127 research outputs found
Electronic structure, mechanical and thermodynamic properties of ThN from first-principles calculations
Lattice parameter, electronic structure, mechanical and thermodynamic
properties of ThN are systematically studied using the projector-augmented-wave
method and the generalized gradient approximation based on the density
functional theory. The calculated electronic structure indicates the important
contributions of Th 6\emph{d}and 5\emph{f} states to the Fermi-level electron
occupation. Through Bader analysis it is found that the effective valencies in
ThN can be represented as Th N. Elastic constant
calculations shows that ThN is mechanically stable and elastically anisotropic.
Furthermore, the melting curve of ThN is presented up to 120 GPa. Based on the
phonon dispersion data, our calculated specific heat capacities including both
lattice and conduction-electron contributions agree well with experimental
results in a wide range of temperature.Comment: 16 pages, 8 figure
Relativistic Astrophysics Explorer
The great success of the Rossi X-Ray Timing Explorer (RXTE) has shown that
X-ray timing is an excellent tool for the study of strong gravitational fields
and the measurement of fundamental physical properties of black holes and
neutron stars. Here, we describe a next-generation X-ray timing mission, the
Relativistic Astrophysics Explorer (RAE), designed to fit within the envelope
of a medium-sized mission. The instruments will be a narrow-field X-ray
detector array with an area of 6 m^2 equal to ten times that of RXTE and a
wide-field X-ray monitor. We describe the science made possible with this
mission, the design of the instruments, and results on prototype large-area
X-ray detectors.Comment: to appear in Advances in Space Research, 6 pages with one color
figure (low-res
A prospective study to assess the value of MMP-9 in improving the appropriateness of urgent referrals for colorectal cancer
Background
Bowel cancer is common and is a major cause of death. Most people with bowel symptoms who meet the criteria for urgent referral to secondary care will not be found to have bowel cancer, and some people who are found to have cancer will have been referred routinely rather than urgently. If general practitioners could better identify people who were likely to have bowel cancer or conditions that may lead to bowel cancer, the pressure on hospital clinics may be reduced, enabling these patients to be seen more quickly. Increased levels of an enzyme called matrix metalloproteinase 9 (MMP-9) have been found to be associated with such conditions, and this can be measured from a blood sample. This study aims to find out whether measuring MMP-9 levels could improve the appropriateness of urgent referrals for patients with bowel symptoms.
Methods
People aged 18 years or older referred to a colorectal clinic will be asked to complete a questionnaire about symptoms, recent injuries or chronic illnesses (these can increase the level of matrix metalloproteinases) and family history of bowel cancer. A blood sample will be taken from people who consent to take part to assess MMP-9 levels, and the results of examination at the clinic and/or investigations arising from the clinic visit will be collected from hospital records. The accuracy of MMP-9 will be assessed by comparing the MMP-9 level with the resulting diagnosis. The combination of factors (e.g. symptoms and MMP-9 level) that best predict a diagnosis of malignancy (invasive disease or polyps) will be determined.
Discussion
Although guidelines are in place to facilitate referrals to colorectal clinics, symptoms alone do not adequately distinguish people with malignancy from people with benign conditions. This study will establish whether MMP-9 could assist this process. If this were the case, measurement of MMP-9 levels could be used by general practitioners to assist in the identification of people who were most likely to have bowel cancer or conditions that may lead to bowel cancer, and who should, therefore, be referred most urgently to secondary car
Sr-Nd isotope geochemistry of the early Precambrian sub-alkaline mafic igneous rocks from the southern Bastar craton, Central India
SrâNd isotope data are reported for the early Precambrian sub-alkaline mafic igneous rocks of the southern Bastar craton, central India. These mafic rocks are mostly dykes but there are a few volcanic exposures. Field relationships together with the petrological and geochemical characteristics of these mafic dykes divide them into two groups; Meso-Neoarchaean sub-alkaline mafic dykes (BD1) and Paleoproterozoic (1.88 Ga) sub-alkaline mafic dykes (BD2). The mafic volcanics are Neoarchaean in age and have very close geochemical relationships with the BD1 type. The two groups have distinctly different concentrations of high-field strength (HFSE) and rare earth elements (REE). The BD2 dykes have higher concentrations of HFSE and REE than the BD1 dykes and associated volcanics and both groups have very distinctive petrogenetic histories. These rocks display a limited range of initial 143Nd/144Nd but a wide range of apparent initial 87Sr/86Sr. Initial 143Nd/144Nd values in the BD1 dykes and associated volcanics vary between 0.509149 and 0.509466 and in the BD2 dykes the variation is between 0.510303 and 0.510511. All samples have positive εNd values the BD1 dykes and associated volcanics have εNd values between +0.3 and +6.5 and the BD2 dykes between +1.9 to +6.0. Trace element and Nd isotope data do not suggest severe crustal contamination during the emplacement of the studied rocks. The positive εNd values suggest their derivation from a depleted mantle source. Overlapping positive εNd values suggest that a similar mantle source tapped by variable melt fractions at different times was responsible for the genesis of BD1 (and associated volcanics) and BD2 mafic dykes. The RbâSr system is susceptible to alteration and resetting during post-magmatic alteration and metamorphism. Many of the samples studied have anomalous apparent initial 87Sr/86Sr suggesting post-magmatic changes of the RbâSr system which severely restricts the use of RbâSr for petrogenetic interpretation
DADA: data assimilation for the detection and attribution of weather and climate-related events
A new nudging method for data assimilation, delayâcoordinate nudging, is presented. Delayâcoordinate nudging makes explicit use of present and past observations in the formulation of the forcing driving the model evolution at each time step. Numerical experiments with a lowâorder chaotic system show that the new method systematically outperforms standard nudging in different model and observational scenarios, also when using an unoptimized formulation of the delayânudging coefficients. A connection between the optimal delay and the dominant Lyapunov exponent of the dynamics is found based on heuristic arguments and is confirmed by the numerical results, providing a guideline for the practical implementation of the algorithm. Delayâcoordinate nudging preserves the easiness of implementation, the intuitive functioning and the reduced computational cost of the standard nudging, making it a potential alternative especially in the field of seasonalâtoâdecadal predictions with large Earth system models that limit the use of more sophisticated data assimilation procedures
Abundances of the elements in the solar system
A review of the abundances and condensation temperatures of the elements and
their nuclides in the solar nebula and in chondritic meteorites. Abundances of
the elements in some neighboring stars are also discussed.Comment: 42 pages, 11 tables, 8 figures, chapter, In Landolt- B\"ornstein, New
Series, Vol. VI/4B, Chap. 4.4, J.E. Tr\"umper (ed.), Berlin, Heidelberg, New
York: Springer-Verlag, p. 560-63
Hierarchical Models in the Brain
This paper describes a general model that subsumes many parametric models for
continuous data. The model comprises hidden layers of state-space or dynamic
causal models, arranged so that the output of one provides input to another. The
ensuing hierarchy furnishes a model for many types of data, of arbitrary
complexity. Special cases range from the general linear model for static data to
generalised convolution models, with system noise, for nonlinear time-series
analysis. Crucially, all of these models can be inverted using exactly the same
scheme, namely, dynamic expectation maximization. This means that a single model
and optimisation scheme can be used to invert a wide range of models. We present
the model and a brief review of its inversion to disclose the relationships
among, apparently, diverse generative models of empirical data. We then show
that this inversion can be formulated as a simple neural network and may provide
a useful metaphor for inference and learning in the brain
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