arrangements, a one-dimensional set of revolute-prismatic (RP) dyads exist to achieve the task positions. Other five-position arrangements are identified where a one-dimensional set of prismatic-revolute (PR) dyads exist to achieve the task positions. For a general case of five task positions, neither PR nor RP dyads are possible. In a general case of four-position rigid-body guidance problems, a unique PR dyad and RP dyad exist. Four-position arrangements are identified where the associated center-point curve includes the line at infinity and admits a PR dyad with a line of slide in any direction. Likewise, arrangements of the four positions are identified where the circle-point curve includes the line at infinity, permitting a one-dimensional set of RP dyads. These special four and five positions lead to dyads that can be coupled to solve a rigid-body guidance synthesis problem with a PRRP or RPPR device which is generally not possible. These solutions are particularly useful in design situations where actuation through a prismatic joint is desired

Kinematic Synthesis of Planar, Shape-Changing, Rigid Body Mechanisms for Design Profiles with Significant Differences in Arc Length

This paper presents a kinematic procedure to synthesize planar mechanisms capable of approximating a shape change defined by a general set of curves. These “morphing curves,” referred to as design profiles, differ from each other by a combination of displacement in the plane, shape variation, and notable differences in arc length. Where previous rigid-body shape-change work focused on mechanisms composed of rigid links and revolute joints to approximate curves of roughly equal arc length, this work introduces prismatic joints into the mechanisms in order to produce the different desired arc lengths. A method is presented to iteratively search along the profiles for locations that are best suited for prismatic joints. The result of this methodology is the creation of a chain of rigid bodies connected by revolute and prismatic joints that can approximate a set of design profiles

Kinematic synthesis of planar, shape-changing, rigid body mechanisms for design profiles with significant differences in arc length

This paper presents a kinematic procedure to synthesize planar mechanisms capable of approximating a shape change defined by a general set of curves. These “morphing curves,” referred to as design profiles, differ from each other by a combination of displacement in the plane, shape variation, and notable differences in arc length. Where previous rigid-body shape-change work focused on mechanisms composed of rigid links and revolute joints to approximate curves of roughly equal arc length, this work introduces prismatic joints into the mechanisms in order to produce the different desired arc lengths. A method is presented to iteratively search along the profiles for locations that are best suited for prismatic joints. The result of this methodology is the creation of a chain of rigid bodies connected by revolute and prismatic joints that can approximate a set of design profiles

Development of a Spring-Based Automotive Starter

Automotive starting systems require substantial amounts of mechanical energy in a short period of time. Lead-acid batteries have historically provided that energy through a starter motor. Springs have been identified as an alternative energy storage medium and are well suited to engine-starting applications due to their ability to rapidly deliver substantial mechanical power and their long service life. This paper presents the development of a conceptual, spring-based starter. The focus of the study was to determine whether a spring of acceptable size could provide the required torque and rotational speed to start an automotive engine. Engine testing was performed on a representative 600 cc, inline 4-cylinder internal combustion engine to determine the required torque and engine speed during the starting cycle. An optimization was performed to identify an appropriate spring design, minimizing its size. Results predict that the test engine could be started by a torsional steel spring with a diameter and length of approximately 150 mm, similar in size, but lower weight than an electrical starting system of the engine. A proof-of-concept prototype has been constructed and evaluated

A Mechanical Regenerative Brake and Launch Assist Using an Open Differential and Elastic Energy Storage

Regenerative brake and launch assist (RBLA) systems are used to capture kinetic energy while a vehicle decelerates and subsequently use that stored energy to assist propulsion. Commercially available hybrid vehicles use generators, batteries and motors to electrically implement RBLA systems. Substantial increases in vehicle efficiency have been widely cited. This paper presents the development of a mechanical RBLA that stores energy in an elastic medium. An open differential is coupled with a variable transmission to store and release energy to an axle that principally rotates in a single direction. The concept applies regenerative braking technology to conventional automobiles equipped with only an internal combustion engine where the electrical systems of hybrid vehicles are not available. Governing performance equations are formulated and design parameters are selected based on an optimization of the vehicle operation over a simulated urban driving cycle. The functionality of this elastically-based regenerative brake device has been demonstrated on a physical prototype

The Synthesis of Function Generating Mechanisms for Periodic Curves Using Large Numbers of Double-Crank Linkages

This paper presents a methodology for synthesizing planar linkages to approximate any prescribed periodic function. The mechanisms selected for this task are the slider-crank and the geared five-bar with connecting rod and sliding output (GFBS), where any number of double-crank (or drag-link) four-bars are used as drivers. A slider-crank mechanism, when comparing the input crank rotation to the output slider displacement, produces a sinusoid-like function. Instead of directly driving the input crank, a drag-link four-bar may be added to drive the crank from its output via a rigid connection between the two. Driving the input of the added four-bar results in a function that modifies the sinusoid-like curve. This process can be continued through the addition of more drag-link mechanisms to the device, progressively altering the curve toward any periodic function with a single maximum. For periodic functions with multiple maxima, a GFBS is used as the terminal linkage added to the chain of drag-link mechanisms. The synthesis process starts by analyzing one period of the function to design either the terminal slidercrank or terminal GFBS. MATLAB's fmincon command is then utilized as the four-bars are added to reduce the structural error between the desired function and the input-output function of the mechanism. Mechanisms have been synthesized in this fashion to include a large number of links that are capable of closely producing functions with a variety of intriguing features

Contribution of Chondroitin Sulfate A to the Binding of Complement Proteins to Activated Platelets

Exposure of chondroitin sulfate A (CS-A) on the surface of activated platelets is well established. The aim of the present study was to investigate to what extent CS-A contributes to the binding of the complement recognition molecule C1q and the complement regulators C1 inhibitor (C1INH), C4b-binding protein (C4BP), and factor H to platelets.Human blood serum was passed over Sepharose conjugated with CS-A, and CS-A-specific binding proteins were identified by Western blotting and mass spectrometric analysis. C1q was shown to be the main protein that specifically bound to CS-A, but C4BP and factor H were also shown to interact. Binding of C1INH was dependent of the presence of C1q and then not bound to CS-A from C1q-depleted serum. The specific interactions observed of these proteins with CS-A were subsequently confirmed by surface plasmon resonance analysis using purified proteins. Importantly, C1q, C4BP, and factor H were also shown to bind to activated platelets and this interaction was inhibited by a CS-A-specific monoclonal antibody, thereby linking the binding of C1q, C4BP, and factor H to exposure of CS-A on activated platelets. CS-A-bound C1q was also shown to amplify the binding of model immune complexes to both microtiter plate-bound CS-A and to activated platelets.This study supports the concept that CS-A contributes to the binding of C1q, C4BP, and factor H to platelets, thereby adding CS-A to the previously reported binding sites for these proteins on the platelet surface. CS-A-bound C1q also seems to amplify the binding of immune complexes to activated platelets, suggesting a role for this molecule in immune complex diseases

Protection in Macaques Immunized with HIV-1 Candidate Vaccines Can Be Predicted Using the Kinetics of Their Neutralizing Antibodies

A vaccine is needed to control the spread of human immunodeficiency virus type 1 (HIV-1). An in vitro assay that can predict the protection induced by a vaccine would facilitate the development of such a vaccine. A potential candidate would be an assay to quantify neutralization of HIV-1.We have used sera from rhesus macaques that have been immunized with HIV candidate vaccines and subsequently challenged with simian human immunodeficiency virus (SHIV). We compared neutralization assays with different formats. In experiments with the standardized and validated TZMbl assay, neutralizing antibody titers against homologous SHIV(SF162P4) pseudovirus gave a variable correlation with reductions in plasma viremia levels. The target cells used in the assays are not just passive indicators of virus infection but are actively involved in the neutralization process. When replicating virus was used with GHOST cell assays, events during the absorption phase, as well as the incubation phase, determine the level of neutralization. Sera that are associated with protection have properties that are closest to the traditional concept of neutralization: the concentration of antibody present during the absorption phase has no effect on the inactivation rate. In GHOST assays, events during the absorption phase may inactivate a fixed number, rather than a proportion, of virus so that while complete neutralization can be obtained, it can only be found at low doses particularly with isolates that are relatively resistant to neutralization.Two scenarios have the potential to predict protection by neutralizing antibodies at concentrations that can be induced by vaccination: antibodies that have properties close to the traditional concept of neutralization may protect against a range of challenge doses of neutralization sensitive HIV isolates; a window of opportunity also exists for protection against isolates that are more resistant to neutralization but only at low challenge doses

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362