12 research outputs found
A vis\~ao da BBChain sobre o contexto tecnol\'ogico subjacente \`a ado\c{c}\~ao do Real Digital
We explore confidential computing in the context of CBDCs using Microsoft's
CCF framework as an example. By developing an experiment and comparing
different approaches and performance and security metrics, we seek to evaluate
the effectiveness of confidential computing to improve the privacy, security,
and performance of CBDCs. Preliminary results suggest that confidential
computing could be a promising solution to the technological challenges faced
by CBDCs. Furthermore, by implementing confidential computing in DLTs such as
Hyperledger Besu and utilizing frameworks such as CCF, we increase transaction
confidentiality and privacy while maintaining the scalability and
interoperability required for a global digital financial system. In conclusion,
confidential computing can significantly bolster CBDC development, fostering a
secure, private, and efficient financial future.
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Exploramos o uso da computa\c{c}\~ao confidencial no contexto das CBDCs
utilizando o framework CCF da Microsoft como exemplo. Via desenvolvimento de
experimentos e compara\c{c}\~ao de diferentes abordagens e m\'etricas de
desempenho e seguran\c{c}a, buscamos avaliar a efic\'acia da computa\c{c}\~ao
confidencial para melhorar a privacidade, seguran\c{c}a e desempenho das CBDCs.
Resultados preliminares sugerem que a computa\c{c}\~ao confidencial pode ser
uma solu\c{c}\~ao promissora para os desafios tecnol\'ogicos enfrentados pelas
CBDCs. Ao implementar a computa\c{c}\~ao confidencial em DLTs, como o
Hyperledger Besu, e utilizar frameworks como o CCF, aumentamos a
confidencialidade e a privacidade das transa\c{c}\~oes, mantendo a
escalabilidade e a interoperabilidade necess\'arias para um sistema financeiro
global e digital. Em conclus\~ao, a computa\c{c}\~ao confidencial pode
refor\c{c}ar significativamente o desenvolvimento do CBDC, promovendo um futuro
financeiro seguro, privado e eficiente.Comment: Comments: 11 pages, 8 figures, in (Brazilian) Portugues
Microencapsulated herbal components in the diet of Lacaune ewes: impacts on physiology and milk production and quality
Abstract This study aimed to determine whether the addition of a microencapsulated herbal blend (MHB) based on thymol, carvacrol, and cinnamaldehyde in dairy sheep feed would improve production efficiency, milk quality, and animal health. Thirty lactating Lacaune ewes were divided into three groups: Control (T0), 150 mg blend/kg of feed (T150), and 250 mg blend/kg of feed (T250). Milk was measured before the beginning of the experiment (d 0), at the end of the adaptation period (d 15), and during the experiment (d 20). In milk samples, was measured the composition, somatic cell count (SCC), reactive oxygen species (ROS), lipoperoxidation (LPO), and total antioxidant capacity. The MHB improved the milk production (only T150 vs. T0 sheep on d 20), productive efficiency and feed efficiency, and reduced the milk SCC (only T250 vs. T0 sheep, on d 20), ROS and tended to reduce the milk levels of LPO (only T250 vs. T0 sheep on d 20). Also, MHB reduced the blood levels of neutrophils and ROS (only T250 vs. T0 sheep on d 20) and increased total protein and globulin levels. Thus, a microencapsulated blend of thymol, carvacrol, and cinnamaldehyde improved the productive performance and milk quality of sheep
Prolonged maternal separation induces undernutrition and systemic inflammation with disrupted hippocampal development in mice
Objective:
Prolonged maternal separation (PMS) in the first 2 wk of life has been associated with poor growth with lasting effects in brain structure and function. This study aimed to investigate whether PMS-induced undernutrition could cause systemic inflammation and changes in nutrition-related hormonal levels, affecting hippocampal structure and neurotransmission in C57BL/6J suckling mice.
Methods:
This study assessed mouse growth parameters coupled with insulin-like growth factor-1 (IGF-1) serum levels. In addition, leptin, adiponectin, and corticosterone serum levels were measured following PMS. Hippocampal stereology and the amino acid levels were also assessed. Furthermore, we measured myelin basic protein and synapthophysin (SYN) expression in the overall brain tissue and hippocampal SYN immunolabeling. For behavioral tests, we analyzed the ontogeny of selected neonatal reflexes. PMS was induced by separating half the pups in each litter from their lactating dams for defined periods each day (4 h on day 1, 8 h on day 2, and 12 h thereafter). A total of 67 suckling pups were used in this study.
Results:
PMS induced significant slowdown in weight gain and growth impairment. Significant reductions in serum leptin and IGF-1 levels were found following PMS. Total CA3 area and volume were reduced, specifically affecting the pyramidal layer in PMS mice. CA1 pyramidal layer area was also reduced. Overall hippocampal SYN immunolabeling was lower, especially in CA3 field and dentate gyrus. Furthermore, PMS reduced hippocampal aspartate, glutamate, and gammaaminobutyric acid levels, as compared with unseparated controls.
Conclusion:
These findings suggest that PMS causes significant growth deficits and alterations in hippocampal morphology and neurotransmission.This work was supported in part by National Institutes of Health (NIH) research grant 5R01HD053131, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the NIH Office of Dietary Supplements, and Brazilian grants from CNPq and CAPES (Grant # RO1 HD053131). The authors would like to thank Dr. Patricia Foley for veterinarian technical support and Dr. Jose Paulo Andrade for the excellent comments and suggestions to improve this manuscript. N.S. contributed with the stereological studies. I.L.F. and R.B.O. contributed with the behavioral studies. I.L.F., R.B.O., and R.L.G. contributed with the study design, study analysis, and manuscript preparation. G.A.M. and P.B.F. contributed with neurochemical brain analyses. J.I.A.L. and G.M.A. contributed with hormonal and CRP serum analyses. D.G.C., K.M.C., and R.S.R. contributed with animal experimentation and data collection
Orientações TCC e Iniciação Científica
Trabalhos dos orientandos da Profa. Denny Thame e materiais para pesquisa de Direito da Informática, da Comunicação, Internacional e Ambiental
NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics
Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data