Estudio de la biocompatibilidad de una nueva aleación beta-titanio de bajo módulo de elasticidad

Peer Reviewe

Implications of instructional strategies in sport teaching: a nonlinear pedagogy-based approach

In this article, we have tried to establish the practical implications of instructional strategies in sport teaching. Firstly, we have highlighted the importance of the Teaching Game for Understanding as a teaching model that is fundamentally based on the use of modified games, whose purpose is for students to learn the tactical aspects of a certain sport, by way of modified versions of the real game. Later on, we have gone further into depth into a new way of understanding the teaching-learning process in sport, non-Linear Pedagogy, which is based on manipulating the relevant determining factors (task, environment and individual) to increase information sources and thus be able to guide students towards obtaining their objectives. Within non-linear pedagogy, verbal instruction (e.g., questioning) is considered to be a determining factor that attempts to channel the search for tactical solutions within a learning environment. Finally, we end the article with a section that refers to practical applications, where we purport to give a series of guidelines on how to implement questioning as a didactical resource whose aim is to improve students’ tactical action capacity

Museos para la "glocalidad": Una propuesta de museo que ayude a analizar los problemas de una región dada en el marco de la situación del mundo

Se contempla en este trabajo la posibilidad de una reorientación de los museos con el fin de que puedan contribuir a la formación ciudadana para hacer frente a la actual situación de emergencia planetaria a partir del nuevo concepto de "glocalidad", como expresión de la estrecha vinculación entre los problemas globales del planeta y los locales de cualquier región. Se ilustra la posibilidad de esta orientación analizando, como ejemplo, el contenido del "Manitoba Museum of Man and Nature", en Winnipeg (Canadá).Palabras Clave: Museos de Ciencia. Museos etnológicos. Relaciones Ciencia, Tecnología, Sociedad y Ambiente. Emergencia planetaria. Sostenibilidad.Museums for "glocality": A museum proposal to analyze the problems of a region in the context of the world situationWe envisage in this paper the possibility of a new orientation of museums which contribute to citizens’ education to face the current situation of planetary emergency, applying the new concept of "glocality" as an expression of the close connection between global problems of the Earth and the local ones of any region. We illustrate the possibility of such an orientation analysing the content of the Manitoba Museum of Man and Nature, exhibited in Winnipeg (Canada).Key words: Science Museums. Ethnological Museums. Science-Technology-Society-Environment Relationships. Planetary emergency. Sustainability

Las exposiciones y museos de ciencias como instrumentos de reflexión sobre los problemas del planeta

Reseñ

Saharan Air Layer (SAL) over Tenerife: summertime statistic analysis from lidar measurements

Comunicación presentada en: 2012 European Aerosol Conference (EAC-2012), B-WG01S2P30, celebrada del 2 al 7 de septiembre de 2012 en Granada.This work is supported by the Spanish Ministry for Research and Innovation (MICINN) under grant CGL2011-24891 (project AMISOC)

Antioxidants and Oxidative Stress in Children: Influence of Puberty and Metabolically Unhealthy Status

Oxidative stress could help explain the relationship between childhood obesity and a metabolically unhealthy (MU) status. Moreover, puberty could also influence this relationship, since it entails physiological cardiometabolic changes. We aimed to evaluate plasma antioxidants and oxidative stress biomarkers in MU and metabolically healthy (MH) prepubertal and pubertal children and their associations with pro-inflammatory and endothelial damage biomarkers, taking puberty into account. A total of 1444 Spanish children aged 3–17 years (48.9% males, 66% prepubertal, 47.1% with obesity) were recruited. Blood pressure, anthropometric and biochemical parameters were measured, and children were categorized as having a MU or MH status according to risk factors. Retinol, carotenes, tocopherols, total antioxidant capacity (TAC), oxidized low-density lipoprotein and selected pro-inflammatory and endothelial damage biomarkers were analyzed. General linear models adjusted for age, sex, recruitment center and body mass index, partial correlations and stepwise linear regressions were performed. Lower carotenes and tocopherols levels were found in MU than in MH children. Plasma TAC was lower in prepubertal and higher in pubertal children with obesity compared to normal-weight children. Antioxidants and oxidative stress biomarkers showed novel associations with several pro-inflammatory and endothelial damage biomarkers, with pubertal differences, supporting the importance of considering both the antioxidant and oxidative stress status and puberty in the prevention of metabolic diseases in childhood.Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I + D + I), Instituto de Salud Carlos III-Health Research Funding (FONDOS FEDER) PI051968 PI11/01425 PI1102042 PI11/02059 PI16/01301 PI16/012 PI1600871CIBEROBN Network CB12/03/30038 CB15/00131 CB15/0004

Prediction of the transmission loss in a flexible chamber

[EN] Acoustic components have been extensively studied supposing perfectly rigid behavior. Although some works have been performed for the radiated sound in the case of a flexible element, an important lack of information exists concerning transmission loss analysis. The current investigation proposes the study for a generic flexible expansion chamber. The analysis has been performed using two different methods: a resolution in the time domain, using a Finite Volume discretization for the fluid domain and a Finite Element discretization for the solid domain, and an approach in the frequency domain, using a Finite Element discretization for both fluid and solid. After studying the rigid case in order to tune up the simulation, the study of the flexible case shows a good agreement among both methods. The comparison of rigid and flexible expansion chambers shows the importance of accounting for these phenomena when the frequency content of the acoustic signal excites the natural modes of the structure.This work has been partially supported by the Spanish Ministerio de Economia y Competitividad through Grant No. DPI2015-70464-R and Generalitat Valenciana by means of project Prometeo/2016/007.Torregrosa, AJ.; Gil, A.; García-Cuevas González, LM.; Quintero-Igeño, P.; Denia, FD. (2018). Prediction of the transmission loss in a flexible chamber. Journal of Fluids and Structures. 82:134-153. https://doi.org/10.1016/j.jfluidstructs.2018.07.003S1341538

Optimal Power Flow for radial and mesh grids using semidefinite programming

Este artículo presenta una formulación convexa para el problema de flujo de potencia óptimo (Optimal Power Flow-OPF) en sistemas de potencia radiales y enmallados, a través de un modelo matemático basado en programación semidefinida (Semidefinite Programming-SDP), el cual trasforma el modelo cuadrático no convexo del OPF en un modelo convexo relajado, que puede ser solucionado de forma mucho más eficiente. El modelo es implementado en MATLAB usando el paquete de optimización convexa CVX. Los resultados obtenidos son comparados con el modelo no lineal del problema implementado en GAMS y MATPOWER usando cuatro sistemas típicos de la literatura especializada, dos de tipo radial y dos enmallado. Las soluciones encontradas por esta aproximación convexa, son muy cercanas a las respuestas presentadas en la literatura especializada para el modelo no lineal. Este tipo de aproximación permite obtener soluciones de muy buena calidad, muy cercanas a la solución óptima del problema en tiempos computacionales menores y susceptibles de aplicarse en problemas de operación y control en tiempo real.This paper presents a convex formulation for optimal power flow (OPF) in both radial and meshed grids. A semidefinite programming (SDP) approximation transforms the quadratic non-convex model into a relaxed convex quadratic model, which can be more efficiently solved. This model is implemented in MATLAB using the CVX package for convex optimization. The results obtained are compared to the non-linear model of the problem implemented in GAMS and MATPOWER by using four typical systems in specialized literature (two radial and two meshed). SDP approximation demonstrated to provide accurate solutions that are close to an optimal solution of the problem in shorter computational times. Such solutions are applicable to real-time operation and control problems

EXPLORING THE IMPACT OF APOE POLYMORPHISM ON THE MOLECULAR, MORPHOLOGICAL AND FUNCTIONAL PROFILE OF iPSC-DERIVED ASTROCYTES FROM ALZHEIMER'S PATIENTS

Comunicación presentada a FENS Forum 2022Alzheimer¿s disease (AD) is pathologically characterised by the presence of amyloid-beta plaques, neurofibrillary tangles containing hyperphosphorylated Tau protein, neuroinflammation and neuronal death leading to progressive cognitive impairment. The ¿4 allele of the gene encoding apolipoprotein E (APOE), which is mainly expressed in glial cells, is the strongest genetic risk factor for sporadic AD. Increasing evidence has shown that APOE4 may disrupt normal astrocyte activity, potentially contributing to AD pathology, but the impact of different APOE alleles on astrocyte differentiation, maturation and function is not yet fully understood. To go in depth on these questions, we obtained induced pluripotent stem cells (iPSCs) from fibroblasts of AD patients carrying ¿3 and ¿4 alleles (in homozygosis) and from healthy patients. We also used gene-edited iPSC lines homozygous for the main APOE variants and an APOE knock-out line. iPSC-derived human astrocytes were generated by establishing a differentiation protocol through the consecutive addition of small molecules and growth factors, and the expression of typical markers (GFAP, GLT1, AQP4 and S100beta) and APOE was analysed. In addition, astrocytes exhibited functional features like glutamate uptake capacity and calcium waves production. They also responded to an inflammatory stimulus (IL-1beta and TNF-alpha) or to the presence of amyloid-beta 1-42 peptide by changing their morphology and increasing the expression levels of pro-inflammatory factors and cytokines. Our results shed light on the potential dual role of APOE polymorphism and the individual¿s genetic background in favouring or perhaps preventing AD pathology