Geometric Aspects of D-branes and T-duality

We explore the differential geometry of T-duality and D-branes. Because D-branes and RR-fields are properly described via K-theory, we discuss the (differential) K-theoretic generalization of T-duality and its application to the coupling of D-branes to RR-fields. This leads to a puzzle involving the transformation of the A-roof genera in the coupling.Comment: 26 pages, JHEP format, uses dcpic.sty; v2: references added, v3: minor change

Ruptured uterus: Fetomaternal outcome among unbooked mothers and antenatal care defaulters at the University of Portharcourt teaching hospital.

BACKGROUND: Unbooked emergencies are major reasons for the high maternal and perinatal mortality and morbidity in Nigeria. Rupture of the gravid uterus in women without antenatal care usually present late to hospital as unbooked emergencies with high perinatal deaths and very poor maternal outcome. AIM: To determine the factors implicated in the poor feto-maternal outcome with ruptured uterus amongst the unbooked mothers at the University of Port Harcourt Teaching Hospital(UPTH).METHOD: A retrospective analysis of case records of 82 consecutive patients without antenatal care who had ruptured uterus between January 2008 and December 2012.RESULT: There were 2133 deliveries among unbooked mothers at the University of Port Harcourt Teaching Hospital over this 5-year period. The incidence of ruptured uterus for the period under review was 3.8%. The mean age was 28.1years and the modal parity was 2. Abdominal massage and prolonged obstructed labor were the commonest predisposing factors, occurring in 43.9% and 34.1% of these women respectively. There were 80 perinatal deaths contributing to 12.2% of the perinatal mortality rate. There were 6 maternal deaths from ruptured uterus which was 10.9% of the maternal mortality ratio of 2578.5 per 100,000 live birth during the study period.CONCLUSION: Perinatal and maternal mortality rates from ruptured uterus were high. The major causes of uterine rupture are abdominal massage and prolonged obstructed labor, which are both preventable. Public enlightenment and condemnation of practices that promote these factors is advocated.KEYWORDS: ruptured uterus, feto-maternal outcome, unbooked, Port Harcourt

Spin glass transition in a magnetic field: a renormalization group study

We study the transition of short range Ising spin glasses in a magnetic field, within a general replica symmetric field theory, which contains three masses and eight cubic couplings, that is defined in terms of the fields representing the replicon, anomalous and longitudinal modes. We discuss the symmetry of the theory in the limit of replica number n to 0, and consider the regular case where the longitudinal and anomalous masses remain degenerate. The spin glass transitions in zero and non-zero field are analyzed in a common framework. The mean field treatment shows the usual results, that is a transition in zero field, where all the modes become critical, and a transition in non-zero field, at the de Almeida-Thouless (AT) line, with only the replicon mode critical. Renormalization group methods are used to study the critical behavior, to order epsilon = 6-d. In the general theory we find a stable fixed-point associated to the spin glass transition in zero field. This fixed-point becomes unstable in the presence of a small magnetic field, and we calculate crossover exponents, which we relate to zero-field critical exponents. In a finite magnetic field, we find no physical stable fixed-point to describe the AT transition, in agreement with previous results of other authors.Comment: 36 pages with 4 tables. To be published in Phys. Rev.

Ramond-Ramond Fields, Fractional Branes and Orbifold Differential K-Theory

We study D-branes and Ramond-Ramond fields on global orbifolds of Type II string theory with vanishing H-flux using methods of equivariant K-theory and K-homology. We illustrate how Bredon equivariant cohomology naturally realizes stringy orbifold cohomology. We emphasize its role as the correct cohomological tool which captures known features of the low-energy effective field theory, and which provides new consistency conditions for fractional D-branes and Ramond-Ramond fields on orbifolds. We use an equivariant Chern character from equivariant K-theory to Bredon cohomology to define new Ramond-Ramond couplings of D-branes which generalize previous examples. We propose a definition for groups of differential characters associated to equivariant K-theory. We derive a Dirac quantization rule for Ramond-Ramond fluxes, and study flat Ramond-Ramond potentials on orbifolds.Comment: 46 pages; v2: typos correcte

CPT and Other Symmetries in String/M Theory

We initiate a search for non-perturbative consistency conditions in M theory. Some non-perturbative conditions are already known in Type I theories; we review these and search for others. We focus principally on possible anomalies in discrete symmetries. It is generally believed that discrete symmetries in string theories are gauge symmetries, so anomalies would provide evidence for inconsistencies. Using the orbifold cosmic string construction, we give some evidence that the symmetries we study are gauged. We then search for anomalies in discrete symmetries in a variety of models, both with and without supersymmetry. In symmetric orbifold models we extend previous searches, and show in a variety of examples that all anomalies may be canceled by a Green-Schwarz mechanism. We explore some asymmetric orbifold constructions and again find that all anomalies may be canceled this way. Then we turn to Type IIB orientifold models where it is known that even perturbative anomalies are non-universal. In the examples we study, by combining geometric discrete symmetries with continuous gauge symmetries, one may define non-anomalous discrete symmetries already in perturbation theory; in other cases, the anomalies are universal. Finally, we turn to the question of CPT conservation in string/M theory. It is well known that CPT is conserved in all string perturbation expansions; here in a number of examples for which a non-perturbative formulation is available we provide evidence that it is conserved exactly.Comment: 52 pages.1 paragraph added in introduction to clarify assumption

The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000-2015).

BACKGROUND: Seronegative villous atrophy (SNVA) is commonly attributed to coeliac disease (CD). However, there are other causes of SNVA. More recently angiotensin-2-receptor-blockers (A2RBs) have been reported as an association but data on SNVA have been limited to centres evaluating complex case referrals and not SNVA in general. OBJECTIVES: To provide clinical outcomes and associations in a large prospective study overseeing all newcomers with SNVA. DESIGN: Over a 15-year period (2000-2015) we evaluated 200 adult patients with SNVA at a UK centre. A diagnosis of either seronegative CD (SNCD) or seronegative non-CD (SN-non-CD) was reached. Baseline comparisons were made between the groups, with 343 seropositive CD subjects serving as controls. RESULTS: Of the 200 SNVA cases, SNCD represented 31% (n=62) and SN-non-CD 69% (n=138). The human leucocyte antigen (HLA)-DQ2 and/or DQ8 genotype was present in 61%, with a 51% positive predictive value for SNCD. The breakdown of identifiable causes in the SN-non-CD group comprised infections (27%, n=54), inflammatory/immune-mediated disorders (17.5%, n=35) and drugs (6.5%, n=13; two cases related to A2RBs). However, no cause was found in 18% (n=36) and of these 72% (n=26/36) spontaneously normalised duodenal histology while consuming a gluten-enriched diet. Following multivariable logistic regression analysis an independent factor associated with SN-non-CD was non-white ethnicity (OR 10.8, 95% CI 2.2 to 52.8); in fact, 66% of non-whites had GI infections. On immunohistochemistry all groups stained positive for CD8-T-cytotoxic intraepithelial lymphocytes. However, additional CD4-T helper intraepithelial lymphocytes were occasionally seen in SN-non-CD mimicking the changes associated with refractory CD. CONCLUSIONS: Most patients with SNVA do not have CD, in particular those who are not white. Furthermore, a subgroup with no obvious aetiology will show spontaneous histological resolution while consuming gluten. These findings suggest caution in empirically prescribing a gluten-free diet without investigation

The geometrical form for the string space-time action

In the present article, we derive the space-time action of the bosonic string in terms of geometrical quantities. First, we study the space-time geometry felt by probe bosonic string moving in antisymmetric and dilaton background fields. We show that the presence of the antisymmetric field leads to the space-time torsion, and the presence of the dilaton field leads to the space-time nonmetricity. Using these results we obtain the integration measure for space-time with stringy nonmetricity, requiring its preservation under parallel transport. We derive the Lagrangian depending on stringy curvature, torsion and nonmetricity.Comment: 13 page

Improving adherence to acute low back pain guideline recommendations with chiropractors and physiotherapists: the ALIGN cluster randomised controlled trial

Background Acute low back pain is a common condition, has high burden, and there are evidence-to-practice gaps in the chiropractic and physiotherapy setting for imaging and giving advice to stay active. The aim of this cluster randomised trial was to estimate the effects of a theory- and evidence-based implementation intervention to increase chiropractors’ and physiotherapists’ adherence to a guideline for acute low back pain compared with the comparator (passive dissemination of the guideline). In particular, the primary aim of the intervention was to reduce inappropriate imaging referral and improve patient low back pain outcomes, and to determine whether this intervention was cost-effective. Methods Physiotherapy and chiropractic practices in the state of Victoria, Australia, comprising at least one practising clinician who provided care to patients with acute low back pain, were invited to participate. Patients attending these practices were included if they had acute non-specific low back pain (duration less than 3 months), were 18 years of age or older, and were able to understand and read English. Practices were randomly assigned either to a tailored, multi-faceted intervention based on the guideline (interactive educational symposium plus academic detailing) or passive dissemination of the guideline (comparator). A statistician independent of the study team undertook stratified randomisation using computer-generated random numbers; four strata were defined by professional group and the rural or metropolitan location of the practice. Investigators not involved in intervention delivery were blinded to allocation. Primary outcomes were X-ray referral self-reported by clinicians using a checklist and patient low back pain-specific disability (at 3 months). Results A total of 104 practices (43 chiropractors, 85 physiotherapists; 755 patients) were assigned to the intervention and 106 practices (45 chiropractors, 97 physiotherapists; 603 patients) to the comparator; 449 patients were available for the patient-level primary outcome. There was no important difference in the odds of patients being referred for X-ray (adjusted (Adj) OR: 1.40; 95% CI 0.51, 3.87; Adj risk difference (RD): 0.01; 95% CI − 0.02, 0.04) or patient low back pain-specific disability (Adj mean difference: 0.37; 95% CI − 0.48, 1.21, scale 0–24). The intervention did lead to improvement for some key secondary outcomes, including giving advice to stay active (Adj OR: 1.96; 95% CI 1.20, 3.22; Adj RD: 0.10; 95% CI 0.01, 0.19) and intending to adhere to the guideline recommendations (e.g. intention to refer for X-ray: Adj OR: 0.27; 95% CI 0.17, 0.44; intention to give advice to stay active: Adj OR: 2.37; 95% CI 1.51, 3.74). Conclusions Intervention group clinicians were more likely to give advice to stay active and to intend to adhere to the guideline recommendations about X-ray referral. The intervention did not change the primary study outcomes, with no important differences in X-ray referral and patient disability between groups, implying that hypothesised reductions in health service utilisation and/or productivity gains are unlikely to offset the direct costs of the intervention. We report these results with the caveat that we enrolled less patients into the trial than our determined sample size. We cannot recommend this intervention as a cost-effective use of resources

Simple advice for a simple ankle sprain? The not so benign ankle injury

Editorial. No abstract available

Relating branes and matrices

We construct a general map between a Dp-brane with magnetic flux and a matrix configuration of D0-branes, by showing how one can rewrite the boundary state of the Dp-brane in terms of its D0-brane constituents. This map gives a simple prescription for constructing the matrices of fuzzy spaces corresponding to branes of arbitrary shape and topology. Since we explicitly identify the D0-brane degrees of freedom on the brane, we also derive the D0-brane charge of the brane in a very direct way including the A-genus term. As a check on our formalism, we use our map to derive the abelian-Born-Infeld equations of motion from the action of the D0-brane matrices.Comment: 28 pages, Late