The impact of the Madden-Julian Oscillation on hydrological extremes

Extreme climate events such as severe droughts and floods have become more frequent and widespread in the 21st Century. Recent studies have revealed the tele-connections between Madden–Julian Oscillation (MJO) and extreme precipitation over different regions such as South America, India and China. This study investigates the influence of MJO on global extreme dry and wet conditions, and how the strength of the relationship changes across the MJO phases over the globe. The Evaporative Stress Index (ESI) calculated from global GLEAM evapotranspiration dataset is used to represent extreme dry and wet conditions. Strong correlations between MJO and extreme dry and wet conditions are found, particularly over monsoon regions such as South Asia, South America and East Africa. The underlying mechanism of the influence of MJO on extreme dry and wet conditions is associated with the variation of precipitation, air temperature and soil moisture modulated by the MJO. The study suggests that MJO impacts on extreme dry and wet conditions should be taken into account in investigation of droughts/floods around the world particularly over monsoon areas

Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker.

Profenofos is a direct acting phosphorothioate organophosphorus (OP) pesticide capable of inhibiting β-esterases such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase. Profenofos is known to be detoxified to the biologically inactive metabolite, 4-bromo-2-chlorophenol (BCP); however, limited data are available regarding the use of urinary BCP as an exposure biomarker in humans. A pilot study conducted in Egyptian agriculture workers, demonstrated that urinary BCP levels prior to application (3.3-30.0 μg/g creatinine) were elevated to 34.5-3,566 μg/g creatinine during the time workers were applying profenofos to cotton fields. Subsequently, the in vitro enzymatic formation of BCP was examined using pooled human liver microsomes and recombinant human cytochrome P-450s (CYPs) incubated with profenofos. Of the nine human CYPs studied, only CYPs 3A4, 2B6, and 2C19 were able to metabolize profenofos to BCP. Kinetic studies indicated that CYP 2C19 has the lowest Km, 0.516 μM followed by 2B6 (Km=1.02 μM) and 3A4 (Km=18.9μM). The Vmax for BCP formation was 47.9, 25.1, and 19.2 nmol/min/nmol CYP for CYP2B6, 2C19, and 3A4, respectively. Intrinsic clearance (Vmax/Km) values of 48.8, 46.9, and 1.02 ml/min/nmol CYP 2C19, 2B6, and 3A4, respectively, indicate that CYP2C19 and CYP2B6 are primarily responsible for the detoxification of profenofos. These findings support the use of urinary BCP as a biomarker of exposure to profenofos in humans and suggest polymorphisms in CYP 2C19 and CYP 2B6 as potential biomarkers of susceptibility

Nonstationary weather and water extremes: a review of methods for their detection, attribution, and management

Hydroclimatic extremes such as intense rainfall, floods, droughts, heatwaves, and wind or storms have devastating effects each year. One of the key challenges for society is understanding how these extremes are evolving and likely to unfold beyond their historical distributions under the influence of multiple drivers such as changes in climate, land cover, and other human factors. Methods for analysing hydroclimatic extremes have advanced considerably in recent decades. Here we provide a review of the drivers, metrics, and methods for the detection, attribution, management, and projection of nonstationary hydroclimatic extremes. We discuss issues and uncertainty associated with these approaches (e.g. arising from insufficient record length, spurious nonstationarities, or incomplete representation of nonstationary sources in modelling frameworks), examine empirical and simulation-based frameworks for analysis of nonstationary extremes, and identify gaps for future research

Muscle-specific overexpression of AdipoR1 or AdipoR2 gives rise to common and discrete local effects whilst AdipoR2 promotes additional systemic effects

Hypoadiponectinemia and adiponectin resistance are implicated in the aetiology of obesity-related cardiometabolic disorders, hence represent a potential therapeutic axis. Here we characterised the effects of in vivo electrotransfer-mediated overexpression of the adiponectin receptors, AdipoR1 or AdipoR2, into tibialis anterior muscle (TAM) of lean or obese mice. In lean mice, TAM-specific overexpression of AdipoR1 (TAMR1) or AdipoR2 (TAMR2) increased phosphorylation of AMPK, AKT and ERK and expression of the insulin responsive glucose transporter glut4. In contrast, only TAMR2 increased pparα and a target gene acox1. These effects were decreased in obese mice despite no reduction in circulating adiponectin levels. TAMR2 also increased expression of adipoQ in TAM of lean and obese mice. Furthermore, in obese mice TAMR2 promoted systemic effects including; decreased weight gain; reduced epididymal fat mass and inflammation; increased epididymal adipoQ expression; increased circulating adiponectin. Collectively, these results demonstrate that AdipoR1 and AdipoR2 exhibit overlapping and distinct effects in skeletal muscle consistent with enhanced adiponectin sensitivity but these appear insufficient to ameliorate established obesity-induced adiponectin resistance. We also identify systemic effects upon TAMR2 in obese mice and postulate these are mediated by altered myokine production. Further studies are warranted to investigate this possibility which may reveal novel therapeutic approaches

Global high-resolution drought indices for 1981-2022

Droughts are among the most complex and devastating natural hazards globally. High-resolution datasets of drought metrics are essential for monitoring and quantifying the severity, duration, frequency and spatial extent of droughts at regional and particularly local scales. However, current global drought indices are available only at a coarser spatial resolution (>50 km). To fill this gap, we developed five high-resolution (5 km) gridded drought records based on the Standardized Precipitation Evaporation Index (SPEI) covering the period 1981–2022. These multi-scale (1–48 months) SPEI indices are computed based on monthly precipitation (P) from the Climate Hazards group InfraRed Precipitation with Station data (CHIRPS, version 2) and Multi-Source Weighted-Ensemble Precipitation (MSWEP, version 2.8) and potential evapotranspiration (PET) from the Global Land Evaporation Amsterdam Model (GLEAM, version 3.7a) and Bristol Potential Evapotranspiration (hPET). We generated four SPEI records based on all possible combinations of P and PET datasets: CHIRPS-GLEAM, CHIRPS-hPET, MSWEP-GLEAM, and MSWEP-hPET. These drought records were evaluated globally and exhibited excellent agreement with observation-based estimates of SPEI, root zone soil moisture, and vegetation health indices. The newly developed high-resolution datasets provide more detailed local information and be used to assess drought severity for particular periods and regions and to determine global, regional, and local trends, thereby supporting the development of site-specific adaptation measures. These datasets are publicly available at the Centre for Environmental Data Analysis (CEDA): https://dx.doi.org/10.5285/ac43da11867243a1bb414e1637802dec (Gebrechorkos et al., 2023)

Reversibility of myocardial metabolism and remodelling in morbidly obese patients 6 months after bariatric surgery

AbstractAIMS: To study myocardial substrate uptake, structure and function, before and after bariatric surgery, to clarify the interaction between myocardial metabolism and cardiac remodelling in morbid obesity.METHODS: We studied 46 obese patients (age 44 ± 10 years, body mass index [BMI] 42 ± 4 kg/m2 ), including 18 with type 2 diabetes (T2D) before and 6 months after bariatric surgery and 25 healthy age-matched control group subjects. Myocardial fasting free fatty acid uptake (MFAU) and insulin-stimulated myocardial glucose uptake (MGU) were measured using positron-emission tomography. Myocardial structure and function, and myocardial triglyceride content (MTGC) and intrathoracic fat were measured using magnetic resonance imaging and magnetic resonance spectroscopy.RESULTS: The morbidly obese study participants, with or without T2D, had cardiac hypertrophy, impaired myocardial function and substrate metabolism compared with the control group. Surgery led to marked weight reduction and remission of T2D in most of the participants. Postoperatively, myocardial function and structure improved and myocardial substrate metabolism normalized. Intrathoracic fat, but not MTGC, was reduced. Before surgery, BMI and MFAU correlated with left ventricular hypertrophy, and BMI, age and intrathoracic fat mass were the main variables associated with cardiac function. The improvement in whole-body insulin sensitivity correlated positively with the increase in MGU and the decrease in MFAU.CONCLUSIONS: In the present study, obesity and age, rather than myocardial substrate uptake, were the causes of cardiac remodelling in morbidly obese patients with or without T2D. Cardiac remodelling and impaired myocardial substrate metabolism are reversible after surgically induced weight loss and amelioration of T2D.</div

Linking Taiwan's subcritical Hsuehshan Range topography and foreland basin architecture

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95204/1/tect2249.pd

Poverty and Wellbeing Impacts of Microfinance : What Do We Know?

Over the last 35 years, microfinance has been generally regarded as an effective policy tool in the fight against poverty. Yet, the question of whether access to credit leads to poverty reduction and improved wellbeing remains open. To address this question, we conduct a systematic review of the quantitative literature of microfinance’s impacts in the developing world, and develop a theory of change that links inputs to impacts on several welfare outcomes. Overall, we find that the limited comparability of outcomes and the heterogeneity of microfinance-lending technologies, together with a considerable variation in socio-economic conditions and contexts in which impact studies have been conducted, render the interpretation and generalization of findings intricate. Our results indicate that, at best, microfinance induces short-term dynamism in the financial life of the poor; however, we do not find compelling evidence that this dynamism leads to increases in income, consumption, human capital and assets, and, ultimately, a reduction in poverty