932 research outputs found
Functional mixed-effect models for electrophysiological responses
In electro/psychophysiological experiments, linear mixed-effect modeling is an effective statistical technique for data repeatedly observed from the same experimental participants or stimulus items. This review describes the application of mixed-ef fect modeling to functional responses, in particular those observed in event-related EEG or MEG experiments, using a discrete wavelet transform. The technique is illustrated with a design with several covariates, and procedures for generating posterior samples and computing a Bayesian false discovery rate are described.Лінійне моделювання з урахуванням змішаних ефектів (mixed-effect modeling, MEM) є корисною статистичною методикою при інтерпретації даних, які повторно реєструються в умовах тестування одного й того самого учасника дослідження або використання ідентичного порядку стимулів у електро-/психофізіологічних експериментах. В огляді описано використання МЕМ при аналізі функціональних відповідей (зокрема, пов’язаних з подією феноменів, що спостерігалися в електро- або магнітоенцефалографічних дослідженнях) із застосуванням дискретного вейвлет-перетворення
On the reheating stage after inflation
We point out that inflaton decay products acquire plasma masses during the
reheating phase following inflation. The plasma masses may render inflaton
decay kinematicaly forbidden, causing the temperature to remain frozen for a
period at a plateau value. We show that the final reheating temperature may be
uniquely determined by the inflaton mass, and may not depend on its coupling.
Our findings have important implications for the thermal production of
dangerous relics during reheating (e.g., gravitinos), for extracting bounds on
particle physics models of inflation from Cosmic Microwave Background
anisotropy data, for the production of massive dark matter candidates during
reheating, and for models of baryogenesis or leptogensis where massive
particles are produced during reheating.Comment: 8 pages, 2 figures. Submitted for publication in Phys. Rev.
Improved parallelization techniques for the density matrix renormalization group
A distributed-memory parallelization strategy for the density matrix
renormalization group is proposed for cases where correlation functions are
required. This new strategy has substantial improvements with respect to
previous works. A scalability analysis shows an overall serial fraction of 9.4%
and an efficiency of around 60% considering up to eight nodes. Sources of
possible parallel slowdown are pointed out and solutions to circumvent these
issues are brought forward in order to achieve a better performance.Comment: 8 pages, 4 figures; version published in Computer Physics
Communication
Computer simulation of bistable switching in a nematic device containing pear-shaped particles
We study the microscopic basis of bistable switching of a confined liquid crystal via Monte Carlo simulations of hard pear-shaped particles. Using both dielectric and dipolar field couplings to this intrinsically flexoelectric fluid, it is shown that pulsed fields of opposing polarity can be used to switch between the vertical and
hybrid aligned states. Further, it is shown that the field-susceptibility of the surface polarisation, rather than the bulk flexoelectricity, is the main driver of this switching
behaviour.</p
A computationally tractable version of the collective model
A computationally tractable version of the Bohr-Mottelson collective model is
presented which makes it possible to diagonalize realistic collective models
and obtain convergent results in relatively small appropriately chosen
subspaces of the collective model Hilbert space. Special features of the
proposed model is that it makes use of the beta wave functions given
analytically by the softened-beta version of the Wilets-Jean model, proposed by
Elliott et al., and a simple algorithm for computing SO(5) > SO(3) spherical
harmonics. The latter has much in common with the methods of Chacon, Moshinsky,
and Sharp but is conceptually and computationally simpler. Results are
presented for collective models ranging from the sherical vibrator to the
Wilets-Jean and axially symmetric rotor-vibrator models.Comment: 16 pages, 9 figure
Black diholes in five dimensions
Using a generalized Weyl formalism, we show how stationary, axisymmetric
solutions of the four-dimensional vacuum Einstein equation can be turned into
static, axisymmetric solutions of five-dimensional dilaton gravity coupled to a
two-form gauge field. This procedure is then used to obtain new solutions of
the latter theory describing pairs of extremal magnetic black holes with
opposite charges, known as black diholes. These diholes are kept in static
equilibrium by membrane-like conical singularities stretching along two
different directions. We also present solutions describing diholes suspended in
a background magnetic field, and with unbalanced charges.Comment: 21 pages, 2 figures; reference adde
Wave Mechanics and General Relativity: A Rapprochement
Using exact solutions, we show that it is in principle possible to regard
waves and particles as representations of the same underlying geometry, thereby
resolving the problem of wave-particle duality
Relationship between protein O -linked glycosylation and insulin-stimulated glucose transport in rat skeletal muscle following calorie restriction or exposure to O -(2-acetamido-2-deoxy-d-glucopyranosylidene)amino- N -phenylcarbamate
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65566/1/j.1365-201X.2004.01403.x.pd
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria : guidelines of the EU-CARDIOPROTECTION COST Action
Full list of the EU-CARDIOPROTECTION COST Action CA16225 Working group members is provided at the end of the article in Acknowledgements section. Funding Information: This article is based on the work from COST Action EU-CARDIOPROTECTION CA16225 supported by COST (European Cooperation in Science and Technology). DJH is supported by the Duke-National University Singapore Medical School, Singapore Ministry of Health’s National Medical Research Council under its Clinician Scientist-Senior Investigator scheme (NMRC/CSA-SI/0011/2017) and Collaborative Centre Grant scheme (NMRC/CGAug16C006). SL is supported by grants from the South African Department of Science and Technology and the South African National Research Foundation. SMD is supported by grants from the British Heart Foundation (PG/19/51/34493 and PG/16/85/32471). GH is supported by the German Research Foundation (SFB 1116 B8). MRM is supported by the Spanish Institute of Health Carlos III (FIS PI19/01196 and CIBER-CV). RS is supported by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [Project number 268555672—SFB 1213, Project B05]. PF is supported by the National Research, Development and Innovation Office of Hungary (Research Excellence Program—TKP, National Heart Program NVKP 16-1-2016-0017) and by the Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the Therapeutic Development thematic program of the Semmelweis University. Funding Information: The IMPACT criteria were presented for approval to the Management Committee of the EU-CARDIOPROTECTION COST Action CA16225: Pavle Adamovski, Ioanna Andreadou, Saime Batirel, Monika Bartekov?, Luc Bertrand, Christophe Beauloye, David Biedermann, Vilmante Borutaite, Hans Erik Botker, Stefan Chlopicki, Maija Dambrova, Sean Davidson, Yvan Devaux, Fabio Di Lisa, Dragan Djuric, David Erlinge, Ines Falcao-Pires, P?ter Ferdinandy, Eleftheria Galatou, Alfonso Garcia-Sosa, Henrique Girao, Zoltan Giricz, Mariann Gyongyosi, Derek J Hausenloy, Donagh Healy, Gerd Heusch, Vladimir Jakovljevic, Jelena Jovanic, George Kararigas, Risto Kerkal, Frantisek Kolar, Brenda Kwak, Przemys?aw Leszek, Edgars Liepinsh , Jacob Lonborg, Sarah Longnus, Jasna Marinovic, Danina Mirela Muntean, Lana Nezic, Michel Ovize, Pasquale Pagliaro, Clarissa Pedrosa Da Costa Gomes, John Pernow, Andreas Persidis, S?ren Erik Pischke, Bruno Podesser, Ines Poto?njak, Fabrice Prunier, Tanya Ravingerova, Marisol Ruiz-Meana, Alina Serban, Katrine Slagsvold, Rainer Schulz, Niels van Royen, Belma Turan, Marko Vendelin, Stewart Walsh, Nace Zidar, Coert Zuurbier, Derek Yellon. Publisher Copyright: © 2021, The Author(s).Acute myocardial infarction (AMI) and the heart failure (HF) which may follow are among the leading causes of death and disability worldwide. As such, new therapeutic interventions are still needed to protect the heart against acute ischemia/reperfusion injury to reduce myocardial infarct size and prevent the onset of HF in patients presenting with AMI. However, the clinical translation of cardioprotective interventions that have proven to be beneficial in preclinical animal studies, has been challenging. One likely major reason for this failure to translate cardioprotection into patient benefit is the lack of rigorous and systematic in vivo preclinical assessment of the efficacy of promising cardioprotective interventions prior to their clinical evaluation. To address this, we propose an in vivo set of step-by-step criteria for IMproving Preclinical Assessment of Cardioprotective Therapies (‘IMPACT’), for investigators to consider adopting before embarking on clinical studies, the aim of which is to improve the likelihood of translating novel cardioprotective interventions into the clinical setting for patient benefit.publishersversionPeer reviewe
Efficient photoionization for barium ion trapping using a dipole-allowed resonant two-photon transition
Two efficient and isotope-selective resonant two-photon ionization techniques
for loading barium ions into radio-frequency (RF)-traps are demonstrated. The
scheme of using a strong dipole-allowed transition at \lambda=553 nm as a first
step towards ionization is compared to the established technique of using a
weak intercombination line (\lambda=413 nm). An increase of two orders of
magnitude in the ionization efficiency is found favoring the transition at 553
nm. This technique can be implemented using commercial all-solid-state laser
systems and is expected to be advantageous compared to other narrowband
photoionization schemes of barium in cases where highest efficiency and
isotope-selectivity are required.Comment: 8 pages, 5 figure
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