Heatwaves, droughts, and fires: exploring compound and cascading dry hazards at the pan-European scale

Compound and cascading natural hazards usually cause more severe impacts than any of the single hazard events alone. Despite the significant impacts of compound hazards, many studies have only focused on single hazards. The aim of this paper is to investigate spatio-temporal patterns of compound and cascading hazards using historical data for dry hazards, namely heatwaves, droughts, and fires across Europe. We streamlined a simple methodology to explore the occurrence of such events on a daily basis. Droughts in soil moisture were analyzed using time series of a threshold-based index, obtained from the LISFLOOD hydrological model forced with observations. Heatwave and fire events were analyzed using the ERA5-based temperature and Fire Weather Index datasets. The data used in this study relates to the summer seasons from 1990 to 2018. Our results show that joint dry hazard occurrences were identified in west, central, and east Europe, and with a lower frequency in southern Europe and eastern Scandinavia. Drought plays a substantial role in the occurrence of the compound and cascading events of dry hazards, especially in southern Europe as it drives duration of cascading events. Moreover, drought is the most frequent hazard-precursor in cascading events, followed by compound drought-fire events. Changing the definition of a cascading dry hazard by increasing the number of days without a hazard from 1 to 21 within the event (inter-event criterion), lowers as expected, the maximum number of cascading events from 94 to 42, and extends the maximum average duration of cascading events from 38 to 86 days. We had to use proxy observed data to determine the three selected dry hazards because long time series of reported dry hazards do not exist. A complete and specific database with reported hazards is a prerequisite to obtain a more comprehensive insight into compound and cascading dry hazards

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

ecmwf/caliver: caliver 1.0

This is the first stable release

The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas

The oncogenic transcription factor Myc is required for the progression and maintenance of diverse tumors. This has led to the concept that Myc itself, Myc-activated gene products, or associated biological processes might constitute prime targets for cancer therapy. Here, we present an in vivo reverse-genetic screen targeting a set of 241 Myc-activated mRNAs in mouse B-cell lymphomas, unraveling a critical role for the mitochondrial ribosomal protein (MRP) Ptcd3 in tumor maintenance. Other MRP-coding genes were also up regulated in Myc-induced lymphoma, pointing to a coordinate activation of the mitochondrial translation machinery. Inhibition of mitochondrial translation with the antibiotic Tigecycline was synthetic-lethal with Myc activation, impaired respiratory activity and tumor cell survival in vitro, and significantly extended lifespan in lymphoma-bearing mice. We have thus identified a novel Myc-induced metabolic dependency that can be targeted by common antibiotics, opening new therapeutic perspectives in Myc-overexpressing tumors

LEXIS weather and climate large-scale pilot

The LEXIS Weather and Climate Large-scale Pilot will deliver a system for prediction of water-food-energy nexus phenomena and their associated socio-economic impacts. The system will be based on multiple model layers chained together, namely global weather and climate models, high-resolution regional weather models, domain-specific application models (such as hydrological, forest fire risk forecasts), impact models providing information for key decision and policy makers (such as air quality, agriculture crop production, and extreme rainfall detection for flood mapping). This paper will report about the first results of this pilot in terms of serving model output data and products with Cloud and High Performance Data Analytics (HPDA) environments, on top a Weather Climate Data APIs (ECMWF), as well as the porting of models on the LEXIS Infrastructure via different virtualization strategies (virtual machine and containers)

A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial

Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in 'real-world' services

Effects of pre‐operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study

We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05-1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4-7 days or >= 8 days of 1.25 (1.04-1.48), p = 0.015 and 1.31 (1.11-1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care