Endothelial Cell von Willebrand Factor Secretion in Health and Cardiovascular Disease

The main function of von Willebrand factor (vWF) is to initiate platelet adhesion upon vascular injury. The hallmark of acute and chronical inflammation is the widespread activation of endothelial cells which provokes excessive vWF secretion from the endothelial cell storage pool. The level of vWF in blood not only reflects the state of endothelial activation early on in the pathogenesis, but also predicts disease outcome. Elevation in the blood level of vWF occurs either by pathologic increase in the rate of basal vWF secretion or by increased evoked vWF release from dysfunctional/activated endothelial cells (ECs). The increase in plasma vWF is predictive of prothrombotic complications and multi-organ system failure associated with reduced survival in the context of severe inflammatory response syndrome, type II diabetes mellitus, stroke and other inflammatory cardiovascular disease states. This chapter focuses on the role of high circulating vWF levels in thrombotic and inflammatory disease while paying attention to the emerging vWF-related drug development strategies

Pattern formation in annular convection

This study of spatio-temporal pattern formation in an annulus is motivated by two physical problems on vastly different scales. The first is atmospheric convection in the equatorial plane between the warm surface of the Earth and the cold tropopause, modeled by the two dimensional Boussinesq equations. The second is annular electroconvection in a thin semetic film, where experiments reveal the birth of convection-like vortices in the plane as the electric field intensity is increased. This is modeled by two dimensional Navier-Stokes equations coupled with a simplified version of Maxwell's equations. The two models share fundamental mathematical properties and satisfy the prerequisites for application of O(2)-equivariant bifurcation theory. We show this can give predictions of interesting dynamics, including stationary and spatio-temporal patterns

How to Display Group Information on Node-Link Diagrams: An Evaluation

We present the results of evaluating four techniques for displaying group or cluster information overlaid on node-link diagrams: node coloring, GMap, BubbleSets, and LineSets. The contributions of the paper are three fold. First, we present quantitative results and statistical analyses of data from an online study in which approximately 800 subjects performed 10 types of group and network tasks in the four evaluated visualizations. Specifically, we show that BubbleSets is the best alternative for tasks involving group membership assessment; that visually encoding group information over basic node-link diagrams incurs an accuracy penalty of about 25 percent in solving network tasks; and that GMap's use of prominent group labels improves memorability. We also show that GMap's visual metaphor can be slightly altered to outperform BubbleSets in group membership assessment. Second, we discuss visual characteristics that can explain the observed quantitative differences in the four visualizations and suggest design recommendations. This discussion is supported by a small scale eye-tracking study and previous results from the visualization literature. Third, we present an easily extensible user study methodology

Endothelial expression of c-kit and CD68 in dental follicles of human impacted third molars

Background: Periodontal tissue remnants of odontogenesis constitute the dental follicle (DF) which is actually considered a stem niche in adults. However, potentialities of local endothelia within this niche seem overlooked. We thus aimed at testing the endothelial cells expression of c-kit, the progenitor cells marker, and CD68, commonly regarded as a monocyte/macrophage marker, in human DFs.Materials and methods: We performed an immunohistochemical study using these two markers which were applied on samples collected from ten adult patients.Results: The markers were positively expressed in endothelial cells, as well as in spindle-shaped stromal cells of the DF.Conclusions: The origin of DF stem or progenitor cells needs reviewing in the light of these findings, as endothelium could be a donor site for niche inhabitants