Aminoacyl tRNA synthetase complex interacting multifunctional protein 1 simultaneously binds Glutamyl-Prolyl-tRNA synthetase and scaffold protein aminoacyl tRNA synthetase complex interacting multifunctional protein 3 of the multi-tRNA synthetase complex

Higher eukaryotes have developed extensive compartmentalization of amino acid (aa) - tRNA coupling through the formation of a multi-synthetase complex (MSC) that is composed of eight aa-tRNA synthetases (ARS) and three scaffold proteins: aminoacyl tRNA synthetase complex interacting multifunctional proteins (AIMP1, 2 and 3). Lower eukaryotes have a much smaller complex while yeast MSC consists of only two ARS (MetRS and GluRS) and one ARS cofactor 1 protein, Arc1p (Simos et al., 1996), the homolog of the mammalian AIMP1. Arc1p is reported to form a tripartite complex with GluRS and MetRS through association of the N-terminus GST-like domains (GST-L) of the three proteins (Koehler et al., 2013). Mammalian AIMP1 has no GST-L domain corresponding to Arc1p N-terminus. Instead, AIMP3, another scaffold protein of 18 kDa composed entirely of a GST-L domain, interacts with Methionyl-tRNA synthetase (MARS) (Quevillon et al., 1999) and Glutamyl-Prolyl-tRNA Synthetase (EPRS) (Cho et al., 2015). Here we report two new interactions between MSC members: AIMP1 binds to EPRS and AIMP1 binds to AIMP3. Interestingly, the interaction between AIMP1 and AIMP3 complex makes it the functional equivalent of a single Arc1p polypeptide in yeast. This interaction is not mapped to AIMP1 N-terminal coiled-coil domain, but rather requires an intact tertiary structure of the entire protein. Since AIMP1 also interacts with AIMP2, all three proteins appear to compose a core docking structure for the eight ARS in the MSC complex

Creating and Implementing Effective Visual Literacy for the Classroom

Over the past 25 years, the way people communicate with one another and others around the world has become less focused on text and more focused on visual imagery. This shift in language makes it increasingly difficult to communicate with students who have been raised in this digital world. Teachers need to have the tools to teach visual literacy techniques, good image resources available to them, and be able to create rich images that improve content comprehension in the classroom. This product, in the form of an interactive website, will empower teachers to understand the impact of visual literacy on learning, provide tools and resources for creating useful visuals, and will provide best-practices for teachers to create effective tools

Advanced Filter Solutions for High-performance Millimetre and Submillimetre-wave Systems

This thesis is devoted to the investigation of advanced filter design solutions for high-performance millimetre and submillimetre-wave systems. Each of the proposed design solutions are enabled using waveguide-based technologies with the aim of advancing future generations of satellite communications, radar, and remote sensing. As trends for frequency allocations move to higher and higher frequency bands, engineers are faced with increasingly complex challenges such as the degradation of component performance, the inability to correctively tune the performance, or scenarios that all together make circuits infeasible. In light of these challenges, this work seeks to advance the current literature on filter design and proposes many unique design solutions for overcoming manufacturing and accuracy limitations, reducing the transmission losses, and reducing the overall design complexity. Each of the proposed filter solutions that are presented in this thesis are based on either a novel structural design or a novel technology. Each of the proposed designs are presented with functional prototypes as a means of verifying the theory. In the majority of cases, prototypes have been manufactured using high-precision computer numerical control (CNC) milling, and in several articles, exploratory activities with the use of alternative technologies such as stereolithography (SLA) 3D-printing and deep-reactive ion etching (DRIE) are presented. Prior to the presentation of the filter designs, an overview on the design and synthesis of millimetre-wave filters and diplexers is provided and serves as a foundation for the coupling matrix descriptions of symmetric and asymmetric resonator designs throughout this work

Relativistically invariant quantum information

We show that quantum information can be encoded into entangled states of multiple indistinguishable particles in such a way that any inertial observer can prepare, manipulate, or measure the encoded state independent of their Lorentz reference frame. Such relativistically invariant quantum information is free of the difficulties associated with encoding into spin or other degrees of freedom in a relativistic context.Comment: 5 pages, published versio

The Anglet: An E/H-plane Bent, 90-Degree Twisted, TE101/TM110-Mode Singlet Building Block

In this work, a subclass of the singlet building block is defined. Termed the anglet, a waveguide cavity-based structure is demonstrated that combines a bend, a 90-degree polarization rotation, and produces one pole and one transmission zero. The anglet is defined due to its unique ability to be viewed as either a TE101-mode singlet or a TM110-mode singlet based on the users coordinate point of view together with the requirements for the bend direction and polarization rotation. Two types of anglets are demonstrated by simulation and a third-order filter is demonstrated for the incorporation of an anglet in a practical design. Emphasis on its unique capabilities are highlighted due to its nature as a fundamental-mode resonator with evanescent bypass coupling. Furthermore, an accurate approximation for the source-load coupling is described and a prototype filter is fabricated and measured in order to validate the concept

W‐band TE102‐mode filter with doubly loaded E‐plane and H‐plane irises

In this correspondence, high-precision computer numerical control milling is utilised to demonstrate a doubly loaded iris, cross-coupled waveguide bandpass filter for inline operation within the W-band. This sixth-order filter is designed in a stacked H-plane configuration and utilises both E-plane and H-plane doubly loaded irises to maintain the flow of a TE102-mode electromagnetic field. In this configuration, a high rejection level is maintained outside of the passband while a good unloaded quality factor is obtained through the support of larger resonator dimensions. The filter is designed for approximately 2% fractional bandwidth centred at 97.5 GHz and has been fabricated as three brass components. Measurements of the filter agree very well with the simulated results and demonstrate a spurious-free design over the full W-band

Quantum Black Holes: Entropy and Entanglement on the Horizon

We are interested in black holes in Loop Quantum Gravity (LQG). We study the simple model of static black holes: the horizon is made of a given number of identical elementary surfaces and these small surfaces all behaves as a spin-s system accordingly to LQG. The chosen spin-s defines the area unit or area resolution, which the observer uses to probe the space(time) geometry. For s=1/2, we are actually dealing with the qubit model, where the horizon is made of a certain number of qubits. In this context, we compute the black hole entropy and show that the factor in front of the logarithmic correction to the entropy formula is independent of the unit s. We also compute the entanglement between parts of the horizon. We show that these correlations between parts of the horizon are directly responsible for the asymptotic logarithmic corrections. This leads us to speculate on a relation between the evaporation process and the entanglement between a pair of qubits and the rest of the horizon. Finally, we introduce a concept of renormalisation of areas in LQG.Comment: Revtex4, 25 pages, 4 figure

Integer Division by Constants: Optimal Bounds

The integer division of a numerator n by a divisor d gives a quotient q and a remainder r. Optimizing compilers accelerate software by replacing the division of n by d with the division of c * n (or c * n + c) by m for convenient integers c and m chosen so that they approximate the reciprocal: c/m ~= 1/d. Such techniques are especially advantageous when m is chosen to be a power of two and when d is a constant so that c and m can be precomputed. The literature contains many bounds on the distance between c/m and the divisor d. Some of these bounds are optimally tight, while others are not. We present optimally tight bounds for quotient and remainder computations

The intoxicated co-witness: effects of alcohol and dyadic discussion on memory conformity and event recall.

Co-witness discussion is common and often witnesses are under the influence of alcohol. As such, it is important to understand how such factors may influence eyewitness testimony. We combined a co-witness memory paradigm with an alcohol administration paradigm to examine the influence of alcohol and dyadic discussion on remembering a mock crime. Intoxicated and sober dyads discussed a previously seen video, whilst in a control condition sober and intoxicated individuals recalled the event on their own. Unknown to the dyads, each discussion partner saw a different version of the video including unique details not present in the other video version. All participants then engaged in a second individual recall attempt. Dyads were more likely to recall misleading details in their individual recall attempts compared to the control group. Intoxicated and sober dyads were equally likely to report misleading information. Alcohol intoxication had no negative impact on individuals' ability to correctly identify the source of their responses. Intoxicated participants recalled fewer details under free recall conditions. Alcohol had a detrimental effect on participants' confidence in their free recall accounts. Possible alcohol-related and social-cognitive mechanisms are discussed which may contribute to the current findings as well as applied implications for interviewing intoxicated witnesses