96 research outputs found
Quasi-Elastic Scattering in the Inclusive (He, t) Reaction
The triton energy spectra of the charge-exchange C(He,t) reaction
at 2 GeV beam energy are analyzed in the quasi-elastic nucleon knock-out
region. Considering that this region is mainly populated by the charge-exchange
of a proton in He with a neutron in the target nucleus and the final proton
going in the continuum, the cross-sections are written in the distorted-wave
impulse approximation. The t-matrix for the elementary exchange process is
constructed in the DWBA, using one pion- plus rho-exchange potential for the
spin-isospin nucleon- nucleon potential. This t-matrix reproduces the
experimental data on the elementary pn np process. The calculated
cross-sections for the C(He,t) reaction at to triton
emission angle are compared with the corresponding experimental data, and are
found in reasonable overall accord.Comment: 19 pages, latex, 11 postscript figures available at
[email protected], submitted to Phy.Rev.
The hyperfine transition in light muonic atoms of odd Z
The hyperfine (hf) transition rates for muonic atoms have been re-measured
for select light nuclei, using neutron detectors to evaluate the time
dependence of muon capture. For F = 5.6 (2)
s for the hf transition rate, a value which is considerably more
accurate than previous measurements. Results are also reported for Na, Al, P,
Cl, and K; that result for P is the first positive identification.Comment: 12 pages including 5 tables and 4 figures, RevTex, submitted to Phys.
Rev.
Ybp2 Associates with the Central Kinetochore of Saccharomyces cerevisiae and Mediates Proper Mitotic Progression
The spindle checkpoint ensures the accurate segregation of chromosomes by monitoring the status of kinetochore attachment to microtubules. Simultaneous mutations in one of several kinetochore and cohesion genes and a spindle checkpoint gene cause a synthetic-lethal or synthetic-sick phenotype. A synthetic genetic array (SGA) analysis using a mad2Δ query mutant strain of yeast identified YBP2, a gene whose product shares sequence similarity with the product of YBP1, which is required for H2O2-induced oxidation of the transcription factor Yap1. ybp2Δ was sensitive to benomyl and accumulated at the mitotic stage of the cell cycle. Ybp2 physically associates with proteins of the COMA complex (Ctf19, Okp1, Mcm21, and Ame1) and 3 components of the Ndc80 complex (Ndc80, Nuf2, and Spc25 but not Spc24) in the central kinetochore and with Cse4 (the centromeric histone and CENP-A homolog). Chromatin-immunoprecipitation analyses revealed that Ybp2 associates specifically with CEN DNA. Furthermore, ybp2Δ showed synthetic-sick interactions with mutants of the genes that encode the COMA complex components. Ybp2 seems to be part of a macromolecular kinetochore complex and appears to contribute to the proper associations among the central kinetochore subcomplexes and the kinetochore-specific nucleosome
Induced pseudoscalar coupling of the proton weak interaction
The induced pseudoscalar coupling is the least well known of the weak
coupling constants of the proton's charged--current interaction. Its size is
dictated by chiral symmetry arguments, and its measurement represents an
important test of quantum chromodynamics at low energies. During the past
decade a large body of new data relevant to the coupling has been
accumulated. This data includes measurements of radiative and non radiative
muon capture on targets ranging from hydrogen and few--nucleon systems to
complex nuclei. Herein the authors review the theoretical underpinnings of
, the experimental studies of , and the procedures and uncertainties
in extracting the coupling from data. Current puzzles are highlighted and
future opportunities are discussed.Comment: 58 pages, Latex, Revtex4, prepared for Reviews of Modern Physic
Nucleon charge exchange on the deuteron: A critical review
The existing experimental data on the d(n,p)nn and d(p,n)pp cross sections in
the forward direction are reviewed in terms of the Dean sum rule. It is shown
that the measurement of the ratio of the charge exchange on the deuteron to
that on the proton might, if taken together with other experimental data, allow
a direct construction of the np -> np scattering amplitude in the backward
direction with few ambiguities.Comment: 7 pages with 3 figure
Mutability and mutational spectrum of chromosome transmission fidelity genes
It has been more than two decades since the original chromosome transmission fidelity (Ctf) screen of Saccharomyces cerevisiae was published. Since that time the spectrum of mutations known to cause Ctf and, more generally, chromosome instability (CIN) has expanded dramatically as a result of systematic screens across yeast mutant arrays. Here we describe a comprehensive summary of the original Ctf genetic screen and the cloning of the remaining complementation groups as efforts to expand our knowledge of the CIN gene repertoire and its mutability in a model eukaryote. At the time of the original screen, it was impossible to predict either the genes and processes that would be overrepresented in a pool of random mutants displaying a Ctf phenotype or what the entire set of genes potentially mutable to Ctf would be. We show that in a collection of 136 randomly selected Ctf mutants, >65% of mutants map to 13 genes, 12 of which are involved in sister chromatid cohesion and/or kinetochore function. Extensive screening of systematic mutant collections has shown that ~350 genes with functions as diverse as RNA processing and proteasomal activity mutate to cause a Ctf phenotype and at least 692 genes are required for faithful chromosome segregation. The enrichment of random Ctf alleles in only 13 of ~350 possible Ctf genes suggests that these genes are more easily mutable to cause genome instability than the others. These observations inform our understanding of recurring CIN mutations in human cancers where presumably random mutations are responsible for initiating the frequently observed CIN phenotype of tumors
Antimatter Regions in the Early Universe and Big Bang Nucleosynthesis
We have studied big bang nucleosynthesis in the presence of regions of
antimatter. Depending on the distance scale of the antimatter region, and thus
the epoch of their annihilation, the amount of antimatter in the early universe
is constrained by the observed abundances. Small regions, which annihilate
after weak freezeout but before nucleosynthesis, lead to a reduction in the 4He
yield, because of neutron annihilation. Large regions, which annihilate after
nucleosynthesis, lead to an increased 3He yield. Deuterium production is also
affected but not as much. The three most important production mechanisms of 3He
are 1) photodisintegration of 4He by the annihilation radiation, 2) pbar-4He
annihilation, and 3) nbar-4He annihilation by "secondary" antineutrons produced
in anti-4He annihilation. Although pbar-4He annihilation produces more 3He than
the secondary nbar-4He annihilation, the products of the latter survive later
annihilation much better, since they are distributed further away from the
annihilation zone.Comment: 15 pages, 9 figures. Minor changes to match the PRD versio
Response of AGATA Segmented HPGe Detectors to Gamma Rays up to 15.1 MeV
The response of AGATA segmented HPGe detectors to gamma rays in the energy
range 2-15 MeV was measured. The 15.1 MeV gamma rays were produced using the
reaction d(11B,ng)12C at Ebeam = 19.1 MeV, while gamma-rays between 2 to 9 MeV
were produced using an Am-Be-Fe radioactive source. The energy resolution and
linearity were studied and the energy-to-pulse-height conversion resulted to be
linear within 0.05%. Experimental interaction multiplicity distributions are
discussed and compared with the results of Geant4 simulations. It is shown that
the application of gamma-ray tracking allows a suppression of background
radiation following neutron capture by Ge nuclei. Finally the Doppler
correction for the 15.1 MeV gamma line, performed using the position
information extracted with Pulse-shape Analysis, is discussed.Comment: 10 pages, 11 figure
The Rts1 Regulatory Subunit of Protein Phosphatase 2A Is Required for Control of G1 Cyclin Transcription and Nutrient Modulation of Cell Size
The key molecular event that marks entry into the cell cycle is transcription of G1 cyclins, which bind and activate cyclin-dependent kinases. In yeast cells, initiation of G1 cyclin transcription is linked to achievement of a critical cell size, which contributes to cell-size homeostasis. The critical cell size is modulated by nutrients, such that cells growing in poor nutrients are smaller than cells growing in rich nutrients. Nutrient modulation of cell size does not work through known critical regulators of G1 cyclin transcription and is therefore thought to work through a distinct pathway. Here, we report that Rts1, a highly conserved regulatory subunit of protein phosphatase 2A (PP2A), is required for normal control of G1 cyclin transcription. Loss of Rts1 caused delayed initiation of bud growth and delayed and reduced accumulation of G1 cyclins. Expression of the G1 cyclin CLN2 from an inducible promoter rescued the delayed bud growth in rts1Δ cells, indicating that Rts1 acts at the level of transcription. Moreover, loss of Rts1 caused altered regulation of Swi6, a key component of the SBF transcription factor that controls G1 cyclin transcription. Epistasis analysis revealed that Rts1 does not work solely through several known critical upstream regulators of G1 cyclin transcription. Cells lacking Rts1 failed to undergo nutrient modulation of cell size. Together, these observations demonstrate that Rts1 is a key player in pathways that link nutrient availability, cell size, and G1 cyclin transcription. Since Rts1 is highly conserved, it may function in similar pathways in vertebrates
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