Effect on hypnotic prescribing of a quality improvement collaborative for primary care of insomnia: segmented regression analysis

Introduction Patients with insomnia commonly present to general practice. Hypnotic misuse and underuse of psychological treatments demonstrates scope for improved care. To explore this, we undertook a feasibility study using a Quality Improvement Collaborative (QIC) across 8 general practices, investigating the effect of implementing sleep assessment and psychological interventions on hypnotic prescribing. Methods We used a before-after analysis of the time series of prescribing of benzodiazepines (e.g. diazepam, temazepam, lorazepam) and Z-drugs (e.g. zopiclone, zolpidem, zaleplon) across intervention practices. We contrasted results with those for 8 control practices not subject to the QIC. Data were constructed as average daily quantity of hypnotic prescribed per Specific Therapeutic group Age-sex weightings Related Prescribing Unit (STAR–PU) for the period October 2005 to March 2010. Modelling was by 2-segment intercept-trend regression performed on the 24 month periods either side of the 6-month operation of the QIC (October 2007 to March 2008). Estimation was by either least squares or corrected using the Prais-Winsten method if error serial correlation was present in the errors. We then jointly re-estimated across all intervention practices (repeated on all control practices) using seemingly unrelated regressions to allow for any potential correlations in the models’ errors. Testing whether the intervention had been successful in inducing a structural break such that post-QIC prescribing of either drug was reduced, we constructed a bespoke test S based on the mean prediction error in the post-QIC period for aggregated intervention practices. Results Comparing the two prescribing periods, there was a noteworthy and significant reduction in benzodiazepine prescribing in intervention practices over the shorter post-QIC term of 12 months (S=-2.46, p=0.007), but this was not sustained for the full 24 months post-QIC (S=-0.72, p=0.236). However, for Z-drugs prescribing reductions in intervention practices were sustained into the longer post-QIC period (12 months: S=-1.98, p=0.024; 24 months, S=-1.90, p=0.029). The before-after comparison to control practices showed no significant reduction in prescribing of either drug. Conclusion Efficacy of the QIC in reducing hypnotic prescribing was shown, giving support to the need for a full scale trial. Varying length of persistence of outcomes warrants attention

STM Observation of the Si(111) - (7×7) Reconstructed Surface Modified by Excess Phosphorus Doping

The electronic properties of semiconductor surfaces change readily upon changing the carrier densities by controlling the dopant concentration. Additionally, excess dopant atoms can exert electric field which would affect the molecular adsorption process and could be used to manipulate the dynamic movement of confined molecules. A mechanism can be developed to control the molecular dynamic movement on modified semiconductor surface by dopants thus changing the effect of the electric field on the active molecules.  In this study, the Si(111) surface was doped with phosphorus excessively using thermal diffusion process. The surface was then reconstructed to the 7 × 7 configuration via heating under UHV conditions and then studied through STM and STS techniques. The protrusions due to surface and subsurface P atoms appear brighter due to the lone electron pair. The 7 × 7 reconstruction would be destabilized after a critical P substitution of Si-adatom concentration due to high surface strain result in P-terminated (6√3 × 6√3)R30º reconstruction

Querying the Queer: A Study of the Queer Identity in the Sri Lankan English Novel

Employing the insights gleaned from queer theory, this paper engages with the literary representation of tabooed sexualities by scrutinizing the depiction of the queer character in the postIndependence Sri Lankan novel. The methodology of the study is based on a textual examination. The primary texts under scrutiny are three texts by the two pioneers of the Sri Lankan English novel, Punyakanthi Wijenaike (Giraya and Amulet) and James Goonewardena (An Asian Gambit); in which one finds the earliest appearance of the queer character in Sri Lankan English fiction. In a nutshell, the paper examines how these authors negotiate with what the feminist critics term, “the perceptual screen provided by our patriarchal cultural conditioning” by attempting to see if the works of these authors hold any subversive potential. This end is achieved by examining whether the depiction of the queer character in the novels of these authors is employed as a means of tracing a redefinition or a reaffirmation of the patriarchal social institutions such as love and family. In the exploration it becomes evident that especially in Wijenaike’s work there is a critical recognition the discriminatory aspects of certain patriarchal institutions. Nevertheless, the study unearths that in spite of the authors’ ostensibly radical move of engaging with tabooed sexualities in the Sri Lankan society in their novels, their depiction of the queer character is predominantly governed by homophobic, heterosexist undercurrents. It is hoped that this paper will throw new light on the preoccupations of the Sri Lankan English writers, enable new readings of old texts, and illuminate a previously unexplored area of experience in Sri Lankan English fiction.Key words: Sri Lankan novel, queer, homosexuality, identity, gender studie

Effectiveness and cost-effectiveness of an educational intervention for practice teams to deliver problem focused therapy for insomnia: rationale and design of a pilot cluster randomised trial

Background: Sleep problems are common, affecting over a third of adults in the United Kingdom and leading to reduced productivity and impaired health-related quality of life. Many of those whose lives are affected seek medical help from primary care. Drug treatment is ineffective long term. Psychological methods for managing sleep problems, including cognitive behavioural therapy for insomnia (CBTi) have been shown to be effective and cost effective but have not been widely implemented or evaluated in a general practice setting where they are most likely to be needed and most appropriately delivered. This paper outlines the protocol for a pilot study designed to evaluate the effectiveness and cost-effectiveness of an educational intervention for general practitioners, primary care nurses and other members of the primary care team to deliver problem focused therapy to adult patients presenting with sleep problems due to lifestyle causes, pain or mild to moderate depression or anxiety. Methods and design: This will be a pilot cluster randomised controlled trial of a complex intervention. General practices will be randomised to an educational intervention for problem focused therapy which includes a consultation approach comprising careful assessment (using assessment of secondary causes, sleep diaries and severity) and use of modified CBTi for insomnia in the consultation compared with usual care (general advice on sleep hygiene and pharmacotherapy with hypnotic drugs). Clinicians randomised to the intervention will receive an educational intervention (2 × 2 hours) to implement a complex intervention of problem focused therapy. Clinicians randomised to the control group will receive reinforcement of usual care with sleep hygiene advice. Outcomes will be assessed via self-completion questionnaires and telephone interviews of patients and staff as well as clinical records for interventions and prescribing. Discussion: Previous studies in adults have shown that psychological treatments for insomnia administered by specialist nurses to groups of patients can be effective within a primary care setting. This will be a pilot study to determine whether an educational intervention aimed at primary care teams to deliver problem focused therapy for insomnia can improve sleep management and outcomes for individual adult patients presenting to general practice. The study will also test procedures and collect information in preparation for a larger definitive cluster-randomised trial. The study is funded by The Health Foundation

Interdependence of Logistics and Tourism: Crafting a Novel Logistics Concept in Tourism

A literal gap has been identified between the concepts of tourism and logistics. Tourism Industry is a dependent industry on Transport, logistics and global supply chain. While all transport modes play an almost equal role of moving the tourists from place to place, logistics plays an indispensable role regarding supply of goods required to fulfil the hospitality needs of tourists. As far as cruise tourism is concerned the entire business model is designed through logistics. Therefore, for the tourism sector to run smoothly the efficient logistics service is required. However, the dependency of the logistics services in an active tourism industry is not explicit other than cruise tourism. This paper reveals a novel concept namely, Tourism Logistics that illustrates the interdependence of Logistics and Tourism. Desk research has been conducted to identify the interdependency of two phenomena while taking the contribution of logistics in the overall supply chain is taken to the limelight. The interdependency of transportation, procurement, delivery and warehousing have been shown via analysis of peer reviewed journal articles regarding interdependency of tourism and logistics. A conceptual model has been introduced to identify the interdependency of tourism and logistics functions, delivery, transportation, warehousing and procurement

Primary care treatment of insomnia: study protocol for a pragmatic, multicentre, randomised controlled trial comparing nurse-delivered sleep restriction therapy to sleep hygiene (the HABIT trial).

Introduction Insomnia is a prevalent sleep disorder that negatively affects quality of life. Multicomponent cognitive-behavioural therapy (CBT) is the recommended treatment but access remains limited, particularly in primary care. Sleep restriction therapy (SRT) is one of the principal active components of CBT and could be delivered by generalist staff in primary care. The aim of this randomised controlled trial is to establish whether nurse-delivered SRT for insomnia disorder is clinically and cost-effective compared with sleep hygiene advice. Methods and analysis In the HABIT (Health-professional Administered Brief Insomnia Therapy) trial, 588 participants meeting criteria for insomnia disorder will be recruited from primary care in England and randomised (1:1) to either nurse-delivered SRT (plus sleep hygiene booklet) or sleep hygiene booklet on its own. SRT will be delivered over 4 weekly sessions; total therapy time is approximately 1 hour. Outcomes will be collected at baseline, 3, 6 and 12 months post-randomisation. The primary outcome is self-reported insomnia severity using the Insomnia Severity Index at 6 months. Secondary outcomes include health-related and sleep-related quality of life, depressive symptoms, use of prescribed sleep medication, diary and actigraphy-recorded sleep parameters, and work productivity. Analyses will be intention-to-treat. Moderation and mediation analyses will be conducted and a cost-utility analysis and process evaluation will be performed. Ethics and dissemination Ethical approval was granted by the Yorkshire and the Humber - Bradford Leeds Research Ethics Committee (reference: 18/YH/0153). We will publish our primary findings in high-impact, peer-reviewed journals. There will be further outputs in relation to process evaluation and secondary analyses focussed on moderation and mediation. Trial results could make the case for the introduction of nurse-delivered sleep therapy in primary care, increasing access to evidence-based treatment for people with insomnia disorder

Digital technology to facilitate Proactive Assessment of Obesity Risk during Infancy (ProAsk): a feasibility study

OBJECTIVE: To assess the feasibility and acceptability of using digital technology for Proactive Assessment of Obesity Risk during Infancy (ProAsk) with the UK health visitors (HVs) and parents. DESIGN: Multicentre, pre- and post-intervention feasibility study with process evaluation. SETTING: Rural and urban deprived settings, UK community care. PARTICIPANTS: 66 parents of infants and 22 HVs. INTERVENTION: ProAsk was delivered on a tablet device. It comprises a validated risk prediction tool to quantify overweight risk status and a therapeutic wheel detailing motivational strategies for preventive parental behaviour. Parents were encouraged to agree goals for behaviour change with HVs who received motivational interviewing training. OUTCOME MEASURES: We assessed recruitment, response and attrition rates. Demographic details were collected, and overweight risk status. The proposed primary outcome measure was weight-for-age z-score. The proposed secondary outcomes were parenting self-efficacy, maternal feeding style, infant diet and exposure to physical activity/sedentary behaviour. Qualitative interviews ascertained the acceptability of study processes and intervention fidelity. RESULTS: HVs screened 324/589 infants for inclusion in the study and 66/226 (29%) eligible infants were recruited. Assessment of overweight risk was completed on 53 infants and 40% of these were identified as above population risk. Weight-for-age z-score (SD) between the infants at population risk and those above population risk differed significantly at baseline (-0.67 SD vs 0.32 SD). HVs were able to collect data and calculate overweight risk for the infants. Protocol adherence and intervention fidelity was a challenge. HVs and parents found the information provided in the therapeutic wheel appropriate and acceptable. CONCLUSION: Study recruitment and protocol adherence were problematic. ProAsk was acceptable to most parents and HVs, but intervention fidelity was low. There was limited evidence to support the feasibility of implementing ProAsk without significant additional resources. A future study could evaluate ProAsk as a HV-supported, parent-led intervention. TRIAL REGISTRATION NUMBER: NCT02314494 (Feasibility Study Results).This work was supported by the Medical Research Council – Public Health Intervention Development Scheme, grant number PHIND 01/14-15

Foveal structure and visual function in nanophthalmos and posterior microphthalmos

Background/aims: The reason for visual impairment in patients with nanophthalmos and posterior microphthalmos is not completely understood. Therefore, this study aims to investigate foveal structure, and the impact of demographic, clinical and imaging parameters on best-corrected visual acuity (BCVA) in these conditions. Methods: Sixty-two eyes of 33 patients with nanophthalmos (n=40) or posterior microphthalmos (n=22), and 114 eyes of healthy controls with high-resolution retinal imaging including spectral-domain or swept-source optical coherence tomography images were included in this cross-sectional case-control study. Foveal retinal layer thickness was determined by two independent readers. A mixed-effect model was used to perform structure-function correlations and predict the BCVA based on subject-specific variables. Results: Most patients (28/33) had altered foveal structure associated with loss of foveal avascular zone and impaired BCVA. However, widening of outer nuclear layer, lengthening of photoreceptor outer segments, normal distribution of macular pigment and presence of Henle fibres were consistently found. Apart from the presence of choroidal effusion, which had significant impact on BCVA, the features age, refractive error, axial length and retinal layer thickness at the foveal centre explained 61.7% of the variability of BCVA. Conclusion: This study demonstrates that choroidal effusion, age, refractive error, axial length and retinal layer thickness are responsible for the majority of interindividual variability of BCVA as well as the morphological foveal heterogeneity in patients with nanophthalmos or posterior microphthalmos. This might give further insights into the physiology of foveal development and the process of emmetropisation, and support clinicians in the assessment of these disease entities