2,439 research outputs found
Reconnaissance Geology of the Frenchman's Cap National Park
Rccconnaissance geological mapping of the Frenchmans Cap National Park confirms
the presence of Precambrian metasedimentary assemblages representative of the Franklin,
Mary and Scotchfire Groups and has documented part of their distribution. The
structural succession of rock groups is shown to be, in descending onder-Franklin,
Mary and Scotchfire. It is suggested that the Scotchfire Group is a stratigraphic
equivalent of the Joyce Group but of slightly lower metamorphic grade
Obstructed and channelized viscoplastic flow in a Hele-Shaw cell
A theoretical study is presented of the flow of viscoplastic fluid through a Hele-Shaw cell that contains various kinds of obstructions. Circular and elliptical blockages of the cell are considered together with stepwise contractions or expansions in slot width, all within the simplifying approximation of a narrow gap. Specific attention is paid to the flow patterns that develop around the obstacles, particularly any stagnant plugged regions, and the asymptotic limits of relatively small or large yield stress. Periodic arrays of circular contractions or expansions are studied to explore the interference between obstructions. Finally, viscoplastic flow through a cell with randomly roughened walls is examined, and it is shown that constructive interference of local contractions and expansions leads to a pronounced channelization of the flow. An optimization algorithm based on minimization of the pressure drop is derived to construct the path of the channels in the limit of relatively large yield stress or, equivalently, relatively slow flow.D.R.H. is grateful to the Killam Foundation for a Postdoctoral Fellowship.This is the author accepted manuscript. The final version is available from Cambridge University Press via http://dx.doi.org/10.1017/jfm.2016.
Dewatering of fibre suspensions by pressure filtration
A theoretical and experimental study of dewatering of fibre suspensions by uniaxial compression is presented. Solutions of a one-dimensional model are discussed and asymptotic limits of fast and slow compression are explored. Particular focus is given to relatively rapid compression and to the corresponding development of spatial variations in the solidity and velocity profiles of the suspension. The results of complementary laboratory experiments are presented for nylon or cellulose fibres suspended in viscous fluid. The constitutive relationships for each suspension were measured independently. Measurements of the load for different fixed compression speeds, together with some direct measurements of the velocity profiles using particle tracking velocimetry, are compared with model predictions. The comparison is reasonable for nylon, but poor for cellulose fibres. An extension to the model, which allows for a strain-rate-dependent component in the network stress, is proposed, and is found to give a dramatic improvement in the model predictions for cellulose fibre suspensions. The reason for this improvement is attributed to the microstructure of cellulose fibres, which, unlike nylon fibres, are themselves porous.Akzo Nobel, Valmet Ltd., Natural Sciences and Engineering Council of Canada, Killam Postdoctoral Fellowshi
Diclofenac Prolongs Repolarization in Ventricular Muscle with Impaired Repolarization Reserve
Background: The aim of the present work was to characterize the electrophysiological effects of the non-steroidal anti-
inflammatory drug diclofenac and to study the possible proarrhythmic potency of the drug in ventricular muscle.
Methods: Ion currents were recorded using voltage clamp technique in canine single ventricular cells and action potentials
were obtained from canine ventricular preparations using microelectrodes. The proarrhythmic potency of the drug was
investigated in an anaesthetized rabbit proarrhythmia model.
Results: Action potentials were slightly lengthened in ventricular muscle but were shortened in Purkinje fibers by diclofenac
(20 mM). The maximum upstroke velocity was decreased in both preparations. Larger repolarization prolongation was
observed when repolarization reserve was impaired by previous BaCl 2 application. Diclofenac (3 mg/kg) did not prolong
while dofetilide (25 mg/kg) significantly lengthened the QT c interval in anaesthetized rabbits. The addition of diclofenac
following reduction of repolarization reserve by dofetilide further prolonged QT c . Diclofenac alone did not induce Torsades
de Pointes ventricular tachycardia (TdP) while TdP incidence following dofetilide was 20%. However, the combination of
diclofenac and dofetilide significantly increased TdP incidence (62%). In single ventricular cells diclofenac (30 mM) decreased
the amplitude of rapid (I Kr ) and slow (I Ks ) delayed rectifier currents thereby attenuating repolarization reserve. L-type calcium
current (I Ca ) was slightly diminished, but the transient outward (I to ) and inward rectifier (I K1 ) potassium currents were not
influenced.
Conclusions: Diclofenac at therapeutic concentrations and even at high dose does not prolong repolarization markedly and
does not increase the risk of arrhythmia in normal heart. However, high dose diclofenac treatment may lengthen
repolarization and enhance proarrhythmic risk in hearts with reduced repolarization reserve
Global image registration using a symmetric block-matching approach.
Most medical image registration algorithms suffer from a directionality bias that has been shown to largely impact subsequent analyses. Several approaches have been proposed in the literature to address this bias in the context of nonlinear registration, but little work has been done for global registration. We propose a symmetric approach based on a block-matching technique and least-trimmed square regression. The proposed method is suitable for multimodal registration and is robust to outliers in the input images. The symmetric framework is compared with the original asymmetric block-matching technique and is shown to outperform it in terms of accuracy and robustness. The methodology presented in this article has been made available to the community as part of the NiftyReg open-source package
Young neutron stars with soft gamma ray emission and anomalous X-ray pulsar
The observational properties of Soft Gamma Repeaters and Ano\-malous X-ray
Pulsars (SGR/AXP) indicate to necessity of the energy source different from a
rotational energy of a neutron star. The model, where the source of the energy
is connected with a magnetic field dissipation in a highly magnetized neutron
star (magnetar) is analyzed. Some observational inconsistencies are indicated
for this interpretation. The alternative energy source, connected with the
nuclear energy of superheavy nuclei stored in the nonequilibrium layer of low
mass neutron star is discussed.Comment: 29 pages, 13 figures, Springer International Publishing Switzerland
2016 A.W. Alsabti, P. Murdin (eds.), Handbook of Supernova
Dioxin Toxicity In Vivo Results from an Increase in the Dioxin-Independent Transcriptional Activity of the Aryl Hydrocarbon Receptor
The Aryl hydrocarbon receptor (Ahr) is the nuclear receptor mediating the toxicity of dioxins -widespread and persistent pollutants whose toxic effects include tumor promotion, teratogenesis, wasting syndrome and chloracne. Elimination of Ahr in mice eliminates dioxin toxicity but also produces adverse effects, some seemingly unrelated to dioxin. Thus the relationship between the toxic and dioxin-independent functions of Ahr is not clear, which hampers understanding and treatment of dioxin toxicity. Here we develop a Drosophila model to show that dioxin actually increases the in vivo dioxin-independent activity of Ahr. This hyperactivation resembles the effects caused by an increase in the amount of its dimerisation partner Ahr nuclear translocator (Arnt) and entails an increased transcriptional potency of Ahr, in addition to the previously described effect on nuclear translocation. Thus the two apparently different functions of Ahr, dioxin-mediated and dioxin-independent, are in fact two different levels (hyperactivated and basal, respectively) of a single function
On the classical equivalence of monodromy matrices in squashed sigma model
We proceed to study the hybrid integrable structure in two-dimensional
non-linear sigma models with target space three-dimensional squashed spheres. A
quantum affine algebra and a pair of Yangian algebras are realized in the sigma
models and, according to them, there are two descriptions to describe the
classical dynamics 1) the trigonometric description and 2) the rational
description, respectively. For every description, a Lax pair is constructed and
the associated monodromy matrix is also constructed. In this paper we show the
gauge-equivalence of the monodromy matrices in the trigonometric and rational
description under a certain relation between spectral parameters and the
rescalings of sl(2) generators.Comment: 32pages, 3figures, references added, introduction and discussion
sections revise
- …