Theory and Practice of Translation: An Original Translation of Regina E. G. Schymiczek’s Die Weide Der Seepferde (The Pasture of the Seahorses)

This study outlines the original translation of the recently published Die Weide der Seepferde (2013) from Regina E. G. Schymizcek. We employ known translation techniques by following Hervey’s (2006) suggested gradients of degrees of translation and cultural transposition. While translating the work we discovered a unique aspect of German-English translation which we believe fundamentally adds to knowledge of translation theory

A study of packaging and shipping procedures for small electroexplosive devices Final report, May 1, 1966 - Aug. 1, 1967

Packaging, shipping, and shielding procedures for electroexplosive device

Repeatability And Validity Of IUATLD Respiratory Questionnaire Responses As A Measure Of Asthma In An Ethiopian Population

EAMJ Dec. Repeatability.indd Objective: To assess the repeatability and validity of the IUATLD respiratory symptoms questionnaire in relation to exercise-induced bronchoconstriction or bronchodilator responses in a community in southern Ethiopia.Design: A case-control study.Setting: Rural and small town setting in southern Ethiopia, April to May 2006.Subjects: Two hundred and forty seven adults and children who previously reported wheeze in the past year, and 174 who did not.Interventions: Administered IUATLD bronchial symptoms questionnaire; standardised free-running exercise test or (for those with airflow obstruction) assessment of bronchodilator response to inhaled salbutamol.Results: Kappa values for four-week repeatability for the wheeze and asthma questions were 0.61 (95% CI 0.52 to 0.70) and 0.75 (0.63 to 0.87), respectively. Of the 58 people who reported wheeze in 2003 and in April 2006, only five had a positive exercise test or bronchodilator challenge (Positive Predictive Value (PPV) 0.09, 95% CI 0.01 to 0.22). Of the 12 who reported asthma in 2003 and April 2006, three had a positive result to either to exercise test or bronchodilator challenge test (PPV 0.25, 95% CI 0.05 to 0.50).Conclusion: Our findings suggest that self-reported wheeze and asthma have good short-term repeatability, but do not closely reflect exercise-induced bronchospasm or bronchodilator responsiveness. The validity of questionnaire methods of studying asthma epidemiology in developing countries needs further investigation

The Post-Eruptive Evolution of a Coronal Dimming

We discuss the post-eruptive evolution of a "coronal dimming" based on observations of the EUV corona from the Solar and Heliospheric Observatory and the Transition Region and Coronal Explorer. This discussion highlights the roles played by magnetoconvection-driven magnetic reconnection and the global magnetic environment of the plasma in the "filling" and apparent motion of the region following the eruption of a coronal mass ejection (CME). A crucial element in our understanding of the dimming region evolution is developed by monitoring the disappearance and reappearance of bright TRACE "moss" around the active region giving rise to the CME. We interpret the change in the TRACE moss as a proxy of the changing coronal magnetic field topology behind the CME front. We infer that the change in global magnetic topology also results in a shift of energy balance in the process responsible for the production of the moss emission while the coronal magnetic topology evolves from closed, to open and back to closed again because, following the eruption, the moss reforms around the active region in almost exactly its pre-event configuration. As a result of the moss evolution, combining our discussion with recent spectroscopic results of an equatorial coronal hole, we suggest that the interchangeable use of the term "transient coronal hole" to describe a coronal dimming is more than just a simple coincidence.Comment: In Press ApJ [May 2007] - 15 pages, 5 figures, 7 movies that are available upon request [contact author

Diabetes status and post-load plasma glucose concentration in relation to site-specific cancer mortality: findings from the original Whitehall study

ObjectiveWhile several studies have reported on the relation of diabetes status with pancreatic cancer risk, the predictive value of this disorder for other malignancies is unclear. Methods: The Whitehall study, a 25year follow-up for mortality experience of 18,006 men with data on post-challenge blood glucose and self-reported diabetes, allowed us to address these issues. Results: There were 2158 cancer deaths at follow-up. Of the 15 cancer outcomes, diabetes status was positively associated with mortality from carcinoma of the pancreas and liver, while the relationship with lung cancer was inverse, after controlling for a range of potential covariates and mediators which included obesity and socioeconomic position. After excluding deaths occurring in the first 10years of follow-up to examine the effect of reverse causality, the magnitude of the relationships for carcinoma of the pancreas and lung was little altered, while for liver cancer it was markedly attenuated. Conclusions: In the present study, diabetes status was related to pancreatic, liver, and lung cancer risk. Cohorts with serially collected data on blood glucose and covariates are required to further examine this area

Unraveling the directional link between adiposity and inflammation: a bidirectional mendelian randomization approach

<b>Context</b>: Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven. <b>Objective</b>: The aim of the study was to explore the causal direction of the relationship between adiposity and inflammation using a bidirectional Mendelian randomization approach. <b>Methods</b>: In the PROSPER study of 5804 elderly patients, we related C-reactive protein (CRP) single nucleotide polymorphisms (SNPs) (rs1800947 and rs1205) and adiposity SNPs (FTO and MC4R) to body mass index (BMI) as well as circulating levels of CRP and leptin. We gave each individual two allele scores ranging from zero to 4, counting each pair of alleles related to CRP levels or BMI. <b>Results</b>: With increasing CRP allele score, there was a stepwise decrease in CRP levels (P for trend < 0.0001) and a 1.98 mg/liter difference between extremes of the allele score distribution, but there was no associated change in BMI or leptin levels (P ≥ 0.89). By contrast, adiposity allele score was associated with 1) an increase in BMI (1.2 kg/m2 difference between extremes; P for trend 0.002); 2) an increase in circulating leptin (5.77 ng/ml difference between extremes; P for trend 0.0027); and 3) increased CRP levels (1.24 mg/liter difference between extremes; P for trend 0.002). <b>Conclusions</b>: Greater adiposity conferred by FTO and MC4R SNPs led to higher CRP levels, with no evidence for any reverse pathway. Future studies should extend our findings to other circulating inflammatory parameters. This study illustrates the potential power of Mendelian randomization to dissect directions of causality between intercorrelated metabolic factors

A conserved set of maternal genes? Insights from a molluscan transcriptome

The early animal embryo is entirely reliant on maternal gene products for a ‘jump-start’ that transforms a transcriptionally inactive embryo into a fully functioning zygote. Despite extensive work on model species, it has not been possible to perform a comprehensive comparison of maternally-provisioned transcripts across the Bilateria because of the absence of a suitable dataset from the Lophotrochozoa. As part of an ongoing effort to identify the maternal gene that determines left-right asymmetry in snails, we have generated transcriptome data from 1 to 2-cell and ~32-cell pond snail (Lymnaea stagnalis) embryos. Here, we compare these data to maternal transcript datasets from other bilaterian metazoan groups, including representatives of the Ecydysozoa and Deuterostomia. We found that between 5 and 10% of all L. stagnalis maternal transcripts (~300-400 genes) are also present in the equivalent arthropod (Drosophila melanogaster), nematode (Caenorhabditis elegans), urochordate (Ciona intestinalis) and chordate (Homo sapiens, Mus musculus, Danio rerio) datasets. While the majority of these conserved maternal transcripts (“COMATs”) have housekeeping gene functions, they are a non-random subset of all housekeeping genes, with an overrepresentation of functions associated with nucleotide binding, protein degradation and activities associated with the cell cycle. We conclude that a conserved set of maternal transcripts and their associated functions may be a necessary starting point of early development in the Bilateria. For the wider community interested in discovering conservation of gene expression in early bilaterian development, the list of putative COMATs may be useful resource