174 research outputs found
A formal concept view of argumentation
International audienceThe paper presents a parallel between two important theories for the treatment of information which address questions that are apparently unrelated and that are studied by different research communities: an enriched view of formal concept analysis and abstract argumentation. Both theories exploit a binary relation (expressing object-property links, attacks between arguments). We show that when an argumentation framework rather considers the complementary relation does not attack, then its stable extensions can be seen as the exact counterparts of formal concepts. This leads to a cube of oppositions, a generalization of the well-known square of oppositions, between eight remarkable sets of arguments. This provides a richer view for argumentation in cases of bi-valued attack relations and fuzzy ones
Acute variceal bleeding in a patient with idiopathic myelofibrosis successfully treated with endoscopic variceal band ligation and chemotherapy: a case report
<p>Abstract</p> <p>Introduction</p> <p>Idiopathic myelofibrosis is a chronic myeloproliferative disorder characterized by leukoerythroblastosis, massive splenomegaly, and increases in the reticular and collagen fibers in the bone marrow. Portal hypertension is observed in some patients with idiopathic myelofibrosis. Gastrointestinal hemorrhages, which are due mostly to the rupture of the esophageal varices, have been sporadically reported to be an infrequent complication of idiopathic myelofibrosis.</p> <p>Case presentation</p> <p>We report a case of a Japanese 63-year-old woman with myelofibrosis and variceal hemorrhage, with a background of concomitant portal and pulmonary hypertension. She was successfully treated through a combination of endoscopic variceal ligation and chemotherapy.</p> <p>Conclusion</p> <p>This is the first known report on the successful application of endoscopic variceal ligation and chemotherapy as the therapeutic procedure for an esophageal variceal hemorrhage in a patient with myelofibrosis.</p
Quantitative Concept Analysis
Formal Concept Analysis (FCA) begins from a context, given as a binary
relation between some objects and some attributes, and derives a lattice of
concepts, where each concept is given as a set of objects and a set of
attributes, such that the first set consists of all objects that satisfy all
attributes in the second, and vice versa. Many applications, though, provide
contexts with quantitative information, telling not just whether an object
satisfies an attribute, but also quantifying this satisfaction. Contexts in
this form arise as rating matrices in recommender systems, as occurrence
matrices in text analysis, as pixel intensity matrices in digital image
processing, etc. Such applications have attracted a lot of attention, and
several numeric extensions of FCA have been proposed. We propose the framework
of proximity sets (proxets), which subsume partially ordered sets (posets) as
well as metric spaces. One feature of this approach is that it extracts from
quantified contexts quantified concepts, and thus allows full use of the
available information. Another feature is that the categorical approach allows
analyzing any universal properties that the classical FCA and the new versions
may have, and thus provides structural guidance for aligning and combining the
approaches.Comment: 16 pages, 3 figures, ICFCA 201
Assessment of left ventricular function by three-dimensional echocardiography.
Accurate determination of LV volume, ejection fraction and segmental wall
motion abnormalities is important for clinical decision-making and
follow-up assessment. Currently, echocardiography is the most common used
method to obtain this information. Three-dimensional echocardiography has
shown to be an accurate and reproducible method for LV quantitation,
mainly by avoiding the use of geometric assumptions. In this review, we
describe various methods to acquire a 3D-dataset for LV volume and wall
motion analysis, including their advantages and limitations. We provide an
overview of studies comparing LV volume and function measurement by
various gated and real-time methods of acquisition compared to magnetic
resonance imaging. New technical improvements, such as automated
endocardial border detection and contrast enhancement, will make accurate
on-line assessment with little operator interaction possible in the near
future
Activating Generalized Fuzzy Implications from Galois Connections
This paper deals with the relation between fuzzy implications and Galois connections, trying to raise the awareness that the fuzzy implications are indispensable to generalise Formal Concept Analysis. The concrete goal of the paper is to make evident that Galois connections, which are at the heart of some of the generalizations of Formal Concept Analysis, can be interpreted as fuzzy incidents. Thus knowledge processing, discovery, exploration and visualization as well as data mining are new research areas for fuzzy implications as they are areas where Formal Concept Analysis has a niche.F.J. Valverde-Albacete—was partially supported by EU FP7 project LiMoSINe, (contract 288024). C. Peláez-Moreno—was partially supported by the Spanish Government-CICYT project 2011-268007/TEC.Publicad
Effects of a Novel Nitroxyl Donor in Acute Heart Failure The STAND-UP AHF Study
Objectives:
The primary objective was to identify well-tolerated doses of cimlanod in patients with acute heart failure (AHF). Secondary objectives were to identify signals of efficacy, including biomarkers, symptoms, and clinical events.
Background:
Nitroxyl (HNO) donors have vasodilator, inotropic and lusitropic effects. Bristol-Myers Squibb-986231 (cimlanod) is an HNO donor being developed for acute heart failure (AHF).
Methods:
This was a phase IIb, double-blind, randomized, placebo-controlled trial of 48-h treatment with cimlanod compared with placebo in patients with left ventricular ejection fraction ≤40% hospitalized for AHF. In part I, patients were randomized in a 1:1 ratio to escalating doses of cimlanod or matching placebo. In part II, patients were randomized in a 1:1:1 ratio to either of the 2 highest tolerated doses of cimlanod from part I or placebo. The primary endpoint was the rate of clinically relevant hypotension (systolic blood pressure <90 mm Hg or patients became symptomatic).
Results:
In part I (n = 100), clinically relevant hypotension was more common with cimlanod than placebo (20% vs. 8%; relative risk [RR]: 2.45; 95% confidence interval [CI]: 0.83 to 14.53). In part II (n = 222), the incidence of clinically relevant hypotension was 18% for placebo, 21% for cimlanod 6 μg/kg/min (RR: 1.15; 95% CI: 0.58 to 2.43), and 35% for cimlanod 12 μg/kg/min (RR: 1.9; 95% CI: 1.04 to 3.59). N-terminal pro–B-type natriuretic peptide and bilirubin decreased during infusion of cimlanod treatment compared with placebo, but these differences did not persist after treatment discontinuation.
Conclusions:
Cimlanod at a dose of 6 μg/kg/min was reasonably well-tolerated compared with placebo. Cimlanod reduced markers of congestion, but this did not persist beyond the treatment period. (Evaluate the Safety and Efficacy of 48-Hour Infusions of HNO (Nitroxyl) Donor in Hospitalized Patients With Heart Failure [STANDUP AHF]; NCT03016325
Observed magnetic resonance imaging changes in pediatric patients treated with stereotactic radiosurgery for intracranial tumors
Primary angioplasty in acute myocardial infarction with right bundle branch block: should new onset right bundle branch block be added to future guidelines as an indication for reperfusion therapy?
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