Exposure to males, but not receipt of sex peptide, accelerates functional aging in female fruit flies

1. Increased exposure to males can affect females negatively, reducing female life span and fitness. These costs could derive from increased mating rate and also harassment by males. Additionally, early investment in reproduction can increase the onset or rate of senescence in reproductive traits. Hence, there is a tight link between reproduction and ageing. 2. Here, we assess how mating and encounter rate with males impacts declines in female functional traits that are not directly involved in reproduction. In Drosophila melanogaster fruit flies, exposure to males and mating reduces female life span through harassment and receipt of seminal proteins, including sex peptide (SP). We manipulated the intensity of female exposure to males and regularly assessed female stress responses and recorded physiological traits over her lifetime. 3. Both mating itself and increased exposure to males accelerate declines in female climbing ability and starvation resistance. However, this is not related to changes in female body mass or fat storage. Moreover, these declines are not driven by the receipt of SP. 4. Our results suggest some synchrony in senescence across traits in response to female exposure to males; however, this is not universal, as we did not find this for physiological traits. Synchrony in senescence has been theorized but little supported in the literature. It is clear that ageing is a multifaceted trait; to understand environmental impacts on ageing rates, we must measure more than life span and indeed measure senescence in multiple traits. Specifically, our work shows that we must identify which female traits are sensitive to elevated mating activity to understand the impact of antagonistic interactions between the sexes on female ageing patterns

Convergent Chaos

Chaos is widely understood as being a consequence of sensitive dependence upon initial conditions. This is the result of an instability in phase space, which separates trajectories exponentially. Here, we demonstrate that this criterion should be refined. Despite their overall intrinsic instability, trajectories may be very strongly convergent in phase space over extremely long periods, as revealed by our investigation of a simple chaotic system (a realistic model for small bodies in a turbulent flow). We establish that this strong convergence is a multi-facetted phenomenon, in which the clustering is intense, widespread and balanced by lacunarity of other regions. Power laws, indicative of scale-free features, characterize the distribution of particles in the system. We use large-deviation and extreme-value statistics to explain the effect. Our results show that the interpretation of the 'butterfly effect' needs to be carefully qualified. We argue that the combination of mixing and clustering processes makes our specific model relevant to understanding the evolution of simple organisms. Lastly, this notion of convergent chaos, which implies the existence of conditions for which uncertainties are unexpectedly small, may also be relevant to the valuation of insurance and futures contracts

The effects of graded levels of calorie restriction : VIII. impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse

We are grateful to the animal house staff for looking after the animals. The work was supported by the UK Biotechnology and Biological Sciences Research Council BBSRC (grants BB/G009953/1 and BB/J020028/1) to JRS and SEM. DD was supported by a studentship from the Centre for Genome Enabled Biology and Medicine, Aberdeen, UK, and CG was supported by a BBSRC EastBio studentship. Joint meetings were funded by a BBSRC China partnering award (BB/JO20028/1).Peer reviewedPublisher PD

The effects of graded levels of calorie restriction : I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse

We acknowledge the BSU staff for their invaluable help with caring for the animals and anonymous referees for their inputs. The work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) of the UK (Standard grant BB/G009953/1 and China partnering award BB/JO20028/1). The authors declare no competing interests.Peer reviewedPublisher PD

Stability of Repulsive Bose-Einstein Condensates in a Periodic Potential

The cubic nonlinear Schr\"odinger equation with repulsive nonlinearity and an elliptic function potential models a quasi-one-dimensional repulsive dilute gas Bose-Einstein condensate trapped in a standing light wave. New families of stationary solutions are presented. Some of these solutions have neither an analog in the linear Schr\"odinger equation nor in the integrable nonlinear Schr\"odinger equation. Their stability is examined using analytic and numerical methods. All trivial-phase stable solutions are deformations of the ground state of the linear Schr\"odinger equation. Our results show that a large number of condensed atoms is sufficient to form a stable, periodic condensate. Physically, this implies stability of states near the Thomas-Fermi limit.Comment: 12 pages, 17 figure

Conditional stability of unstable viscous shock waves in compressible gas dynamics and MHD

Extending our previous work in the strictly parabolic case, we show that a linearly unstable Lax-type viscous shock solution of a general quasilinear hyperbolic--parabolic system of conservation laws possesses a translation-invariant center stable manifold within which it is nonlinearly orbitally stable with respect to small $L^1\cap H^3$ perturbations, converging time-asymptotically to a translate of the unperturbed wave. That is, for a shock with $p$ unstable eigenvalues, we establish conditional stability on a codimension-$p$ manifold of initial data, with sharp rates of decay in all $L^p$. For $p=0$, we recover the result of unconditional stability obtained by Mascia and Zumbrun. The main new difficulty in the hyperbolic--parabolic case is to construct an invariant manifold in the absence of parabolic smoothing.Comment: 32p

Inhomogeneous magnetization in dipolar ferromagnetic liquids

At high densities fluids of strongly dipolar spherical particles exhibit spontaneous long-ranged orientational order. Typically, due to demagnetization effects induced by the long range of the dipolar interactions, the magnetization structure is spatially inhomogeneous and depends on the shape of the sample. We determine this structure for a cubic sample by the free minimization of an appropriate microscopic density functional using simulated annealing. We find a vortex structure resembling four domains separated by four domain walls whose thickness increases proportional to the system size L. There are indications that for large L the whole configuration scales with the system size. Near the axis of the mainly planar vortex structure the direction of the magnetization escapes into the third dimension or, at higher temperatures, the absolute value of the magnetization is strongly reduced. Thus the orientational order is characterized by two point defects at the top and the bottom of the sample, respectively. The equilibrium structure in an external field and the transition to a homogeneous magnetization for strong fields are analyzed, too.Comment: 17 postscript figures included, submitted to Phys. Rev.

Stability of Attractive Bose-Einstein Condensates in a Periodic Potential

Using a standing light wave trap, a stable quasi-one-dimensional attractive dilute-gas Bose-Einstein condensate can be realized. In a mean-field approximation, this phenomenon is modeled by the cubic nonlinear Schr\"odinger equation with attractive nonlinearity and an elliptic function potential of which a standing light wave is a special case. New families of stationary solutions are presented. Some of these solutions have neither an analog in the linear Schr\"odinger equation nor in the integrable nonlinear Schr\"odinger equation. Their stability is examined using analytic and numerical methods. Trivial-phase solutions are experimentally stable provided they have nodes and their density is localized in the troughs of the potential. Stable time-periodic solutions are also examined.Comment: 12 pages, 18 figure

No Intra-Locus Sexual Conflict over Reproductive Fitness or Ageing in Field Crickets

Differences in the ways in which males and females maximize evolutionary fitness can lead to intra-locus sexual conflict in which genes delivering fitness benefits to one sex are costly when expressed in the other. Trade-offs between current reproductive effort and future reproduction and survival are fundamental to the evolutionary biology of ageing. This leads to the prediction that sex differences in the optimization of age-dependent reproductive effort may generate intra-locus sexual conflict over ageing rates. Here we test for intra-locus sexual conflict over age-dependent reproductive effort and longevity in the black field cricket, Teleogryllus commodus. Using a half-sib breeding design, we show that the most important components of male and female reproductive effort (male calling effort and the number of eggs laid by females) were positively genetically correlated, especially in early adulthood. However, the genetic relationships between longevity and reproductive effort were different for males and females, leading to low genetic covariation between male and female longevity. The apparent absence of intra-locus sexual conflict over ageing suggests that male and female longevity can evolve largely independently of one another