160 research outputs found
Fiber Orientation Estimation Guided by a Deep Network
Diffusion magnetic resonance imaging (dMRI) is currently the only tool for
noninvasively imaging the brain's white matter tracts. The fiber orientation
(FO) is a key feature computed from dMRI for fiber tract reconstruction.
Because the number of FOs in a voxel is usually small, dictionary-based sparse
reconstruction has been used to estimate FOs with a relatively small number of
diffusion gradients. However, accurate FO estimation in regions with complex FO
configurations in the presence of noise can still be challenging. In this work
we explore the use of a deep network for FO estimation in a dictionary-based
framework and propose an algorithm named Fiber Orientation Reconstruction
guided by a Deep Network (FORDN). FORDN consists of two steps. First, we use a
smaller dictionary encoding coarse basis FOs to represent the diffusion
signals. To estimate the mixture fractions of the dictionary atoms (and thus
coarse FOs), a deep network is designed specifically for solving the sparse
reconstruction problem. Here, the smaller dictionary is used to reduce the
computational cost of training. Second, the coarse FOs inform the final FO
estimation, where a larger dictionary encoding dense basis FOs is used and a
weighted l1-norm regularized least squares problem is solved to encourage FOs
that are consistent with the network output. FORDN was evaluated and compared
with state-of-the-art algorithms that estimate FOs using sparse reconstruction
on simulated and real dMRI data, and the results demonstrate the benefit of
using a deep network for FO estimation.Comment: A shorter version is accepted by MICCAI 201
Data on the verification and validation of segmentation and registration methods for diffusion MRI.
The verification and validation of segmentation and registration methods is a necessary assessment in the development of new processing methods. However, verification and validation of diffusion MRI (dMRI) processing methods is challenging for the lack of gold-standard data. The data described here are related to the research article entitled "Surface-driven registration method for the structure-informed segmentation of diffusion MR images" [1], in which publicly available data are used to derive golden-standard reference-data to validate and evaluate segmentation and registration methods in dMRI
Estimation of Fiber Orientations Using Neighborhood Information
Data from diffusion magnetic resonance imaging (dMRI) can be used to
reconstruct fiber tracts, for example, in muscle and white matter. Estimation
of fiber orientations (FOs) is a crucial step in the reconstruction process and
these estimates can be corrupted by noise. In this paper, a new method called
Fiber Orientation Reconstruction using Neighborhood Information (FORNI) is
described and shown to reduce the effects of noise and improve FO estimation
performance by incorporating spatial consistency. FORNI uses a fixed tensor
basis to model the diffusion weighted signals, which has the advantage of
providing an explicit relationship between the basis vectors and the FOs. FO
spatial coherence is encouraged using weighted l1-norm regularization terms,
which contain the interaction of directional information between neighbor
voxels. Data fidelity is encouraged using a squared error between the observed
and reconstructed diffusion weighted signals. After appropriate weighting of
these competing objectives, the resulting objective function is minimized using
a block coordinate descent algorithm, and a straightforward parallelization
strategy is used to speed up processing. Experiments were performed on a
digital crossing phantom, ex vivo tongue dMRI data, and in vivo brain dMRI data
for both qualitative and quantitative evaluation. The results demonstrate that
FORNI improves the quality of FO estimation over other state of the art
algorithms.Comment: Journal paper accepted in Medical Image Analysis. 35 pages and 16
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A multi-contrast MRI study of microstructural brain damage in patients with mild cognitive impairment.
OBJECTIVES: The aim of this study was to investigate pathological mechanisms underlying brain tissue alterations in mild cognitive impairment (MCI) using multi-contrast 3 T magnetic resonance imaging (MRI).
METHODS: Forty-two MCI patients and 77 healthy controls (HC) underwent T1/T2* relaxometry as well as Magnetization Transfer (MT) MRI. Between-groups comparisons in MRI metrics were performed using permutation-based tests. Using MRI data, a generalized linear model (GLM) was computed to predict clinical performance and a support-vector machine (SVM) classification was used to classify MCI and HC subjects.
RESULTS: Multi-parametric MRI data showed microstructural brain alterations in MCI patients vs HC that might be interpreted as: (i) a broad loss of myelin/cellular proteins and tissue microstructure in the hippocampus (p ≤ 0.01) and global white matter (p < 0.05); and (ii) iron accumulation in the pallidus nucleus (p ≤ 0.05). MRI metrics accurately predicted memory and executive performances in patients (p ≤ 0.005). SVM classification reached an accuracy of 75% to separate MCI and HC, and performed best using both volumes and T1/T2*/MT metrics.
CONCLUSION: Multi-contrast MRI appears to be a promising approach to infer pathophysiological mechanisms leading to brain tissue alterations in MCI. Likewise, parametric MRI data provide powerful correlates of cognitive deficits and improve automatic disease classification based on morphometric features
Migraineurs without aura show microstructural abnormalities in the cerebellum and frontal lobe.
The involvement of the cerebellum in migraine pathophysiology is not well understood. We used a biparametric approach at high-field MRI (3 T) to assess the structural integrity of the cerebellum in 15 migraineurs with aura (MWA), 23 migraineurs without aura (MWoA), and 20 healthy controls (HC). High-resolution T1 relaxation maps were acquired together with magnetization transfer images in order to probe microstructural and myelin integrity. Clusterwise analysis was performed on T1 and magnetization transfer ratio (MTR) maps of the cerebellum of MWA, MWoA, and HC using an ANOVA and a non-parametric clusterwise permutation F test, with age and gender as covariates and correction for familywise error rate. In addition, mean MTR and T1 in frontal regions known to be highly connected to the cerebellum were computed. Clusterwise comparison among groups showed a cluster of lower MTR in the right Crus I of MWoA patients vs. HC and MWA subjects (p = 0.04). Univariate and bivariate analysis on T1 and MTR contrasts showed that MWoA patients had longer T1 and lower MTR in the right and left pars orbitalis compared to MWA (p < 0.01 and 0.05, respectively), but no differences were found with HC. Lower MTR and longer T1 point at a loss of macromolecules and/or micro-edema in Crus I and pars orbitalis in MWoA patients vs. HC and vs. MWA. The pathophysiological implications of these findings are discussed in light of recent literature
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