85 research outputs found
A functional role of the SNP -592 of human IL10 gene regulatory region is associated with an increased IL-10 expression and risk for human papillomavirus cervical lesion and cervical cancer development
EstandarizaciĂłn del Test de Dependencia al Celular para estudiantes universitarios de Arequipa
The objective of this study is to determine validity and reliability of the Mobile Phone Dependency Test (CPDT), in a 22 items Likert scale-based instrument. The Test was administered to two samples, a public university (N=1044) and a private university (N=356) in the Peruvian city of Arequipa. Validity was determined using an exploratory factor analysis. Three factors were identified: abstinence and tolerance (α=0,901), abuse and problems with impulse control (α=0,853), and problems with excessive mobile phone use (α=0,853). Additionally, percentile ranks were created for both public and private universities.Se aportan evidencias de validez y confiabilidad del Test de Dependencia al MĂłvil, el cual consta de 22 Ătems en una escala tipo Likert. El instrumento fue aplicado a dos muestras de estudiantes de una universidad pĂșblica (N=1044) y otra privada (N=356) de la ciudad de Arequipa. Para analizar su validez, se realizĂł un anĂĄlisis factorial exploratorio. Se identificaron tres factores. El primer factor fue denominado abstinencia y tolerancia (α=0,901); el segundo, abuso y dificultad para controlar el impulso (α=0,853), y el tercero, problemas ocasionados por el uso excesivo (α=0,762). Se crearon normas de administraciĂłn y baremos en percentiles para estudiantes de la universidad pĂșblica y de la privada
EstandarizaciĂłn del Test de Dependencia al Celular para estudiantes universitarios de Arequipa
The objective of this study is to determine validity and reliability of the Mobile Phone
Dependency Test (CPDT), in a 22 items Likert scale-based instrument. The Test was
administered to two samples, a public university (N=1044) and a private university
(N=356) in the Peruvian city of Arequipa. Validity was determined using an exploratory
factor analysis. Three factors were identified: abstinence and tolerance (α=0,901),
abuse and problems with impulse control (α=0,853), and problems with excessive
mobile phone use (α=0,853). Additionally, percentile ranks were created for both public
and private universities.Se aportan evidencias de validez y confiabilidad del Test de Dependencia al MĂłvil, el cual
consta de 22 Ătems en una escala tipo Likert. El instrumento fue aplicado a dos muestras
de estudiantes de una universidad pĂșblica (N=1044) y otra privada (N=356) de la ciudad
de Arequipa. Para analizar su validez, se realizĂł un anĂĄlisis factorial exploratorio.
Se identificaron tres factores. El primer factor fue denominado abstinencia y tolerancia
(α=0,901); el segundo, abuso y dificultad para controlar el impulso (α=0,853), y el
tercero, problemas ocasionados por el uso excesivo (α=0,762). Se crearon normas de
administraciĂłn y baremos en percentiles para estudiantes de la universidad pĂșblica
y de la privada
Uso de compuestos nutracĂ©uticos en nuevas formulaciones de piensos acuĂcolas
Trabajo presentado en las X Jornadas de Acuicultura en el Litoral SuratlĂĄntico: Nuevos retos y perspectivas para la sostenibilidad de la acuicultura, celebrado entre el 22 y 23 de noviembre de 2023 en Huelva.[EN] Different strategies have been followed to improve the aquaculture of main European farmed fish, such as genetic selection, refinements in culture conditions or enhanced feed formulation and management. However,
more knowledge is required to exploit fish phenotypic plasticity to obtain those that better match aquaculture or market conditions. The overall objective of this mini-review is to identify the latest productive traits recently
performed, mainly in commercial carnivorous species, and underlying biological processes that would be susceptible to improve the competitivity of aquaculture sector through nutritional issues. Thus, this work is
framed within the concepts of Circular Economy and Blue Growth, where it is intended to point out the use of natural compounds extracted from seaweeds, microalgae and by-products of the industry for their inclusion in
aquafeeds, allowing a more efficient use of more sustainable vegetable protein sources, and also to evaluate if these nutraceutical compounds counteract detrimental effects observed by nutritional interventions or
environmentally challenged.[ES] La producciĂłn acuĂcola ha seguido diferentes estrategias para su optimizaciĂłn a lo largo de las Ășltimas dĂ©cadas, como el desarrollo de la selecciĂłn genĂ©tica, la mejora de las condiciones de cultivo, o el avance en la
formulaciĂłn y gestiĂłn de los piensos. Sin embargo, se requiere mĂĄs conocimiento para explotar la plasticidad fenotĂpica de los peces para obtener aquellos que se ajusten mejor a las condiciones de la acuicultura o del
mercado. El objetivo general de esta mini-revisiĂłn es identificar los Ășltimos avances realizados recientemente, principalmente en especies carnĂvoras comerciales, y los procesos biolĂłgicos subyacentes que serĂan
susceptibles de mejorar la competitividad del sector acuĂcola a travĂ©s de intervenciones nutricionales. AsĂ, este trabajo se enmarca dentro de los conceptos de EconomĂa Circular y Crecimiento Azul, donde se pretende señalar el uso de compuestos naturales extraĂdos de algas, microalgas y subproductos de la industria para su inclusiĂłn en alimentos acuĂcolas, permitiendo un uso mĂĄs eficiente de fuentes de proteĂnas vegetales mĂĄs sostenibles, y tambiĂ©n evaluar si estos compuestos nutracĂ©uticos son capaces de contrarrestar los efectos perjudiciales observados por las formulaciones inadecuadas o desafiados por factores ambientales estresantes.This work was supported by the Projects âFEDER-UCA18-107182â, âFisioBream-II Call for Young Researchers CEIâ
MAR 2019â, âALGAE4FISH-CEI·MAR Empresa 2018â, âVALINVA-CEI·MAR Empresa 2019â, âSeriBlue-CEI·MAR Empresa 2020â, and co-financed by the spin-off LifeBioencapsulation S.L. (AlmerĂa) and Biotechnology Biopolym S.A. (Granada)
The management of acute venous thromboembolism in clinical practice. Results from the European PREFER in VTE Registry
Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in Europe. Data from real-world registries are necessary, as clinical trials do not represent the full spectrum of VTE patients seen in clinical practice. We aimed to document the epidemiology, management and outcomes of VTE using data from a large, observational database. PREFER in VTE was an international, non-interventional disease registry conducted between January 2013 and July 2015 in primary and secondary care across seven European countries. Consecutive patients with acute VTE were documented and followed up over 12 months. PREFER in VTE included 3,455 patients with a mean age of 60.8 ± 17.0 years. Overall, 53.0 % were male. The majority of patients were assessed in the hospital setting as inpatients or outpatients (78.5 %). The diagnosis was deep-vein thrombosis (DVT) in 59.5 % and pulmonary embolism (PE) in 40.5 %. The most common comorbidities were the various types of cardiovascular disease (excluding hypertension; 45.5 %), hypertension (42.3 %) and dyslipidaemia (21.1 %). Following the index VTE, a large proportion of patients received initial therapy with heparin (73.2 %), almost half received a vitamin K antagonist (48.7 %) and nearly a quarter received a DOAC (24.5 %). Almost a quarter of all presentations were for recurrent VTE, with >80 % of previous episodes having occurred more than 12 months prior to baseline. In conclusion, PREFER in VTE has provided contemporary insights into VTE patients and their real-world management, including their baseline characteristics, risk factors, disease history, symptoms and signs, initial therapy and outcomes
Global urban environmental change drives adaptation in white clover.
Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural clines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters.
Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs).
Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001).
Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio
The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications
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