Weather Map:A Diachronic Visual Model for Controversy Mapping

The Weather Map is a visual model to investigate public debates on media. Relying on the Media Cloud archives, the visual model transforms a simple query into a sophisticated visualization by employing the visual grammar of synoptic weather charts. Peaks of pressure and clashes between air masses are used to describe the conflicts in media through the temporal dimension, diving into the human and non-human dynamics that make the controversy alive. The Weather Map was conceived as a digital tool to help students and scholars analyze public debates, according to the controversy mapping field founded by Bruno Latour. In particular, the visual model pushes the boundaries of network visualization, exploring advanced techniques of graphic design. The outcome is a web-based application developed in JavaScript and Python at the disposal of education and research

Foundations of Session Types and Behavioural Contracts

International audienceBehavioural type systems, usually associated to concurrent or distributed computations, encompass concepts such as interfaces, communication protocols, and contracts, in addition to the traditional input/output operations. The behavioural type of a software component specifies its expected patterns of interaction using expressive type languages, so that types can be used to determine automatically whether the component interacts correctly with other components. Two related important notions of behavioural types are those of session types and behavioural contracts. This paper surveys the main accomplishments of the last twenty years within these two approaches

Overexpression of CD85j in TNBC patients inhibits Cetuximab-mediated NK-cell ADCC but can be restored with CD85j functional blockade

Clinical studies suggest that triple negative breast cancer (TNBC) patients with epidermal growth factor receptor (EGFR)-expressing tumors could benefit from therapy with Cetuximab, which targets EGFR. NK cells are the primary effectors of antibody (Ab)-dependent cell-mediated cytotoxicity (ADCC) and thus play a role in Ab-based therapies. We have previously described diminished levels of Cetuximab-mediated ADCC in vitro in patients with advanced breast cancer. Here, we investigated the potential causes of this NK-cell functional deficiency. We characterized NK-cell activating/inhibitory receptors in the peripheral blood of breast cancer patients and found CD85j inhibitory receptor overexpression. The capacity of NK cells to perform Cetuximab-triggered ADCC against TNBC cells correlated inversely with CD85j expression, even in the presence of the stimulatory cytokines IL-2 or IL-15. Hence, patients expressing high levels of CD85j had an impaired ability to lyse TNBC cells in the presence of Cetuximab. We also found that CD85j overexpression was associated with HLA-I and soluble HLA-G expression by tumors. A CD85j functional blockade with a CD85j antagonist Ab restored ADCC levels in breast cancer patients and reverted this negative effect. Our data suggest that strategies that overcome the hurdles of immune activation could improve Cetuximab clinical efficacy.Fil: Roberti, María Paula. Fundación Cáncer. Centro de Investigaciones Oncológicas; ArgentinaFil: Juliá, Estefanía Paula. Fundación Cáncer. Centro de Investigaciones Oncológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rocca, Yamila. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Amat, Mora. Instituto Alexander Fleming; ArgentinaFil: Bravo, Alicia Inés. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Perón"; ArgentinaFil: Loza, José. Instituto Alexander Fleming; ArgentinaFil: Coló, Federico. Instituto Médico Especializado Alexander Fleming; ArgentinaFil: Loza, Carlos Martín. Instituto Médico Especializado Alexander Fleming; ArgentinaFil: Fabiano, Verónica. Instituto Médico Especializado Alexander Fleming; ArgentinaFil: Maino, Merecedes. Instituto Médico Especializado Alexander Fleming; ArgentinaFil: Podhorzer, Ariel. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fainboim, Leonardo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín. Laboratorio de Inmunogenética; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Barrio, Maria Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Cáncer. Centro de Investigaciones Oncológicas; ArgentinaFil: Mordoh, Jose. Fundación Cáncer. Centro de Investigaciones Oncológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Levy, Estrella Mariel. Fundación Cáncer. Centro de Investigaciones Oncológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Changes of T-lymphocyte subpopulation and differential expression pattern of the T-bet and GATA-3 genes in diffuse large B-cell lymphoma patients after chemotherapy

BACKGROUND AND OBJECTIVE: T cell-mediated immunity plays an important role in enhancing antitumor response.This study aimed to investigate the changes in the T-lymphocyte subpopulation and to characterize the differential expression pattern of corresponding regulatory genes in peripheral blood mononuclear cells (PBMCs) from diffuse large B cell lymphoma (DLBCL) patients before and after chemotherapy. METHODS: A total of 56 DLBCL patients were recruited for analysis of T-cell subset distribution in the peripheral blood using flow cytometry; serum interferon (IFN)-γ and interleukin (IL)-4 levels using enzyme-linked immunosorbent assays; and early growth response protein 1 (EGR-1), T-bet, GATA-binding protein 3 (GATA-3), and transforming growth factor (TGF)-β mRNA levels using quantitative reverse-transcription polymerase chain reaction. Twenty-six healthy subjects served as controls. RESULTS: The percentage of CD3(+)CD4(+)T lymphocytes in peripheral blood from DLBCL patients was significantly decreased, whereas the percentages of CD3(+)CD8(+)T and CD4(+)CD25(+)T cells were significantly increased compared to those in controls (p < 0.05). Serum levels of IFN-γ and IL-4 were also significantly lower in DLBCL patients than those in controls (p < 0.05), and the levels of EGR-1, T-bet, and GATA-3 mRNA in PBMCs were lower (2.69 ± 1.48, 9.43 ± 2.14, and 20.83 ± 9.05 fold, respectively) in DLBCL patients than those in controls. Furthermore, there was a positive association between the levels of EGR-1 and T-bet mRNA (p = 0.001). However, the level of TGF-β mRNA was significantly increased in DLBCL patients, which was inversely associated with the T-bet mRNA level (p = 0.008), but positively associated with the percentage of T regulatory cells in PBMCs (p = 0.011). After three cycles of chemotherapy, the distribution of T-lymphocyte subsets in DLBCL patients were changed, and the levels of EGR-1, T-bet, and GATA-3 mRNA were significantly increased (p < 0.05) compared to those before chemotherapy. CONCLUSIONS: These results demonstrate the changes in T-lymphocyte subpopulations and the altered expression 34 pattern of the corresponding regulatory genes in PBMCs from DLBCL patients after chemotherapy, which are associated with the response of patients to treatment. The preferential expression of the T-bet gene after chemotherapy was closely correlated with the increased expression of the EGR-1 gene and decreased expression of the TGF-β gene

Weather Map:A Diachronic Visual Model for Controversy Mapping

The Weather Map is a visual model to investigate public debates on media. Relying on the Media Cloud archives, the visual model transforms a simple query into a sophisticated visualization by employing the visual grammar of synoptic weather charts. Peaks of pressure and clashes between air masses are used to describe the conflicts in media through the temporal dimension, diving into the human and non-human dynamics that make the controversy alive. The Weather Map was conceived as a digital tool to help students and scholars analyze public debates, according to the controversy mapping field founded by Bruno Latour. In particular, the visual model pushes the boundaries of network visualization, exploring advanced techniques of graphic design. The outcome is a web-based application developed in JavaScript and Python at the disposal of education and research

Banlieues de Toulouse

Danielou G. Banlieues de Toulouse. In: Revue géographique des Pyrénées et du Sud-Ouest, tome 49, fascicule 3, 1978. Nuisances. pp. 415-417

Gospel Message and Hellenistic Culture

Londonvii,540 p.; 22 c

La rebelión de los jóvenes

En los acontecimientos de mayo ha habido aspectos diversos. Se trataba de poner en tela de juicio a una universidad cuyos planes no están ya adaptados al crecimiento demográfico y que no prepara a los estudiantes para las “salidas” que harían falta. Se trataba también de la acción de grupos políticos, para los que el sabotaje de la Universidad es el medio para una acción subversiva que tiende a hacer saltar toda la sociedad actual. Pero se trataba también de otra cosa. Estaba latente la insatisfacción de los jóvenes ante una sociedad tecnocrática que los utiliza para sus fines, pero que no responde a sus problemas fundamentales. En este punto los análisis de Marcuse son exactos. No se trata primordialmente de una crisis económica sino de una crisis psicológica. La civilización técnica constituye un cuerpo nuevo. Pero es un cuerpo que no ha encontrado todavía su alma. Un inmenso clamor surge pidiendo a la creación, a la imaginación y a la invención los elementos que permitan describir los caminos del futuro

Les tambours

Le sam phor ou ta phon ressemble au maddalam indien. C’est un tambour cylindrique horizontal dont on frappe les deux extrémités avec les mains. Le corps du tambour est fait d’une seule pièce de bois de tek creusée. Les deux extrémités, dont l’une est plus large que l’autre (24 cm et 22 cm environ), sont recouvertes de parchemin attaché avec des lanières de cuir, la longueur est d’environ 48 cm, la circonférence de 106 cm. Le centre des deux peaux est alourdi avec une pâte de farine de riz et ..