UPAYA PENGELOLA WISATA DOLAN DESO BORO DALAM MENGHADAPI PANDEMI COVID-19 DI DESA BANJARASRI, KECAMATAN KALIBAWANG, KABUPATEN KULON PROGO, D.I. YOGYAKARTA

Pandemi Covid-19 manimbulkan pengaruh yang sangat besar, mulai dari sektor ekonomi, Pendidikan, sosial, pariwisata dan lain-lain. Untuk sektor pariwisata dari tahun 2018 hingga tahun 2020 terlihat penurunan jumlah wisatawan yang cukup signifikan. Bila dipersentasekan penurunan kunjungan wisatawan dari tahun 2019 hingga tahun 2020 menurun sebanyak 73,03%. Begitu juga dengan Wisata Dolan Deso Boro yang mana satu demi satu wisatawan membatalkan pesanannya. Dengan kurangnya wisatawan yang berkunjung ke Dolan Deso Boro, maka pemasukan/pendapatan yang diterima berkurang. Sedangkan pengelola Wisata Dolan Deso Boro masih perlu memenuhi kebutuhan di area wisatanya seperti pendanaan air, listrik, pajak dan perawatan fasilitas lainnya. Sehingga tujuan dari penelitian ini adalah untuk mengetahui upaya yang dilakukan pengelola Wisata Dolan Deso dalam menghadapi masa pandemic Covid-19. Serta apa saja faktor penghambat/kendala yang dihadapi pengelola Wisata Dolan Deso Boro. Jenis penelitian yang digunakan dalam penelitian ini adalah kualitatif dengan menggunakan metode deskriptif. Teknik pengumpulan data dalam penelitian ini dilakukan dengan menggunakan metode observasi, wawancara dan dokumentasi. Hasil penelitian ini menunjukan bahwa upaya yang dilakukan pengelola Wisata Dolan Deso Boro dalam menghadapi pandemic Covid-19 ada 3 (tiga) strategi yaitu Inovasi, Adaptasi dan Kolaborasi. Inovasi berkaitan dengan pembaruan produk dan memanfaatkan perkembangan teknologi inoformasi. Adaptasi yang dilakukan berkaitan dengan standar protocol kesehatan CHSE atau biasa disebut dengan cleanliness (Kebersihan), Health (Kesehatan), Safety (Keamanan), dan Environment Sustainability (Kelestarian lingkungan). Kolaborasi yang dilakukan terbagi menjadi tiga aktor yaitu pemerintah, sektor swasta, dan masyarakat. Sedangkan Sedangkan hambatan dan kendala yang dihadapi adalah informasi, partisipasi dan dana

Predictors of change in carotid atherosclerotic plaque inflammation and burden as measured by 18-FDG-PET and MRI, respectively, in the dal-PLAQUE study

Baseline predictors of response to treatment of patients with coronary heart disease (CHD) with respect to vascular inflammation and atherosclerotic plaque burden are poorly understood. From post hoc analysis of the dal-PLAQUE study (NCT00655473), 18F–fluorodeoxyglucose-positron emission tomography (18-FDG-PET) imaging and carotid black blood magnetic resonance imaging (MRI) were used to track changes in these vascular parameters. Baseline demographics, imaging, and biomarkers were collected/measured in 130 patients with CHD or CHD risk-equivalents, and imaging follow-up at 6 months (PET) and 24 months (MRI) was performed. Using stepwise linear regression, predictors of change in carotid plaque inflammation by PET [target-to-background ratio (TBR), n = 92] and plaque burden by MRI [wall area (WA) and total vessel area (TVA), n = 89] were determined. Variables with p < 0.05 in multivariable models were considered independently significant. Interleukin-6, systolic blood pressure and standard deviation of wall thickness (WT) at baseline were independently positively associated with 18-FDG uptake (mean of maximum [MeanMax] TBR change over 6 months). Mean of mean TBR, phospholipase A(2), apolipoprotein A-I, and high-sensitivity C-reactive protein at baseline were independently negatively associated with MeanMax TBR change over 6 months. Mean WT and plasminogen activator inhibitor-1 (PAI-1) activity at baseline, and age, were independently associated with change in WA over 24 months. For TVA changes; mean WA and PAI-1 activity at baseline, age, and female gender were independent predictors. These findings may help determine patients most suitable for clinical trials employing plaque inflammation or burden changes as endpoints

Iron oxide core oil-in-water emulsions as a multifunctional nanoparticle platform for tumor targeting and imaging

Nanoemulsions are increasingly investigated for the delivery of hydrophobic drugs to improve their bioavailability or make their administration possible. In the current study, oil-in-water emulsions with three different mean diameters (30, 60, and 95 nm) were developed as a new multimodality nanoparticle platform for tumor targeting and imaging. To that aim, hydrophobically coated iron oxide particles were included in the soybean oil core of the nanoemulsions to enable their detection with magnetic resonance imaging (MRI), while the conjugation of a near infrared fluorophore allowed optical imaging. The accumulation of this novel nanocomposite in subcutaneous human tumors in nude mice was demonstrated with MRI and fluorescence imaging in vivo, and with Perl's staining of histological tumor sections ex viv