Combining CV and RP data: a note on the relationship between consistency and rationality

In this paper, we show that, when combining revealed (RP) and stated (SP) data, for marginal changes in quality of environmental goods, rationality implies consistency, as the consistency conditions coincide with a subset of the conditions for rationality.combined (RP and SP) individual data; rationality; data consistency

SHStream: Self-Healing Framework for HTTP Video-Streaming

HTTP video-streaming is leading delivery of video content over the Internet. This phenomenon is explained by the ubiquity of web browsers, the permeability of HTTP traffic and the recent video technologies around HTML5. However, the inclusion of multimedia requests imposes new requirements on web servers due to responses with lifespans that can reach dozens of minutes and timing requirements for data fragments transmitted during the response period. Consequently, web- servers require real-time performance control to avoid playback outages caused by overloading and performance anomalies. We present SHStream , a self-healing framework for web servers delivering video-streaming content that provides (1) load admit- tance to avoid server overloading; (2) prediction of performance anomalies using online data stream learning algorithms; (3) continuous evaluation and selection of the best algorithm for prediction; and (4) proactive recovery by migrating the server to other hosts using container-based virtualization techniques. Evaluation of our framework using several variants of Hoeffding trees and ensemble algorithms showed that with a small number of learning instances, it is possible to achieve approximately 98% of recall and 99% of precision for failure predictions. Additionally, proactive failover can be performed in less than 1 secon

Combining Averting Behavior and Contingent Valuation Data: An Application to Drinking Water Treatment

This paper is an empirical application that combines averting behavior with contingent valuation data. Consistency tests are performed incorporating alternative heteroscedastic structures in the bivariate probit models by taking advantage of the different information content that characterizes each data source. We look at three covariates not yet examined in the literature when combining stated and revealed preferred data to explain the variance in the models: income, the bid in the contingent valuation questionnaire, and the distance between the bid and the averting expenditures with drinking water. The models estimated include between and within data sources heteroscedasticity. The results obtained allow the combination of the two data sources under a common preference structure.averting behavior, combination of data sets, consistency tests, contingent valuation, revealed preferred data

Reboot-based Recovery of Performance Anomalies in Adaptive Bitrate Video-Streaming Services

Performance anomalies represent one common type of failures in Internet servers. Overcoming these failures without introducing server downtimes is of the utmost importance in video-streaming services. These services have large user abandon- ment costs when failures occur after users watch a significant part of a video. Reboot is the most popular and effective technique for overcoming performance anomalies but it takes several minutes from start until the server is warmed-up again to run at its full capacity. During that period, the server is unavailable or provides limited capacity to process end-users’ requests. This paper presents a recovery technique for performance anomalies in HTTP Streaming services, which relies on Container-based Virtualization to implement an efficient multi-phase server reboot technique that minimizes the service downtime. The recovery process includes analysis of variance of request-response times to delimit the server warm-up period, after which the server is running at its full capacity. Experimental results show that the Virtual Container recovery process completes in 72 seconds, which contrasts with the 434 seconds required for full operating system recovery. Both recovery types generate service downtimes imperceptible to end-users

Plant protein blends in diets for Senegalese sole affect skeletal muscle growth, flesh texture and the expression of related genes

Author's accepted version (postprint).Available from 26/11/2017.Skeletal muscle growth and flesh quality of Senegalese sole fed diets containing increasing levels of plant protein blends to replace fishmeal were evaluated using muscle cellularity, texture profile and gene expression. A control fish meal-based diet (FM) was compared with three isonitrogenous (54%) and isolipidic (9%) diets with increasing levels of plant protein (PP) blends (50% PP50, 75% PP75 and 100% PP100). By the end of the experiment sole fed PP50 and PP75 had a final body length similar to the CTR (25 cm), but fish fed PP100 were significantly smaller (23 cm). Total FM replacement by PP sources resulted in significantly smaller muscle cross sectional area (CSA) mainly due to a decrease in the muscle fibre size as the total number of fibres did not vary significantly among treatments. The dietary incorporation of PP significantly reduced the expression of several key genes involved in myogenesis and muscle growth (mrf4, fgf6, myhc and mylc2). Fillet texture analysed instrumentally was affected by the total substitution of FM. Fish fed PP100 diet had a significantly higher modulus of elasticity, i.e. lower flesh stiffness, compared with the other groups. Muscle fibre size was moderately related (r = − 0.573) to the modulus of elasticity and positively correlated with the expression of lysyl oxidase (r = 0.495). The observed changes in muscle cellularity could not be associated with the expression of texture-related genes (capn2, ctsb, ctsd), since no significant differences were observed among diets. The present results point towards a modulation of the expression of several muscle growth related genes by increasing levels of PP sources that alter muscle cellularity and textural properties of Senegalese sole when total FM is replaced by PP

Cyclobenzaprine raises ROS levels in Leishmania infantum and reduces parasite burden in Infected mice

11 p.-5 fig. Ferreira Cunha-Júnior, Edézio et al.Background The leishmanicidal action of tricyclic antidepressants has been studied and evidences have pointed that their action is linked to inhibition of trypanothione reductase, a key enzyme in the redox metabolism of pathogenic trypanosomes. Cyclobenzaprine (CBP) is a tricyclic structurally related to the antidepressant amitriptyline, differing only by the presence of a double bond in the central ring. This paper describes the effect of CBP in experimental visceral leishmaniasis, its inhibitory effect in trypanothione reductase and the potential immunomodulatory activity.Methodology/Principal Findings In vitro antileishmanial activity was determined in promastigotes and in L. infantum-infected macrophages. For in vivo studies, L. infantum-infected BALB/c mice were treated with CBP by oral gavage for five days and the parasite load was estimated. Trypanothione reductase activity was assessed in the soluble fraction of promastigotes of L. infantum. For evaluation of cytokines, L. infantum-infected macrophages were co-cultured with BALB/c splenocytes and treated with CBP for 48 h. The supernatant was analyzed for IL-6, IL-10, MCP-1, IFN-γ and TNF-α. CBP demonstrated an IC50 of 14.5±1.1μM and an IC90 of 74.5±1.2 μM in promastigotes and an IC50 of 12.6±1.05 μM and an IC90 of 28.7±1.3 μM in intracellular amastigotes. CBP also reduced the parasite load in L. infantum-infected mice by 40.4±10.3% and 66.7±10.5% in spleen at 24.64 and 49.28 mg/kg, respectively and by 85.6±5.0 and 89.3±4.8% in liver at 24.64 and 49.28mg/kg, after a short-term treatment. CBP inhibited the trypanothione reductase activity with a Ki of 86 ± 7.7 μM and increased the ROS production in promastigotes. CBP inhibited in 53% the production of IL-6 in infected macrophages coculture.Conclusion/Significance To the best of our knowledge, this study is the first report of the in vivo antileishmanial activity of the FDA-approved drug CBP. Modulation of immune response and induction of oxidative stress in parasite seem to contribute to this efficacy.This work was supported by Programa Estratégico de Apoio à Pesquisa em Saúde,FIOCRUZ/Conselho Nacional de Desenvolvimento Científico e Tecnológico - www.cnpq.br, (PAPES/ CNPq 407680/2012-8 to ECTS and 407590/2012-9 to EEAA), Fundação de Apoio a Pesquisa do Estado do Rio de Janeiro ± www.faperj.br (Fellow and grant E-26/010.001828/2016 to EFCJ), Conselho Nacional de Desenvolvimento CientõÂfico e TecnoloÂgico (CNPq/Universal grant 470627/2013-1 to EEAA), São Paulo Research Foundation - www.fapesp.br (FAPESP 2015/23403-9 to AGT),Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad FEDER - www.idi.mineco.gob.es/ (SAF2015-65740-R) and Subdirección General de Redes y Centros de Investigación Cooperativa-FEDER -www.isciii.es/ (RD12/0018/0007) (to LR).Peer reviewe

Monitoring programmes: the fundamental component of estuaries management: how to design one?

This article focuses on the design of a conceptual framework to design and assess environmental estuarine monitoring programmes, including the networks, to detect quality status changes in coastal areas within environmental management programmes. Monitoring is a fundamental component in any management system, and in particular in sensitive areas under strong human pressures, like estuaries. These pressures will be reflected in impacts in the ecosystem and also in responses from it. A monitoring program including the network and the indicators measured, should be designed to be able to identify the i) pressures, ii) the state and effects, and iii) the responses of human action in the estuary according to casualty chains, also the monitoring performance should be measured to assess the effectiveness of the monitoring program itself. Answers to these needs are studied in this article, namely in what concerns the selection and location of the monitoring stations. To evaluate the “best” monitoring design one should first clearly identify the objectives of the network and which indicators (in the sense of important variables that reflect environmental attributes) are most appropriate for the particular situation. In this work two methods for monitoring network design will be evaluated, namely i) variance-reduction based, and ii) space-filling. These two are examples of a statistically-based method, and of a random-allocation-based method. The most appropriate objective functions are used to reflect the objectives of the monitoring. In all cases the objective function models are solved with the simulated annealing meta-heuristic algorithm, implemented by the team to solve monitoring optimisation problems. Due to the amount and quality of the information available, the Sado estuary is used as a case-study to demonstrate the results of the methods and helping in the comparative analysis.info:eu-repo/semantics/publishedVersio

The effects of different concentrations of the α2-Adrenoceptor Agonist Medetomidine on basal excitatory synaptic transmission and synaptic plasticity in hippocampal slices of adult mice

α2-Adrenoceptor agonists are used frequently in human and veterinary anesthesia as sedative/analgesic drugs. However, they can impair cognition. Little is known about the concentration-dependent effects of α2-adrenoceptor agonists on synaptic plasticity, the neurophysiological basis of learning and memory. Therefore, we investigated the effects of different concentrations of medetomidine, an α2-adrenoceptor agonist, on basal excitatory synaptic transmission and on 2 forms of synaptic plasticity: paired-pulse facilitation (PPF) and long-term potentiation (LTP).Funding: This work was supported by FCT (Lisbon, Portugal) and cofunded by COMPETE: 01-0124-FEDER-009497 (Lisbon, Portugal), through the project grants PTDC/CVT/099022/2008 and PTDC/SAU-NSC/122254/2010 and through a personal PhD grant (SFRH /BD/48883/2008) to Patrícia do Céu Oliveira Ribeiro and by QREN (09-68-ESR-FP-010).info:eu-repo/semantics/publishedVersio

Role of Visual Assessment of High-Quality Cakes in Emotional Response of Consumers

[EN] Thinking of the present gastronomic trends is inevitable when talking about innovation in haute pastry. Launching a successful product that meets consumers' high expectations despite the rising demand for new creations is increasingly complex. For this reason, sensory analysis studies are more and more interested in studying the emotional response evoked by these products to better understand and improve user experiences. The main goal of this work was to conduct a study to analyze the emotional arousal of consumers after the visualization of five haute patisserie cakes. An online questionnaire with the EsSense Profile (R) scale and CATA methodology were used for data collection. The EsSense Profile (R) is a predefined and validated scale that measures food-related emotions, which includes 39 terms. When analyzing the emotions expressed by all the participants, 22 were statistically significant, of which 14 were classified as positive, 6 as neutral, and only 2 were negative. By analyzing the responses by gender, we observed differences in the number of elicited emotional terms: females showed significant differences between cakes for 18 emotion terms compared to 8 terms for males. The results obtained support the importance of the emotional profile to understand consumers' expectations and behavior.Author Cunha acknowledges financial support from National Funds from FCT-Fundacao para a Ciencia e a Tecnologia within the scope of UIDB/05748/2020 and UIDP/05748/2020.Alba-Martínez, J.; Bononad-Olmo, A.; Igual Ramo, M.; Cunha, LM.; Martínez-Monzó, J.; García-Segovia, P. (2022). Role of Visual Assessment of High-Quality Cakes in Emotional Response of Consumers. Foods. 11(10):1-15. https://doi.org/10.3390/foods11101412115111