Doctoral dissertation management at the University of Granada

La Universidad de Granada (UGR) cuenta desde 2005 con el Proyecto DIGIBUG, un modelo que mejora la visibilidad y accesibilidad de su producción científica, con el objetivo de acercarla a los investigadores, doctorandos, estudiantes y a la sociedad en general, ofreciendo una nueva perspectiva de difusión, utilización, citación y seguimiento de las diferentes líneas de investigación existentes en la UGR.Since 2005 the University of Granada (UGR) has implemented the DIGIBUG Project, which aims to improve visibility of and access to its scientific output so as to bring it closer to researchers, doctorate and undergraduate students and society in general, providing a new way of disseminating, using, citing and following up the different lines of enquiry at the UGR

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans