Non-Riemannian vortex geometry of rotational viscous fluids and breaking of the acoustic Lorentz invariance

Acoustic torsion recently introduced in the literature (Garcia de Andrade,PRD(2004),7,64004) is extended to rotational incompressible viscous fluids represented by the generalised Navier-Stokes equation. The fluid background is compared with the Riemann-Cartan massless scalar wave equation, allowing for the generalization of Unruh acoustic metric in the form of acoustic torsion, expressed in terms of viscosity, velocity and vorticity of the fluid. In this work the background vorticity is nonvanishing but the perturbation of the flow is also rotational which avoids the problem of contamination of the irrotational perturbation by the background vorticity. The acoustic Lorentz invariance is shown to be broken due to the presence of acoustic torsion in strong analogy with the Riemann-Cartan gravitational case presented recently by Kostelecky (PRD 69,2004,105009). An example of analog gravity describing acoustic metric is given based on the teleparallel loop where the acoustic torsion is given by the Lense-Thirring rotation and the acoustic line element corresponds to the Lense-Thirring metric

On the nature of X-Ray Flashes in the SWIFT era

X-Ray Flashes (XRFs) are soft gamma-ray bursts whose nature is not clear. Their soft spectrum can be due to cosmological effects (high redshift), an off-axis view of the jet or can be intrinsic to the source. We use SWIFT observations to investigate different scenarios proposed to explain their origin. We have made a systematic analysis of the afterglows of XRFs with known redshift observed by SWIFT. We derive their redshift and luminosity distributions, and compare their properties with a sample of normal GRBs observed by the same instrument. The high distance hypothesis is ruled out by the redshift distribution of our sample of XRFs, indicating that, at least for our sample, the off-axis and sub-energetic hypotheses are preferred. Of course, this does not exclude that some XRFs without known redshift could be at high distance. However we find that taking into account the sensitivity of the BAT instrument, XRFs cannot be detected by SWIFT beyond ~ 3. The luminosity distribution of XRF afterglows is similar to the GRB one. This would rule out most off-axis models, but for the homogeneous jet model. However this model predicts a GRB rate uncomfortably near the observed rate of supernovae. This implies that XRFs, at least those of our sample, are intrinsically soft.Comment: 4 pages, 2 color figures. Astronomy and Astrophysics Letters, accepte

Doxycycline, an inhibitor of mitochondrial biogenesis, effectively reduces cancer stem cells (CSCs) in early breast cancer patients : a clinical pilot study

Background and objectives: Cancer stem cells (CSCs) have been implicated in tumor initiation, recurrence, metastatic spread and poor survival in multiple tumor types, breast cancers included. CSCs selectively overexpress key mitochondrial-related proteins and inhibition of mitochondrial function may represent a new potential approach for the eradication of CSCs. Because mitochondria evolved from bacteria, many classes of FDA-approved antibiotics, including doxycycline, actually target mitochondria. Our study aimed to determine whether short-term pre-operative treatment with oral doxycycline results in reduction of CSCs in early breast cancer patients. Methods: Doxycycline was administered orally for 14 days before surgery for a daily dose of 200 mg. Immuno-histochemical analysis of formalin-fixed paraffin-embedded (FFPE) samples from 15 patients, of which 9 were treated with doxycycline and 6 controls (no treatment), was performed with known biomarkers of “stemness” (CD44, ALDH1), mitochondrial mass (TOMM20), cell proliferation (Ki67, p27), apoptosis (cleaved caspase-3) and neo-angiogenesis (CD31). For each patient, the analysis was performed both on pre-operative specimens (core-biopsies) and surgical specimens. Changes from baseline to post-treatment were assessed with MedCalc 12 (unpaired t-test). Results: Post-doxycycline tumor samples demonstrated a statistically significant decrease in the stemness marker CD44 (p-value < 0.005), when compared to pre-doxycycline tumor samples. More specifically, CD44 levels were reduced between 17.65% and 66.67%, in 8 out of 9 patients treated with doxycycline. In contrast, only one patient showed a rise in CD44, by 15%. Overall, this represents a positive response rate of nearly 90%. Similar results were also obtained with ALDH1, another marker of stemness. In contrast, markers of mitochondrial mass, proliferation, apoptosis and neo-angiogenesis, were all similar between the two groups. Conclusions: Quantitative decreases in CD44 and ALDH1 expression are consistent with pre-clinical experiments and suggest that doxycycline can selectively eradicate CSCs in breast cancer patients in vivo. Future studies (with larger numbers of patients) will be conducted to validate these promising pilot studies

Identifying relationship patterns inside communities

Community detection is an important problem for Computer and other sciences. Following Agarwal and Kempe one of the most important reasons to make clustering over a network is to identify the function/role of each element in a community. If the communities have hundreds or thousands of elements, it is important to understand the functions of internal elements, but that will require an automatic process. In this context, we propose to develop a model, capable to identify elements with common features in different communities, based on the connection between elements and communities, agreeing with Newman and Girvan model features. (Párrafo extraído del texto a modo de resumen)Sociedad Argentina de Informática e Investigación Operativa (SADIO

It May Be Far to Tipperary : It\u27s a Longer Way to Tennessee

https://digitalcommons.library.umaine.edu/mmb-vp/4923/thumbnail.jp

Diffusion and wave behaviour in linear Voigt model

A boundary value problem related to a third- order parabolic equation with a small parameter is analized. This equation models the one-dimensional evolution of many dissipative media as viscoelastic fluids or solids, viscous gases, superconducting materials, incompressible and electrically conducting fluids. Moreover, the third-order parabolic operator regularizes various non linear second order wave equations. In this paper, the hyperbolic and parabolic behaviour of the solution is estimated by means of slow time and fast time. As consequence, a rigorous asymptotic approximation for the solution is established

A systematically coarse-grained model for DNA, and its predictions for persistence length, stacking, twist, and chirality

We introduce a coarse-grained model of DNA with bases modeled as rigid-body ellipsoids to capture their anisotropic stereochemistry. Interaction potentials are all physicochemical and generated from all-atom simulation/parameterization with minimal phenomenology. Persistence length, degree of stacking, and twist are studied by molecular dynamics simulation as functions of temperature, salt concentration, sequence, interaction potential strength, and local position along the chain, for both single- and double-stranded DNA where appropriate. The model of DNA shows several phase transitions and crossover regimes in addition to dehybridization, including unstacking, untwisting, and collapse which affect mechanical properties such as rigidity and persistence length. The model also exhibits chirality with a stable right-handed and metastable left-handed helix.Comment: 30 pages, 20 figures, Supplementary Material available at http://www.physics.ubc.ca/~steve/publications.htm

Shaping, imaging and controlling plasmonic interference fields at buried interfaces

Filming and controlling plasmons at buried interfaces with nanometer (nm) and femtosecond (fs) resolution has yet to be achieved and is critical for next generation plasmonic/electronic devices. In this work, we use light to excite and shape a plasmonic interference pattern at a buried metal-dielectric interface in a nanostructured thin film. Plasmons are launched from a photoexcited array of nanocavities and their propagation is filmed via photon-induced near-field electron microscopy (PINEM). The resulting movie directly captures the plasmon dynamics, allowing quantification of their group velocity at approximately 0.3c, consistent with our theoretical predictions. Furthermore, we show that the light polarization and nanocavity design can be tailored to shape transient plasmonic gratings at the nanoscale. These results, demonstrating dynamical imaging with PINEM, pave the way for the fs/nm visualization and control of plasmonic fields in advanced heterostructures based on novel 2D materials such as graphene, MoS$_2$, and ultrathin metal films.Comment: 16 pages, 5 figures, 3 supplementary figure

From attosecond to zeptosecond coherent control of free-electron wave functions using semi-infinite light fields

Light-electron interaction in empty space is the seminal ingredient for free-electron lasers and also for controlling electron beams to dynamically investigate materials and molecules. Pushing the coherent control of free electrons by light to unexplored timescales, below the attosecond, would enable unprecedented applications in light-assisted electron quantum circuits and diagnostics at extremely small timescales, such as those governing intramolecular electronic motion and nuclear phenomena. We experimentally demonstrate attosecond coherent manipulation of the electron wave function in a transmission electron microscope, and show that it can be pushed down to the zeptosecond regime with existing technology. We make a relativistic pulsed electron beam interact in free space with an appropriately synthesized semi-infinite light field generated by two femtosecond laser pulses reflected at the surface of a mirror and delayed by fractions of the optical cycle. The amplitude and phase of the resulting coherent oscillations of the electron states in energymomentum space are mapped via momentum-resolved ultrafast electron energy-loss spectroscopy. The experimental results are in full agreement with our theoretical framework for light-electron interaction, which predicts access to the zeptosecond timescale by combining semi-infinite X-ray fields with free electrons.Comment: 22 pages, 6 figure

Swinging and tumbling of elastic capsules in shear flow

The deformation of an elastic micro-capsule in an infinite shear flow is studied numerically using a spectral method. The shape of the capsule and the hydrodynamic flow field are expanded into smooth basis functions. Analytic expressions for the derivative of the basis functions permit the evaluation of elastic and hydrodynamic stresses and bending forces at specified grid points in the membrane. Compared to methods employing a triangulation scheme, this method has the advantage that the resulting capsule shapes are automatically smooth, and few modes are needed to describe the deformation accurately. Computations are performed for capsules both with spherical and ellipsoidal unstressed reference shape. Results for small deformations of initially spherical capsules coincide with analytic predictions. For initially ellipsoidal capsules, recent approximative theories predict stable oscillations of the tank-treading inclination angle, and a transition to tumbling at low shear rate. Both phenomena have also been observed experimentally. Using our numerical approach we could reproduce both the oscillations and the transition to tumbling. The full phase diagram for varying shear rate and viscosity ratio is explored. While the numerically obtained phase diagram qualitatively agrees with the theory, intermittent behaviour could not be observed within our simulation time. Our results suggest that initial tumbling motion is only transient in this region of the phase diagram.Comment: 20 pages, 7 figure