Siderophores as anchors in artificial metalloenzymes

Fundacao de Amparo a Pesquisa do Estado de Sao PauloConselho Nacional de Desenvolvimento Cientifico e TecnologicoCAPESInst Chem UNESP, Araraquara, SP, Brazil|Univ Fed Sao Paulo, EPM, Dept Pharmacol, Sao Paulo, SP, BrazilInst Chem USP, Sao Carlos, SP, BrazilUniv Fed Sao Paulo, EPM, Dept Pharmacol, Sao Paulo, SP, BrazilFAPESP: 2016/177115CNPqCAPESWeb of Scienc

Synthesis, characterization, and thermal behavior of palladium(II) coordination compounds containing isonicotinamide

Palladium(II) coordination compounds of general formula trans-[PdX(2)(isn)(2)], X = Cl(-) (1), N(3) (-) (2), SCN(-) (3), NCO(-) (4), isn = isonicotinamide; were synthesized and characterized in solid state by elemental analysis, infrared spectroscopy, and simultaneous TG-DTA. TG experiments reveal that the compounds 1-4 undergo thermal decomposition in three or four stages, yielding Pd(0) as final residue, according to calculus and identification by X-ray powder diffraction

Pyrazolyl Pd(II) complexes containing triphenylphosphine: Synthesis and antimycobacterial activity

Complexes of the type trans-[PdCl2(HL)(PPh3)], where HL = pyrazole (1); 3,5-dimethylpyrazole (2); 4-nitropyrazole (3); 4-iodopyrazole (4) and PPh3 = triphenylphosphine, were synthesized and characterized by elemental analyses, infrared and H-1 NMR spectroscopies. Single-crystal X-ray diffraction determination on 3.0.9 CHCl3 and 4 showed that the coordination geometry around Pd(II) is nearly square-planar, with the chloro ligands in a trans configuration. In vitro antimycobacterial evaluation demonstrated that compound 4 displayed a minimum inhibitory concentration (MIC) of 7.61 +/- 2.18 mu M, being superior to the values observed for some commonly used antituberculosis drugs and other metal-based complexes. (C) 2015 Elsevier Ltd. All rights reserved