548 research outputs found
Compliance error compensation in robotic-based milling
The paper deals with the problem of compliance errors compensation in
robotic-based milling. Contrary to previous works that assume that the
forces/torques generated by the manufacturing process are constant, the
interaction between the milling tool and the workpiece is modeled in details.
It takes into account the tool geometry, the number of teeth, the feed rate,
the spindle rotation speed and the properties of the material to be processed.
Due to high level of the disturbing forces/torques, the developed compensation
technique is based on the non-linear stiffness model that allows us to modify
the target trajectory taking into account nonlinearities and to avoid the
chattering effect. Illustrative example is presented that deals with
robotic-based milling of aluminum alloy
The evolution of bits and bottlenecks in a scientific workflow trying to keep up with technology: Accelerating 4D image segmentation applied to nasa data
In 2016, a team of earth scientists directly engaged a team of computer scientists to identify cyberinfrastructure (CI) approaches that would speed up an earth science workflow. This paper describes the evolution of that workflow as the two teams bridged CI and an image segmentation algorithm to do large scale earth science research. The Pacific Research Platform (PRP) and The Cognitive Hardware and Software Ecosystem Community Infrastructure (CHASE-CI) resources were used to significantly decreased the earth science workflow's wall-clock time from 19.5 days to 53 minutes. The improvement in wall-clock time comes from the use of network appliances, improved image segmentation, deployment of a containerized workflow, and the increase in CI experience and training for the earth scientists. This paper presents a description of the evolving innovations used to improve the workflow, bottlenecks identified within each workflow version, and improvements made within each version of the workflow, over a three-year time period
Entanglement dynamics of two qubits under the influence of external kicks and Gaussian pulses
We have investigated the dynamics of entanglement between two spin-1/2 qubits
that are subject to independent kick and Gaussian pulse type external magnetic
fields analytically as well as numerically. Dyson time ordering effect on the
dynamics is found to be important for the sequence of kicks. We show that
"almost-steady" high entanglement can be created between two initially
unentangled qubits by using carefully designed kick or pulse sequences
State of the Art and Future Challenges in Multiple Sclerosis Research and Medical Management: An Insight into the 5th International Porto Congress of Multiple Sclerosis
The 5th International Porto Congress of Multiple Sclerosis took place between the 14th and 16th of February 2019 in Porto, Portugal. Its intensive programme covered a wide-range of themes—including many of the hot topics, challenges, pitfalls and yet unmet needs in the field of multiple sclerosis (MS)—led by a number of well-acknowledged world experts. This meeting review summarizes the talks that took place during the congress, which focussed on issues in MS as diverse as the development and challenges of progressive MS, epidemiology, differential diagnosis, medical management, molecular research and imaging tools
Overview on the phenomenon of two-qubit entanglement revivals in classical environments
The occurrence of revivals of quantum entanglement between separated open
quantum systems has been shown not only for dissipative non-Markovian quantum
environments but also for classical environments in absence of back-action.
While the phenomenon is well understood in the first case, the possibility to
retrieve entanglement when the composite quantum system is subject to local
classical noise has generated a debate regarding its interpretation. This
dynamical property of open quantum systems assumes an important role in quantum
information theory from both fundamental and practical perspectives. Hybrid
quantum-classical systems are in fact promising candidates to investigate the
interplay among quantum and classical features and to look for possible control
strategies of a quantum system by means of a classical device. Here we present
an overview on this topic, reporting the most recent theoretical and
experimental results about the revivals of entanglement between two qubits
locally interacting with classical environments. We also review and discuss the
interpretations provided so far to explain this phenomenon, suggesting that
they can be cast under a unified viewpoint.Comment: 16 pages, 9 figures. Chapter written for the upcoming book "Lectures
on general quantum correlations and their applications
ENGOT-ov-6/TRINOVA-2: Randomised, double-blind, phase 3 study of pegylated liposomal doxorubicin plus trebananib or placebo in women with recurrent partially platinum-sensitive or resistant ovarian cancer
Aims: Trebananib, a peptide-Fc fusion protein, inhibits angiogenesis by inhibiting binding of angiopoietin-1/2 to the receptor tyrosine kinase Tie2. This randomised, double-blind, placebo-controlled phase 3 study evaluated whether trebananib plus pegylated liposomal doxorubicin (PLD) improved progression-free survival (PFS) in patients with recurrent epithelial ovarian cancer. / Methods: Women with recurrent ovarian cancer (platinum-free interval ≤12 months) were randomised to intravenous PLD 50 mg/m2 once every 4 weeks plus weekly intravenous trebananib 15 mg/kg or placebo. PFS was the primary end-point; key secondary end-points were objective response rate (ORR) and duration of response (DOR). Owing to PLD shortages, enrolment was paused for 13 months; the study was subsequently truncated. / Results: Two hundred twenty-three patients were enrolled. Median PFS was 7.6 months (95% CI, 7.2–9.0) in the trebananib arm and 7.2 months (95% CI, 4.8–8.2) in the placebo arm, with a hazard ratio of 0.92 (95% CI, 0.68–1.24). However, because the proportional hazards assumption was not fulfilled, the standard Cox model did not provide a reliable estimate of the hazard ratio. ORR in the trebananib arm was 46% versus 21% in the placebo arm (odds ratio, 3.43; 95% CI, 1.78–6.64). Median DOR was improved (trebananib, 7.4 months [95% CI, 5.7–7.6]; placebo, 3.9 months [95% CI, 2.3–6.5]). Adverse events with a greater incidence in the trebananib arm included localised oedema (61% versus 32%), ascites (29% versus 9%) and vomiting (45% versus 33%). / Conclusions: Trebananib demonstrated anticancer activity in this phase 3 study, indicated by improved ORR and DOR. Median PFS was not improved. No new safety signals were identified. / Trial registration: ClinicalTrials.gov, NCT0128125
Nanomaterial-based Sensors for the Study of DNA Interaction with Drugs
The interaction of drugs with DNA has been searched thoroughly giving rise to an endless number of findings of undoubted importance, such as a prompt alert to harmful substances, ability to explain most of the biological mechanisms, or provision of important clues in targeted development of novel chemotherapeutics. The existence of some drugs that induce oxidative damage is an increasing point of concern as they can cause cellular death, aging, and are closely related to the development of many diseases. Because of a direct correlation between the response, strength/ nature of the interaction and the pharmaceutical action of DNA-targeted drugs, the electrochemical analysis is based on the signals of DNA before and after the interaction with the DNA-targeted drug. Nowadays, nanoscale materials are used extensively for offering fascinating characteristics that can be used in designing new strategies for drug-DNA interaction detection. This work presents a review of nanomaterials (NMs) for the study of drug-nucleic acid interaction. We summarize types of drug-DNA interactions, electroanalytical techniques for evidencing these interactions and quantification of drug and/or DNA monitoring
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