Análisis de la melodía: oraciones simples vs. compuestas

El objetivo de la investigación que aquí se presenta es comparar la melodía (Frecuencia Fundamental o F0) de un conjunto de oraciones simples (de conclusión y de no conclusión), coordinadas (copulativas y adversativas) y subordinadas (condicionales con si y causales con porque) delimitadas a partir de textos orales, elegidos al azar, emitidos en un estilo semiespontáneo por 43 informantes con un nivel de instrucción medio-alto o alto de las capitales de las Islas Canarias. Nuestro interés se ha centrado en la inflexión final (tonema) y en la dirección de la F0 en tres líneas de declinación trazadas a partir del punto de partida y el punto de llegada de las curvas de F0 (D1) y de los picos de altura tonal: la línea de altura tonal (D2) y la de los valles tonales (D3). El análisis acústico se efectuó con el CSL 4300 de Kay Elemetric Co.The aim of the following research is to compare the melody (the Fundamental Frequency or F0) in a set of simple conclusion and no conclusion sentences, of compound copulative and adversative clauses and of conditional and causal subordinated clauses. These sentences have been chosen at random and taken from semispontaneus speech by 43 middle-high or high level informants, from the very principal cities of the Canary Islands. Our interest has centred on the final inflexion tonema) and the direction of the F0 on three declination lines planned from the initial point to the arrival one of the F0 curves (D1), and from the Turning points: the Topline (D2) and the Baseline or Bottom line (D3). The acoustic analysis was carried out with the CSL 4300 of Kay Elemetric Co.El objetivo de la investigación que aquí se presenta es comparar la melodía (Frecuencia Fundamental o F0) de un conjunto de oraciones simples (de conclusión y de no conclusión), coordinadas (copulativas y adversativas) y subordinadas (condicionales con si y causales con porque) delimitadas a partir de textos orales, elegidos al azar, emitidos en un estilo semiespontáneo por 43 informantes con un nivel de instrucción medio-alto o alto de las capitales de las Islas Canarias. Nuestro interés se ha centrado en la inflexión final (tonema) y en la dirección de la F0 en tres líneas de declinación trazadas a partir del punto de partida y el punto de llegada de las curvas de F0 (D1) y de los picos de altura tonal: la línea de altura tonal (D2) y la de los valles tonales (D3). El análisis acústico se efectuó con el CSL 4300 de Kay Elemetric Co

Propuestas de trabajo innovadoras y colaborativas e-learning 2.0 como demanda de la sociedad del conocimiento

La evolución del tradicional concepto de e-learning está presente, en gran medida, gracias a la introducción de herramientas web 2.0 en los procesos de enseñanza-aprendizaje en la Universidad. Una evolución (e-learning 2.0) que advierte de la promoción de un alumno o alumna comprometido con su aprendizaje, que construye significativamente, que potencia el trabajo en red y que subraya capacidad ante los procesos innovadores mediante el cambio de actitud necesario. El proyecto Redes Interuniversitarias no es más que la verificación y proyección de dichos principios en el intento de la mejora de la calidad

A comprehensive study of reported high metallicity giant HII regions. I. Detailed abundance analysis

We present long-slit observations in the optical and near infrared of fourteen HII regions in the spiral galaxies: NGC 628, NGC 925, NGC 1232 and NGC 1637, all of them reported to have solar or oversolar abundances according to empirical calibrations. For seven of the observed regions, ion-weighted temperatures from optical forbidden auroral to nebular line ratios have been obtained and for six of them, the oxygen abundances derived by standard methods turn out to be significantly lower than solar. The other one, named CDT1 in NGC 1232, shows an oxygen abundance of 12+log(O/H) = 8.95+-0.20 and constitutes, to the best of our knowledge, the first high metallicity HII region for which accurate line temperatures, and hence elemental abundances, have been derived. For the rest of the regions no line temperature measurements could be made and the metallicity has been determined by means of both detailed photoionisation modelling and the sulphur abundance parameter S_23. Only one of these regions shows values of O_23 and S_23 implying a solar or oversolar metallicity. According to our analysis, only two of the observed regions can therefore be considered as of high metallicity. The two of them fit the trends previously found in other high metallicity HII regions, i.e. N/O and S/O abundance ratios seem to be higher and lower than solar respectively.Comment: Accepted for publication by MNRA

Effect of confinement by SARS-CoV-2 on the degree of steatohepatitis in university students from Reynosa, Tamaulipas

Introduction: Healthy lifestyles are relevant for several diseases, steatohepatitis, although little known, is common in young people. There are reasons to be concerned about homebound college youth who are at risk for steatohepatitis. By restricting the mobility of the population, the risk factors for weight gain and the intake of calorie-dense foods increase, which are elements associated with steatohepatitis. Objective: To determine the effect of confinement during the COVID-19 pandemic on the degree of steatohepatitis by comparing transient elastography results taken before and after confinement. Method: Longitudinal study. A sample of 114 young university students of random sex was included. The transient elastography technique (FibroScan) was implemented, determining the degrees of steatosis and hepatic fibrosis by performing the test before and after the confinement of the participants. Student´s t-test was used to analyse the differences in the degrees of steatohepatitis before and after confinement. Results: the degrees of steatosis during the first sampling were S0 (52.6%), S1 (14.9%), S2 (5.3%) and S3 (27.2%) (m = 250.89, DE= ± 56.91), in the second sampling were presented S0 (56.1%), S1 (13.2%), S2 (5.3%) and S3 (5.4%) (m = 243.81, DE = ± 52.330), the relation of both samples was (p = 0.131). The results in the degrees of fibrosis in the first sampling were F0 (91.4%), F1 (6.1%). F2 (2.6%) (m= 4.80, DE = ±1.11), in the second F1 (95.6%), F2 (3.5) and F2 (0.9%) (m = 4.33, DE = ±1.16) and the relation of the two sampling was (p= 0.000). Conclusions: The degrees of hepatic fibrosis presented significant changes, on the other hand, steatosis tends to decrease, but the change is not significant, however, it is necessary to investigate with third variables to detect other factors involved in the changes

Pharmacogenetic Modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease.

Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expansion of a CAG repeat in the huntingtin (htt) gene, which results in an aberrant form of the protein (mhtt). This leads to motor and cognitive deficits associated with corticostriatal and hippocampal alterations. The levels of STriatal-Enriched protein tyrosine Phosphatase (STEP), a neural-specific tyrosine phosphatase that opposes the development of synaptic strengthening, are decreased in the striatum of HD patients and also in R6/1 mice, thereby contributing to the resistance to excitotoxicity described in this HD mouse model. Here, we aimed to analyze whether STEP inactivation plays a role in the pathophysiology of HD by investigating its effect on motor and cognitive impairment in the R6/1 mouse model of HD. We found that genetic deletion of STEP delayed the onset of motor dysfunction and prevented the appearance of cognitive deficits in R6/1 mice. This phenotype was accompanied by an increase in pERK1/2 levels, a delay in the decrease of striatal DARPP-32 levels and a reduction in the size of mhtt aggregates, both in the striatum and CA1 hippocampal region. We also found that acute pharmacological inhibition of STEP with TC-2153 improved cognitive function in R6/1 mice. In conclusion, our results show that deletion of STEP has a beneficial effect on motor coordination and cognition in a mouse model of HD suggesting that STEP inhibition could be a good therapeutic strategy in HD patients

C-GOALS II. Chandra Observations of the Lower Luminosity Sample of Nearby Luminous Infrared Galaxies in GOALS

We analyze Chandra X-ray observatory data for a sample of 63 luminous infrared galaxies (LIRGs), sampling the lower-infrared luminosity range of the Great Observatories All-Sky LIRG survey (GOALS), which includes the most luminous infrared selected galaxies in the local universe. X-rays are detected for 84 individual galaxies within the 63 systems, for which arcsecond resolution X-ray images, fluxes, infrared and X-ray luminosities, spectra and radial profiles are presented. Using X-ray and MIR selection criteria, we find AGN in (31$\pm$5)% of the galaxy sample, compared to the (38$\pm$6)% previously found for GOALS galaxies with higher infrared luminosities (C-GOALS I). Using mid-infrared data, we find that (59$\pm$9)% of the X-ray selected AGN in the full C-GOALS sample do not contribute significantly to the bolometric luminosity of the host galaxy. Dual AGN are detected in two systems, implying a dual AGN fraction in systems that contain at least one AGN of (29$\pm$14)%, compared to the (11$\pm$10)% found for the C-GOALS I sample. Through analysis of radial profiles, we derive that most sources, and almost all AGN, in the sample are compact, with half of the soft X-ray emission generated within the inner $\sim 1$ kpc. For most galaxies, the soft X-ray sizes of the sources are comparable to those of the MIR emission. We also find that the hard X-ray faintness previously reported for the bright C-GOALS I sources is also observed in the brightest LIRGs within the sample, with $L_{\rm FIR}>8\times10^{10}$ L$_{\odot}$.Comment: 24 pages, 13 figures, 11 tables, accepted for publication in A&

Activation of pro- and anti-inflammatory responses in lung tissue injury during the acute phase of PRRSV-1 infection with the virulent strain Lena

Porcine reproductive and respiratory syndrome virus (PRRSV) plays a key role in porcine respiratory disease complex modulating the host immune response and favouring secondary bacterial infections. Pulmonary alveolar macrophages (PAMs) are the main cells supporting PRRSV replication, with CD163 as the essential receptor for viral infection. Although interstitial pneumonia is by far the representative lung lesion, suppurative bronchopneumonia is described for PRRSV virulent strains. This research explores the role of several immune markers potentially involved in the regulation of the inflammatory response and sensitisation of lung to secondary bacterial infections by PRRSV-1 strains of different virulence. Conventional pigs were intranasally inoculated with the virulent subtype 3 Lena strain or the low virulent subtype 1 3249 strain and euthanised at 1, 3, 6 and 8 dpi. Lena-infected pigs exhibited more severe clinical signs, macroscopic lung score and viraemia associated with an increase of IL-6 and IFN-γ in sera compared to 3249-infected pigs. Extensive areas of lung consolidation corresponding with suppurative bronchopneumonia were observed in Lena-infected pigs. Lung viral load and PRRSV-N-protein+ cells were always higher in Lena-infected animals. PRRSV-N-protein+ cells were linked to a marked drop of CD163+ macrophages. The number of CD14+ and iNOS+ cells gradually increased along PRRSV-1 infection, being more evident in Lena-infected pigs. The frequency of CD200R1+ and FoxP3+ cells peaked late in both PRRSV-1 strains, with a strong correlation between CD200R1+ cells and lung injury in Lena-infected pigs. These results highlight the role of molecules involved in the earlier and higher extent of lung lesions in piglets infected with the virulent Lena strain, pointing out the activation of routes potentially involved in the restraint of the local inflammatory response.info:eu-repo/semantics/acceptedVersio