Peer-review in a world with rational scientists: Toward selection of the average

One of the virtues of peer review is that it provides a self-regulating selection mechanism for scientific work, papers and projects. Peer review as a selection mechanism is hard to evaluate in terms of its efficiency. Serious efforts to understand its strengths and weaknesses have not yet lead to clear answers. In theory peer review works if the involved parties (editors and referees) conform to a set of requirements, such as love for high quality science, objectiveness, and absence of biases, nepotism, friend and clique networks, selfishness, etc. If these requirements are violated, what is the effect on the selection of high quality work? We study this question with a simple agent based model. In particular we are interested in the effects of rational referees, who might not have any incentive to see high quality work other than their own published or promoted. We find that a small fraction of incorrect (selfish or rational) referees can drastically reduce the quality of the published (accepted) scientific standard. We quantify the fraction for which peer review will no longer select better than pure chance. Decline of quality of accepted scientific work is shown as a function of the fraction of rational and unqualified referees. We show how a simple quality-increasing policy of e.g. a journal can lead to a loss in overall scientific quality, and how mutual support-networks of authors and referees deteriorate the system.Comment: 5 pages 4 figure

Nuclear Activity and the Conditions of Star-formation at the Galactic Center

The Galactic Center is the closest galactic nucleus that can be studied with unprecedented angular resolution and sensitivity. We summarize recent basic observational results on Sagittarius A* and the conditions for star formation in the central stellar cluster. We cover results from the radio, infrared, and X-ray domain and include results from simulation as well. From (sub-)mm and near-infrared variability and near-infrared polarization data we find that the SgrA* system (supermassive black hole spin, a potential temporary accretion disk and/or outflow) is well ordered in its geometrical orientation and in its emission process that we assume to reflect the accretion process onto the supermassive black hole (SMBH).Comment: 11 pages, 4 figures, 1 table; published in PoS-SISSA Proceedings of the: Frontier Research in Astrophysics - II, 23-28 May 2016, Mondello (Palermo), Ital

Experimental Indicators of Accretion Processes in Active Galactic Nuclei

Bright Active Galactic Nuclei are powered by accretion of mass onto the super massive black holes at the centers of the host galaxies. For fainter objects star formation may significantly contribute to the luminosity. We summarize experimental indicators of the accretion processes in Active Galactic Nuclei (AGN), i.e., observable activity indicators that allow us to conclude on the nature of accretion. The Galactic Center is the closest galactic nucleus that can be studied with unprecedented angular resolution and sensitivity. Therefore, here we also include the presentation of recent observational results on Sagittarius A* and the conditions for star formation in the central stellar cluster. We cover results across the electromagnetic spectrum and find that the Sagittarius A* (SgrA*) system is well ordered with respect to its geometrical orientation and its emission processes of which we assume to reflect the accretion process onto the super massive black hole.Comment: 16 pages, 4 figures, conference proceeding: Accretion Processes in Cosmic Sources - APCS2016 - 5-10 September 2016, Saint Petersburg, Russi

How to Create an Innovation Accelerator

Too many policy failures are fundamentally failures of knowledge. This has become particularly apparent during the recent financial and economic crisis, which is questioning the validity of mainstream scholarly paradigms. We propose to pursue a multi-disciplinary approach and to establish new institutional settings which remove or reduce obstacles impeding efficient knowledge creation. We provided suggestions on (i) how to modernize and improve the academic publication system, and (ii) how to support scientific coordination, communication, and co-creation in large-scale multi-disciplinary projects. Both constitute important elements of what we envision to be a novel ICT infrastructure called "Innovation Accelerator" or "Knowledge Accelerator".Comment: 32 pages, Visioneer White Paper, see http://www.visioneer.ethz.c

SINFONI in the Galactic Center: young stars and IR flares in the central light month

We report 75 milli-arcsec resolution, near-IR imaging spectroscopy within the central 30 light days of the Galactic Center [...]. To a limiting magnitude of K~16, 9 of 10 stars in the central 0.4 arcsec, and 13 of 17 stars out to 0.7 arcsec from the central black hole have spectral properties of B0-B9, main sequence stars. [...] all brighter early type stars have normal rotation velocities, similar to solar neighborhood stars. We [...] derive improved 3d stellar orbits for six of these S-stars in the central 0.5 arcsec. Their orientations in space appear random. Their orbital planes are not co-aligned with those of the two disks of massive young stars 1-10 arcsec from SgrA*. We can thus exclude [...] that the S-stars as a group inhabit the inner regions of these disks. They also cannot have been located/formed in these disks [...]. [...] we conclude that the S-stars were most likely brought into the central light month by strong individual scattering events. The updated estimate of distance to the Galactic center from the S2 orbit fit is Ro = 7.62 +/- 0.32 kpc, resulting in a central mass value of 3.61 +/- 0.32 x 10^6 Msun. We happened to catch two smaller flaring events from SgrA* [...]. The 1.7-2.45 mum spectral energy distributions of these flares are fit by a featureless, red power law [...]. The observed spectral slope is in good agreement with synchrotron models in which the infrared emission comes from [...] radiative inefficient accretion flow in the central R~10 Rs region.Comment: 50 pages, 10 figures, 2 tables, submitted to ApJ, February 6th, 2005, abstract abridge

Probing the embedded YSOs of the R CrA region through VLT-ISAAC spectroscopy

Near IR spectra obtained with ISAAC at VLT, have been used to pose constraints on the evolutionary state and accretion properties of a sample of five embedded YSOs located in the R CrA core. This sample includes three Class I sources (HH100 IR, IRS2 and IRS5), and two sources with NIR excesses (IRS6 and IRS3). Absorption lines have been detected in the medium resolution spectra of all the observed targets, together with emission lines likely originating in the disk-star-wind connected regions. We derived spectral types, veiling and stellar luminosity of the five observed sources, which in turn have been used to infer their mass and age adopting pre-main sequence evolutionary tracks. We find that in HH100 IR and IRS2 most of the bolometric luminosity is due to accretion, while the other three investigated sources, including the Class I object IRS5a, present a low accretion activity (L_{acc}/L_{bol} < 0.2). We observe a general correlation between the accretion luminosity, the IR veiling and the emission line activity of the sources. A correlation between the accretion activity and the spectral energy distribution slope is recognizable but with the notable exception of IRS5a. Our analysis therefore shows how the definition of the evolutionary stage of deeply embedded YSOs by means of IR colors needs to be more carefully refined.Comment: 17 pages, 13 figures, accepted on A&

Lipidomics Reveals Early Metabolic Changes in Subjects with Schizophrenia: Effects of Atypical Antipsychotics

There is a critical need for mapping early metabolic changes in schizophrenia to capture failures in regulation of biochemical pathways and networks. This information could provide valuable insights about disease mechanisms, trajectory of disease progression, and diagnostic biomarkers. We used a lipidomics platform to measure individual lipid species in 20 drug-naïve patients with a first episode of schizophrenia (FE group), 20 patients with chronic schizophrenia that had not adhered to prescribed medications (RE group), and 29 race-matched control subjects without schizophrenia. Lipid metabolic profiles were evaluated and compared between study groups and within groups before and after treatment with atypical antipsychotics, risperidone and aripiprazole. Finally, we mapped lipid profiles to n3 and n6 fatty acid synthesis pathways to elucidate which enzymes might be affected by disease and treatment. Compared to controls, the FE group showed significant down-regulation of several n3 polyunsaturated fatty acids (PUFAs), including 20:5n3, 22:5n3, and 22:6n3 within the phosphatidylcholine and phosphatidylethanolamine lipid classes. Differences between FE and controls were only observed in the n3 class PUFAs; no differences where noted in n6 class PUFAs. The RE group was not significantly different from controls, although some compositional differences within PUFAs were noted. Drug treatment was able to correct the aberrant PUFA levels noted in FE patients, but changes in re patients were not corrective. Treatment caused increases in both n3 and n6 class lipids. These results supported the hypothesis that phospholipid n3 fatty acid deficits are present early in the course of schizophrenia and tend not to persist throughout its course. These changes in lipid metabolism could indicate a metabolic vulnerability in patients with schizophrenia that occurs early in development of the disease. © 2013 McEvoy et al

The S-Star Cluster at the Center of the Milky Way: On the nature of diffuse NIR emission in the inner tenth of a parsec

Sagittarius A*, the super-massive black hole at the center of the Milky Way, is surrounded by a small cluster of high velocity stars, known as the S-stars. We aim to constrain the amount and nature of stellar and dark mass associated with the cluster in the immediate vicinity of Sagittarius A*. We use near-infrared imaging to determine the $K_\mathrm{s}$-band luminosity function of the S-star cluster members, and the distribution of the diffuse background emission and the stellar number density counts around the central black hole. This allows us to determine the stellar light and mass contribution expected from the faint members of the cluster. We then use post-Newtonian N-body techniques to investigate the effect of stellar perturbations on the motion of S2, as a means of detecting the number and masses of the perturbers. We find that the stellar mass derived from the $K_\mathrm{s}$-band luminosity extrapolation is much smaller than the amount of mass that might be present considering the uncertainties in the orbital motion of the star S2. Also the amount of light from the fainter S-cluster members is below the amount of residual light at the position of the S-star cluster after removing the bright cluster members. If the distribution of stars and stellar remnants is strongly enough peaked near Sagittarius A*, observed changes in the orbital elements of S2 can be used to constrain both their masses and numbers. Based on simulations of the cluster of high velocity stars we find that at a wavelength of 2.2 $\mu$m close to the confusion level for 8 m class telescopes blend stars will occur (preferentially near the position of Sagittarius A*) that last for typically 3 years before they dissolve due to proper motions.Comment: 14 pages, 11 figures, minor changes to match the published version in Astronomy & Astrophysic

Plasma Cholesterol Ester Fatty Acids: A New Biochemical Abnormality in Obstructive Jaundice

Changes in fatty acid patterns may explain many of the observed abnormalities found in obstructive jaundice. This study looked at fatty acids in plasma cholesterol esters, in a group of patients with obstructive jaundice and a matched group of controls. Significant abnormalities were demonstrated, most importantly a fall in essential fatty acids, in the jaundiced group. Overall the saturation of this fraction, as assessed by double bond index, rose. The essential fatty acids are important as factors in membrane function and as precursors of eicosanoids. The abnormalities found in this study provide further evidence of the significance of EFA in patients with obstructive jaundice