202 research outputs found
Modelling the future of the Hawaiian honeycreeper : an ecological and epidemiological problem
The Hawaiian honeycreeper (Drepanididae) faces the threat of extinction; this is believed to be due primarily to predation from alien animals, endemic avian malaria (Plasmodium relictum) and climate change. A deterministic SI modelling approach is developed, incorporating these three factors and a metapopulation approach in conjunction with a quasi-equilibrium assumption to simplify the vector populations. This enables the qualitative study of the behaviour of the system. Numerical results suggest that although (partial) resistance to avian malaria may be advantageous for individual birds, allowing them to survive infection, this allows them to become carriers of infection and hence greatly increases the spread of this disease. Predation obviously reduces the life-expectancy of honeycreepers, but in turn this reduces the spread of infection from resistant carriers; therefore the population-level impact of predation is reduced. Various control strategies proposed in the literature are also considered and it is shown that predation control could either help or hinter, depending upon resistance of the honeycreeper species. Captive propagation or habitat restoration may be the best feasible solution to the loss of both heterogeneity within the population and the loss of the species as a whole
Magnetic Order in YBaCuO Superconductors
Polarized and unpolarized neutron diffraction has been used to search for
magnetic order in YBaCuO superconductors. Most of the
measurements were made on a high quality crystal of YBaCuO. It
is shown that this crystal has highly ordered ortho-II chain order, and a sharp
superconducting transition. Inelastic scattering measurements display a very
clean spin-gap and pseudogap with any intensity at 10 meV being 50 times
smaller than the resonance intensity. The crystal shows a complicated magnetic
order that appears to have three components. A magnetic phase is found at high
temperatures that seems to stem from an impurity with a moment that is in the
- plane, but disordered on the crystal lattice. A second ordering occurs
near the pseudogap temperature that has a shorter correlation length than the
high temperature phase and a moment direction that is at least partly along the
c-axis of the crystal. Its moment direction, temperature dependence, and Bragg
intensities suggest that it may stem from orbital ordering of the -density
wave (DDW) type. An additional intensity increase occurs below the
superconducting transition. The magnetic intensity in these phases does not
change noticeably in a 7 Tesla magnetic field aligned approximately along the
c-axis. Searches for magnetic order in YBaCuO show no signal
while a small magnetic intensity is found in YBaCuO that is
consistent with c-axis directed magnetic order. The results are contrasted with
other recent neutron measurements.Comment: 11 pages with 10 figure
Physiologic-Based Cord Clamping Maintains Core Temperature vs. Immediate Cord Clamping in Near-Term Lambs
Background: Physiologic-based cord clamping (PBCC) involves deferring umbilical
cord clamping until after lung aeration. It is unclear if infant is at risk of becoming
hypothermic during PBCC.
Objectives: To test if PBCC would maintain core temperature more effectively than
immediate cord clamping (ICC).
Design: At 0.93 gestation, fetal lambs were surgically exteriorized and instrumented
from pregnant ewes under general anesthesia. Prior to the start of the experiment,
lambs were thoroughly dried, placed on hot water bottles, and core temperature
was continuously monitored using a rectal thermometer. PBCC lambs (n = 21),
received intermittent positive pressure ventilation (iPPV) for ≥5 min prior to umbilical
cord clamping. In ICC lambs (n = 23), iPPV commenced within 60 s after umbilical
cord clamping. iPPV was provided with heated/humidified gas. Lambs were moved
under a radiant warmer after umbilical cord clamping. Additional warmth was provided
using a plastic overlay, hairdryer, and extra water bottles, as needed. Two-way mixed
and repeated measures one-way ANOVAs were used to compare temperature changes
between and within a single group, respectively, over time.
Results: Basal fetal parameters including core temperature were similar between
groups. ICC lambs had a significant reduction in temperature compared to PBCC lambs
(p < 0.001), evident by 1 min (p = 0.002). ICC lambs decreased temperature by 0.51◦C
(± 0.42) and 0.79◦C (± 0.55) at 5 and 10 min respectively (p <
Topological Defects as Seeds for Eternal Inflation
We investigate the global structure of inflationary universe both by
analytical methods and by computer simulations of stochastic processes in the
early Universe. We show that the global structure of the universe depends
crucially on the mechanism of inflation. In the simplest models of chaotic
inflation the Universe looks like a sea of thermalized phase surrounding
permanently self-reproducing inflationary domains. In the theories where
inflation occurs near a local extremum of the effective potential corresponding
to a metastable state, the Universe looks like de Sitter space surrounding
islands of thermalized phase. A similar picture appears even if the state is unstable but the effective potential has a discrete symmetry . In this case the Universe becomes divided into domains containing
different phases. These domains will be separated from each other by domain
walls. However, unlike ordinary domain walls, these domain walls will inflate,
and their thickness will exponentially grow. In the theories with continuous
symmetries inflation generates exponentially expanding strings and monopoles
surrounded by thermalized phase. Inflating topological defects will be stable,
and they will unceasingly produce new inflating topological defects. This means
that topological defects may play a role of indestructible seeds for eternal
inflation.Comment: 21 pages, 17 figures (not included), Stanford University preprint
SU--ITP--94--
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
The present and future of QCD
This White Paper presents an overview of the current status and future perspective of QCD research, based on the community inputs and scientific conclusions from the 2022 Hot and Cold QCD Town Meeting. We present the progress made in the last decade toward a deep understanding of both the fundamental structure of the sub-atomic matter of nucleon and nucleus in cold QCD, and the hot QCD matter in heavy ion collisions. We identify key questions of QCD research and plausible paths to obtaining answers to those questions in the near future, hence defining priorities of our research over the coming decades
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