3,588 research outputs found
Physics Potential of Very Intense Conventional Neutrino Beams
The physics potential of high intensity conventional beams is explored. We
consider a low energy super beam which could be produced by a proposed new
accelerator at CERN, the Super Proton Linac. Water Cherenkov and liquid oil
scintillator detectors are studied as possible candidates for a neutrino
oscillation experiment which could improve our current knowledge of the
atmospheric parameters and measure or severely constrain the parameter
connecting the atmospheric and solar realms. It is also shown that a very large
water detector could eventually observe leptonic CP violation. The reach of
such an experiment to the neutrino mixing parameters would lie in-between the
next generation of neutrino experiments (MINOS, OPERA, etc) and a future
neutrino factory.Comment: Talk given at the Venice Conference on Neutrino Telescopes, Venice,
March, 200
Brain-specific tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain
In this study we report on the developmental and regional expression of two brain-specific isoforms of tropomyosin, TMBr-1 and TMBr-3, that are generated from the rat alpha-tropomyosin gene via the use of alternative promoters and alternative RNA splicing. Western blot analysis using an exon-specific peptide polyclonal antibody revealed that the two isoforms are differentially expressed in development with TMBr-3 appearing in the embryonic brain at 16 days of gestation, followed by the expression of TMBr-1 at 20 days after birth. TMBr-3 was detected in all brain regions examined, whereas TMBr-1 was detected predominantly in brain areas that derived from the prosencephalon. Immunocytochemical studies on mixed primary cultures made from rat embryonic midbrain indicate that expression of the brain-specific epitope is restricted to neurons. The developmental pattern and neuronal localization of these forms of tropomyosin suggest that these isoforms have a specialized role in the development and plasticity of the nervous system
Genetic instrumental variable regression: Explaining socioeconomic and health outcomes in nonexperimental data
Identifying causal effects in nonexperimental data is an enduring challenge. One proposed solution that recently gained popularity is the idea to use genes as instrumental variables [i.e., Mendelian randomization (MR)]. However, this approach is problematic because many variables of interest are genetically correlated, which implies the possibility that many genes could affect both the exposure and the outcome directly or via unobserved confounding factors. Thus, pleiotropic effects of genes are themselves a source of bias in nonexperimental data that would also undermine the ability of MR to correct for endogeneity bias from nongenetic sources. Here, we propose an alternative approach, genetic instrumental variable (GIV) regression, that provides estimates for the effect of an exposure on an outcome in the presence of pleiotropy. As a valuable byproduct, GIV regression also provides accurate estimates of the chip heritability of the outcome variable. GIV regression uses polygenic scores (PGSs) for the outcome of interest which can be constructed from genome-wide association study (GWAS) results. By splitting the GWAS sample for the outcome into nonoverlapping subsamples, we obtain multiple indicators of the outcome PGSs that can be used as instruments for each other and, in combination with other methods such as sibling fixed effects, can address endogeneity bias from both pleiotropy and the environment. In two empirical applications, we demonstrate that our approach produces reasonable estimates of the chip heritability of educational attainment (EA) and show that standard regression and MR provide upwardly biased estimates of the effect of body height on EA
Cowpeas - A New Forage Crop for South Dakota
In the northern Great Plains, cool-season pastures decline in productivity during summer. This reduces available forage supplies. Solutions to forage shortages during the summer traditionally have included the use of perennial and annual warm-season species for pastures, hay, or silage. Cowpeas, a non-traditional crop suitable for summer forage, have been investigated recently at SDSU. Cowpeas (Vigna unguiculata [L.] Walp.) are an important legume in the southeastern United States, but since 1940 they have been replaced gradually by soybeans, clovers, and other legumes. Referred to as “black-eyed peas,” cowpeas are grown primarily for human consumption but also are suitable for hay, silage, and pasture
Pilot testing of a novel surgical simulator for endoscopic zenker’s diverticulotomy
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136304/1/lary26129.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136304/2/lary26129_am.pd
A study of atmospheric neutrinos with the IMB detector
A sample of 401 contained neutrino interactions collected in the 3300 metric ton fiducial mass IMB detector was used to study neutrino oscillations, geomagnetic modulation of the flux and to search for point sources. The majority of these events are attributed to neutrino interactions. For the most part, these neutrinos are believed to originate as tertiary products of cosmic ray interactions in the atmosphere. The neutrinos are a mixture of v sub e and v sub micron
Neutrino oscillation physics with a higher -beam
The precision measurement and discovery potential of a neutrino factory based
on a storage ring of boosted radioactive ions (-beam) is re-examined. In
contrast with past designs, which assume ion factors of and
baselines of L=130 km, we emphasize the advantages of boosting the ions to
higher and increasing the baseline proportionally. In particular, we
consider a medium- scenario (, L=730 km) and a
high- scenario (, L = 3000 km).The increase in
statistics, which grow linearly with the average beam energy, the ability to
exploit the energy dependence of the signal and the sizable matter effects at
this longer baseline all increase the discovery potential of such a machine
very significantly.Comment: An error corrected, conclusions unchanged. Revised version to appear
in Nuclear Physics
Analytic Results for the Gravitational Radiation from a Class of Cosmic String Loops
Cosmic string loops are defined by a pair of periodic functions and
, which trace out unit-length closed curves in three-dimensional
space. We consider a particular class of loops, for which lies along
a line and lies in the plane orthogonal to that line. For this class
of cosmic string loops one may give a simple analytic expression for the power
radiated in gravitational waves. We evaluate exactly in
closed form for several special cases: (1) a circle traversed
times; (2) a regular polygon with sides and interior vertex angle
; (3) an isosceles triangle with semi-angle .
We prove that case (1) with is the absolute minimum of within
our special class of loops, and identify all the stationary points of
in this class.Comment: 15 pages, RevTex 3.0, 7 figures available via anonymous ftp from
directory pub/pcasper at alpha1.csd.uwm.edu, WISC-MILW-94-TH-1
Off-diagonal structure of neutrino mass matrix in see-saw mechanism and electron-muon-tau lepton universality
By a simple extension of the standard model in which ()
universality is not conserved, we present a scenario within the framework of
see-saw mechanism in which the neutrino mass matrix is strictly off-diagonal in
the flavor basis. We show that a version of this scenario can accomodate the
atmospheric neutrino oscillations and
oscillations claimed by the LSND collaboration.
PACS: 14.60.Pq; 14.60.St;13.15.+gComment: 5 pages, Revtex, 1 figure: The model accomodate another version which
explains atmospheric neutrino data and the observed solar neutrino
oscillations (large angle solution). In the previous version the value of
\lambda parameter is changed to the expected one. This version now
accomodates LSND result and solar neutrino oscillations (small angle MSW
solution
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