The ovipositing female of Ooencyrtus telenomicida relies on physiological mechanisms to mediate intrinsic competition with Trissolcus basalis

Ongoing studies by our group showed that the outcome of the intrinsic competition between two solitary egg parasitoids, Trissolcus basalis (Wollaston) (Hymenoptera: Scelionidae) and Ooencyrtus telenomicida (Vassiliev) (Hymenoptera: Encyrtidae), is dominated by O. telenomicida. In this article we investigated the role played by the ovipositing O. telenomicida female in the suppression of a T. basalis competitor. Laboratory experiments were conducted by allowing an O. telenomicida female to puncture the eggs of Nezara viridula (L.) (Heteroptera: Pentatomidae) with her ovipositor (= no oviposition) or to parasitize them. The results show that O. telenomicida relies on some physiological mechanisms to mediate its interspecific intrinsic competition with T. basalis. In fact, the emergence of T. basalis was strongly reduced in host eggs that were parasitized either before or after being punctured by O. telenomicida at fixed time intervals (5, 15, 30, or 45 h). The low percentage of emergence of T. basalis (ranging from approximately 420%) was a consequence of the delay and growth rate reduction of larval development. Furthermore, the percentage of eclosion of N. viridula nymphs was negatively affected by the O. telenomicida females punctures (96% from healthy host eggs, 4% from punctured host eggs). Host eggs punctured or oviposited in by O. telenomicida showed alterations in the ooplasm including some melanized-like areas near the hole made with the ovipositor; such alterations indicate that the adult parasitoid releases substances that affect the host eggs survival. These results suggest that the O. telenomicida female influences both the physiological interspecific parasitoid-parasitoid interaction, as well as the host-parasitoid interaction, providing, for the first time in egg parasitoids, evidence that physiological suppression of some competitive egg parasitoids is mediated by the ovipositing female

Identifying Risk Factors for Incautious Use of Non-Prescription Drugs Among Higher Education Institutions' Students in Emirates

Objective: The aim of this research is to identify risk factors for incautious use of oral non-prescription drugs (ONPD) and inform recommendations that promote cautious ONPD use among HEI students in the UAE. Methods: A cross-sectional survey-based study was conducted with 2875 students in three randomly selected UAE universities between January and April 2014. Results: More than half (1348; 57) of participants reported using of ONPD in the past 90 days before study commencement. Of 1348 participants reported using ONPD, one-quarter (1348; 22.2) of ONPD was classified as incautious ONPD usage. Analgesic/antipyretic (84.9), non-steroidal anti-inflammatory drugs (NSAIDs) (1028; 76.3), and cough and cold drugs (562; 41.7) were reported by the majority of participants as the most commonly used ONPD. 10 risk factors were identified for incautious ONPD use. Participants with age group of 21 years and older (OR=0.554, 95; CI=0.373-0.823; p<0.001), female (OR=0.339, 95; CI=0.236-0.486; p<0.001), and students from medical schools (OR=0.619, 95; CI=0.435-0.882; p=0.008) had lower odds of being incautious users compared to lower age group, males, and students from non-medical schools. Furthermore, participants with a polypharmacy behavior had higher odds of being irresponsible ONPD user than monopharmacy users (OR=1.400, 95; CI=1.030- 1.02; p<0.001). Conclusion: One of five students is an incautious ONPD user. There is a need for an educational and behavioral intervention to motivate students to be cautious users. © 2017 The Authors

What Drives Using Antibiotic without Prescriptions? A Qualitative Interview Study of University Students in United Arab Emirates

Bacterial resistance to antibiotics is considered as natural phenomenon that occurs over the time due to genetic changes. Bacterial resistance to antibiotics is significantly increasing in the UAE. Self-medication with antibiotics has been identified as a major factor for the development of antibiotic resistance, which is significantly increasing in the UAE.The purpose of this study was to explore the factors that contribute to the use of antibiotics without prescriptions among first year healthcare university students in UAE.Based on the findings of an earlier survey study, a qualitative interview study was designed to explore common themes related to student's knowledge, awareness, attitude, views, and perceptions. Data were analyzed thematically for the identification of themes and subthemes within the data through the use of coding.The interview study identified four main themes with multiple subthemes related to the use of antibiotics without a physician's prescription by first-year healthcare students. The thematic analysis of the interviews revealed four main themes; medication habits and practices; reasons for self-medication; access to antibiotics without a prescription and gaps in students' knowledge regarding antibiotic resistance.Healthcare students in UAE are influenced by several factors including parents and friends influence, successful previous experience and investment of time and money to visit a physician. Our sample of healthcare students has a misconception about the use of antibiotics. The current interview study identified six new reasons for using antibiotics without prescriptions as compared to our earlier survey study. There is a need of multifaceted strategies to decrease unnecessary antibiotic use in our population sample

Spectroscopic Signature of Oxidized Oxygen States in Peroxides

Recent debates on the oxygen redox behaviors in battery electrodes have triggered a pressing demand for the reliable detection and understanding of non-divalent oxygen states beyond conventional absorption spectroscopy. Here, enabled by high-efficiency mapping of resonant inelastic X-ray scattering (mRIXS) coupled with first-principles calculations, we report distinct mRIXS features of the oxygen states in Li2O, Li2CO3, and especially, Li2O2, which are successfully reproduced and interpreted theoretically. mRIXS signals are dominated by valence-band decays in Li2O and Li2CO3. However, the oxidized oxygen in Li2O2 leads to partially unoccupied O-2p states that yield a specific intra-band excitonic feature in mRIXS. Such a feature displays a specific emission energy in mRIXS, which disentangles the oxidized oxygen states from the dominating transition-metal/oxygen hybridization features in absorption spectroscopy, thus providing critical hints for both detecting and understanding the oxygen redox reactions in transition-metal oxide based battery materials.Comment: 25 pages, 4 figures, plus 11 pages of Supplementary Information with 4 figure

Impact of tapering targeted therapies (bDMARDs or JAKis) on the risk of serious infections and adverse events of special interest in patients with rheumatoid arthritis or spondyloarthritis : a systematic analysis of the literature and meta-analysis

To systematically review the impact of tapering targeted therapies (bDMARDs or JAKis) on the risk of serious infections and severe adverse events (SAEs) in patients with rheumatoid arthritis (RA) or axial spondyloarthritis (axSpA) in remission or low disease activity (LDA) state. A meta-analysis based on a systematic review of PubMed, Embase, Cochrane, until August 2019, as well as relevant databases of international conferences, was used to evaluate the risk difference (RD) at 95% confidence interval (95% CI) of incidence density of serious infections, SAEs, malignancies, cardiovascular adverse events (CV AEs), or deaths after tapering (dose reduction or spacing) compared to continuation of targeted therapies. Of the 1957 studies initially identified, 13 controlled trials (9 RA and 4 SpA trials) were included in the meta-analysis. 1174 patient-years were studied in the tapering group (TG) versus 1086 in the usual care group (UC). There were 1.7/100 patient-year (p-y) serious infections in TG versus 2.6/100 p-y in UC (RD (95% CI) 0.01 (0.00 to 0.02), p = 0.13) and 7.4/100 p-y SAEs in TG versus 6.7/100 p-y in UC (RD 0.00 (− 0.02 to 0.02), p = 0.82). The risk of malignancies, CV AEs, or deaths did not differ between the tapering and the usual care groups. Subgroup analysis (RA and SpA) detected no significant differences between the two groups. We could not show significant impact of tapering bDMARD or JAKi over continuation concerning the risk of serious infections, SAEs, malignancies, CV AEs, or deaths in RA and SpA patients in remission or LDA state

Erratum to: What drives using antibiotic without prescriptions? A qualitative interview study of university students in United Arab Emirates

The authors acknowledge that Liz Ellis did not co-author this article and was erroneously listed as co-author. Editor’s note: COPE flowchart Changes in authorship d) (“Request for removal of author after publication”) was followed

Community-Based Homestay Service: A Proposed Livelihood Project for the Dumagats

The study is founded on a sustainable eco-tourism built on indigenous peoples’ economic empowerment without compromising their cultural heritage. The main objective of the study was to assess the economic viability of the community-based homestay service as a livelihood project to help improve the quality of life of the Dumagats who are native residents of Daraitan. The main service of the project is to provide accommodation and campsite for tourists who usually go for trekking at Mt. Daraitan. The descriptive survey method was employed in this study. Validated survey questionnaires were given out to 430 local and foreign tourists who visited the nature reserve. Data were tabulated and analyzed using the descriptive statistics and financial ratios; such as liquidity ratios, test of return on sales, gross profit ratio, and return on capital. The financial assessment of the homestay service yielded an average of 21.7% return on sales; 83.47% gross profit ratio, and 79.37% return on capital. A portion of the profit will be appropriated for charitable purposes. Mt. Daraitan is one of the to-go-to spots in the Philippines, where nature still can be seen at its most pristine state. Results of financial estimates showed that the economic viability of the project, through development, preservation of the natural architecture of the park, and a livelihood program for the natives that inhabit the area, are very strong reasons to push through with the proposal

Localisation of renin-angiotensin system (RAS) components in breast

Angiotensin II has mitogenic and angiogenic effects and its receptors are widespread, particularly in epithelial tissue. Tissue renin angiotensin systems (tRASs) may be a local source of angiotensin II that has specific paracrine functions. To investigate the presence of a tRAS in normal human breast and tumours. Immunocytochemistry, and quantitative RT–PCR was used to establish: (i) the presence and localisation of RAS components, (ii) the possibility of their involvement in cancer. (1) mRNA coding for angiotensinogen, prorenin, angiotensin converting enzyme (ACE), and both AT1 and AT2 receptors was demonstrated in normal and diseased breast tissues. (2) (pro)renin was identified in epithelial cells in both normal and diseased tissue, but in invasive carcinoma, its distribution was mostly confined to fibroblasts or could not be detected at all. (3) Angiotensin converting enzyme was shown in epithelial cells in both normal and malignant tissue. The results are consistent with the hypothesis that a tRAS is present in the breast, and is disrupted in invasive cancer