Appetite, energy intake, and PYY3-36 responses to energy-matched continuous exercise and submaximal high-intensity exercise.

High-intensity intermittent exercise induces physiological adaptations similar to energy-matched continuous exercise, but the comparative appetite and energy balance responses are unknown. Twelve healthy males (mean ± SD: age, 22 ± 3 years; body mass index, 23.7 ± 3.0 kg·m(-2); maximum oxygen uptake, 52.4 ± 7.1 mL·kg(-1)·min(-1)) completed three 8 h trials (control, steady-state exercise (SSE), high-intensity intermittent exercise (HIIE)) separated by 1 week. Trials commenced upon completion of a standardized breakfast. Exercise was performed from hour 2 to hour 3. In SSE, 60 min of cycling at 59.5% ± 1.6% of maximum oxygen uptake was performed. In HIIE, ten 4-min cycling intervals were completed at 85.8% ± 4.0% of maximum oxygen uptake, with a 2-min rest between each interval. A standardized lunch and an ad libitum afternoon meal were provided at hours 3.75 and 7, respectively. Appetite ratings and peptide YY3-36 concentrations were measured throughout each trial. Appetite was acutely suppressed during exercise, but more so during HIIE (p < 0.05). Peptide YY3-36 concentrations increased significantly upon cessation of exercise in SSE (p = 0.002), but were highest in the hours after exercise in HIIE (p = 0.05). Exercise energy expenditure was not different between HIIE and SSE (p = 0.649), but perceived exertion was higher in HIIE (p < 0.0005). Ad libitum energy intake did not differ between trials (p = 0.833). Therefore, relative energy intake (energy intake minus the net energy expenditure of exercise) was lower in the SSE and HIIE trials than in the control trial (control, 4759 ± 1268 kJ; SSE, 2362 ± 1224 kJ; HIIE, 2523 ± 1402 kJ; p < 0.0005). An acute bout of energy-matched continuous exercise and HIIE were equally effective at inducing an energy deficit without stimulating compensatory increases in appetite

Astroclimatic Characterization of Vallecitos: A candidate site for the Cherenkov Telescope Array at San Pedro Martir

We conducted an 18 month long study of the weather conditions of the Vallecitos, a proposed site in Mexico to harbor the northern array of the Cherenkov Telescope Array (CTA). It is located in Sierra de San Pedro Martir (SPM) a few kilometers away from Observatorio Astron\'omico Nacional. The study is based on data collected by the ATMOSCOPE, a multi-sensor instrument measuring the weather and sky conditions, which was commissioned and built by the CTA Consortium. Additionally, we compare the weather conditions of the optical observatory at SPM to the Vallecitos regarding temperature, humidity, and wind distributions. It appears that the excellent conditions at the optical observatory benefit from the presence of microclimate established in the Vallecitos.Comment: 16 pages, 16 figures, Publication of the Astronomical Society of the Pacific, accepte

Pampering, Well-Being And Women’s Bodies In The Therapeutic Spaces Of The Spa

This is an Author's Accepted Manuscript of an article published in Social and Cultural Geography, 2013, Vol. 14 Issue 1 pp. 41-58 © 2012 copyright Taylor & Francis, available online at: http://www.tandfonline.com/ DOI: 10.1080/14649365.2012.734846This paper develops and extends recent work in geography on therapeutic landscapes and the body in an examination of pampering practices in the contemporary spa. Drawing on feminist research on health, gender identity and the body, the paper explores the importance of escape, relaxation and other strategies to combat stress on the well-being practices and routines of women. Using original data collected from interviews in two spas in the South West of England, the paper argues that a visit to the spa is increasingly being seen as an important part of women’s wider health and bodily maintenance providing a space for relaxation and withdrawal from responsibilities of the home and workplace. The pampering treatments reinforce the therapeutic benefits of the spa creating a sense of luxury and a focus on the self. The paper locates these arguments within the twin theoretical concerns of the ‘care of the self’ and disciplining the body, suggesting that any attempts to understand the practices and therapies for maintaining bodily well-being must incorporate a recognition of their simultaneous role in regulating the size and shape of women’s bodies

WASP-86b and WASP-102b: super-dense versus bloated planets

We report the discovery of two transiting planetary systems: a super dense, sub-Jupiter mass planet WASP-86b (Mpl = 0.82 ± 0.06 MJ; Rpl = 0.63 ± 0.01 RJ), and a bloated, Saturn-like planet WASP-102b (Mpl = 0.62 ± 0.04 MJ; Rpl = 1.27 ± 0.03 RJ). They orbit their host star every ∼5.03, and ∼2.71 days, respectively. The planet hosting WASP-86 is a F7 star (Teff = 6330±110 K, [Fe/H] = +0.23 ± 0.14 dex, and age ∼0.8–1 Gyr); WASP-102 is a G0 star (Teff = 5940±140 K, [Fe/H] = −0.09± 0.19 dex, and age ∼1 Gyr). These two systems highlight the diversity of planetary radii over similar masses for giant planets with masses between Saturn and Jupiter. WASP-102b shows a larger than model-predicted radius, indicating that the planet is receiving a strong incident flux which contributes to the inflation of its radius. On the other hand, with a density of ρpl = 3.24± 0.3 ρJ, WASP-86b is the densest gas giant planet among planets with masses in the range 0.05 Mpl J. With a stellar mass of 1.34 M⊙ and [Fe/H]= +0.23 dex, WASP-86 could host additional massive and dense planets given that its protoplanetary disc is expected to also have been enriched with heavy elements. In order to match WASP-86b’s density, an extrapolation of theoretical models predicts a planet composition of more than 80% in heavy elements (whether confined in a core or mixed in the envelope). This fraction corresponds to a core mass of approximately 210M⊕ for WASP-86b’s mass of Mpl∼260 M⊕. Only planets with masses larger than about 2 MJ have larger densities than that of WASP-86b, making it exceptional in its mass range

Antibody mediated targeting of the FGFR1c isoform increases glucose uptake in white and brown adipose tissue in male mice

The increased prevalence of obesity and its cardiometabolic implications demonstrates the imperative to identify novel therapeutic targets able to effect meaningful metabolic changes in this population. Antibody-mediated targeting of fibroblast growth factor receptor 1c isoform (FGFR1c) has been shown to ameliorate hyperglycaemia and protect from diet- and genetically-induced obesity in rodents and non-human primates. However, it is currently unknown which tissue(s) contribute to this glucose lowering effect. Thus, to elucidate this effect we treated euglycaemic mice with H7, a monoclonal antibody which selectively targets the FGFR1c isoform, and employed whole body positron emission computed tomography with a glucose tracer (18F-flurodeoxyglucose). Treatment with H7 increased basal glucose uptake in white and brown adipose tissues (WAT and BAT respectively), the brain and liver, but reduced it in the quadricep muscles. Consequentially, blood glucose was significantly reduced in response to treatment. Under insulin-stimulated conditions, the effects of H7 were maintained in WAT, BAT, liver and muscle. Treatment with H7 decreased triglyceride content and increased adipose triglyceride lipase content in white adipose tissue, whilst increasing activation of acetyl coenzyme A carboxylase, suggesting futile cycling of triglycerides, albeit favouring net hydrolysis. We demonstrated, in vitro, this is a direct effect of treatment in adipose tissue as basal cellular respiration and glucose uptake were increased in response to treatment. Taken together, these data suggest that antibody-mediated targeting of FGFR1c exerts its powerful glucose-lowering efficacy primarily due to increased glucose uptake in adipose tissue

Where form and substance meet: using the narrative approach of re-storying to generate research findings and community rapprochement in (university) mathematics education

Storytelling is an engaging way through which lived experience can be shared and reflected upon, and a tool through which difference, diversity—and even conflict—can be acknowledged and elaborated upon. Narrative approaches to research bring the richness and vibrancy of storytelling into how data is collected and interpretations of it shared. In this paper, I demonstrate the potency of the narrative approach of re-storying for a certain type of university mathematics education research (non-deficit, non-prescriptive, context-specific, example-centred and mathematically focused) conducted at the interface of two communities: mathematics education and mathematics. I do so through reference to Amongst Mathematicians (Nardi, 2008), a study carried out in collaboration with 20 university mathematicians from six UK mathematics departments. The study deployed re-storying to present data and analyses in the form of a dialogue between two fictional, yet entirely data-grounded, characters—M, mathematician, and RME, researcher in mathematics education. In the dialogues, the typically conflicting epistemologies—and mutual perceptions of such epistemologies—of the two communities come to the fore as do the feasibility-of, benefits-from, obstacles-in and conditions-for collaboration between these communities. First, I outline the use of narrative approaches in mathematics education research. Then, I introduce the study and its use of re-storying, illustrating this with an example: the construction of a dialogue from interview data in which the participating mathematicians discuss the potentialities and pitfalls of visualisation in university mathematics teaching. I conclude by outlining re-storying as a vehicle for community rapprochement achieved through generating and sharing research findings—the substance of research—in forms that reflect the fundamental principles and aims that underpin this research. My conclusions resonate with sociocultural constructs that view mathematics teacher education as contemporary praxis and the aforementioned inter-community discussion as taking place within a third space

WASP-113b and WASP-114b, two inflated hot Jupiters with contrasting densities

Aims. We present the discovery and characterisation of the exoplanets WASP-113b and WASP-114b by the WASP surveys, SOPHIE and CORALIE. Methods. The planetary nature of the systems was established by performing follow-up photometric and spectroscopic observations. The follow-up data were combined with the WASP-photometry and analysed with an MCMC code to obtain system parameters. Results. The host stars WASP-113 and WASP-114 are very similar. They are both early G-type stars with an effective temperature of ~5900 K, [Fe/H] ~ 0.12, and log g~ 4.1 dex. However, WASP-113 is older than WASP-114. Although the planetary companions have similar radii, WASP-114b is almost four times heavier than WASP-113b. WASP-113b has a mass of 0.48 MJup and an orbital period of ~4.5 days; WASP-114b has a mass of 1.77 MJup and an orbital period of ~1.5 days. Both planets have inflated radii, in particular WASP-113 with a radius anomaly of ℜ = 0.35. The high scale height of WASP-113b (~950 km) makes it a good target for follow-up atmospheric observations.Publisher PDFPeer reviewe