Formal and Informal Volunteering and Health in Mediterranean Europe

In this paper, we compare the correlation among formal and informal volunteering and self-perceived health across Mediterranean European countries after controlling for socio-economic characteristics, housing features, neighborhood quality, size of municipality, social and cultural participation and regional dummies. We find that informal volunteering has a significant, positive correlation with self-perceived health in France, Spain, Greece and a significant, negative relationship in Italy

Afterglows from precursors in Gamma Ray Bursts. Application to the optical afterglow of GRB 091024

About 15% of Gamma Ray Bursts have precursors, i.e. emission episodes preceding the main event, whose spectral and temporal properties are similar to the main emission. We propose that precursors have their own fireball, producing afterglow emission due to the dissipation of the kinetic energy via external shock. In the time lapse between the precursor and the main event, we assume that the central engine is not completely turned off, but it continues to eject relativistic material at a smaller rate, whose emission is below the background level. The precursor fireball generates a first afterglow by the interaction with the external circumburst medium. Matter injected by the central engine during the "quasi-quiescent" phase replenishes the external medium with material in relativistic motion. The fireball corresponding to the main prompt emission episode crashes with this moving material, producing a second afterglow, and finally catches up and merges with the first precursor fireball. We apply this new model to GRB 091024, an event with a precursor in the prompt light curve and two well defined bumps in the optical afterglow, obtaining an excellent agreement with the existing data.Comment: 11 pages, 6 figures, 3 tables. Accepted for publication in MNRAS, Main Journa

Unveiling the population of orphan Gamma Ray Bursts

Gamma Ray Bursts are detectable in the gamma-ray band if their jets are oriented towards the observer. However, for each GRB with a typical theta_jet, there should be ~2/theta_jet^2 bursts whose emission cone is oriented elsewhere in space. These off-axis bursts can be eventually detected when, due to the deceleration of their relativistic jets, the beaming angle becomes comparable to the viewing angle. Orphan Afterglows (OA) should outnumber the current population of bursts detected in the gamma-ray band even if they have not been conclusively observed so far at any frequency. We compute the expected flux of the population of orphan afterglows in the mm, optical and X-ray bands through a population synthesis code of GRBs and the standard afterglow emission model. We estimate the detection rate of OA by on-going and forthcoming surveys. The average duration of OA as transients above a given limiting flux is derived and described with analytical expressions: in general OA should appear as daily transients in optical surveys and as monthly/yearly transients in the mm/radio band. We find that ~ 2 OA yr^-1 could already be detected by Gaia and up to 20 OA yr^-1 could be observed by the ZTF survey. A larger number of 50 OA yr^-1 should be detected by LSST in the optical band. For the X-ray band, ~ 26 OA yr^-1 could be detected by the eROSITA. For the large population of OA detectable by LSST, the X-ray and optical follow up of the light curve (for the brightest cases) and/or the extensive follow up of their emission in the mm and radio band could be the key to disentangle their GRB nature from other extragalactic transients of comparable flux density.Comment: 9 pages, 4 figures, 2 tables. Accepted for publication by Astronomy and Astrophysic

Quality of life in alopecia areata: A disease-specific questionnaire

Background Alopecia areata (AA) is an autoimmune disease affecting about 2% of the population, which has a considerable impact on quality of life (QoL). There are no disease-specific questionnaires to assess QoL in patients suffering from AA. Objective To validate a new disease-specific questionnaire for AA, named AA-QLI, and to compare the consequent Quality of Life Index (QLI) with the commonly known Dermatology Life Quality Index (DLQI) to verify if it can provide a more comprehensive tool for patients. Methods A total of 50 patients affected by AA were administered both the AA-QLI, created by us, and the well-known DLQI. With the aim to detect suitable QLI, we propose to use two multivariate analyses: a principal component analysis approach on the data collected with both questionnaires to compare their capability to measure the QoL; a structural equation modelling on our AA-QLI to identify which category of symptoms mostly affects the QoL. Results The scores of both the questionnaires are quite close, except for a few cases. Statistical analysis shows a higher specificity of the AA-QLI for evaluating QoL. Among the three areas in which AA-QLI is divided, 'Relationship' has a major impact on the QLI, followed by 'Subjective symptoms'; 'Objective signs' has a lower weight on the QLI. Conclusion AA-QLI is a good instrument to evaluate the real impact of AA on QoL. It can be helpful both for the physician and for the patient. © 2012 European Academy of Dermatology and Venereology

Short GRBs at the dawn of the gravitational wave era

We derive the luminosity function and redshift distribution of short Gamma Ray Bursts (SGRBs) using (i) all the available observer-frame constraints (i.e. peak flux, fluence, peak energy and duration distributions) of the large population of Fermi SGRBs and (ii) the rest-frame properties of a complete sample of Swift SGRBs. We show that a steep $\phi(L)\propto L^{-a}$ with a>2.0 is excluded if the full set of constraints is considered. We implement a Monte Carlo Markov Chain method to derive the $\phi(L)$ and $\psi(z)$ functions assuming intrinsic Ep-Liso and Ep-Eiso correlations or independent distributions of intrinsic peak energy, luminosity and duration. To make our results independent from assumptions on the progenitor (NS-NS binary mergers or other channels) and from uncertainties on the star formation history, we assume a parametric form for the redshift distribution of SGRBs. We find that a relatively flat luminosity function with slope ~0.5 below a characteristic break luminosity ~3$\times10^{52}$ erg/s and a redshift distribution of SGRBs peaking at z~1.5-2 satisfy all our constraints. These results hold also if no Ep-Liso and Ep-Eiso correlations are assumed. We estimate that, within ~200 Mpc (i.e. the design aLIGO range for the detection of GW produced by NS-NS merger events), 0.007-0.03 SGRBs yr$^{-1}$ should be detectable as gamma-ray events. Assuming current estimates of NS-NS merger rates and that all NS-NS mergers lead to a SGRB event, we derive a conservative estimate of the average opening angle of SGRBs: $\theta_{jet}$~3-6 deg. Our luminosity function implies an average luminosity L~1.5$\times 10^{52}$ erg/s, nearly two orders of magnitude higher than previous findings, which greatly enhances the chance of observing SGRB "orphan" afterglows. Efforts should go in the direction of finding and identifying such orphan afterglows as counterparts of GW events.Comment: 13 pages, 5 figures, 2 tables. Accepted for publication in Astronomy & Astrophysics. Figure 5 and angle ranges corrected in revised versio

FFAs and QT intervals in obese women with visceral adiposity: Effects of sustained weight loss over 1 year

We evaluated 66 obese patients grouped by waist-to-hip ratio (WHR) into group A (WHR > 0.85, n = 30) and group B (WHR ≤ 0.85, n = 36), before and after 1 yr of diet-induced weight loss compared with 25 nonobese women. Before diet, the longest values of QT intervals and the highest levels of FFA and catecholamines were in group A (P < 0.01). In obese women (both groups), the corrected QT (QTc); interval correlated with plasma FFA (P < 0.01) and catecholamine (P < 0.02) concentrations. After 1 yr of diet, at the same levels of body weight reduction, the decrement of the QTc interval (P < 0.02), FFA (P < 0.01) and catecholamine (P < 0.02) levels were significantly greater in-group A than group B. In multivariate analysis, the decline of the QTc interval after weight loss was associated with changes in plasma FFA independently of changes in WHR and plasma catecholamines. Our data suggest that the QTc interval is tightly correlated with plasma FFA levels; shortening of cardiac repolarization times in the course of long-lasting weight reduction may reduce the risk of ventricular electrical instability, especially in women with abdominal adiposity

The high-redshift gamma-ray burst GRB140515A

High-redshift gamma-ray bursts have several advantages for the study of the distant universe, providing unique information about the structure and properties of the galaxies in which they exploded. Spectroscopic identification with large ground-based telescopes has improved our knowledge of the class of such distant events. We present the multi-wavelength analysis of the high-$z$ Swift gamma-ray burst GRB140515A ($z = 6.327$). The best estimate of the neutral hydrogen fraction of the intergalactic medium (IGM) towards the burst is $x_{HI} \leq 0.002$. The spectral absorption lines detected for this event are the weakest lines ever observed in gamma-ray burst afterglows, suggesting that GRB140515A exploded in a very low density environment. Its circum-burst medium is characterised by an average extinction (A$_{\rm V} \sim 0.1$) that seems to be typical of $z \ge 6$ events. The observed multi-band light curves are explained either with a very flat injected spectrum ($p = 1.7$) or with a multi-component emission ($p = 2.1$). In the second case a long-lasting central engine activity is needed in order to explain the late time X-ray emission. The possible origin of GRB140515A from a Pop III (or from a Pop II stars with local environment enriched by Pop III) massive star is unlikely.Comment: 10 pages, 8 figures, 5 tables, submitted to Astronomy & Astrophysic

How neuronal migration contributes to the morphogenesis of the CNS: insights from the zebrafish

We used transgenic zebrafish expressing GFP or YFP in subpopulations of neurons to study the migration, homing process and axon extension of groups of CNS neurons in different regions of the zebrafish brain. We found that extensive migration takes place at all levels of the CNS and gives rise to nuclei or cell populations with specific identities. Here, we describe 4 previously unknown or only partially characterized migratory events taking place in the zebrafish telencephalon and rhombic lip, using 3 different transgenic lines, and identify the phenotypes of the cells undertaking these migrations. The migration of a subgroup of mitral cell precursors from the dorsocaudal telencephalon to the olfactory bulb, visualized in the tg(tbr1:YFP) transgenic line, is coupled with morphogenetic transformation of the dorsal telencephalon. The tg(1.4dlx5a-6a:GFP) transgenic line provides a means to analyze the migration of GABAergic interneurons from the ventral to the dorsal telencephalon, thus extending the occurrence of this migration to another vertebrate. The tg(Xeom:GFP) transgenic line provides the first demonstration of the dorsoventral migration of glutamatergic septal neurons, present in mammals and now described in fish, thus reconciling the contrasting evidence of dorsal patterning genes (tbr1, eomes) expressed in a ventral cell population. Furthermore, migration studies in the tg(1.4dlx5a-6a:GFP) and tg(Xeom:GFP) lines help determine the origin of 2 important cell populations in the fish cerebellum: projection neurons and Purkinje cells. These examples reinforce the concept that migratory events contribute to the distribution of cell types with diverse identities through the CNS and that zebrafish transgenic lines represent excellent tools to study these events. Copyrigh