Mahlon Pitney and Caroline Pitney to Dalrymple Family, December 29, 1820

Legal Indenture from Mahlon Pitney, Samuel P. Dalrymple, John Dalrymple, Phebe Ann Dalrymple, and Frederick B. Dalrymple to Caroline Pitney for money due for Grays Hollow lot. People Included: Samuel Pitney, James Pitney, Diziah Dalrymplehttps://digitalcommons.kean.edu/lhc_1820s/1140/thumbnail.jp

Towards an Understanding of Factors Controlling Seed Bank Composition and Longevity in the Alpine Environment

The ability of seeds to regenerate from soil seed banks has long been recognized as a key survival strategy for plants establishing new niches in highly variable climates of alpine environments. However, the fundamental aspects of evolutionary/selective forces for seed bank development in alpine ecosystems are largely unknown. Here, we developed a model that describes dormancy, a high temperature requirement and a specific light/darkness regime at the time of seed shedding can preclude autumn germination, thus contributing to seed persistence until the next growing season. The benefits of these factors synchronising germination with the growing season are reviewed. Additionally, the importance of climatic variations of maternal environment affecting some of these factors is also discussed. It is suggested that the environmental conditions during the growing season partly control the seed persistence and seeds that fail to germinate are carried over to the next season. Species that have small (<3 mg) and round-shaped seeds tend to persist more easily in soil for over five years, than do the large or flat seeds. However, some large-seeded species also have the potential to establish short-term persistence bank. A literature survey reveals 88% of the alpine seeds have a mass <3 mg. Seed size has only a weak relationship with mean germination timing (MGT) indicating that reduced persistence in large-seeded species cannot be counteracted by quicker germination, but combined effects of other factors stimulating germination remain an open area to be studied. It is proposed that long distance dispersal (LDD) is limited in most-but not all-species, primarily due to the absence of specialized dispersal structures. However, among numerous dispersal modes, most species tend to be dispersed by wind. Thus, spermatophytes of alpine environments have a greater tendency to establish seed banks and spread the risk of germination to many years, rather than being dispersed to other micro-climates

Transplacental haemorrhage and the mode of placental delivery

A study was undertaken to determine whether the incidence and degree of transplacental haemorrhage would be affected by the following methods of placental  delivery: Brandt-Andrew's manoeuvre, spontaneous or natural delivery, and manual removal. A total of 445 patients were studied, 10-1% of whom were found to have had evidence of a clinically significant foeto-maternal haemorrhage. Except for manual removal, foeto-maternal transfer was not affected by the method of handling of the third stage

Treatment-seeking rates in malaria endemic countries

BACKGROUND: The proportion of individuals who seek treatment for fever is an important quantity in understanding access to and use of health systems, as well as for interpreting data on disease incidence from routine surveillance systems. For many malaria endemic countries (MECs), treatment-seeking information is available from national household surveys. The aim of this paper was to assemble sub-national estimates of treatment-seeking behaviours and to predict national treatment-seeking measures for all MECs lacking household survey data. METHODS: Data on treatment seeking for fever were obtained from Demographic and Health Surveys, Malaria Indicator Surveys and Multiple Cluster Indicator Surveys for every MEC and year that data were available. National-level social, economic and health-related variables were gathered from the World Bank as putative covariates of treatment-seeking rates. A generalized additive mixed model (GAMM) was used to estimate treatment-seeking behaviours for countries where survey data were unavailable. Two separate models were developed to predict the proportion of fever cases that would seek treatment at (1) a public health facility or (2) from any kind of treatment provider. RESULTS: Treatment-seeking data were available for 74 MECs and modelled for the remaining 24. GAMMs found that the percentage of pregnant women receiving prenatal care, vaccination rates, education level, government health expenditure, and GDP growth were important predictors for both categories of treatment-seeking outcomes. Treatment-seeking rates, which varied both within and among regions, revealed that public facilities were not always the primary facility type used. CONCLUSIONS: Estimates of treatment-seeking rates show how health services are utilized and help correct reported malaria case numbers to obtain more accurate measures of disease burden. The assembled and modelled data demonstrated that while treatment-seeking rates have overall increased over time, access remains low in some malaria endemic regions and utilization of government services is in some areas limited

Age of the Peach Springs Tuff, Southeastern California and Western Arizona

Sanidine separates from pumice of the early Miocene Peach Springs Tuff are concordantly dated at 18.5 ± 0.2 Ma by two isotopic techniques. The Peach Springs Tuff is the only known unit that can be correlated between isolated outcrops of Miocene strata from the central Mojave Desert of southeastern California to the western Colorado Plateau in Arizona, across five structural provinces, a distance of 350 km. Thus the age of the Peach Springs Tuff is important to structural and paleogeographic reconstructions of a large region. Biotite and sanidine separates from bulk samples of the Peach Springs Tuff from zones of welding and vapor-phase alteration have not produced consistent ages by the K-Ar method. Published ages of mineral separates from 17 localities ranged from 16.2 to 20.5 Ma. Discordant 40Ar/39Ar incremental release spectra were obtained for one biotite and two of the sanidine separates. Ages that correspond to the last gas increments are as old as 27 Ma. The 40Ar/39Ar incremental release determinations on sanidine separated from blocks of Peach Springs Tuff pumice yield ages of 18.3 ± 0.3 and 18.6 ± 0.4 Ma. Laser fusion measurements yield a mean age of 18.51 ± 0.10. The results suggest that sanidine and biotite K-Ar ages older than about 18.5 Ma are due to inherited Ar from pre-Tertiary contaminants, which likely were incorporated into the tuff during deposition. Sanidine K-Ar ages younger than 18 Ma probably indicate incomplete extraction of radiogenic 40Ar, whereas laser fusion dates of biotite and hornblende younger than 18 Ma likely are due to postdepositional alteration. Laser fusion ages as high as 19.01 Ma on biotite grains from pumice suggest that minerals from pre-Tertiary country rocks also were incorporated in the magma chamber

Nontangential limits and Fatou-type theorems on post-critically finite self-similar sets

In this paper we study the boundary limit properties of harmonic functions on $\mathbb R_+\times K$, the solutions $u(t,x)$ to the Poisson equation $$\frac{\partial^2 u}{\partial t^2} + \Delta u = 0,$$ where $K$ is a p.c.f. set and $\Delta$ its Laplacian given by a regular harmonic structure. In particular, we prove the existence of nontangential limits of the corresponding Poisson integrals, and the analogous results of the classical Fatou theorems for bounded and nontangentially bounded harmonic functions.Comment: 22 page

Identifying Hallmark Symptoms of Developmental Prosopagnosia for Non-Experts

Developmental prosopagnosia (DP) is characterised by a severe and relatively selective deficit in face recognition, in the absence of neurological injury. Because public and professional awareness of DP is low, many adults and children are not identified for formal testing. This may partly result from the lack of appropriate screening tools that can be used by non-experts in either professional or personal settings. To address this issue, the current study sought to (a) explore when DP can first be detected in oneself and another, and (b) identify a list of the condition’s everyday behavioural manifestations. Questionnaires and interviews were administered to large samples of adult DPs, their unaffected significant others, and parents of children with the condition; and data were analysed using inductive content analysis. It was found that DPs have limited insight into their difficulties, with most only achieving realisation in adulthood. Nevertheless, the DPs’ reflections on their childhood experiences, together with the parental responses, revealed specific indicators that can potentially be used to spot the condition in early childhood. These everyday hallmark symptoms may aid the detection of individuals who would benefit from objective testing, in oneself (in adults) or another person (for both adults and children)

Seismic Structure, Gravity Anomalies and Flexure Along the Emperor Seamount Chain

The Hawaiian-Emperor seamount chain in the Pacific Ocean has provided fundamental insights into hotspot generated intraplate volcanism and the long-term strength of oceanic lithosphere. However, only a few seismic experiments to determine crustal and upper mantle structure have been carried out on the Hawaiian Ridge, and no deep imaging has ever been carried out along the Emperor seamounts. Here, we present the results of an active source seismic experiment using 29 Ocean-Bottom Seismometers (OBS) carried out along a strike profile of the seamounts in the region of Jimmu and Suiko guyots. Joint reflection and refraction tomographic inversion of the OBS data show the upper crust is highly heterogeneous with P wave velocities <4–5 km s−1, which are attributed to extrusive lavas and clastics. In contrast, the lower crust is remarkably homogeneous with velocities of 6.5–7.2 km s−1, which we attribute to oceanic crust and mafic intrusions. Moho is identified by a strong PmP arrival at offsets of 20–80 km, yielding depths of 13–16 km. The underlying mantle is generally homogeneous with velocities in the range 7.9–8.0 km s−1. The crust and mantle velocity structure has been verified by gravity modeling. While top of oceanic crust prior to volcano loading is not recognized as a seismic or gravity discontinuity, flexural modeling reveals a ∼5.0–5.5 km thick preexisting oceanic crust that is overlain by a ∼8 km thick volcanic edifice. Unlike at the Hawaiian Ridge, we find no evidence of magmatic underplating

Developing Intensity-Duration-Frequency (IDF) Curves From Satellite-Based Precipitation: Methodology and Evaluation

Given the continuous advancement in the retrieval of precipitation from satellites, it is important to develop methods that incorporate satellite-based precipitation data sets in the design and planning of infrastructure. This is because in many regions around the world, in situ rainfall observations are sparse and have insufficient record length. A handful of studies examined the use of satellite-based precipitation to develop intensity-duration-frequency (IDF) curves; however, they have mostly focused on small spatial domains and relied on combining satellite-based with ground-based precipitation data sets. In this study, we explore this issue by providing a methodological framework with the potential to be applied in ungauged regions. This framework is based on accounting for the characteristics of satellite-based precipitation products, namely, adjustment of bias and transformation of areal to point rainfall. The latter method is based on previous studies on the reverse transformation (point to areal) commonly used to obtain catchment-scale IDF curves. The paper proceeds by applying this framework to develop IDF curves over the contiguous United States (CONUS); the data set used is Precipitation Estimation from Remotely Sensed Information Using Artificial Neural Networks – Climate Data Record (PERSIANN-CDR). IDFs are then evaluated against National Oceanic and Atmospheric Administration (NOAA) Atlas 14 to provide a quantitative estimate of their accuracy. Results show that median errors are in the range of (17–22%), (6–12%), and (3–8%) for one-day, two-day and three-day IDFs, respectively, and return periods in the range (2–100)&nbsp;years. Furthermore, a considerable percentage of satellite-based IDFs lie within the confidence interval of NOAA Atlas 14

Informed consent and assent guide for paediatric clinical trials in Europe

Objective Clinical trial sponsors spend considerable resources preparing informed consent (IC) and assent documentation for multinational paediatric clinical trial applications in Europe due to the limited and dispersed patient populations, the variation of national legal and ethical requirements, and the lack of detailed guidance. The aim of this study was to design new easy-to-use guide publicly available on European Medicines Agency's, Enpr-EMA website for all stakeholders. Methods Current EU legal, ethical and regulatory guidance for paediatric clinical trials were collated, analysed and divided into 30 subject elements in two tables. The European Network of Young Person's Advisory Group reviewed the data and provided specific comments. A three-level recommendation using 'traffic light' symbols was designed for four age groups of children, according to relevance and the requirements. Results A single guide document includes two tables: (1) general information and (2) trial-specific information. In the age group of 6-9 years old, 92% of the trial-specific subject elements can be or should be included in the IC discussion. Even in the youngest possible age group (2-5 years old children), the number of elements considered was, on average, 52%. Conclusion The EU Clinical Trial Regulation (2014) does not contain specific requirements exclusively for paediatric clinical trials. This work is the first to extensively collate all the current legal, regulatory and ethical documentation on the IC process, together with input from adolescents. This guide may increase the ethical standards in paediatric clinical trials. Young people and researchers gathered together to synthesise and rate the advice from all the EU systems they could find about paediatric clinical trials to create a simpler, patient-led, framework for information to aid meaningful trial consent discussions.Peer reviewe