Investigation of fiber/matrix adhesion: test speed and specimen shape effects in the cylinder test

The cylinder test, developed from the microdroplet test, was adapted to assess the interfacial adhesion strength between fiber and matrix. The sensitivity of cylinder test to pull-out speed and specimen geometry was measured. It was established that the effect of test speed can be described as a superposition of two opposite, simultaneous effects which have been modeled mathematically by fitting two parameter Weibull curves on the measured datas. Effects of the cylinder size and its geometrical relation on the measured strength values have been analyzed by finite element method. It was concluded that the geometry has a direct influence on the stress formation. Based on the results achieved, recommendations were given on how to perform the novel single fiber cylinder test

CARE MODEL IN PRIMARY HEALTH CARE: ACCESS AND COMPREHENSIVE CARE DURING THE COVID-19 PANDEMIC

Objective: To analyze the care model in Primary Health Care from the perspective of access and comprehensive care.Method: Qualitative research, with data collected from May to December 2021 in each regional health center in the state of Paraná through recorded interviews using a semi-structured script with 26 managers. IRAMUTEQ  software was used to process and group the data into five classes. The results were analyzed using dialectical hermeneutics.Results: Two classes showed actions related to the attributes of access and comprehensiveness present in the care model. Actions to increase access included the participation of a multi-professional team to promote comprehensive care and the use of technological resources while maintaining the biomedical model. Final considerations: During the pandemic, there was adaptation and resilience on the part of managers who organized the care model and the inclusion of technological tools to facilitate access and continuity of care

ExacTrac Dynamic workflow evaluation: Combined surface optical/thermal imaging and X‐ray positioning

In modern radiotherapy (RT), especially for stereotactic radiotherapy or stereotactic radiosurgery treatments, image guidance is essential. Recently, the ExacTrac Dynamic (EXTD) system, a new combined surface-guided RT and image-guided RT (IGRT) system for patient positioning, monitoring, and tumor targeting, was introduced in clinical practice. The purpose of this study was to provide more information about the geometric accuracy of EXTD and its workflow in a clinical environment. The surface optical/thermal- and the stereoscopic X-ray imaging positioning systems of EXTD was evaluated and compared to cone-beam computed tomography (CBCT). Additionally, the congruence with the radiation isocenter was tested. A Winston Lutz test was executed several times over 1 year, and repeated end-to-end positioning tests were performed. The magnitude of the displacements between all systems, CBCT, stereoscopic X-ray, optical-surface imaging, and MV portal imaging was within the submillimeter range, suggesting that the image guidance provided by EXTD is accurate at any couch angle. Additionally, results from the evaluation of 14 patients with intracranial tumors treated with open-face masks are reported, and limited differences with a maximum of 0.02 mm between optical/thermal- and stereoscopic X-ray imaging were found. As the optical/thermal positioning system showed a comparable accuracy to other IGRT systems, and due to its constant monitoring capability, it can be an efficient tool for detecting intra-fractional motion and for real-time tracking of the surface position during RT

Del amateurismo al fútbol-espectáculo: una reflexión sobre los clubes de fútbol brasileños

The article focuses on the transition process from professional football to spectacle football, especially considering the potential power of Brazilian clubs in relation to other institutions of this field. At first, it is intended to highlight the main features of each stage of the transition and notice which institutions and agents held greater potential of power. Secondly, the attempt is to compare currently the ways of getting income in foreign and Brazilian clubs, considering the spectacularized logic in which the football is inserted. It is possible to affirm that the modernization process of Brazilian football is still incomplete. The transition from professional football to spectacle football, at least for the clubs, has not yet occurred in full.O objetivo desta pesquisa consta em uma reflexão acerca do processo de transição do futebol profissional para futebol espetáculo, considerando principalmente os potenciais de poder dos clubes brasileiros em relação a outros agentes atuantes neste campo. Pretende-se, num primeiro momento, destacar as principais características de cada uma das fases do processo de transição desde o amadorismo até o futebol espetáculo e perceber quais agentes detinham maiores potenciais de poder. Num segundo momento intenta-se comparar, na atualidade, as formas de obtenção de receitas de clubes estrangeiros e brasileiros, já considerando a lógica espetacularizada na qual o futebol está inserido. Tornou-se possível afirmar que o processo de modernização do futebol brasileiro ainda está incompleto, ou seja, a transição do futebol profissional para o futebol espetáculo, pelo menos para os clubes, ainda não ocorreu de forma plena.El objetivo de esta investigación consiste en una reflexión sobre el proceso de transición desde el fútbol profesional hacia el fútbol espectáculo, sobre todo teniendo en cuenta el potencial poder de los clubes brasileños en relación con otros agentes que actúan en este campo. Se pretende, en un primer momento, destacar las principales características de cada etapa de la transición del amateurismo al fútbol espectáculo y percibir cuales agentes detentan un mayor poder potencial. En un segundo momento, el intento es comparar, en la actualidad, las formas de obtener ingresos por parte de los clubes extranjeros y brasileños, teniendo en cuenta la lógica espectacularizada en la que se inserta el fútbol. Es posible afirmar que el proceso de modernización del fútbol brasileño está aún incompleto, es decir, la transición de fútbol profesional para el fútbol espectáculo, por lo menos para los clubes, aún no ha tenido lugar en su totalidad

The MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset

The MOF (males absent on the first)-containing NSL (non-specific lethal) complex binds to a subset of active promoters in Drosophila melanogaster and is thought to contribute to proper gene expression. The determinants that target NSL to specific promoters and the circumstances in which the complex engages in regulating transcription are currently unknown. Here, we show that the NSL complex primarily targets active promoters and in particular housekeeping genes, at which it colocalizes with the chromatin remodeler NURF (nucleosome remodeling factor) and the histone methyltransferase Trithorax. However, only a subset of housekeeping genes associated with NSL are actually activated by it. Our analyses reveal that these NSL-activated promoters are depleted of certain insulator binding proteins and are enriched for the core promoter motif ‘Ohler 5’. Based on these results, it is possible to predict whether the NSL complex is likely to regulate a particular promoter. We conclude that the regulatory capacity of the NSL complex is highly context-dependent. Activation by the NSL complex requires a particular promoter architecture defined by combinations of chromatin regulators and core promoter motifs

ANÁLISE DA COBERTURA VACINAL E HESITAÇÃO VACINAL DE CRIANÇAS DO LITORAL DO PARANÁ DE 2015 A 2021

O objetivo do estudo foi analisar a cobertura vacinal (CV) e a ocorrência da hesitação vacinal, sobre a perspectiva dos cuidadores, na vacinação de crianças de 0 a 10 anos residentes no litoral do Paraná nos municípios que compreendem a primeira regional de saúde (1ª RS - Paranaguá: Antonina, Guaraqueçaba, Guaratuba, Matinhos, Morretes, Paranaguá e Pontal do Paraná), no período de 2015 a 2021. Trata-se de um estudo quantitativo transversal realizado em duas etapas: a primeira foi a coleta e análise de dados secundários referente a cobertura vacinal referentes às vacinas recomendadas para crianças de 0 a 10 anos, a segunda foi a aplicação de questionário online para verificar a hesitação vacinal de pais/responsáveis. Os resultados referentes a CV possibilitam observar que todos os imunobiológicos que foram analisados sofreram queda na cobertura no período de análise, mas principalmente nos anos de 2020 e 2021 (anos pandêmicos) não chegando a 80% de cobertura em grande parte dos municípios de 1ªRS Paranaguá. A hesitação vacinal foi confirmada pela baixa CV, mas em relação aos determinantes sociais analisados, encontrou-se associação estatisticamente significativa com a baixa escolaridade. Conclui-se que ocorreu queda na CV no litoral do Paraná desde 2016 e que houve piora durante a pandemia de COVID-19, a hesitação vacinal foi observada de maneira sutil pois foi analisada em um número baixo de pessoas em relação a população total da região.Palavras-chave: Saúde da criança; Vacinação; Vacinas; Recusa de Vacinação

Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol

© 2017 The Author(s). Toll-like receptors (TLRs) are major players of the innate immune system. Once activated, they trigger a signalling cascade that leads to NF-ΰ B translocation from the cytoplasm to the nucleus. Single cell analysis shows that NF-ΰ B signalling dynamics are a critical determinant of transcriptional regulation. Moreover, the outcome of innate immune response is also affected by the cross-talk between TLRs and estrogen signalling. Here, we characterized the dynamics of TLR5 signalling, responsible for the recognition of flagellated bacteria, and those changes induced by estradiol in its signalling at the single cell level. TLR5 activation in MCF7 cells induced a single and sustained NF-k B translocation into the nucleus that resulted in high NF-k B transcription activity. The overall magnitude of NF-k B transcription activity was not influenced by the duration of the stimulus. No significant changes are observed in the dynamics of NF-k B translocation to the nucleus when MCF7 cells are incubated with estradiol. However, estradiol significantly decreased NF-k B transcriptional activity while increasing TLR5-mediated AP-1 transcription. The effect of estradiol on transcriptional activity was dependent on the estrogen receptor activated. This fine tuning seems to occur mainly in the nucleus at the transcription level rather than affecting the translocation of the NF-k B transcription factor

Critical analysis of information security culture definitions

This article aims to advance the understanding of information security culture through a critical reflection on the wide-ranging definitions of information security culture in the literature. It uses the hermeneutic approach for conducting literature reviews. The review identifies 16 definitions of information security culture in the literature. Based on the analysis of these definitions, four different views of culture are distinguished. The shared values view highlights the set of cultural value patterns that are shared across the organization. An action-based view highlights the behaviors of individuals in the organization. A mental model view relates to the abstract view of the individual’s thinking on how information security culture must work. Finally, a problem-solving view emphasizes a combination of understanding from shared value-based and action-based views. The paper analyzes and presents the limitations of these four views of information security culture definitions

Gestão de resíduos sólidos: estudo de caso do município de SINOP -MT / Solid waste management: a case study of the municipality of SINOP-MT

Atualmente, um dos maiores desafios para as cidades que estão em fase de crescimento é a geração, coleta e destinação dos resíduos sólidos urbanos, pois com o crescimento das cidades aumenta a quantidade de resíduos e são necessárias propostas de intervenção para os destinos já existentes. Diante desse fato, este trabalho vem apresentar uma análise da gestão de resíduos sólidos no município de Sinop, situado no norte de Mato Grosso, região conhecida também como Amazônia Legal, sendo uma cidade muito nova, foi verificada a atual situação, realizando um diagnóstico, prognóstico e propondo melhorias que se adequem ao município em questão. Como resultado da análise percebeu-se que não existe, no município, um sistema de coleta seletiva, bem como uma usina de reciclagem. Além disso, existe um convenio com empresa para a coleta de lixo, porém as instalações de trabalho são inadequadas aos catadores. Para uma melhoria dos problemas observados propõe-se a construção de aterro sanitário que já está em projeto, o início da prática de coleta seletiva adequada, a implantação de sistemas de biodigestores, e a reciclagem de resíduos de construção civil, para que, dessa forma, os impactos sobre o meio ambiente sejam diminuídos e os resíduos que antes seriam poluentes, passem a ser reutilizados como fonte de energia ou matéria prima, por exemplo