A new Euclidean tight 6-design

We give a new example of Euclidean tight 6-design in $\mathbb R^{22}$.Comment: 9 page

Dietary intakes in adult patients with cystic fibrosis–do they achieve guidelines?

AbstractBackground: Most patients with cystic fibrosis (CF) require a higher energy and protein intake than their healthy peer group. There are few data on dietary intakes of adult patients. The aim of this study was to determine nutritional intakes in an adult population with CF. The impact of nutritional intervention and disease on macronutrient intake was examined. Methods: Retrospective cross-sectional analysis of 94 unweighed food diaries at annual review (1995–2000). Energy and protein intakes were compared to the estimated average requirement (EAR) for energy and reference nutrient intake (RNI) for protein. The effect of diet alone, oral supplements, enteral tube feeding, and cystic fibrosis related diabetes (CFRD), on macronutrient intake was examined and impact of pancreatic sufficency (PS) and lung transplantation. Results: Mean energy and protein intakes approached recommended CF guidelines, but in 72% of assessments these values were not achieved. Mean energy and protein intakes for patients on diet alone and protein intake for those with CFRD failed to meet recommendations. Oral supplementation and enteral tube feeding regimens increased energy and protein intake above recommended levels. No group achieved 40% total energy from fat. Patients receiving enteral tube feeds had the highest mean energy and protein intakes but lowest body mass index (BMI) and lung function. Conclusion: Adequate mean energy and protein intakes in adult patients with CF mask subgroups of patients who fail to meet recommendations ie. diet alone, diabetic. Oral supplementation and enteral tube feeding increase energy and protein intake but fail to achieve an adequate BMI level in subjects with a decreased clinical status. Individual nutritional assessment remains essential

A pilot study of zafirlukast as an anti-inflammatory agent in the treatment of adults with cystic fibrosis

AbstractBackground: Persistent endobronchial inflammation is in part responsible for the attrition of lung function seen in cystic fibrosis. Leukotrienes act as pro-inflammatory mediators. The aim of this study was to assess the efficacy of the leukotriene receptor antagonist zafirlukast as a potential anti-inflammatory agent in the treatment of adult patients with cystic fibrosis. Methods: Clinically stable patients were enrolled in the study if they had no history or clinical evidence of asthma, bronchial hyper-reactivity, or aspergillosis. They were randomised to receive zafirlukast 20 mg twice daily with all routine treatment for four months or routine treatment alone in an open cross-over design. Primary endpoints were changes in respiratory function tests and a modified NIH clinical score. Results: Thirty patients were enrolled and 25 completed. There was a significant improvement in the modified NIH clinical score but no significant increase in respiratory function with zafirlukast. Conclusions: Patients receiving a leukotriene receptor antagonist in addition to routine treatments showed significant improvement in a clinical score which is a composite of clinical wellbeing, chest radiograph appearance, and physical examination. Respiratory function showed a non-significant trend towards improvement with treatment. Zafirlukast may benefit patients with CF. An adequately powered study is justified on the basis of these results

Cystic fibrosis co-existing with trisomy 21

AbstractPrevious reports of children with co-existence of cystic fibrosis and full trisomy 21 suggest a very poor prognosis, with the majority of cases dying in infancy and the oldest reported survivor being 6years of age. We report the case of a young man with genetically confirmed trisomy 21 and homozygous for the F508del cystic fibrosis mutation. Despite the diagnosis of cystic fibrosis being delayed until the age of 2years he has transitioned to adult services and is now 25years of age. Currently he has poor lung function and a continuous ambulatory oxygen requirement

Steiner t-designs for large t

One of the most central and long-standing open questions in combinatorial design theory concerns the existence of Steiner t-designs for large values of t. Although in his classical 1987 paper, L. Teirlinck has shown that non-trivial t-designs exist for all values of t, no non-trivial Steiner t-design with t > 5 has been constructed until now. Understandingly, the case t = 6 has received considerable attention. There has been recent progress concerning the existence of highly symmetric Steiner 6-designs: It is shown in [M. Huber, J. Algebr. Comb. 26 (2007), pp. 453-476] that no non-trivial flag-transitive Steiner 6-design can exist. In this paper, we announce that essentially also no block-transitive Steiner 6-design can exist.Comment: 9 pages; to appear in: Mathematical Methods in Computer Science 2008, ed. by J.Calmet, W.Geiselmann, J.Mueller-Quade, Springer Lecture Notes in Computer Scienc

Contextual representations of negative images modulate intrusion frequency in an intrusion provocation paradigm

Background and objectives: To understand how memories of negative events become highly accessible in the context of trauma, we tested the hypothesis that contextual information modulates how easily intrusions can be provoked by perceptual stimuli. Methods: Healthy participants viewed pictures depicting trauma scenes either with or without accompanying moderate (i.e. survival, recovery) or severe (i.e. fatality, permanent injury) outcome information. All participants viewed the same depictions of trauma scenes. Involuntary memories for the pictures were assessed using self-report diaries and an adapted version of the Impact of Event Scales (IES). A blurred picture perceptual priming paradigm was adapted to be used as an intrusion provocation task. Results: The severe outcome group experienced a significantly higher frequency of intrusions on the intrusion provocation task in comparison to both moderate outcome and control (no-context) conditions. The severe outcome condition did not increase intrusions on the self-report diaries or the adapted IES. There was no effect of condition on ratings for the emotionality, self-relevance, valence, or seriousness of the trauma scenes. Limitations: The analogue method should not be generalized directly to incidences of real-life trauma. It was unclear why differences in intrusion frequency were found in the provocation task only. The relative amount of individual conceptual and data-driven processing adopted by the participants was not assessed. Conclusions: Manipulating contextual information that determines the meaning of sensory-perceptual features for a trauma scene can modulate subsequent intrusion frequency in response to visually similar cues

Duality Orbits, Dyon Spectrum and Gauge Theory Limit of Heterotic String Theory on T^6

For heterotic string theory compactified on T^6, we derive the complete set of T-duality invariants which characterize a pair of charge vectors (Q,P) labelling the electric and magnetic charges of the dyon. Using this we can identify the complete set of dyons to which the previously derived degeneracy formula can be extended. By going near special points in the moduli space of the theory we derive the spectrum of quarter BPS dyons in N=4 supersymmetric gauge theory with simply laced gauge groups. The results are in agreement with those derived from field theory analysis.Comment: LaTeX file, 22 page

Freedom and constraints in the K3 landscape

We consider ``magnetized brane'' compactifications of the type I/heterotic string on K3 with U(1) background fluxes. The gauge group and matter content of the resulting six-dimensional vacua are parameterized by a matrix encoding a lattice contained within the even, self-dual lattice Γ[superscript 3,19]. Mathematical results of Nikulin on lattice embeddings make possible a simple classification of all such solutions. We find that every six-dimensional theory parameterized in this way by a negative semi-definite matrix whose trace satisfies a simple tadpole constraint can be realized as a K3 compactification. This approach makes it possible to explicitly and efficiently construct all models in this class with any particular allowed gauge group and matter content, so that one can immediately ``dial-a-model'' with desired properties

Baseline study of Essential Ocean Variable monitoring in Irish waters; current measurement programmes & data quality

This report provides an initial assessment of Ireland’s current measurement programmes and capacity for Essential Ocean Variables (EOV) data collection. These are typically programmes that involve physical sampling of the marine environment, using a combination of ship-based measurements, fixed platforms e.g. tide and wave gauges, offshore buoys, autonomous platforms e.g. underwater gliders, and conventional collection of physical samples that are analysed on board ships or in shore-based laboratories. Systematic measurement of essential ocean variables underpins the delivery of services to government and the public in terms of real-time decision support, assessments of ocean health e.g. Marine Strategy Framework Directive (MSFD), Oslo & Paris Conventions (OSPAR), International Council on the Exploration of the Sea (ICES) and long-term observations to inform policy on marine climate change and provide climate information to guide related adaptation measures required under climate change sectoral adaptation plans e.g. seafood sector, transport, biodiversity, and built heritage