Advanced solid-state array spectroradiometer data collection during HAPEX-2 Sahel

Data collection using the Advanced Solid-state Array Spectroradiometer (ASAS) during the Hydrologic Atmospheric Pilot Experiment in the Sahel (HAPEX-II Sahel) field campaign in the Republic of Niger, West Central Africa from 22 Aug. to 19 Sep. 1992 is documented. Details on the ASAS system such as the hardware, data collection methods, information on system calibration, and data processing procedures are included. The ASAS configuration deployed for HAPEX-II Sahel contains several new components, including a new sensor array and pointing system. Because of this, new calibration procedures are being developed at the same time that the first ASAS images from HAPEX-II Sahel are being processed. These new calibration procedures will be documented in a future publication

Integrated Genomic Characterization of Papillary Thyroid Carcinoma

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic alterations (relative to other carcinomas) and extended the set of known PTC driver alterations to include EIF1AX, PPM1D, and CHEK2 and diverse gene fusions. These discoveries reduced the fraction of PTC cases with unknown oncogenic driver from 25% to 3.5%. Combined analyses of genomic variants, gene expression, and methylation demonstrated that different driver groups lead to different pathologies with distinct signaling and differentiation characteristics. Similarly, we identified distinct molecular subgroups of BRAF-mutant tumors, and multidimensional analyses highlighted a potential involvement of onco-miRs in less-differentiated subgroups. Our results propose a reclassification of thyroid cancers into molecular subtypes that better reflect their underlying signaling and differentiation properties, which has the potential to improve their pathological classification and better inform the management of the diseaseclose6