45 research outputs found
A Case Study on Formal Verification of Self-Adaptive Behaviors in a Decentralized System
- Author
- Publication venue
- 'Open Publishing Association'
- Publication date
- 01/01/2012
- Field of study
Self-adaptation is a promising approach to manage the complexity of modern
software systems. A self-adaptive system is able to adapt autonomously to
internal dynamics and changing conditions in the environment to achieve
particular quality goals. Our particular interest is in decentralized
self-adaptive systems, in which central control of adaptation is not an option.
One important challenge in self-adaptive systems, in particular those with
decentralized control of adaptation, is to provide guarantees about the
intended runtime qualities. In this paper, we present a case study in which we
use model checking to verify behavioral properties of a decentralized
self-adaptive system. Concretely, we contribute with a formalized architecture
model of a decentralized traffic monitoring system and prove a number of
self-adaptation properties for flexibility and robustness. To model the main
processes in the system we use timed automata, and for the specification of the
required properties we use timed computation tree logic. We use the Uppaal tool
to specify the system and verify the flexibility and robustness properties.Comment: In Proceedings FOCLASA 2012, arXiv:1208.432
Lighting during grow-out and Salmonella in broiler flocks
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
<p>Abstract</p> <p>Background</p> <p>Lighting is used during conventional broiler grow-out to modify bird behaviour to reach the goals of production and improve bird welfare. The protocols for lighting intensity vary. In a field study, we evaluated if the lighting practices impact the burden of <it>Salmonella </it>in broiler flocks.</p> <p>Methods</p> <p>Conventional grow-out flocks reared in the states of Alabama, Mississippi and Texas, USA in 2003 to 2006 were sampled 1 week before harvest (<it>n </it>= 58) and upon arrival for processing (<it>n </it>= 56) by collecting feathered carcass rinsate, crop and one cecum from each of 30 birds, and during processing by collecting rinsate of 30 carcasses at pre-chilling (<it>n </it>= 56) and post-chilling points (<it>n </it>= 54). Litter samples and drag swabs of litter were collected from the grow-out houses after bird harvest (<it>n </it>= 56). Lighting practices for these flocks were obtained with a questionnaire completed by the growers. Associations between the lighting practices and the burden of <it>Salmonella </it>in the flocks were tested while accounting for variation between the grow-out farms, their production complexes and companies.</p> <p>Results</p> <p>Longer relative duration of reduced lights during the grow-out period was associated with reduced detection of <it>Salmonella </it>on the exterior of birds 1 week before harvest and on the broiler carcasses at the post-chilling point of processing. In addition, starting reduced lights for ≥18 hours per day later in the grow-out period was associated with decreased detection of <it>Salmonella </it>on the exterior of broilers arriving for processing and in the post-harvest drag swabs of litter from the grow-out house.</p> <p>Conclusions</p> <p>The results of this field study show that lighting practices implemented during broiler rearing can impact the burden of <it>Salmonella </it>in the flock. The underlying mechanisms are likely to be interactive.</p
Software Engineering for Self-Adaptive Systems: A second Research Roadmap
- Author
- Andersson Jesper
- Baresi Luciano
- Becker Basil
- Bencomo Nelly
- Brun Yuriy
- Cikic Bojan
- de Lemos Rogerio
- Desmarais Ron
- Dustdar Schahram
- Engels Gregor
- Geihs Kurt
- Giese Holger
- Goeschka Karl M.
- Gorla Alessandra
- Grassi Vincenzo
- Inverardi Poala
- Karsai Gabor
- Kramer Jeff
- Litoiu Marin
- Lopes Antonia
- Magee Jeff
- Malek Sam
- Mankovskii Serge
- Mirandola Raffaela
- Mylopoulos John
- Nierstrasz Oscar
- Prehofer Christian
- Schlichting Wilhelm
- Schmerl Bradley
- Shaw Mary
- Smith Dennis B.
- Sousa Joao P.
- Tahvildari Ladan
- Tamura Gabriel
- Villegas Norha M.
- Vogel Thomas
- Weyns Danny
- Wong Kenny
- Wuttke Jochen
- Publication venue
- Dagstuhl Seminar Proceedings. 10431 - Software Engineering for Self-Adaptive Systems
- Publication date
- 01/01/2011
- Field of study
The goal of this roadmap paper is to summarize the state of-the-art and identify research challenges when developing, deploying and managing self-adaptive software systems. Instead of dealing with a wide range of topics associated with the field, we focus on four essential topics of self-adaptation:
design space for adaptive solutions, processes, from centralized to decentralized control, and practical run-time verification and validation. For each topic, we present an overview, suggest future directions, and focus on selected challenges. This paper complements and extends a previous roadmap
on software engineering for self-adaptive systems published in 2009 covering a different set of topics, and reflecting in part on the previous paper. This roadmap is one of the many results of the Dagstuhl Seminar 10431 on Software
Engineering for Self-Adaptive Systems, which took place in October 2010
SOX9 Governs Differentiation Stage-Specific Gene Expression in Growth Plate Chondrocytes via Direct Concomitant Transactivation and Repression
- Author
- A Nagy
- A Novak
- A Ruiz i Altaba
- Angel C. Y. Mak
- B St-Jacques
- BA Alman
- BF Eames
- BL Huang
- Bo Gao
- C Magee
- CD Oh
- CE Scott
- D Chambers
- D Ikegami
- D Wilhelm
- Danny Chan
- DM Bell
- E Koyama
- E Mau
- G Karsenty
- G Zhou
- H Akiyama
- H Akiyama
- H Kondoh
- HL Park
- HM Kronenberg
- I Sekiya
- Ian G. Melhado
- J Guo
- J Jiang
- James Y. B. Lau
- JM Hernandez-Hernandez
- K Amano
- K Mukhopadhyay
- K Nishioka
- Kathryn S. E. Cheah
- Keith K. H. Leung
- KK Mak
- KM Kwan
- KS Joeng
- KY Tsang
- L Koziel
- LJ Ng
- M Cheung
- M Inada
- M Wilson
- M Wuelling
- MA Arnold
- MS Ho
- Nelson W. F. Dung
- P Ducy
- Q Zhao
- Q Zheng
- R Mo
- R Rosati
- R Sekido
- R Zhou
- RB Vega
- RY Kong
- S Gebhard
- S Riemer
- S Yamashita
- Sarah L. Wynn
- T Hattori
- T Kobayashi
- T Saito
- Tiffany Y. K. Au
- V Lefebvre
- V Lefebvre
- V Lefebvre
- Veronica van Heyningen
- Victor Y. L. Leung
- VP Lu
- W Bi
- W Bi
- WF Xie
- X Chen
- Y Han
- Y Kamachi
- Y Liu
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, and transition to a non-mitotic hypertrophic state. The restricted and reciprocal expression of the collagen X gene, Col10a1, in hypertrophic chondrocytes and Sox9 in immature chondrocytes epitomise the precise spatiotemporal control of gene expression as chondrocytes progress through phases of differentiation, but how this is achieved is not clear. Here, we have identified a regulatory element upstream of Col10a1 that enhances its expression in hypertrophic chondrocytes in vivo. In immature chondrocytes, where Col10a1 is not expressed, SOX9 interacts with a conserved sequence within this element that is analogous to that within the intronic enhancer of the collagen II gene Col2a1, the known transactivation target of SOX9. By analysing a series of Col10a1 reporter genes in transgenic mice, we show that the SOX9 binding consensus in this element is required to repress expression of the transgene in non-hypertrophic chondrocytes. Forced ectopic Sox9 expression in hypertrophic chondrocytes in vitro and in mice resulted in down-regulation of Col10a1. Mutation of a binding consensus motif for GLI transcription factors, which are the effectors of Indian hedgehog signaling, close to the SOX9 site in the Col10a1 regulatory element, also derepressed transgene expression in non-hypertrophic chondrocytes. GLI2 and GLI3 bound to the Col10a1 regulatory element but not to the enhancer of Col2a1. In addition to Col10a1, paired SOX9–GLI binding motifs are present in the conserved non-coding regions of several genes that are preferentially expressed in hypertrophic chondrocytes and the occurrence of pairing is unlikely to be by chance. We propose a regulatory paradigm whereby direct concomitant positive and negative transcriptional control by SOX9 ensures differentiation phase-specific gene expression in chondrocytes. Discrimination between these opposing modes of transcriptional control by SOX9 may be mediated by cooperation with different partners such as GLI factors
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
- Author
- Abel K
- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
- Ahmed R
- Ahwireng Nyarko
- Ainsworth Mark
- Al-Sheklly B.
- Alamoudi Asma
- Alfaro-Almagro Fidel
- Ali Mariam
- Aljaroof M
- Allan L
- Allen R J
- Allerton Lisa
- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
- Alvarez Corral Maria
- Amoils S.
- Anderson David
- Antoniades C
- Arbane Gill
- Arias Ava Maria
- Armour C.
- Armstrong Lisa
- Armstrong Natalie
- Arnold David
- Arnold H
- Ashish A
- Ashworth Andrew
- Ashworth M
- Aslani S
- Assefa-Kebede Hosanna
- Atkin C
- Atkin Paul
- Aul Raminder
- Aung H
- Austin Liam
- Avram Cristina
- Ayoub A.
- Babores M.
- Baggott R
- Bagshaw J
- Baguley D
- Bailey L
- Baillie J.K.
- Bain S
- Bakali M
- Bakau M
- Baldry E
- Baldwin D
- Baldwin M
- Ballard C
- Bandula Steven
- Banerjee A
- Bang Dongchun
- Barker R E
- Barman L
- Barratt Shaney
- Barrett Fiona
- Basire Donna
- Basu N.
- Bates A
- Bates M
- Batterham R
- Baxendale H
- Bayes Hannah
- Beadsworth M.
- Beckett P
- Beggs Mark
- Begum M
- Beirne Paul
- Bell Murdina
- Bell R
- Bennett Kaytie
- Beranova Eva
- Bermperi Areti
- Berridge Anthony
- Berry C.
- Betts Sarah
- Bevan Emily
- Bhui K
- Bingham Michelle
- Birchall K
- Bishop L.
- Bisnauthsing Karen
- Blaikely J.
- Bloss Angela
- Bolger A.
- Bolton Charlotte E.
- Bonnington J.
- Botkai A
- Bourne Charlotte
- Bourne Michelle
- Bramham K.
- Brear Lucy
- Breen G
- Breeze Jonathon
- Briggs A.
- Bright E
- Brightling Christopher E
- Brill Simon
- Brindle K
- Broad Lauren
- Broadley A
- Brookes C
- Broome M
- Brown Ammani
- Brown Angela
- Brown J.
- Brown Jeremy S
- Brown Jo
- Brown M.
- Brown M.
- Brown V.
- Brugha Terry
- Brunskill Nigel
- Buch M.
- Buckley Phil
- Bularga A.
- Bullmore E
- Bunker Jenny
- Burden L.
- Burdett Tracy
- Burn D.
- Burns A.
- Burns G.
- Busby J.
- Butcher Robyn
- Butt Al-Tahoor
- Byrne S.
- Cairns P
- Calder P C
- Calvelo Ellen
- Carborn H
- Card Bethany
- Carr Caitlin
- Carr Liesel
- Carson G
- Carter Penny
- Casey A
- Cassar Mark P.
- Cavanagh J
- Chablani Manish
- Chalder Trudie
- Chalmers James D.
- Chambers R C
- Chan Flora
- Channon K M
- Chapman Kerry
- Charalambou A
- Chaudhuri N
- Checkley A
- Chen Jin
- Cheng Yutung
- Chetham Luke
- Childs C
- Chilvers Edwin R
- Chinoy H
- Chiribiri Amedeo
- Chong-James K.
- Choudhury Gourab
- Choudhury N.
- Chowienczyk P
- Christie C
- Chrystal Melanie
- Clark Cameron
- Clark D
- Clarke Jude
- Clohisey S.
- Coakley G.
- Coburn Zach
- Coetzee S.
- Cole Joby
- Coleman C
- Conneh Florence
- Connell David
- Connolly B.
- Connor Lynda
- Cook Amanda
- Cooper B
- Cooper J
- Cooper Shirley
- Copeland D.
- Cosier Tracey
- Coulding Martina
- Coupland C.
- Cox Eleanor
- Craig T.
- Crisp P
- Cristiano Daniele
- Crooks M.G.
- Cross Andy
- Cruz Isabel
- Cullinan P.
- Cuthbertson Dan J
- Daines L
- Dalton Matthhew
- Daly Patrick
- Daniels Alison
- Dark P
- Dasgin J
- David A
- David C.
- Davies Ellie
- Davies Ffyon
- Davies Gareth
- Davies Gwyneth A
- Davies Kim
- Davies Melanie J
- Dawson Joy
- Daynes E
- De Soyza Anthony
- Deakin B
- Deans Andrew
- Deas C.
- Deery Joanne
- Defres S.
- Dell Amanda
- Dempsey K.
- Denneny E
- Dennis J
- Dewar A.
- Dharmagunawardena R
- Diar Bakerly Nawar
- Dickens C
- Dipper A.
- Diver Sarah
- Diwanji Shalin N
- Dixon Myles
- Djukanovic R
- Dobson H.
- Dobson S.L.
- Docherty Annemarie B.
- Donaldson A.
- Dong T.
- Dormand N.
- Dougherty Andrew
- Dowling R
- Drain S.
- Draxlbauer K
- Drury Katie
- Dulawan Pearl
- Dunleavy A
- Dunn Sarah
- Dupont Catherine
- Earley Joanne
- Easom Nicholas
- Echevarria Carlos
- Edwards Sarah
- Edwardson C
- El-Taweel Hosni
- Elliott Anne
- Elliott K
- Ellis Y.
- Elmer Anne
- Elneima Omer
- Evans D
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- Evans R
- Evans Rachael A
- Evans Ranuromanana I.
- Evans Teriann
- Evenden Cerys
- Evison Lynsey
- Fabbri L
- Fairbairn Sara
- Fairman Alexandra
- Fallon K.
- Faluyi David
- Favager Clair
- Fayzan Tamanah
- Featherstone James
- Felton T.
- Ferreira Vanessa M.
- Finch J
- Finney Selina
- Finnigan J
- Finnigan Lucy
- Fisher Helen
- Fletcher S
- Flockton Rachel
- Flynn Margaret
- Foot H
- Foote David
- Ford Amber
- Forton D
- Fraile Eva
- Francis C.
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- Francis Susan
- Frankel A.
- Fraser Emily
- Free Rob
- French N.
- Fu X
- Fuld Jonathan
- Furniss J.
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- Gill Mandy
- Gill Rhyan
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- Gleeson Fergus
- Glossop Jodie
- Glover Sarah
- Goodman N
- Goodwin Camelia
- Gooptu Bibek
- Gordon Hussain
- Gorsuch T.
- Greatorex M
- Greenhaff P.L.
- Greenhalf William
- Greenhalgh Alan
- Greening Neil J
- Greenwood John P
- Gregory Heidi
- Gregory Rebecca
- Grieve D.
- Griffin Denise
- Griffiths L
- Guerdette Anne-Marie
- Guillen Guio Beatriz
- Gummadi Mahitha
- Gupta Ayushman
- Gurram Sambasivarao
- Guthrie E
- Guy Z
- Hadley K
- Haggar Ahmed
- Hainey Kera
- Hairsine Brigid
- Haldar Pranab
- Hall I
- Hall Lucy
- Halling-Brown Mark
- Hamil R.
- Hancock Alyson
- Hancock Kia
- Hanley N.A.
- Haq Sulaimaan
- Hardwick H.E.
- Hardy E
- Hardy Tim
- Hargadon Beverley
- Harrington Kate
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- Harrison Ewen M.
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- Hart Nicholas
- Harvey Alice
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- Harvie M
- Haslam L
- Hastie Claire
- Havinden-Williams May
- Hawkes Jenny
- Hawkings Nancy
- Haworth Jill
- Hayday A.
- Haynes Matthew
- Hazeldine J
- Hazelton Tracy
- Heaney Liam G.
- Heeley Cheryl
- Heeney J L
- Heightman M
- Heller S.
- Henderson M
- Henson Helen
- Hesselden L
- Hewitt Melanie
- Highett Victoria
- Hillman T
- Hiwot T
- Ho Ling-Pei
- Hoare Amy
- Hoare Michaela
- Hockridge J
- Hogarth Philip
- Holbourn Ailsa
- Holden S
- Holdsworth L.
- Holgate D
- Holland Maureen
- Holloway Leah
- Holmes Katie
- Holmes Megan
- Holroyd-Hind B
- Holt L
- Hormis Anil
- Horsley Alexander
- Hosseini A.
- Hotopf M
- Houchen-Wolloff Linzy
- Howard K
- Howard Luke S.
- Howell Alice
- Hufton E
- Hughes A D
- Hughes Joan
- Hughes Paul J C
- Hughes Rachel Ann
- Humphries Amy
- Huneke N
- Hurditch E
- Hurst John R
- Husain M
- Hussell T.
- Hutchinson John
- Ibrahim W
- Ilyas F
- Ingham Julie
- Ingram L
- Ionita D
- Isaacs K
- Ismail K.
- Jackson T
- Jacob Joseph
- James W.Y.
- Jang W.
- Jarman Claire
- Jarrold I.
- Jarvis Hannah
- Jastrub Roman
- Jayaraman Bhagy
- Jenkins R Gisli
- Jezzard Peter
- Jiwa Kasim
- Johnson C
- Johnson S
- Johnston D.
- Jolley Caroline J.
- Jones Don
- Jones G.
- Jones H.
- Jones Heather
- Jones I.
- Jones L.
- Jones Mark G
- Jones S.
- Jose Sherly
- Kabir T.
- Kaltsakas G.
- Kamwa V
- Kanellakis N.
- Kaprowska Sabina
- Kausar Zunaira
- Keenan Natalie
- Kelly Matthew
- Kelly S.
- Kemp Graham J
- Kerr Steven
- Kerslake Helen
- Key Angela L.
- Khan F
- Khunti Kamlesh
- Kilroy Susan
- King Bernie
- King Clara
- Kingham L
- Kirk Jill
- Kitterick P
- Klenerman P
- Knibbs Lucy
- Knight Sean
- Knighton Abigail
- Kon Onn M
- Kon S
- Kon Samantha S
- Korszun A.
- Koychev Ivan
- Kurasz Claire
- Kurupati Prathiba
- Laing C
- Lamlum Hanan
- Landers G
- Langenberg C
- Lasserson D
- Lavelle-Langham L.
- Lawrie Allan
- Lawson C
- Lawson Cathy
- Layton Alison
- Lea A
- Leavy Olivia C
- Lee D
- Lee Elvina
- Lee Ju Hee
- Leitch Karen
- Lenagh Rebecca
- Lewis D
- Lewis J.
- Lewis Keir E
- Lewis Victoria
- Lewis-Burke N.
- Li X
- Light Tessa
- Lightstone L.
- Lilaonitkul W
- Lim Lai
- Linford S.
- Lingford-Hughes A.
- Lipman M
- Liyanage Kamal
- Lloyd Arwel
- Logan S
- Lomas D
- Lone Nazir I.
- Loosley Ronda
- Lord J M
- Lota Harpreet
- Lovegrove Wayne
- Lucey Alice
- Lukaschuk Elena
- Lye Alison
- Lynch Ceri
- MacDonald S
- MacGowan G.
- Macharia Irene
- Mackie J
- Macliver L.
- Madathil S
- Madzamba Gladys
- Magee N.
- Magtoto Murphy M.
- Mairs N
- Majeed N
- Major E.
- Malein Flora
- Malim M.
- Mallison Georgia
- Man William D-C.
- Mandal S
- Mangion K.
- Manisty Charlotte
- Manley R.
- March Katherine
- Marciniak S.
- Marino Philip
- Mariveles Myril
- Marks Michael
- Marouzet E
- Marsh Sophie
- Marshall B
- Marshall M
- Martin Jane
- Martineau A.
- Martinez L.M.
- Maskell Nick
- Matila Darwin
- Matimba-Mupaya Wadzanai
- Matthews Laura
- Mbuyisa Angeline
- McAdoo S.
- McAllister-Williams H.
- McArdle A
- McArdle P
- McAulay D.
- McAuley Hamish J C
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- McCormick Jacqueline
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- McGarvey L.
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- Mcgee K
- McGinness Jade
- McGlynn Kevin
- McGovern A
- McGuinness Heather
- McInnes I.B.
- McIntosh Jerome
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- McMahon A.
- McMahon Michael J.
- McMorrow L
- Mcnally T
- McNarry M
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- McQueen Alison
- McShane H.
- Mears Chloe
- Megson Clare
- Megson Sharon
- Mehta P
- Meiring J
- Melling Lucy
- Mencias Mark
- Menke Ricarda
- Menzies Daniel
- Merida Morillas Marta
- Michael Alice
- Miiler K
- Miller Christopher A
- Miller Karla
- Milligan L.
- Mills Clare
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- Mills N.L.
- Milner L
- Misra S
- Mitchell J.
- Mohamed Abdelrahman
- Mohamed Noura
- Mohammed S.
- Molyneaux P.L.
- Monteiro Will
- Moriera Silvia
- Morley Anna
- Morrison Leigh
- Morriss R
- Morrow A.
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- Motohashi K
- Msimanga N
- Mukaetova-Ladinska Elizabeta
- Munawar Unber
- Murira Jennifer
- Nanda U
- Nassa Heeah
- Nasseri Mariam
- Nathu Rashmita
- Neal A
- Needham Robert
- Neill Paula
- Neubauer Stefan
- Newby D E
- Newell Helen
- Newman J
- Newman Tom
- Newton-Cox A
- Nichols Thomas E
- Nicholson T.
- Nicoll Debby
- Nikolaidis Athanasios
- Nikolaidou Chrysovalantou
- Nolan C.M.
- Noonan Matthew J.
- Norman C
- Novotny Petr
- Nunag Jose Lloyd
- Nwafor Lorenza
- Nwanguma Uchechi
- Nyaboko J
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- O'Brien Linda
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- O'Regan Declan P
- Odell Natasha
- Ogbole Godwin
- Ogg G.
- Olaosebikan Olaoluwa
- Oliver Catherine
- Omar Zohra
- Openshaw Peter J.M.
- Orriss-Dib Lorna
- Osborne Lynn
- Osbourne Rebecca
- Ostermann Marlies
- Overton Charlotte
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- Oxton J
- Pack Jamie
- Pacpaco Edmund
- Paddick S.
- Painter Sharon
- Pakzad A
- Palmer Sue
- Papineni Padmasayee
- Paques K
- Paradowski Kerry
- Pareek Manish
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- Parfrey H
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- Patel Manish
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- Pattenadk Dibya
- Pavlides M.
- Payne Sheila
- Pearce Lorraine
- Pearl John E
- Peckham D.
- Pendlebury Jessica
- Peng Yanchun
- Pennington Chris
- Peralta Ida
- Perkins Emma
- Peterkin Z
- Peto T.
- Petousi Nayia
- Petrie J
- Pfeffer Paul
- Phipps Janet
- Piechnik Stefan K
- Pimm John
- Piper Hanley K.
- Pius R
- Plant Hannah
- Plein Sven
- Plekhanova Tatiana
- Plowright Megan
- Poinasamy Krisnah
- Polgar Oliver
- Poll L.
- Popescu Iulia
- Porter Joanna C
- Porter Julie
- Portukhay Sofiya
- Powell Natassia
- Prabhu A.
- Pratt James
- Price Andrea
- Price Carly
- Price Claire
- Price D.
- Price L
- Price L.
- Prickett A
- Prosper Sabrina
- Pugmire S.
- Quaid Sheena
- Quigley Jackie
- Quint Jennifer
- Qureshi H
- Qureshi I N
- Radhakrishnan K.
- Rahman Najib M.
- Ralser M
- Raman Betty
- Ramos Albert
- Ramos Hazel
- Rangeley Jade
- Rangelov B
- Ratcliffe L
- Ravencroft Phillip
- Reddington A
- Reddy A
- Reddy R.
- Redfearn H
- Redwood Dawn
- Reed Annabel
- Rees Meryl
- Rees Tabitha
- Regan Karen
- Reynolds W
- Ribeiro Carla
- Richards A.
- Richardson Emma
- Richardson Matthew
- Rivera-Ortega P.
- Roberts K.
- Robertson E.
- Robinson E
- Robinson Leanne
- Roche Lisa
- Roddis C
- Rodger J
- Rogers Natalie
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- Ross Gavin
- Rossdale J.
- Rostron A
- Rowe Anna
- Rowland A
- Rowland J.
- Rowland Matthew J.
- Rowland-Jones Sarah L
- Roy K
- Roy Maura
- Rudan I
- Russell Emily
- Russell Richard
- Saalmink Gwen
- Sabit Ramsey
- Sage E.K.
- Samakomva T
- Samani Nilesh
- Samat Azlan Helmy A
- Sampson Claire
- Samuel Katherine
- Samuel R
- Sanders Zeena-Britt
- Sanderson Amy
- Sapey E
- Saralaya Dinesh
- Sargant J
- Sarginson C
- Sass T
- Sattar N
- Saunders Kathryn
- Saunders Laura C
- Saunders Peter
- Saunders Ruth M
- Savill Heather
- Saxon W.
- Sayer A.
- Schronce J.
- Schwaeble W
- Scott Janet T.
- Scott Kathryn
- Selby N.
- Semple Malcolm G.
- Sereno Marco
- Sewell Terri Ann
- Shah Ajay M
- Shah K.
- Shah P.
- Shankar-Hari M
- Sharma M
- Sharpe C.
- Sharpe M.
- Shashaa Sharlene
- Shaw Alison
- Shaw Karen
- Shaw V.
- Sheikh Aziz
- Shelton Sarah
- Shenton Liz
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- Turton Helena
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- Valabhji J.
- Ventura M
- Vere Joanne
- Vickers Carinna
- Vinson B
- Wade Elaine
- Wade Phillip
- Wain Louise V
- Wainwright Tania
- Wajero Lilian O.
- Walder S
- Walker S
- Walker S.
- Wall E
- Wallis T
- Walmsley S
- Walsh J.A.
- Walsh S.
- Warburton Louise
- Ward T J C
- Warwick Katie
- Wassall Helen
- Waterson Samuel
- Watson Ekaterina
- Watson James
- Watson L.
- Webster M
- Weir-McCall Jonathan R
- Welch C
- Welch H.
- Welsh B.
- Wessely S.
- West Sophie
- Weston Heather
- Wheeler H
- White Sonia
- Whitehead Victoria
- Whitney J.
- Whittaker S
- Whittam Beverley
- Whitworth V
- Wight A
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- Wilkinson D
- Williams B
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- Williams Nick
- Williams-Howard S.A.
- Willicombe M.
- Willis Gemma
- Willoughby J
- Wilson Ann
- Wilson D
- Wilson Imogen
- Window Nicola
- Witham M.
- Wolf-Roberts Rebecca
- Wood Chloe
- Woodhead F
- Woods Janet
- Wootton Daniel G.
- Wormleighton J
- Worsley J.
- Wraith D
- Wrey Brown Caroline
- Wright C.
- Wright L
- Wright S.
- Wyles J.
- Wynter Inez
- Xie Cheng
- Xu M
- Yasmin Najira
- Yasmin S
- Yates Tom
- Yip K P
- Young A.
- Young B.
- Young Susan
- Yousuf A J
- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
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- Barve Minal
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- Bauman Julie
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- Bauml Joshua
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- Bornschlegl Svetlana
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- Delogu Lucia
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- Demaria Sandra
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- Deng Liang
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- Facciponte John
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- Femel Julia
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- Ylösmäki Erkko
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- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zappasodi Roberta
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
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- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain A.
- Ajith Parameswaran
- Akutsu Tomotada
- Albanesi S.
- Alfaidi R. A.
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Amato Alex
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Arnaud Nicolas
- Arogeti M.
- Aronson S. M.
- Arène M.
- Asada Hideki
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae S.
- Bae Y.
- Bagnasco Stefano
- Bai Y.
- Baier J. G.
- Baird J.
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
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- Barish B. C.
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- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
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- Basti A.
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- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
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- Chaty Sylvain
- Chatziioannou Katerina
- Chen ChianShu
- Chen Dan
- Chen Hsin-Yu
- Chen Junxin
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
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- Árpád Gergely László
- 劉 國欽
- 曹周键
- 王谨
- 都丸 隆行
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
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- Adya V. B.
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- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
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- Andrea Prodi Giovanni
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- Antonio Font Roda Jose
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- Maliakal S.
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- mantovani maddalena
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- Marx E. J.
- María Ezquiaga Jose
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- Vidyant S.
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- Villa-Ortega Verónica
- Vincent Erin
- Vinet J. -Y.
- Viret S.
- VIRGO Collaboration
- Virtuoso Andrea
- Vitale Salvatore
- Vocca H.
- Voigt Daniel
- von Reis E. R. G.
- von Wrangel J. S. A.
- Vyatchanin Sergey P.
- Wade L. E.
- Wade Madeline
- Wagner Katelyn
- Walet R. C.
- Walker M.
- Wallace G. S.
- Wallace L.
- Wang Haoyu
- Wang J. Z.
- Wang W. H.
- Ward R. L.
- Warner J.
- Was Michal
- Washimi Tatsuki
- Washington N. Y.
- Watada K.
- Watarai D.
- Wayt K. E.
- Weaver B.
- Weaving C. R.
- Webster S. A.
- Weinert M.
- Weinstein Alan J.
- Weiss R.
- Weller C. M.
- Weller Robert
- Wellmann F.
- Wen L.
- Wette Karl
- Weßels P.
- Whelan John
- White D. D.
- Whiting Bernard F.
- Whittle Chris
- Wildberger J. B.
- Wilk O. S.
- Wilken Dennis
- Willetts K.
- Williams Daniel
- Williams Michael J.
- Williamson Andrew R.
- Willis Joshua
- Willke Benno
- Wils Milan
- Wipf C. C.
- Woan Graham
- Woehler J.
- Wofford Jared
- Won Lee Hyung
- Won Seo Jin
- Wong D.
- Wong Henry T.
- Wright Mick
- Wu Chien-Ming
- Wu David S.
- Wu Hsun-Chung
- Wysocki Daniel
- Xiao Liting
- Xu Victoria
- Yaala M. Ben
- Yadav Nikesh
- Yakovlev Alexey
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto M.
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yang Fengwei
- Yang Kate Z.
- Yang L. -C.
- Yang Y. -C.
- Yang Yang
- Yang Yi
- Yap M. J.
- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhang Yanqi
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
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- Babak Stanislav
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- de rossi camilla
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- Errico L.
- error error
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- Zhao Yuhang
- Zheng Yanyan
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- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM