Visitor profiling at the Museum of Human Evolution of Burgos (Spain)

This paper presents the first study ever conducted on the profile of visitors to the Museum of Human Evolution of Burgos (Spain), which exhibits the finds of the Atapuerca archaeo-paleontological sites. The research was guided by the principles of public communication of science and the methodology of the studies on museum visitors. The analysis reveals a positive perception; the Museum is associated with the sites and they are valued as cultural heritage. Complaints are very limited but useful to produce a set of recommendations to further improve the exhibition. In addition, the findings are placed in the context of similar research carried out at other museums in Spain.Fil: Conforti, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Investigaciones Arqueológicas y Paleontológicas del Cuaternario Pampeano. Universidad Nacional del Centro de la Provincia de Buenos Aires. Investigaciones Arqueológicas y Paleontológicas del Cuaternario Pampeano; ArgentinaFil: Chaparro, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Investigaciones Arqueológicas y Paleontológicas del Cuaternario Pampeano. Universidad Nacional del Centro de la Provincia de Buenos Aires. Investigaciones Arqueológicas y Paleontológicas del Cuaternario Pampeano; ArgentinaFil: Degele, Pamela Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Investigaciones Arqueológicas y Paleontológicas del Cuaternario Pampeano. Universidad Nacional del Centro de la Provincia de Buenos Aires. Investigaciones Arqueológicas y Paleontológicas del Cuaternario Pampeano; ArgentinaFil: Diez Fernandez Lomana, Juan Carlos. Universidad de Burgos; Españ

Comentario sobre el proyecto de modificación del código penal en relación a las medidas de seguridad. Grupo de “etica y legislación” Asociación Española de Neuropsiquiatría (AEN)

El proyecto de modificación del CódigoPenal que propone el Gobierno introduce elementosque pueden ser seriamente lesivos para los derechos ylibertades de las personas que padecen algún trastornomental. El presente documento hace un análisis dedicho proyecto en lo que se refiere especialmente a lasmedidas de seguridad, propone una serie de enmiendasy fija la posición de la AEN en este tema.ABSTRACT: The project of modification of the PenalCode that the Government proposes introduceselements that can be seriously harmful for the rightsand freedoms of the persons who suffer some mentaldisorder. The present document does an analysis of theabove mentioned project in what it refers specially tothe safety measures, proposes a series of amendmentsand fixes the position of the AEN in this topic

Comentario sobre el proyecto de modificación del código penal en relación a las medidas de seguridad. Grupo de “etica y legislación” Asociación Española de Neuropsiquiatría (AEN)

El proyecto de modificación del CódigoPenal que propone el Gobierno introduce elementosque pueden ser seriamente lesivos para los derechos ylibertades de las personas que padecen algún trastornomental. El presente documento hace un análisis dedicho proyecto en lo que se refiere especialmente a lasmedidas de seguridad, propone una serie de enmiendasy fija la posición de la AEN en este tema.ABSTRACT: The project of modification of the PenalCode that the Government proposes introduceselements that can be seriously harmful for the rightsand freedoms of the persons who suffer some mentaldisorder. The present document does an analysis of theabove mentioned project in what it refers specially tothe safety measures, proposes a series of amendmentsand fixes the position of the AEN in this topic

Brain and immune system-derived extracellular vesicles mediate regulation of complement system, extracellular matrix remodeling, brain repair and antigen tolerance in Multiple sclerosis

Background: Multiple sclerosis (MS) is an immune-mediated central nervous system disease whose course is unpredictable. Finding biomarkers that help to better comprehend the disease's pathogenesis is crucial for supporting clinical decision-making. Blood extracellular vesicles (EVs) are membrane-bound particles secreted by all cell types that contain information on the disease's pathological processes. Purpose: To identify the immune and nervous system-derived EV profile from blood that could have a specific role as biomarker in MS and assess its possible correlation with disease state. Results: Higher levels of T cell-derived EVs and smaller size of neuron-derived EVs were associated with clinical relapse. The smaller size of the oligodendrocyte-derived EVs was related with motor and cognitive impairment. The proteomic analysis identified mannose-binding lectin serine protease 1 and complement factor H from immune system cell-derived EVs as autoimmune disease-associated proteins. We observed hepatocyte growth factor-like protein in EVs from T cells and inter-alpha-trypsin inhibitor heavy chain 2 from neurons as white matter injury-related proteins. In patients with MS, a specific protein profile was found in the EVs, higher levels of alpha-1-microglobulin and fibrinogen β chain, lower levels of C1S and gelsolin in the immune system-released vesicles, and Talin-1 overexpression in oligodendrocyte EVs. These specific MS-associated proteins, as well as myelin basic protein in oligodendrocyte EVs, correlated with disease activity in the patients with MS. Conclusion: Neural-derived and immune-derived EVs found in blood appear to be good specific biomarkers in MS for reflecting the disease state.This work was sponsored by a grant from Miguel Servet (CP20/00024 to Laura Otero-Ortega), Miguel Servet (CPII20/00002 to María Gutiérrez-Fernández), a predoctoral fellowship (FI18/00026 to Fernando Laso-García), a Río-Hortega grant (CM22/00065 to Gabriel Torres Iglesias and CM20/00047 to Elisa Alonso-López) and by Research Project (PI21/00918) from the Instituto de Salud Carlos III and co-funded by the European Union and by a grant CA1/RSUE/2021-00753 to Dolores Piniella funded by Ministerio de Universidades, Plan de Recuperación, Transformación y Resiliencia y la Universidad Autónoma de Madrid.S

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Haciéndonos humanos: Análisis de una exhibición científica en Argentina

En este artículo se analiza la exhibición "Evolución: Haciéndonos Humanos" presentada en la megaferia de ciencias de Argentina, TECNÓPOLIS, desde la perspectiva de la comunicación pública de la ciencia. Para su contextualización se realizan algunas apreciaciones generales acerca del surgimiento de las exposiciones de ciencias y su vinculación con los Estados nacionales y el evolucionismo. El abordaje metodológico se basó en los estudios de público que combinan el análisis del guión y la opinión de los visitantes. Este relevamiento se complementó con entrevistas a diferentes actores sociales involucrados en la organización de la muestra, lo que posibilitó un abordaje integral acerca de los procesos de comunicación que esta propone. A partir de los resultados se señalan fortalezas y debilidades de la misma y plantean cuestiones que podrían contribuir a la discusión de la comunicación de contenidos científicos en diferentes contextos.In this article, the exhibition "Evolution: Making us Human" presented in the TECNOPOLIS science megafair in Argentina is analyzed from the perspective of the public communication of science. To contextualize it, a general assessment about the rise of science fairs and their link with the state and evolutionism is made. The methodological approach was based on studies that combine public script analysis and the opinion of visitors. This survey was supplemented by interviews with various stakeholders involved in the organization of the exhibition, enabling a comprehensive analysis of its communication processes. From the results, strengths and weaknesses are identified and they raise issues that could contribute to the discussion of the communication of scientific content in different contexts.Fil: Conforti, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Investigaciones Arqueológicas y Paleontológicas del Cuaternario Pampeano. Universidad Nacional del Centro de la Provincia de Buenos Aires. Investigaciones Arqueológicas y Paleontológicas del Cuaternario Pampeano; ArgentinaFil: Chaparro, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Investigaciones Arqueológicas y Paleontológicas del Cuaternario Pampeano. Universidad Nacional del Centro de la Provincia de Buenos Aires. Investigaciones Arqueológicas y Paleontológicas del Cuaternario Pampeano; ArgentinaFil: Mariano, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Investigaciones Arqueológicas y Paleontológicas del Cuaternario Pampeano. Universidad Nacional del Centro de la Provincia de Buenos Aires. Investigaciones Arqueológicas y Paleontológicas del Cuaternario Pampeano; ArgentinaFil: Díez Fernández Lomana, Carlos. Universidad de Burgos; Españ

Comentario sobre el proyecto de modificación del código penal en relación a las medidas de seguridad. Grupo de “etica y legislación” Asociación Española de Neuropsiquiatría (AEN)

El proyecto de modificación del CódigoPenal que propone el Gobierno introduce elementosque pueden ser seriamente lesivos para los derechos ylibertades de las personas que padecen algún trastornomental. El presente documento hace un análisis dedicho proyecto en lo que se refiere especialmente a lasmedidas de seguridad, propone una serie de enmiendasy fija la posición de la AEN en este tema.ABSTRACT: The project of modification of the PenalCode that the Government proposes introduceselements that can be seriously harmful for the rightsand freedoms of the persons who suffer some mentaldisorder. The present document does an analysis of theabove mentioned project in what it refers specially tothe safety measures, proposes a series of amendmentsand fixes the position of the AEN in this topic

Proyecto PARTIC : cliqueando vamos avanzando

El trabajo no ha sido publicado. El resumen está basado en una ficha elaborada por los autores o el responsableSe ha realizado en el colegio San José-Niño Jesús, centro al que pertenecen el coordinador y los 27 profesores de educación infantil y primaria implicados en el proyecto. Los objetivos de este son mejorar el nivel de implantación de las TIC en la practica habitual del proceso de enseñanza y aprendizaje, llevar la informática al aula, llevar a la clase a la sala de informática, y mejorar la formación del profesorado en TIC. Para estos se han seguido tres pasos: formación del profesorado en TIC; llevar las TIC al proyecto curricular; manejo de aplicaciones CLIC. Se ha realizado una encuesta a los 21 profesores asistentes a la última sesión, de la que cabe destacar que considera como 'muy bien' la 'elevación el nivel de usuario en TIC', y el trabajo con las 'actividades CLIC'; además se cree que favorece el aprendizaje de los alumnos.Consejería de Educación y Juventud de CantabriaES